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Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

Villa-Pulgarín JA, Gajate C, Botet J, Jimenez A, Justies N, Varela-M RE, Cuesta-Marbán Á, Müller I, Modolell M, Revuelta JL, Mollinedo F.

PLoS Negl Trop Dis. 2017 Aug 22;11(8):e0005805. doi: 10.1371/journal.pntd.0005805. eCollection 2017 Aug.


Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites.

Tajebe F, Getahun M, Adem E, Hailu A, Lemma M, Fikre H, Raynes J, Tamiru A, Mulugeta Z, Diro E, Toulza F, Shkedy Z, Ayele T, Modolell M, Munder M, Müller I, Takele Y, Kropf P.

PLoS Negl Trop Dis. 2017 Jul 21;11(7):e0005727. doi: 10.1371/journal.pntd.0005727. eCollection 2017 Jul.


Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions.

Yizengaw E, Getahun M, Tajebe F, Cruz Cervera E, Adem E, Mesfin G, Hailu A, Van der Auwera G, Yardley V, Lemma M, Skhedy Z, Diro E, Yeshanew A, Melkamu R, Mengesha B, Modolell M, Munder M, Müller I, Takele Y, Kropf P.

Front Immunol. 2016 Nov 29;7:517. eCollection 2016.


Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function.

Takele Y, Adem E, Getahun M, Tajebe F, Kiflie A, Hailu A, Raynes J, Mengesha B, Ayele TA, Shkedy Z, Lemma M, Diro E, Toulza F, Modolell M, Munder M, Müller I, Kropf P.

PLoS One. 2016 Aug 22;11(8):e0157919. doi: 10.1371/journal.pone.0157919. eCollection 2016.


Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production.

Adem E, Tajebe F, Getahun M, Kiflie A, Diro E, Hailu A, Shkedy Z, Mengesha B, Mulaw T, Atnafu S, Deressa T, Mathewos B, Abate E, Modolell M, Munder M, Müller I, Takele Y, Kropf P.

PLoS Negl Trop Dis. 2016 Mar 10;10(3):e0004468. doi: 10.1371/journal.pntd.0004468. eCollection 2016 Mar.


Protein energy malnutrition increases arginase activity in monocytes and macrophages.

Corware K, Yardley V, Mack C, Schuster S, Al-Hassi H, Herath S, Bergin P, Modolell M, Munder M, Müller I, Kropf P.

Nutr Metab (Lond). 2014 Oct 24;11(1):51. doi: 10.1186/1743-7075-11-51. eCollection 2014.


Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.

Cloke T, Munder M, Bergin P, Herath S, Modolell M, Taylor G, Müller I, Kropf P.

PLoS One. 2013 Sep 9;8(9):e72034. doi: 10.1371/journal.pone.0072034. eCollection 2013.


Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia.

Abebe T, Takele Y, Weldegebreal T, Cloke T, Closs E, Corset C, Hailu A, Hailu W, Sisay Y, Corware K, Corset M, Modolell M, Munder M, Tacchini-Cottier F, Müller I, Kropf P.

PLoS Negl Trop Dis. 2013;7(3):e2134. doi: 10.1371/journal.pntd.0002134. Epub 2013 Mar 28.


Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of Slc7a2 (CAT2), and susceptibility to Leishmania infection is reduced.

Sans-Fons MG, Yeramian A, Pereira-Lopes S, Santamaría-Babi LF, Modolell M, Lloberas J, Celada A.

J Infect Dis. 2013 Jun 1;207(11):1684-93. doi: 10.1093/infdis/jit084. Epub 2013 Mar 4.


Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection.

Takele Y, Abebe T, Weldegebreal T, Hailu A, Hailu W, Hurissa Z, Ali J, Diro E, Sisay Y, Cloke T, Modolell M, Munder M, Tacchini-Cottier F, Müller I, Kropf P.

PLoS Negl Trop Dis. 2013;7(1):e1977. doi: 10.1371/journal.pntd.0001977. Epub 2013 Jan 17. Erratum in: PLoS Negl Trop Dis. 2013 Jan;7(1). doi: 10.1371/annotation/9e89dee8-e2b7-4559-bd4e-933692403410.


Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.

Abebe T, Hailu A, Woldeyes M, Mekonen W, Bilcha K, Cloke T, Fry L, Seich Al Basatena NK, Corware K, Modolell M, Munder M, Tacchini-Cottier F, Müller I, Kropf P.

PLoS Negl Trop Dis. 2012;6(6):e1684. doi: 10.1371/journal.pntd.0001684. Epub 2012 Jun 12.


