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The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.

Sherrer SM, Penland E, Modrich P.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7314-7319. doi: 10.1073/pnas.1807319115. Epub 2018 Jun 25.


Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.

Genschel J, Kadyrova LY, Iyer RR, Dahal BK, Kadyrov FA, Modrich P.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4930-4935. doi: 10.1073/pnas.1702561114. Epub 2017 Apr 24.


Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).

Modrich P.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8490-501. doi: 10.1002/anie.201601412. Epub 2016 May 20. Review.


The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage.

Lindahl T, Modrich P, Sancar A.

J Assoc Genet Technol. 2016;42(1):37-41.


MutL traps MutS at a DNA mismatch.

Qiu R, Sakato M, Sacho EJ, Wilkins H, Zhang X, Modrich P, Hingorani MM, Erie DA, Weninger KR.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10914-9. doi: 10.1073/pnas.1505655112. Epub 2015 Aug 17.


Hydrolytic function of Exo1 in mammalian mismatch repair.

Shao H, Baitinger C, Soderblom EJ, Burdett V, Modrich P.

Nucleic Acids Res. 2014 Jun;42(11):7104-12. doi: 10.1093/nar/gku420. Epub 2014 May 14.


Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.

Lindsey-Boltz LA, Kemp MG, Reardon JT, DeRocco V, Iyer RR, Modrich P, Sancar A.

J Biol Chem. 2014 Feb 21;289(8):5074-82. doi: 10.1074/jbc.M113.542787. Epub 2014 Jan 8.


Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation.

Pluciennik A, Burdett V, Baitinger C, Iyer RR, Shi K, Modrich P.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12277-82. doi: 10.1073/pnas.1311325110. Epub 2013 Jul 9.


Christian Raetz: scientist and friend extraordinaire.

Dowhan W, Nikaido H, Stubbe J, Kozarich JW, Wickner WT, Russell DW, Garrett TA, Brozek K, Modrich P.

Annu Rev Biochem. 2013;82:1-24. doi: 10.1146/annurev-biochem-012512-091530. Epub 2013 Mar 7.


PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro.

Liu Y, Kadyrov FA, Modrich P.

DNA Repair (Amst). 2011 Nov 10;10(11):1145-53. doi: 10.1016/j.dnarep.2011.08.012. Epub 2011 Sep 25.


Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ.

Tseng Q, Orans J, Hast MA, Iyer RR, Changela A, Modrich PL, Beese LS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):947-52. doi: 10.1107/S1744309111019300. Epub 2011 Jul 26.


Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.

Orans J, McSweeney EA, Iyer RR, Hast MA, Hellinga HW, Modrich P, Beese LS.

Cell. 2011 Apr 15;145(2):212-23. doi: 10.1016/j.cell.2011.03.005.


BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC.

Genes Dev. 2011 Feb 15;25(4):350-62. doi: 10.1101/gad.2003811.


PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair.

Pluciennik A, Dzantiev L, Iyer RR, Constantin N, Kadyrov FA, Modrich P.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16066-71. doi: 10.1073/pnas.1010662107. Epub 2010 Aug 16.


PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.

van Oers JM, Roa S, Werling U, Liu Y, Genschel J, Hou H Jr, Sellers RS, Modrich P, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13384-9. doi: 10.1073/pnas.1008589107. Epub 2010 Jul 12.


Structure of the endonuclease domain of MutL: unlicensed to cut.

Pillon MC, Lorenowicz JJ, Uckelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC, Simmons LA, Friedhoff P, Guarné A.

Mol Cell. 2010 Jul 9;39(1):145-51. doi: 10.1016/j.molcel.2010.06.027.


MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.

Iyer RR, Pluciennik A, Genschel J, Tsai MS, Beese LS, Modrich P.

J Biol Chem. 2010 Apr 9;285(15):11730-9. doi: 10.1074/jbc.M110.104125. Epub 2010 Feb 12.


Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.

Liu Y, Fang Y, Shao H, Lindsey-Boltz L, Sancar A, Modrich P.

J Biol Chem. 2010 Feb 19;285(8):5974-82. doi: 10.1074/jbc.M109.076109. Epub 2009 Dec 22.


Involvement of the beta clamp in methyl-directed mismatch repair in vitro.

Pluciennik A, Burdett V, Lukianova O, O'Donnell M, Modrich P.

J Biol Chem. 2009 Nov 20;284(47):32782-91. doi: 10.1074/jbc.M109.054528. Epub 2009 Sep 25.


Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.

Genschel J, Modrich P.

J Biol Chem. 2009 Aug 7;284(32):21536-44. doi: 10.1074/jbc.M109.021287. Epub 2009 Jun 10.


Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.

Zhao J, Jain A, Iyer RR, Modrich PL, Vasquez KM.

Nucleic Acids Res. 2009 Jul;37(13):4420-9. doi: 10.1093/nar/gkp399. Epub 2009 May 25.


A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.

Kadyrov FA, Genschel J, Fang Y, Penland E, Edelmann W, Modrich P.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8495-500. doi: 10.1073/pnas.0903654106. Epub 2009 May 6.


Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.

