Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 67

1.

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.

Stoll GA, Oda SI, Chong ZS, Yu M, McLaughlin SH, Modis Y.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15042-15051. doi: 10.1073/pnas.1901318116. Epub 2019 Jul 9.

2.

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

Zhang Z, Gothe F, Pennamen P, James JR, McDonald D, Mata CP, Modis Y, Alazami AM, Acres M, Haller W, Bowen C, Döffinger R, Sinclair J, Brothers S, Zhang Y, Matthews HF, Naudion S, Pelluard F, Alajlan H, Yamazaki Y, Notarangelo LD, Thaventhiran JE, Engelhardt KR, Al-Mousa H, Hambleton S, Rooryck C, Smith KGC, Lenardo MJ.

J Exp Med. 2019 Jun 3;216(6):1311-1327. doi: 10.1084/jem.20182304. Epub 2019 Apr 30.

3.

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling.

Hwang MS, Boulanger J, Howe JD, Albecka A, Pasche M, Mureşan L, Modis Y.

FEBS J. 2019 Apr;286(8):1543-1560. doi: 10.1111/febs.14772. Epub 2019 Feb 16.

4.

Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.

Yu Q, Qu K, Modis Y.

Mol Cell. 2018 Dec 20;72(6):999-1012.e6. doi: 10.1016/j.molcel.2018.10.012. Epub 2018 Nov 15.

5.

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

Sng CCT, O'Byrne S, Prigozhin DM, Bauer MR, Harvey JC, Ruhle M, Challis BG, Lear S, Roberts LD, Workman S, Janowitz T, Magiera L, Doffinger R, Buckland MS, Jodrell DJ, Semple RK, Wilson TJ, Modis Y, Thaventhiran JED.

J Allergy Clin Immunol. 2018 Jul;142(1):311-314.e6. doi: 10.1016/j.jaci.2018.01.048. Epub 2018 Mar 6. No abstract available.

6.

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y.

Nat Commun. 2018 Feb 13;9(1):651. doi: 10.1038/s41467-018-03045-x.

7.

Structural studies of viperin, an antiviral radical SAM enzyme.

Fenwick MK, Li Y, Cresswell P, Modis Y, Ealick SE.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6806-6811. doi: 10.1073/pnas.1705402114. Epub 2017 Jun 12.

8.

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ.

Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5.

9.

Corrigendum: IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses.

Lee CM, He CH, Nour AM, Zhou Y, Ma B, Park JW, Kim KH, Cruz CD, Sharma L, Nasr ML, Modis Y, Lee CG, Elias JA.

Nat Commun. 2016 Nov 14;7:13541. doi: 10.1038/ncomms13541. No abstract available.

10.

Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation.

Willensky S, Bar-Rogovsky H, Bignon EA, Tischler ND, Modis Y, Dessau M.

PLoS Pathog. 2016 Oct 26;12(10):e1005948. doi: 10.1371/journal.ppat.1005948. eCollection 2016 Oct.

11.

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses.

Lee CM, He CH, Nour AM, Zhou Y, Ma B, Park JW, Kim KH, Dela Cruz C, Sharma L, Nasr ML, Modis Y, Lee CG, Elias JA.

Nat Commun. 2016 Sep 15;7:12752. doi: 10.1038/ncomms12752. Erratum in: Nat Commun. 2016 Nov 14;7:13541.

12.

Leveraging protein quaternary structure to identify oncogenic driver mutations.

Ryslik GA, Cheng Y, Modis Y, Zhao H.

BMC Bioinformatics. 2016 Mar 22;17:137. doi: 10.1186/s12859-016-0963-3.

13.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

14.

P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5).

Wong EV, Cao W, Vörös J, Merchant M, Modis Y, Hackney DD, Montpetit B, De La Cruz EM.

J Mol Biol. 2016 Jan 29;428(2 Pt B):492-508. doi: 10.1016/j.jmb.2015.12.018. Epub 2015 Dec 28.

15.

Functional assessment and structural basis of antibody binding to human papillomavirus capsid.

Zhang X, Li S, Modis Y, Li Z, Zhang J, Xia N, Zhao Q.

Rev Med Virol. 2016 Mar;26(2):115-28. doi: 10.1002/rmv.1867. Epub 2015 Dec 17. Review.

PMID:
26676802
16.

Flunarizine arrests hepatitis C virus membrane fusion.

Prigozhin DM, Modis Y.

Hepatology. 2016 Jan;63(1):14-6. doi: 10.1002/hep.28224. Epub 2015 Oct 30. No abstract available.

17.

