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Items: 1 to 50 of 321

1.

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.

Teles RMB, Lu J, Tió-Coma M, Goulart IMB, Banu S, Hagge D, Bobosha K, Ottenhoff THM, Pellegrini M, Geluk A, Modlin RL.

PLoS Negl Trop Dis. 2019 Oct 10;13(10):e0007764. doi: 10.1371/journal.pntd.0007764. eCollection 2019 Oct.

2.

Correction: IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth.

Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW.

J Immunol. 2019 Oct 1;203(7):2020. doi: 10.4049/jimmunol.1900859. Epub 2019 Aug 30. No abstract available.

PMID:
31471522
3.

Corrigendum: IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth.

Yang R, Yao L, Shen L, Sha W, Modlin RL, Shen H, Chen ZW.

Front Immunol. 2019 Jul 26;10:1742. doi: 10.3389/fimmu.2019.01742. eCollection 2019.

4.

The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy.

R Andrade P, Mehta M, Lu J, M B Teles R, Montoya D, O Scumpia P, Nunes Sarno E, Ochoa MT, Ma F, Pellegrini M, Modlin RL.

PLoS Negl Trop Dis. 2019 Jul 25;13(7):e0007589. doi: 10.1371/journal.pntd.0007589. eCollection 2019 Jul.

5.

IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.

Weiss DI, Ma F, Merleev AA, Maverakis E, Gilliet M, Balin SJ, Bryson BD, Ochoa MT, Pellegrini M, Bloom BR, Modlin RL.

J Immunol. 2019 Aug 15;203(4):911-921. doi: 10.4049/jimmunol.1900318. Epub 2019 Jun 24.

PMID:
31235553
6.

Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis.

Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT.

mSphere. 2019 Jun 5;4(3). pii: e00327-19. doi: 10.1128/mSphere.00327-19.

7.

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis.

Bryson BD, Rosebrock TR, Tafesse FG, Itoh CY, Nibasumba A, Babunovic GH, Corleis B, Martin C, Keegan C, Andrade P, Realegeno S, Kwon D, Modlin RL, Fortune SM.

Nat Commun. 2019 May 27;10(1):2329. doi: 10.1038/s41467-019-10065-8.

8.

IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth.

Yang R, Yao L, Shen L, Sha W, Modlin RL, Shen H, Chen ZW.

Front Immunol. 2019 Apr 26;10:913. doi: 10.3389/fimmu.2019.00913. eCollection 2019. Erratum in: Front Immunol. 2019 Jul 26;10:1742.

9.

Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.

Dang AT, Teles RM, Liu PT, Choi A, Legaspi A, Sarno EN, Ochoa MT, Parvatiyar K, Cheng G, Gilliet M, Bloom BR, Modlin RL.

JCI Insight. 2019 Apr 18;4(8). pii: 126955. doi: 10.1172/jci.insight.126955. eCollection 2019 Apr 18.

10.

IL-26 contributes to host defense against intracellular bacteria.

Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL.

J Clin Invest. 2019 Apr 2;129(5):1926-1939. doi: 10.1172/JCI99550. eCollection 2019 Apr 2.

11.

Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions.

Cheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin RL, Hoffmann A.

Sci Rep. 2019 Mar 27;9(1):5288. doi: 10.1038/s41598-019-40503-y.

12.

Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response.

Montoya DJ, Andrade P, Silva BJA, Teles RMB, Ma F, Bryson B, Sadanand S, Noel T, Lu J, Sarno E, Arnvig KB, Young D, Lahiri R, Williams DL, Fortune S, Bloom BR, Pellegrini M, Modlin RL.

Cell Rep. 2019 Mar 26;26(13):3574-3585.e3. doi: 10.1016/j.celrep.2019.02.109.

13.

Plasticity of antimicrobial and phagocytic programs in human macrophages.

Montoya D, Mehta M, Ferguson BG, Teles RMB, Krutzik SR, Cruz D, Pellegrini M, Modlin RL.

Immunology. 2019 Feb;156(2):164-173. doi: 10.1111/imm.13013. Epub 2018 Nov 11.

PMID:
30357820
14.

Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.

