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Items: 1 to 50 of 306

1.

Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.

Kim EW, Teles RMB, Haile S, Liu PT, Modlin RL.

PLoS Negl Trop Dis. 2018 Jul 2;12(7):e0006608. doi: 10.1371/journal.pntd.0006608. eCollection 2018 Jul.

2.

Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.

Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL.

J Immunol. 2018 May 1;200(9):3244-3258. doi: 10.4049/jimmunol.1701733. Epub 2018 Apr 2.

PMID:
29610140
3.

Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages.

Cheng L, Marinelli LJ, Grosset N, Fitz-Gibbon ST, Bowman CA, Dang BQ, Russell DA, Jacobs-Sera D, Shi B, Pellegrini M, Miller JF, Gautier M, Hatfull GF, Modlin RL.

BMC Microbiol. 2018 Mar 1;18(1):19. doi: 10.1186/s12866-018-1159-y.

4.

IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth.

Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW.

J Immunol. 2018 Apr 1;200(7):2405-2417. doi: 10.4049/jimmunol.1701073. Epub 2018 Feb 16.

PMID:
29453279
5.

SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles.

Lopez D, Montoya D, Ambrose M, Lam L, Briscoe L, Adams C, Modlin RL, Pellegrini M.

BMC Genomics. 2017 Oct 25;18(1):824. doi: 10.1186/s12864-017-4167-7.

6.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L.

Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030.

7.

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.

Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST.

PLoS Pathog. 2017 Jul 13;13(7):e1006496. doi: 10.1371/journal.ppat.1006496. eCollection 2017 Jul.

8.

Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes.

Yu Y, Champer J, Agak GW, Kao S, Modlin RL, Kim J.

J Invest Dermatol. 2016 Nov;136(11):2221-2228. doi: 10.1016/j.jid.2016.06.615. Epub 2016 Jul 1.

9.

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843.

10.

Jagged1 Instructs Macrophage Differentiation in Leprosy.

Kibbie J, Teles RM, Wang Z, Hong P, Montoya D, Krutzik S, Lee S, Kwon O, Modlin RL, Cruz D.

PLoS Pathog. 2016 Aug 17;12(8):e1005808. doi: 10.1371/journal.ppat.1005808. eCollection 2016 Aug.

11.

Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.

Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A.

Nat Commun. 2016 Aug 1;7:12348. doi: 10.1038/ncomms12348.

12.

S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL.

PLoS Pathog. 2016 Jun 29;12(6):e1005705. doi: 10.1371/journal.ppat.1005705. eCollection 2016 Jun.

13.

Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages.

Bloom BR, Modlin RL.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0006-2015. Review.

PMID:
27337485
14.

Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae.

Schenk M, Mahapatra S, Le P, Kim HJ, Choi AW, Brennan PJ, Belisle JT, Modlin RL.

Infect Immun. 2016 Aug 19;84(9):2429-38. doi: 10.1128/IAI.00334-16. Print 2016 Sep.

15.

Thomas Herald Rea, MD (1929-2016).

Ochoa MT, Vaccaro S, Jerskey R, Mora H, Peng D, Modlin RL.

Lepr Rev. 2016 Mar;87(1):130-1. No abstract available.

PMID:
27255071
16.

Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages.

Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M.

J Immunol. 2016 Jul 1;197(1):222-32. doi: 10.4049/jimmunol.1502407. Epub 2016 May 27.

17.

Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis.

Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S; TBornotTB Network.

Am J Respir Crit Care Med. 2016 Aug 1;194(3):345-55. doi: 10.1164/rccm.201509-1746OC.

18.

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.

Demaria O, De Gassart A, Coso S, Gestermann N, Di Domizio J, Flatz L, Gaide O, Michielin O, Hwu P, Petrova TV, Martinon F, Modlin RL, Speiser DE, Gilliet M.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13. doi: 10.1073/pnas.1512832112. Epub 2015 Nov 25.

19.

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M.

Nat Immunol. 2015 Sep;16(9):970-9. doi: 10.1038/ni.3211. Epub 2015 Jul 13.

20.

IL-27 Suppresses Antimicrobial Activity in Human Leprosy.

Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL.

J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.

21.

Combinatorial code governing cellular responses to complex stimuli.

Cappuccio A, Zollinger R, Schenk M, Walczak A, Servant N, Barillot E, Hupé P, Modlin RL, Soumelis V.

Nat Commun. 2015 Apr 21;6:6847. doi: 10.1038/ncomms7847.

22.

Bee venom processes human skin lipids for presentation by CD1a.

Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G.

J Exp Med. 2015 Feb 9;212(2):149-63. doi: 10.1084/jem.20141505. Epub 2015 Jan 12.

23.

Carbohydrate-dependent binding of langerin to SodC, a cell wall glycoprotein of Mycobacterium leprae.

Kim HJ, Brennan PJ, Heaslip D, Udey MC, Modlin RL, Belisle JT.

J Bacteriol. 2015 Feb;197(3):615-25. doi: 10.1128/JB.02080-14. Epub 2014 Nov 24.

24.

IL-32 is a molecular marker of a host defense network in human tuberculosis.

Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL.

Sci Transl Med. 2014 Aug 20;6(250):250ra114. doi: 10.1126/scitranslmed.3009546.

25.

Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.

Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M.

J Invest Dermatol. 2015 Jan;135(1):151-159. doi: 10.1038/jid.2014.352. Epub 2014 Aug 11.

26.

Impact of vitamin D on immune function: lessons learned from genome-wide analysis.

Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M.

