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Vaccine strategies for prevention of community-acquired pneumonia in Canada: Who would benefit most from pneumococcal immunization?

Kaplan A, Arsenault P, Aw B, Brown V, Fox G, Grossman R, Jadavji T, Laferrière C, Levitz S, Loeb M, McIvor A, Mody CH, Poulin Y, Shapiro M, Tessier D, Théorêt F, Weiss K, Yaremko J, Zhanel G.

Can Fam Physician. 2019 Sep;65(9):625-633. Review.


A longitudinal characterization of the Non-Cystic Fibrosis Bronchiectasis airway microbiome.

Woo TE, Lim R, Heirali AA, Acosta N, Rabin HR, Mody CH, Somayaji R, Surette MG, Sibley CD, Storey DG, Parkins MD.

Sci Rep. 2019 May 3;9(1):6871. doi: 10.1038/s41598-019-42862-y.


Natural killer cells kill Burkholderia cepacia complex via a contact-dependent and cytolytic mechanism.

Li SS, Saleh M, Xiang RF, Ogbomo H, Stack D, Huston SH, Mody CH.

Int Immunol. 2019 May 21;31(6):385-396. doi: 10.1093/intimm/dxz016.


Microbial killing by NK cells.

Mody CH, Ogbomo H, Xiang RF, Kyei SK, Feehan D, Islam A, Li SS.

J Leukoc Biol. 2019 Jun;105(6):1285-1296. doi: 10.1002/JLB.MR0718-298R. Epub 2019 Mar 1. Review.


Granule-Dependent NK Cell Killing of Cryptococcus Requires Kinesin to Reposition the Cytolytic Machinery for Directed Cytotoxicity.

Ogbomo H, Timm-McCann M, Barnes T, Xiang RF, Jamil K, Ganguly A, Stack D, Huston SM, Li SS, Colarusso P, Mody CH.

Cell Rep. 2018 Sep 11;24(11):3017-3032. doi: 10.1016/j.celrep.2018.08.027.


β1 Integrins Are Required To Mediate NK Cell Killing of Cryptococcus neoformans.

Xiang RF, Li S, Ogbomo H, Stack D, Mody CH.

J Immunol. 2018 Oct 15;201(8):2369-2376. doi: 10.4049/jimmunol.1701805. Epub 2018 Sep 10.


Epidemiology and natural history of Pseudomonas aeruginosa airway infections in non-cystic fibrosis bronchiectasis.

Woo TE, Lim R, Surette MG, Waddell B, Bowron JC, Somayaji R, Duong J, Mody CH, Rabin HR, Storey DG, Parkins MD.

ERJ Open Res. 2018 Jun 18;4(2). pii: 00162-2017. doi: 10.1183/23120541.00162-2017. eCollection 2018 Apr.


Effectiveness of a standardized electronic admission order set for acute exacerbation of chronic obstructive pulmonary disease.

Pendharkar SR, Ospina MB, Southern DA, Hirani N, Graham J, Faris P, Bhutani M, Leigh R, Mody CH, Stickland MK.

BMC Pulm Med. 2018 May 30;18(1):93. doi: 10.1186/s12890-018-0657-x.


Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida.

Li SS, Ogbomo H, Mansour MK, Xiang RF, Szabo L, Munro F, Mukherjee P, Mariuzza RA, Amrein M, Vyas JM, Robbins SM, Mody CH.

Nat Commun. 2018 Feb 21;9(1):751. doi: 10.1038/s41467-018-03014-4.


Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis.

Lee EKS, Gillrie MR, Li L, Arnason JW, Kim JH, Babes L, Lou Y, Sanati-Nezhad A, Kyei SK, Kelly MM, Mody CH, Ho M, Yipp BG.

Cell Host Microbe. 2018 Jan 10;23(1):121-133.e4. doi: 10.1016/j.chom.2017.11.009. Epub 2017 Dec 28.