Nimonkar AV, Ozsoy AZ, Genschel J, Modrich P, Kowalczykowski SC.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16906-11. doi: 10.1073/pnas.0809380105. Epub 2008 Oct 29.


Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.

Maxwell JA, Johnson SP, McLendon RE, Lister DW, Horne KS, Rasheed A, Quinn JA, Ali-Osman F, Friedman AH, Modrich PL, Bigner DD, Friedman HS.

Clin Cancer Res. 2008 Aug 1;14(15):4859-68. doi: 10.1158/1078-0432.CCR-07-4807.


The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.

Iyer RR, Pohlhaus TJ, Chen S, Hura GL, Dzantiev L, Beese LS, Modrich P.

J Biol Chem. 2008 May 9;283(19):13310-9. doi: 10.1074/jbc.M800606200. Epub 2008 Mar 7.


Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha.

Sacho EJ, Kadyrov FA, Modrich P, Kunkel TA, Erie DA.

Mol Cell. 2008 Jan 18;29(1):112-21. doi: 10.1016/j.molcel.2007.10.030.


Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.

Kadyrov FA, Holmes SF, Arana ME, Lukianova OA, O'Donnell M, Kunkel TA, Modrich P.

J Biol Chem. 2007 Dec 21;282(51):37181-90. Epub 2007 Oct 19.


Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair.

Pluciennik A, Modrich P.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12709-13. Epub 2007 Jul 9.


Structure of the human MutSalpha DNA lesion recognition complex.

Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS.

Mol Cell. 2007 May 25;26(4):579-92.


Mechanisms in eukaryotic mismatch repair.

Modrich P.

J Biol Chem. 2006 Oct 13;281(41):30305-9. Epub 2006 Aug 11. Review. No abstract available.


Endonucleolytic function of MutLalpha in human mismatch repair.

Kadyrov FA, Dzantiev L, Constantin N, Modrich P.

Cell. 2006 Jul 28;126(2):297-308.


Analysis of the excision step in human DNA mismatch repair.

Genschel J, Modrich P.

Methods Enzymol. 2006;408:273-84.


Engineering life: building a fab for biology.

Bio FAB Group, Baker D, Church G, Collins J, Endy D, Jacobson J, Keasling J, Modrich P, Smolke C, Weiss R.

Sci Am. 2006 Jun;294(6):44-51. No abstract available.


The beta sliding clamp binds to multiple sites within MutL and MutS.

López de Saro FJ, Marinus MG, Modrich P, O'Donnell M.

J Biol Chem. 2006 May 19;281(20):14340-9. Epub 2006 Mar 16.


DNA mismatch repair: functions and mechanisms.

Iyer RR, Pluciennik A, Burdett V, Modrich PL.

Chem Rev. 2006 Feb;106(2):302-23. Review. No abstract available.


A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group.

Chintagumpala MM, Friedman HS, Stewart CF, Kepner J, McLendon RE, Modrich PL, McCluggage C, Burger P, Holmes E, Thompson S, Rutka J, Michalski J, Woo S, Blaney SM, Kun LE, Horowitz ME; Pediatric Oncology Group Study.

J Neurooncol. 2006 Apr;77(2):193-8.


Human mismatch repair: reconstitution of a nick-directed bidirectional reaction.

Constantin N, Dzantiev L, Kadyrov FA, Modrich P.

J Biol Chem. 2005 Dec 2;280(48):39752-61. Epub 2005 Sep 27.


Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.

Cheng CL, Johnson SP, Keir ST, Quinn JA, Ali-Osman F, Szabo C, Li H, Salzman AL, Dolan ME, Modrich P, Bigner DD, Friedman HS.

Mol Cancer Ther. 2005 Sep;4(9):1364-8.


HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P, Huang LE.

Mol Cell. 2005 Mar 18;17(6):793-803.


Methyl-directed repair of DNA base-pair mismatches in vitro. 1983.

Lu AL, Clark S, Modrich P.

DNA Repair (Amst). 2005 Jan 2;4(1):134-8; discussion 133, 139. No abstract available.


Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.

Bacolod MD, Johnson SP, Pegg AE, Dolan ME, Moschel RC, Bullock NS, Fang Q, Colvin OM, Modrich P, Bigner DD, Friedman HS.

Mol Cancer Ther. 2004 Sep;3(9):1127-35.


A defined human system that supports bidirectional mismatch-provoked excision.

Dzantiev L, Constantin N, Genschel J, Iyer RR, Burgers PM, Modrich P.

Mol Cell. 2004 Jul 2;15(1):31-41.


Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G.

Chem Biol. 2004 Jun;11(6):787-97.


Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites.

Martik D, Baitinger C, Modrich P.

J Biol Chem. 2004 Jul 2;279(27):28402-10. Epub 2004 Apr 22.


The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.

Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC.

Oncogene. 2004 May 6;23(21):3749-56.


Mechanism of 5'-directed excision in human mismatch repair.

Genschel J, Modrich P.

Mol Cell. 2003 Nov;12(5):1077-86.


Assembly and molecular activities of the MutS tetramer.

Bjornson KP, Blackwell LJ, Sage H, Baitinger C, Allen D, Modrich P.

J Biol Chem. 2003 Sep 5;278(36):34667-73. Epub 2003 Jun 25.

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