Front Physiol. 2014 Apr 21;5:151. doi: 10.3389/fphys.2014.00151. eCollection 2014. Review.

27.

TB or not TB: that is no longer the question.

Modlin RL, Bloom BR.

Sci Transl Med. 2013 Nov 27;5(213):213sr6. doi: 10.1126/scitranslmed.3007402. Review.

28.

Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells.

Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, Montoya D, Liu PT, Modlin RL.

Immunology. 2014 Feb;141(2):174-80. doi: 10.1111/imm.12167.

29.

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL.

Science. 2013 Mar 22;339(6126):1448-53. doi: 10.1126/science.1233665. Epub 2013 Feb 28.

30.

Propionibacterium acnes strain populations in the human skin microbiome associated with acne.

Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, Modlin RL, Miller JF, Sodergren E, Craft N, Weinstock GM, Li H.

J Invest Dermatol. 2013 Sep;133(9):2152-60. doi: 10.1038/jid.2013.21. Epub 2013 Jan 21.

31.

CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes.

Klug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M.

Immunology. 2013 May;139(1):121-8. doi: 10.1111/imm.12062.

32.

Galectin-3 regulates the innate immune response of human monocytes.

Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Rea TH, Stenger S, Modlin RL, Lee DJ.

J Infect Dis. 2013 Mar 15;207(6):947-56. doi: 10.1093/infdis/jis920. Epub 2012 Dec 18.

33.

Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.

Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J.

J Invest Dermatol. 2013 May;133(5):1231-9. doi: 10.1038/jid.2012.399. Epub 2012 Nov 29.

34.

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G.

Nat Immunol. 2012 Dec;13(12):1155-61. doi: 10.1038/ni.2460. Epub 2012 Nov 11.

35.

On the nature of mycobacteriophage diversity and host preference.

Jacobs-Sera D, Marinelli LJ, Bowman C, Broussard GW, Guerrero Bustamante C, Boyle MM, Petrova ZO, Dedrick RM, Pope WH; Science Education Alliance Phage Hunters Advancing Genomics And Evolutionary Science Sea-Phages Program, Modlin RL, Hendrix RW, Hatfull GF.

Virology. 2012 Dec 20;434(2):187-201. doi: 10.1016/j.virol.2012.09.026. Epub 2012 Oct 22. Review.

36.

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates.

Marinelli LJ, Fitz-Gibbon S, Hayes C, Bowman C, Inkeles M, Loncaric A, Russell DA, Jacobs-Sera D, Cokus S, Pellegrini M, Kim J, Miller JF, Hatfull GF, Modlin RL.

MBio. 2012 Sep 25;3(5). pii: e00279-12. doi: 10.1128/mBio.00279-12. Print 2012.

37.

Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages.

Bruns H, Stegelmann F, Fabri M, Döhner K, van Zandbergen G, Wagner M, Skinner M, Modlin RL, Stenger S.

J Immunol. 2012 Oct 15;189(8):4069-78. doi: 10.4049/jimmunol.1201538. Epub 2012 Sep 17.

38.

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37.

Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M.

Blood. 2012 Nov 1;120(18):3699-707. doi: 10.1182/blood-2012-01-401364. Epub 2012 Aug 27.

39.

Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells.

Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D.

Glycobiology. 2012 Aug;22(8):1118-27. doi: 10.1093/glycob/cws078. Epub 2012 Apr 25.

40.

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.

Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL.

Nat Med. 2012 Mar 25;18(4):555-63. doi: 10.1038/nm.2650.

41.
42.

Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells.

Hou W, Gibbs JS, Lu X, Brooke CB, Roy D, Modlin RL, Bennink JR, Yewdell JW.

Blood. 2012 Mar 29;119(13):3128-31. doi: 10.1182/blood-2011-09-379479. Epub 2012 Feb 6.

43.

MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.

Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL.

Nat Med. 2012 Jan 29;18(2):267-73. doi: 10.1038/nm.2584.

44.

Innate immunity: ignored for decades, but not forgotten.

Modlin RL.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):882-6. doi: 10.1038/jid.2011.373. Epub 2011 Dec 8. Review.

45.

Shedding light on the vitamin D-tuberculosis-HIV connection.

Realegeno S, Modlin RL.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18861-2. doi: 10.1073/pnas.1116513108. Epub 2011 Nov 14. No abstract available.

46.

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.

Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL.

Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

47.

Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses.

Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MV, Stenger S, Modlin RL, Schlesinger LS.

J Biol Chem. 2011 Oct 14;286(41):35438-46. doi: 10.1074/jbc.M111.232587. Epub 2011 Aug 22.

48.

Cord blood vitamin D status impacts innate immune responses.

Walker VP, Zhang X, Rastegar I, Liu PT, Hollis BW, Adams JS, Modlin RL.

J Clin Endocrinol Metab. 2011 Jun;96(6):1835-43. doi: 10.1210/jc.2010-1559. Epub 2011 Apr 6.

49.

Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections.

Cho JS, Zussman J, Donegan NP, Ramos RI, Garcia NC, Uslan DZ, Iwakura Y, Simon SI, Cheung AL, Modlin RL, Kim J, Miller LS.

J Invest Dermatol. 2011 Apr;131(4):907-15. doi: 10.1038/jid.2010.417. Epub 2010 Dec 30.

50.

Editorial overview.

Glimcher LH, Martinon F, Modlin RL.

Curr Opin Immunol. 2011 Feb;23(1):1-2. doi: 10.1016/j.coi.2010.12.001. Epub 2010 Dec 23. No abstract available.

PMID:
21185707

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