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Kim E, Ilagan JO, Liang Y, Daubner GM, Lee SC, Ramakrishnan A, Li Y, Chung YR, Micol JB, Murphy ME, Cho H, Kim MK, Zebari AS, Aumann S, Park CY, Buonamici S, Smith PG, Deeg HJ, Lobry C, Aifantis I, Modis Y, Allain FH, Halene S, Bradley RK, Abdel-Wahab O.

Cancer Cell. 2015 May 11;27(5):617-30. doi: 10.1016/j.ccell.2015.04.006.

18.

Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles.

Espósito DL, Nguyen JB, DeWitt DC, Rhoades E, Modis Y.

J Gen Virol. 2015 Jul;96(Pt 7):1702-11. doi: 10.1099/vir.0.000113. Epub 2015 Mar 4.

19.

An Inheritable variant of the innate immune receptor melanoma differentiation-associated gene 5 promotes clearance of hepatitis C virus.

Modis Y.

Hepatology. 2015 Feb;61(2):418-20. doi: 10.1002/hep.27439. Epub 2015 Jan 5. No abstract available.

20.

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.

Reikine S, Nguyen JB, Modis Y.

Front Immunol. 2014 Jul 23;5:342. doi: 10.3389/fimmu.2014.00342. eCollection 2014. Review.

21.

Exploiting subtle structural differences in heavy-atom derivatives for experimental phasing.

Wang J, Li Y, Modis Y.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1873-83. doi: 10.1107/S1399004714008943. Epub 2014 Jun 29.

22.

A spatial simulation approach to account for protein structure when identifying non-random somatic mutations.

Ryslik GA, Cheng Y, Cheung KH, Bjornson RD, Zelterman D, Modis Y, Zhao H.

BMC Bioinformatics. 2014 Jul 3;15:231. doi: 10.1186/1471-2105-15-231.

23.

Endosomal vesicles as vehicles for viral genomes.

Nour AM, Modis Y.

Trends Cell Biol. 2014 Aug;24(8):449-54. doi: 10.1016/j.tcb.2014.03.006. Epub 2014 Apr 15. Review.

24.

Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses.

Wang J, Li Y, Modis Y.

Virology. 2014 Apr;454-455:93-101. doi: 10.1016/j.virol.2014.02.015. Epub 2014 Feb 25.

25.

A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.

Ryslik GA, Cheng Y, Cheung KH, Modis Y, Zhao H.

BMC Bioinformatics. 2014 Mar 26;15:86. doi: 10.1186/1471-2105-15-86.

26.

A novel membrane fusion protein family in Flaviviridae?

Li Y, Modis Y.

Trends Microbiol. 2014 Apr;22(4):176-82. doi: 10.1016/j.tim.2014.01.008. Epub 2014 Feb 23.

27.

Relating structure to evolution in class II viral membrane fusion proteins.

Modis Y.

Curr Opin Virol. 2014 Apr;5:34-41. doi: 10.1016/j.coviro.2014.01.009. Epub 2014 Feb 11. Review.

28.

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

Rigby RE, Webb LM, Mackenzie KJ, Li Y, Leitch A, Reijns MA, Lundie RJ, Revuelta A, Davidson DJ, Diebold S, Modis Y, MacDonald AS, Jackson AP.

EMBO J. 2014 Mar 18;33(6):542-58. doi: 10.1002/embj.201386117. Epub 2014 Feb 10.

29.

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties.

Zhao Q, Li S, Yu H, Xia N, Modis Y.

Trends Biotechnol. 2013 Nov;31(11):654-63. doi: 10.1016/j.tibtech.2013.09.002. Epub 2013 Oct 11. Review.

PMID:
24125746
30.

Viral membrane fusion and nucleocapsid delivery into the cytoplasm are distinct events in some flaviviruses.

Nour AM, Li Y, Wolenski J, Modis Y.

PLoS Pathog. 2013;9(9):e1003585. doi: 10.1371/journal.ppat.1003585. Epub 2013 Sep 5.

31.

Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2.

He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, Ma B, Herzog EL, Rosenberg SA, Li Y, Nour AM, Parikh CR, Schmidt I, Modis Y, Cantley L, Elias JA.

Cell Rep. 2013 Aug 29;4(4):830-41. doi: 10.1016/j.celrep.2013.07.032. Epub 2013 Aug 22. Erratum in: Cell Rep. 2013 Nov 27;5(4):1156. Cell Rep. 2015 Mar 3;10(8):1433.

32.

Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A.

Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y.

Chem Biol. 2013 Aug 22;20(8):991-1001. doi: 10.1016/j.chembiol.2013.06.011. Epub 2013 Jul 25.

33.

Class II fusion proteins.

Modis Y.

Adv Exp Med Biol. 2013;790:150-66. doi: 10.1007/978-1-4614-7651-1_8. Review.