Zavala K, Gottlieb CA, Teles RM, Adams JS, Hewison M, Modlin RL, Liu PT.

PLoS Negl Trop Dis. 2018 Oct 9;12(10):e0006815. doi: 10.1371/journal.pntd.0006815. eCollection 2018 Oct.

15.

Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria.

Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL.

Sci Immunol. 2018 Aug 31;3(26). pii: eaat7668. doi: 10.1126/sciimmunol.aat7668.

16.

Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.

Kim EW, Teles RMB, Haile S, Liu PT, Modlin RL.

PLoS Negl Trop Dis. 2018 Jul 2;12(7):e0006608. doi: 10.1371/journal.pntd.0006608. eCollection 2018 Jul.

17.

Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.

Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL.

J Immunol. 2018 May 1;200(9):3244-3258. doi: 10.4049/jimmunol.1701733. Epub 2018 Apr 2.

18.

Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages.

Cheng L, Marinelli LJ, Grosset N, Fitz-Gibbon ST, Bowman CA, Dang BQ, Russell DA, Jacobs-Sera D, Shi B, Pellegrini M, Miller JF, Gautier M, Hatfull GF, Modlin RL.

BMC Microbiol. 2018 Mar 1;18(1):19. doi: 10.1186/s12866-018-1159-y.

19.

IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth.

Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW.

J Immunol. 2018 Apr 1;200(7):2405-2417. doi: 10.4049/jimmunol.1701073. Epub 2018 Feb 16. Erratum in: J Immunol. 2019 Oct 1;203(7):2020.

20.

SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles.

Lopez D, Montoya D, Ambrose M, Lam L, Briscoe L, Adams C, Modlin RL, Pellegrini M.

BMC Genomics. 2017 Oct 25;18(1):824. doi: 10.1186/s12864-017-4167-7.

21.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L.

Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030.

22.

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.

Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST.

PLoS Pathog. 2017 Jul 13;13(7):e1006496. doi: 10.1371/journal.ppat.1006496. eCollection 2017 Jul.

23.

Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes.

Yu Y, Champer J, Agak GW, Kao S, Modlin RL, Kim J.

J Invest Dermatol. 2016 Nov;136(11):2221-2228. doi: 10.1016/j.jid.2016.06.615. Epub 2016 Jul 1.

24.

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843. doi: 10.1172/jci.insight.88843.

25.

Jagged1 Instructs Macrophage Differentiation in Leprosy.

Kibbie J, Teles RM, Wang Z, Hong P, Montoya D, Krutzik S, Lee S, Kwon O, Modlin RL, Cruz D.

PLoS Pathog. 2016 Aug 17;12(8):e1005808. doi: 10.1371/journal.ppat.1005808. eCollection 2016 Aug.

26.

Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.

Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A.

Nat Commun. 2016 Aug 1;7:12348. doi: 10.1038/ncomms12348.

27.

S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL.

PLoS Pathog. 2016 Jun 29;12(6):e1005705. doi: 10.1371/journal.ppat.1005705. eCollection 2016 Jun.

28.

Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages.

Bloom BR, Modlin RL.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0006-2015. Review.

29.

Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae.

Schenk M, Mahapatra S, Le P, Kim HJ, Choi AW, Brennan PJ, Belisle JT, Modlin RL.

Infect Immun. 2016 Aug 19;84(9):2429-38. doi: 10.1128/IAI.00334-16. Print 2016 Sep.

30.

Thomas Herald Rea, MD (1929-2016).

Ochoa MT, Vaccaro S, Jerskey R, Mora H, Peng D, Modlin RL.

Lepr Rev. 2016 Mar;87(1):130-1. No abstract available.

PMID:
27255071
31.

Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages.

Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M.

J Immunol. 2016 Jul 1;197(1):222-32. doi: 10.4049/jimmunol.1502407. Epub 2016 May 27.

32.

Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis.

Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S; TBornotTB Network.

Am J Respir Crit Care Med. 2016 Aug 1;194(3):345-55. doi: 10.1164/rccm.201509-1746OC.

33.

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.