Epidemiology and trends of cryptococcosis in the United States from 2000 to 2007: A population-based study.

Shaheen AA, Somayaji R, Myers R, Mody CH.

Int J STD AIDS. 2018 Apr;29(5):453-460. doi: 10.1177/0956462417732649. Epub 2017 Oct 3.


Cryptococcal Lung Infections.

Skolnik K, Huston S, Mody CH.

Clin Chest Med. 2017 Sep;38(3):451-464. doi: 10.1016/j.ccm.2017.04.007. Review.


Granule-Dependent Natural Killer Cell Cytotoxicity to Fungal Pathogens.

Ogbomo H, Mody CH.

Front Immunol. 2017 Jan 11;7:692. doi: 10.3389/fimmu.2016.00692. eCollection 2016. Review.


Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation.

Xu H, Su C, Pearson A, Mody CH, Zheng C.

J Virol. 2017 Mar 13;91(7). pii: e00025-17. doi: 10.1128/JVI.00025-17. Print 2017 Apr 1.


NKp46 Is an NK Cell Fungicidal Pattern Recognition Receptor.

Li SS, Mody CH.

Trends Microbiol. 2016 Dec;24(12):929-931. doi: 10.1016/j.tim.2016.10.002. Epub 2016 Nov 3.


TNFα Augments Cytokine-Induced NK Cell IFNγ Production through TNFR2.

Almishri W, Santodomingo-Garzon T, Le T, Stack D, Mody CH, Swain MG.

J Innate Immun. 2016;8(6):617-629. Epub 2016 Aug 25.


A Series of Transbronchial Removal of Intracavitary Pulmonary Aspergilloma.

Stather DR, Tremblay A, Dumoulin E, MacEachern P, Chee A, Hergott C, Gelberg J, Gelfand GA, Burrowes P, MacGregor JH, Mody CH.

Ann Thorac Surg. 2017 Mar;103(3):945-950. doi: 10.1016/j.athoracsur.2016.08.069. Epub 2016 Oct 17.


Mechanisms by Which Interleukin-12 Corrects Defective NK Cell Anticryptococcal Activity in HIV-Infected Patients.

Kyei SK, Ogbomo H, Li S, Timm-McCann M, Xiang RF, Huston SM, Ganguly A, Colarusso P, Gill MJ, Mody CH.

mBio. 2016 Aug 23;7(4). pii: e00878-16. doi: 10.1128/mBio.00878-16.


Fungal Infection in the Brain: What We Learned from Intravital Imaging.

Shi M, Mody CH.

Front Immunol. 2016 Aug 2;7:292. doi: 10.3389/fimmu.2016.00292. eCollection 2016. Review.


Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing.

Huston SM, Ngamskulrungroj P, Xiang RF, Ogbomo H, Stack D, Li SS, Timm-McCann M, Kyei SK, Oykhman P, Kwon-Chung KJ, Mody CH.

J Immunol. 2016 Feb 1;196(3):1259-71. doi: 10.4049/jimmunol.1501089. Epub 2016 Jan 6.


Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.

Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13936-41. doi: 10.1073/pnas.1404769111. Epub 2014 Sep 9.


Twenty-five-year outbreak of Pseudomonas aeruginosa infecting individuals with cystic fibrosis: identification of the prairie epidemic strain.

Parkins MD, Glezerson BA, Sibley CD, Sibley KA, Duong J, Purighalla S, Mody CH, Workentine ML, Storey DG, Surette MG, Rabin HR.

J Clin Microbiol. 2014 Apr;52(4):1127-35. doi: 10.1128/JCM.03218-13. Epub 2014 Jan 22.


The NK receptor NKp30 mediates direct fungal recognition and killing and is diminished in NK cells from HIV-infected patients.

Li SS, Kyei SK, Timm-McCann M, Ogbomo H, Jones GJ, Shi M, Xiang RF, Oykhman P, Huston SM, Islam A, Gill MJ, Robbins SM, Mody CH.