PMID:
23884590
34.

Utilizing protein structure to identify non-random somatic mutations.

Ryslik GA, Cheng Y, Cheung KH, Modis Y, Zhao H.

BMC Bioinformatics. 2013 Jun 13;14:190. doi: 10.1186/1471-2105-14-190.

35.

Crystal structure of glycoprotein E2 from bovine viral diarrhea virus.

Li Y, Wang J, Kanai R, Modis Y.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6805-10. doi: 10.1073/pnas.1300524110. Epub 2013 Apr 8.

36.

Crystal structure of an insect antifreeze protein and its implications for ice binding.

Hakim A, Nguyen JB, Basu K, Zhu DF, Thakral D, Davies PL, Isaacs FJ, Modis Y, Meng W.

J Biol Chem. 2013 Apr 26;288(17):12295-304. doi: 10.1074/jbc.M113.450973. Epub 2013 Mar 12.

37.

Crystal structure of glycoprotein C from Rift Valley fever virus.

Dessau M, Modis Y.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1696-701. doi: 10.1073/pnas.1217780110. Epub 2013 Jan 14.

38.

Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme.

Dessau M, Goldhill D, McBride R, Turner PE, Modis Y.

PLoS Genet. 2012;8(11):e1003102. doi: 10.1371/journal.pgen.1003102. Epub 2012 Nov 29. Erratum in: PLoS Genet. 2012 Dec;8(12). doi: 10.1371/annotation/aa9bff6f-92c4-4efb-9b7f-de96e405e9d3. McBride, Robert L [corrected to McBride, Robert C].

39.

Structural basis of innate immune recognition of viral RNA.

Berke IC, Li Y, Modis Y.

Cell Microbiol. 2013 Mar;15(3):386-94. doi: 10.1111/cmi.12061. Epub 2012 Nov 21. Review.

PMID:
23110455
40.

Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1.

Nguyen JB, Modis Y.

J Struct Biol. 2013 Jan;181(1):82-8. doi: 10.1016/j.jsb.2012.10.006. Epub 2012 Oct 23.

41.

MDA5 assembles into a polar helical filament on dsRNA.

Berke IC, Yu X, Modis Y, Egelman EH.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18437-41. doi: 10.1073/pnas.1212186109. Epub 2012 Oct 22.

42.

Quantification of the affinities and kinetics of protein interactions using silicon nanowire biosensors.

Duan X, Li Y, Rajan NK, Routenberg DA, Modis Y, Reed MA.

Nat Nanotechnol. 2012 May 27;7(6):401-7. doi: 10.1038/nnano.2012.82.

43.

Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity.

Zhao Q, Modis Y, High K, Towne V, Meng Y, Wang Y, Alexandroff J, Brown M, Carragher B, Potter CS, Abraham D, Wohlpart D, Kosinski M, Washabaugh MW, Sitrin RD.

Virol J. 2012 Feb 22;9:52. doi: 10.1186/1743-422X-9-52.

44.

Exploiting structural biology in the fight against parasitic diseases.

Modis Y.

Trends Parasitol. 2012 Apr;28(4):124-30. doi: 10.1016/j.pt.2012.01.003. Epub 2012 Feb 15.

PMID:
22341779
45.

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.

Berke IC, Modis Y.

EMBO J. 2012 Apr 4;31(7):1714-26. doi: 10.1038/emboj.2012.19. Epub 2012 Feb 7.

46.

DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature.

Li Y, Berke IC, Modis Y.

EMBO J. 2012 Feb 15;31(4):919-31. doi: 10.1038/emboj.2011.441. Epub 2011 Dec 6.

47.

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.

Zhou K, Kanai R, Lee P, Wang HW, Modis Y.

J Struct Biol. 2012 Feb;177(2):402-9. doi: 10.1016/j.jsb.2011.12.002. Epub 2011 Dec 8.

PMID:
22173220
48.

Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins.

Kucera K, Harrison LM, Cappello M, Modis Y.

J Mol Biol. 2011 Apr 22;408(1):9-17. doi: 10.1016/j.jmb.2011.02.033. Epub 2011 Feb 23.

49.

Protein crystallization for X-ray crystallography.

Dessau MA, Modis Y.

J Vis Exp. 2011 Jan 16;(47). pii: 2285. doi: 10.3791/2285.

50.

Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11.

Kucera K, Koblansky AA, Saunders LP, Frederick KB, De La Cruz EM, Ghosh S, Modis Y.

J Mol Biol. 2010 Nov 5;403(4):616-29. doi: 10.1016/j.jmb.2010.09.022. Epub 2010 Sep 17.

Supplemental Content

Support Center