In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.

Varela-M RE, Villa-Pulgarin JA, Yepes E, Müller I, Modolell M, Muñoz DL, Robledo SM, Muskus CE, López-Abán J, Muro A, Vélez ID, Mollinedo F.

PLoS Negl Trop Dis. 2012;6(4):e1612. doi: 10.1371/journal.pntd.0001612. Epub 2012 Apr 10.


Arginine and macrophage activation.

Comalada M, Yeramian A, Modolell M, Lloberas J, Celada A.

Methods Mol Biol. 2012;844:223-35. doi: 10.1007/978-1-61779-527-5_16.


Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.

Modolell M, Choi BS, Ryan RO, Hancock M, Titus RG, Abebe T, Hailu A, Müller I, Rogers ME, Bangham CR, Munder M, Kropf P.

PLoS Negl Trop Dis. 2009 Jul 14;3(7):e480. doi: 10.1371/journal.pntd.0000480.


Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.

Mollinedo F, Gajate C, Morales AI, del Canto-Jañez E, Justies N, Collía F, Rivas JV, Modolell M, Iglesias A.

J Pharmacol Exp Ther. 2009 May;329(2):439-49. doi: 10.1124/jpet.108.148254. Epub 2009 Feb 25.


Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages.

Choi BS, Martinez-Falero IC, Corset C, Munder M, Modolell M, Müller I, Kropf P.

J Leukoc Biol. 2009 Feb;85(2):268-77. doi: 10.1189/jlb.0508310. Epub 2008 Nov 13.


Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.

Fitzpatrick JM, Fuentes JM, Chalmers IW, Wynn TA, Modolell M, Hoffmann KF, Hesse M.

Int J Parasitol. 2009 Feb;39(3):267-79. doi: 10.1016/j.ijpara.2008.06.015. Epub 2008 Aug 6.


Age-related alteration of arginase activity impacts on severity of leishmaniasis.

Müller I, Hailu A, Choi BS, Abebe T, Fuentes JM, Munder M, Modolell M, Kropf P.

PLoS Negl Trop Dis. 2008 May 14;2(5):e235. doi: 10.1371/journal.pntd.0000235.


Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy.

Kropf P, Baud D, Marshall SE, Munder M, Mosley A, Fuentes JM, Bangham CR, Taylor GP, Herath S, Choi BS, Soler G, Teoh T, Modolell M, Müller I.

Eur J Immunol. 2007 Apr;37(4):935-45.


Suppression of T-cell functions by human granulocyte arginase.

Munder M, Schneider H, Luckner C, Giese T, Langhans CD, Fuentes JM, Kropf P, Mueller I, Kolb A, Modolell M, Ho AD.

Blood. 2006 Sep 1;108(5):1627-34. Epub 2006 May 18.


Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.

Yeramian A, Martin L, Arpa L, Bertran J, Soler C, McLeod C, Modolell M, Palacín M, Lloberas J, Celada A.

Eur J Immunol. 2006 Jun;36(6):1516-26.


Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages.

Yeramian A, Martin L, Serrat N, Arpa L, Soler C, Bertran J, McLeod C, Palacín M, Modolell M, Lloberas J, Celada A.

J Immunol. 2006 May 15;176(10):5918-24.


Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.

Martín L, Comalada M, Marti L, Closs EI, MacLeod CL, Martín del Río R, Zorzano A, Modolell M, Celada A, Palacín M, Bertran J.

Am J Physiol Cell Physiol. 2006 May;290(5):C1364-72. Epub 2005 Dec 21.


Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?

Martin P, Wallich R, Pardo J, Müllbacher A, Munder M, Modolell M, Simon MM.

Blood. 2005 Oct 15;106(8):2871-8. Epub 2005 Jul 5.


Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.

Kropf P, Fuentes JM, Fähnrich E, Arpa L, Herath S, Weber V, Soler G, Celada A, Modolell M, Müller I.

FASEB J. 2005 Jun;19(8):1000-2. Epub 2005 Apr 5.


Arginine metabolism during macrophage autocrine activation and infection with mouse hepatitis virus 3.

Moreira C, Tsuhako MH, de Franco MT, Modolell M, Pereira CA.

Immunobiology. 2004;209(8):585-98.


Gene expression in IFN-gamma-activated murine macrophages.

Pereira CA, Modolell M, Frey JR, Lefkovits I.

Braz J Med Biol Res. 2004 Dec;37(12):1795-809. Epub 2004 Nov 17.


Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

Munder M, Mollinedo F, Calafat J, Canchado J, Gil-Lamaignere C, Fuentes JM, Luckner C, Doschko G, Soler G, Eichmann K, Müller FM, Ho AD, Goerner M, Modolell M.

Blood. 2005 Mar 15;105(6):2549-56. Epub 2004 Nov 16.


Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication.

Kropf P, Freudenberg N, Kalis C, Modolell M, Herath S, Galanos C, Freudenberg M, Müller I.

J Leukoc Biol. 2004 Jul;76(1):48-57. Epub 2004 Mar 23.


Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major.

Kropf P, Freudenberg MA, Modolell M, Price HP, Herath S, Antoniazi S, Galanos C, Smith DF, Müller I.

Infect Immun. 2004 Apr;72(4):1920-8.


Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice.

Kropf P, Herath S, Weber V, Modolell M, Müller I.

Parasite Immunol. 2003 Aug-Sep;25(8-9):439-47.


Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis.

Jost MM, Ninci E, Meder B, Kempf C, Van Royen N, Hua J, Berger B, Hoefer I, Modolell M, Buschmann I.

FASEB J. 2003 Dec;17(15):2281-3. Epub 2003 Oct 2.


Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways.

Soler C, Felipe A, García-Manteiga J, Serra M, Guillén-Gómez E, Casado FJ, MacLeod C, Modolell M, Pastor-Anglada M, Celada A.

Biochem J. 2003 Nov 1;375(Pt 3):777-83.


Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.

Hesse M, Modolell M, La Flamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ, Wynn TA.

J Immunol. 2001 Dec 1;167(11):6533-44.


Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and -independent mechanisms.

Soler C, Valdés R, Garcia-Manteiga J, Xaus J, Comalada M, Casado FJ, Modolell M, Nicholson B, MacLeod C, Felipe A, Celada A, Pastor-Anglada M.

J Biol Chem. 2001 Aug 10;276(32):30043-9. Epub 2001 May 9.


Direct stimulation of macrophages by IL-12 and IL-18 - a bridge built on solid ground.

Munder M, Mallo M, Eichmann K, Modolell M.

Immunol Lett. 2001 Jan 1;75(2):159-60. No abstract available.


Down-regulation of Bgp1(a) viral receptor by interferon-gamma is related to the antiviral state and resistance to mouse hepatitis virus 3 infection.

Vassão RC, de Franco MT, Hartz D, Modolell M, Sippel AE, Pereira CA.

Virology. 2000 Sep 1;274(2):278-83.


Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells.

Gajate C, Santos-Beneit AM, Macho A, Lazaro Md, Hernandez-De Rojas A, Modolell M, Muñoz E, Mollinedo F.

Int J Cancer. 2000 Apr 15;86(2):208-18.


Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis.

Gajate C, Fonteriz RI, Cabaner C, Alvarez-Noves G, Alvarez-Rodriguez Y, Modolell M, Mollinedo F.

Int J Cancer. 2000 Mar 1;85(5):674-82.


Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells.

Munder M, Eichmann K, Morán JM, Centeno F, Soler G, Modolell M.

J Immunol. 1999 Oct 1;163(7):3771-7.


A new antioxidative vitamin B6 analogue modulates pathophysiological cell proliferation and damage.

Kesel AJ, Sonnenbichler I, Polborn K, Gürtler L, Klinkert WE, Modolell M, Nüssler AK, Oberthür W.

Bioorg Med Chem. 1999 Feb;7(2):359-67.


A fetal sheep liver extract reverses age-related increments in spontaneous and induced cytokine production by indirect environmental effects.

Gorczynski RM, Bessler WG, Chung S, Cinader B, Hoffmann P, Modolell M, Ramakrishna V, Reischel ET, Waelli T, Westphal O.

Immunol Lett. 1998 Feb;60(2-3):157-64.


Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis.

Alonso MT, Gajate C, Mollinedo F, Modolell M, Alvarez J, García-Sancho J.

Br J Pharmacol. 1997 Aug;121(7):1364-8.


Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).

Mollinedo F, Fernández-Luna JL, Gajate C, Martín-Martín B, Benito A, Martínez-Dalmau R, Modolell M.

Cancer Res. 1997 Apr 1;57(7):1320-8.


Involvement of protein kinase A in the induction of arginase in murine bone marrow-derived macrophages.

Corraliza IM, Modolell M, Ferber E, Soler G.

Biochim Biophys Acta. 1997 Mar 15;1334(2-3):123-8.


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