Cell Host Microbe. 2013 Oct 16;14(4):387-97. doi: 10.1016/j.chom.2013.09.007.


Requirement and redundancy of the Src family kinases Fyn and Lyn in perforin-dependent killing of Cryptococcus neoformans by NK cells.

Oykhman P, Timm-McCann M, Xiang RF, Islam A, Li SS, Stack D, Huston SM, Ma LL, Mody CH.

Infect Immun. 2013 Oct;81(10):3912-22. doi: 10.1128/IAI.00533-13. Epub 2013 Aug 5.


An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation.

Islam A, Li SS, Oykhman P, Timm-McCann M, Huston SM, Stack D, Xiang RF, Kelly MM, Mody CH.

PLoS Pathog. 2013;9(7):e1003439. doi: 10.1371/journal.ppat.1003439. Epub 2013 Jul 11.


Myxoma virus infection promotes NK lysis of malignant gliomas in vitro and in vivo.

Ogbomo H, Zemp FJ, Lun X, Zhang J, Stack D, Rahman MM, McFadden G, Mody CH, Forsyth PA.

PLoS One. 2013 Jun 10;8(6):e66825. doi: 10.1371/journal.pone.0066825. Print 2013.


Cryptococcus gattii is killed by dendritic cells, but evades adaptive immunity by failing to induce dendritic cell maturation.

Huston SM, Li SS, Stack D, Timm-McCann M, Jones GJ, Islam A, Berenger BM, Xiang RF, Colarusso P, Mody CH.

J Immunol. 2013 Jul 1;191(1):249-61. doi: 10.4049/jimmunol.1202707. Epub 2013 Jun 5.


Bronchoscopic removal of a large intracavitary pulmonary aspergilloma.

Stather DR, Tremblay A, MacEachern P, Chee A, Dumoulin E, Tourin O, Gelfand GA, Mody CH.

Chest. 2013 Jan;143(1):238-241. doi: 10.1378/chest.12-0400.


Real-time in vivo imaging of fungal migration to the central nervous system.

Shi M, Colarusso P, Mody CH.

Cell Microbiol. 2012 Dec;14(12):1819-27. doi: 10.1111/cmi.12027. Epub 2012 Oct 11. Review. Erratum in: Cell Microbiol. 2013 May;15(5):841. Calaruso, Pina [corrected to Colarusso, Pina].


Cryptococcus gattii pneumonia.

Johannson KA, Huston SM, Mody CH, Davidson W.

CMAJ. 2012 Sep 4;184(12):1387-90. doi: 10.1503/cmaj.111346. Epub 2012 Aug 13. No abstract available.


Management of fungal lung disease in the immunocompromised.

Islam A, Mody CH.

Ther Adv Respir Dis. 2011 Oct;5(5):305-24. doi: 10.1177/1753465811398720. Epub 2011 Aug 1. Review.


Visual function following photodynamic therapy for central serous chorioretinopathy: a comparison of automated macular microperimetry versus best-corrected visual acuity.

Ehrlich R, Mawer NP, Mody CH, Brand CS, Squirrell D.

Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):e32-9. doi: 10.1111/j.1442-9071.2011.02654.x. Epub 2011 Sep 19.


Immunotherapy in gliomas: limitations and potential of natural killer (NK) cell therapy.

Ogbomo H, Cinatl J Jr, Mody CH, Forsyth PA.

Trends Mol Med. 2011 Aug;17(8):433-41. doi: 10.1016/j.molmed.2011.03.004. Epub 2011 Apr 19. Review.


Membrane CD14, but not soluble CD14, is used by exoenzyme S from P. aeruginosa to signal proinflammatory cytokine production.

Berenger BM, Hamill J, Stack D, Montgomery E, Huston SM, Timm-McCann M, Epelman S, Mody CH.

J Leukoc Biol. 2011 Jul;90(1):189-98. doi: 10.1189/jlb.0510265. Epub 2011 Apr 15.