Demaria O, De Gassart A, Coso S, Gestermann N, Di Domizio J, Flatz L, Gaide O, Michielin O, Hwu P, Petrova TV, Martinon F, Modlin RL, Speiser DE, Gilliet M.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13. doi: 10.1073/pnas.1512832112. Epub 2015 Nov 25.

34.

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M.

Nat Immunol. 2015 Sep;16(9):970-9. doi: 10.1038/ni.3211. Epub 2015 Jul 13.

35.

IL-27 Suppresses Antimicrobial Activity in Human Leprosy.

Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL.

J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.

36.

Combinatorial code governing cellular responses to complex stimuli.

Cappuccio A, Zollinger R, Schenk M, Walczak A, Servant N, Barillot E, Hupé P, Modlin RL, Soumelis V.

Nat Commun. 2015 Apr 21;6:6847. doi: 10.1038/ncomms7847.

37.

Bee venom processes human skin lipids for presentation by CD1a.

Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G.

J Exp Med. 2015 Feb 9;212(2):149-63. doi: 10.1084/jem.20141505. Epub 2015 Jan 12.

38.

Carbohydrate-dependent binding of langerin to SodC, a cell wall glycoprotein of Mycobacterium leprae.

Kim HJ, Brennan PJ, Heaslip D, Udey MC, Modlin RL, Belisle JT.

J Bacteriol. 2015 Feb;197(3):615-25. doi: 10.1128/JB.02080-14. Epub 2014 Nov 24.

39.

IL-32 is a molecular marker of a host defense network in human tuberculosis.

Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL.

Sci Transl Med. 2014 Aug 20;6(250):250ra114. doi: 10.1126/scitranslmed.3009546.

40.

Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.

Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M.

J Invest Dermatol. 2015 Jan;135(1):151-159. doi: 10.1038/jid.2014.352. Epub 2014 Aug 11.

41.

Impact of vitamin D on immune function: lessons learned from genome-wide analysis.

Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M.

Front Physiol. 2014 Apr 21;5:151. doi: 10.3389/fphys.2014.00151. eCollection 2014. Review.

42.

TB or not TB: that is no longer the question.

Modlin RL, Bloom BR.

Sci Transl Med. 2013 Nov 27;5(213):213sr6. doi: 10.1126/scitranslmed.3007402. Review.

43.

Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells.

Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, Montoya D, Liu PT, Modlin RL.

Immunology. 2014 Feb;141(2):174-80. doi: 10.1111/imm.12167.

44.

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL.

Science. 2013 Mar 22;339(6126):1448-53. doi: 10.1126/science.1233665. Epub 2013 Feb 28.

45.

Propionibacterium acnes strain populations in the human skin microbiome associated with acne.

Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, Modlin RL, Miller JF, Sodergren E, Craft N, Weinstock GM, Li H.

J Invest Dermatol. 2013 Sep;133(9):2152-60. doi: 10.1038/jid.2013.21. Epub 2013 Jan 21.

46.

CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes.

Klug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M.

Immunology. 2013 May;139(1):121-8. doi: 10.1111/imm.12062.

47.

Galectin-3 regulates the innate immune response of human monocytes.

Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Rea TH, Stenger S, Modlin RL, Lee DJ.

J Infect Dis. 2013 Mar 15;207(6):947-56. doi: 10.1093/infdis/jis920. Epub 2012 Dec 18.

48.

Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.

Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J.

J Invest Dermatol. 2013 May;133(5):1231-9. doi: 10.1038/jid.2012.399. Epub 2012 Nov 29.

49.

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G.

Nat Immunol. 2012 Dec;13(12):1155-61. doi: 10.1038/ni.2460. Epub 2012 Nov 11.

50.

On the nature of mycobacteriophage diversity and host preference.

Jacobs-Sera D, Marinelli LJ, Bowman C, Broussard GW, Guerrero Bustamante C, Boyle MM, Petrova ZO, Dedrick RM, Pope WH; Science Education Alliance Phage Hunters Advancing Genomics And Evolutionary Science Sea-Phages Program, Modlin RL, Hendrix RW, Hatfull GF.

Virology. 2012 Dec 20;434(2):187-201. doi: 10.1016/j.virol.2012.09.026. Epub 2012 Oct 22. Review.

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