An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.

Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group.

Am J Respir Crit Care Med. 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST.


Granulysin production and anticryptococcal activity is dependent upon a far upstream enhancer that binds STAT5 in human peripheral blood CD4+ T cells.

Xing J, Wu F, Wang S, Krensky AM, Mody CH, Zheng C.

J Immunol. 2010 Nov 1;185(9):5074-81. doi: 10.4049/jimmunol.1001725. Epub 2010 Oct 1.


Direct microbicidal activity of cytotoxic T-lymphocytes.

Oykhman P, Mody CH.

J Biomed Biotechnol. 2010;2010:249482. doi: 10.1155/2010/249482. Epub 2010 Jun 23. Review.



Li SS, Mody CH.

Proc Am Thorac Soc. 2010 May;7(3):186-96. doi: 10.1513/pats.200907-063AL. Review.


Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain.

Shi M, Li SS, Zheng C, Jones GJ, Kim KS, Zhou H, Kubes P, Mody CH.

J Clin Invest. 2010 May;120(5):1683-93. doi: 10.1172/JCI41963. Epub 2010 Apr 26.


Visual outcome after intravitreal ranibizumab for wet age-related macular degeneration: a comparison between best-corrected visual acuity and microperimetry.

Squirrell DM, Mawer NP, Mody CH, Brand CS.

Retina. 2010 Mar;30(3):436-42. doi: 10.1097/IAE.0b013e3181bd2f29.


Cryptococcosis: an emerging respiratory mycosis.

Huston SM, Mody CH.

Clin Chest Med. 2009 Jun;30(2):253-64, vi. doi: 10.1016/j.ccm.2009.02.006. Review.


Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity.

Marr KJ, Jones GJ, Zheng C, Huston SM, Timm-McCann M, Islam A, Berenger BM, Ma LL, Wiseman JC, Mody CH.

Infect Immun. 2009 Jun;77(6):2436-46. doi: 10.1128/IAI.01232-08. Epub 2009 Mar 23.


In contrast to anti-tumor activity, YT cell and primary NK cell cytotoxicity for Cryptococcus neoformans bypasses LFA-1.

Jones GJ, Wiseman JC, Marr KJ, Wei S, Djeu JY, Mody CH.

Int Immunol. 2009 Apr;21(4):423-32. doi: 10.1093/intimm/dxp010. Epub 2009 Mar 4.


Pleural mesothelial cells express both BLT2 and PPARalpha and mount an integrated response to pleural leukotriene B4.

Pace E, Ferraro M, Mody CH, Melis MR, Scafidi V, Bonanno A, Profita M, Giarratano A, Gjomarkaj M.

J Immunol. 2008 Nov 15;181(10):7292-9.


Microbial products activate monocytic cells through detergent-resistant membrane microdomains.

Epelman S, Berenger B, Stack D, Neely GG, Ma LL, Mody CH.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):657-65. doi: 10.1165/rcmb.2007-0390OC. Epub 2008 Jun 6.


Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.

Zheng CF, Jones GJ, Shi M, Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH.

J Immunol. 2008 Jun 1;180(11):7221-9.


The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1.

Kelly MM, McNagny K, Williams DL, van Rooijen N, Maxwell L, Gwozd C, Mody CH, Kubes P.

Am J Respir Cell Mol Biol. 2008 Feb;38(2):227-38. Epub 2007 Aug 23.


Antigen and memory CD8 T cells: were they both right?

Epelman S, Mody CH.

Allergy Asthma Clin Immunol. 2007 Jun 15;3(2):37-9. doi: 10.1186/1710-1492-3-2-37. Epub 2007 Jun 15.


Perforin-dependent cryptococcal microbicidal activity in NK cells requires PI3K-dependent ERK1/2 signaling.

Wiseman JC, Ma LL, Marr KJ, Jones GJ, Mody CH.

J Immunol. 2007 May 15;178(10):6456-64.

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