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Items: 1 to 50 of 116

1.

Corrigendum to: "Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment" [Exp. Cell. Res. 2014 15 323(1) 155-64].

Kim JH, Frantz AM, Anderson KL, Graef AJ, Scott MC, Robinson S, Sharkey LC, O'Brien TD, Dickerson EB, Modiano JF.

Exp Cell Res. 2018 Oct 1;371(1):299. doi: 10.1016/j.yexcr.2018.07.012. Epub 2018 Jul 14. No abstract available.

PMID:
30017210
2.

SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma.

Sakthikumar S, Elvers I, Kim J, Arendt ML, Thomas R, Turner-Maier J, Swofford R, Johnson J, Schumacher SE, Alföldi J, Axelsson E, Couto CG, Kisseberth WC, Pettersson ME, Getz G, Meadows JRS, Modiano JF, Breen M, Kierczak M, Forsberg-Nilsson K, Marinescu VD, Lindblad-Toh K.

Cancer Res. 2018 Jul 1;78(13):3421-3431. doi: 10.1158/0008-5472.CAN-17-3558. Epub 2018 May 3.

PMID:
29724721
3.

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.

Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ.

J Immunother Cancer. 2017 Dec 19;5(1):98. doi: 10.1186/s40425-017-0305-7.

4.

Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers.

Kim JH, Frantz AM, Sarver AL, Gorden Klukas BH, Lewellen M, O'Brien TD, Dickerson EB, Modiano JF.

Vet Comp Oncol. 2018 Mar;16(1):E176-E184. doi: 10.1111/vco.12368. Epub 2017 Nov 20. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.

PMID:
29152836
5.

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.

Scott MC, Temiz NA, Sarver AE, LaRue RS, Rathe SK, Varshney J, Wolf NK, Moriarity BS, O'Brien TD, Spector LG, Largaespada DA, Modiano JF, Subramanian S, Sarver AL.

Cancer Res. 2018 Jan 15;78(2):326-337. doi: 10.1158/0008-5472.CAN-17-0576. Epub 2017 Oct 24.

6.

Comparative Pathogenesis of Cancers in Animals and Humans.

Modiano JF.

Vet Sci. 2016 Sep 13;3(3). pii: E24. doi: 10.3390/vetsci3030024. No abstract available.

7.

Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats.

Cannon CM, Trembley JH, Kren BT, Unger GM, O'Sullivan MG, Cornax I, Modiano JF, Ahmed K.

Am J Vet Res. 2017 Aug;78(8):946-953. doi: 10.2460/ajvr.78.8.946.

PMID:
28738012
8.

Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer.

Cannon CM, Trembley JH, Kren BT, Unger GM, O'Sullivan MG, Cornax I, Modiano JF, Ahmed K.

Hum Gene Ther Clin Dev. 2017 Jun;28(2):80-86. doi: 10.1089/humc.2017.008. Epub 2017 Mar 23.

9.

Evaluation of 18-F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma - A pilot study.

Borgatti A, Winter AL, Stuebner K, Scott R, Ober CP, Anderson KL, Feeney DA, Vallera DA, Koopmeiners JS, Modiano JF, Froelich J.

PLoS One. 2017 Feb 21;12(2):e0172651. doi: 10.1371/journal.pone.0172651. eCollection 2017.

10.

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.

Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.

11.

Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis.

Murahari S, Jalkanen AL, Kulp SK, Chen CS, Modiano JF, London CA, Kisseberth WC.

BMC Cancer. 2017 Jan 21;17(1):67. doi: 10.1186/s12885-017-3046-6.

12.

Canine cancer immunotherapy studies: linking mouse and human.

Park JS, Withers SS, Modiano JF, Kent MS, Chen M, Luna JI, Culp WTN, Sparger EE, Rebhun RB, Monjazeb AM, Murphy WJ, Canter RJ.

J Immunother Cancer. 2016 Dec 20;4:97. doi: 10.1186/s40425-016-0200-7. eCollection 2016. Review.

13.

Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type.

Im KS, Kim JH, Graef AJ, Cornax I, Seelig DM, O'Sullivan MG, Kovi RC, Modiano JF.

J Comp Pathol. 2017 Jan;156(1):37-41. doi: 10.1016/j.jcpa.2016.11.271. Epub 2016 Dec 20.

14.

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.

Seelig DM, Ito D, Forster CL, Yoon UA, Breen M, Burns LJ, Bachanova V, Lindblad-Toh K, O'Brien TD, Schmechel SC, Rizzardi AE, Modiano JF, Linden MA.

Leuk Lymphoma. 2017 Jul;58(7):1702-1710. doi: 10.1080/10428194.2016.1260122. Epub 2016 Dec 8.

PMID:
27931134
15.

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior.

Scott MC, Tomiyasu H, Garbe JR, Cornax I, Amaya C, O'Sullivan MG, Subramanian S, Bryan BA, Modiano JF.

Dis Model Mech. 2016 Dec 1;9(12):1435-1444. Epub 2016 Nov 3.

16.

Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.

Weiskopf K, Anderson KL, Ito D, Schnorr PJ, Tomiyasu H, Ring AM, Bloink K, Efe J, Rue S, Lowery D, Barkal A, Prohaska S, McKenna KM, Cornax I, O'Brien TD, O'Sullivan MG, Weissman IL, Modiano JF.

Cancer Immunol Res. 2016 Dec;4(12):1072-1087. Epub 2016 Nov 14.

17.

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.

Fenger JM, Roberts RD, Iwenofu OH, Bear MD, Zhang X, Couto JI, Modiano JF, Kisseberth WC, London CA.

BMC Cancer. 2016 Oct 10;16(1):784.

18.

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.

Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH.

Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658.

19.

Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells.

Lin W, Modiano JF, Ito D.

J Vet Sci. 2017 Mar 30;18(1):101-104. doi: 10.4142/jvs.2017.18.1.101.

20.

A phase I clinical study to evaluate safety of orally administered, genetically engineered Salmonella enterica serovar Typhimurium for canine osteosarcoma.

Fritz SE, Henson MS, Greengard E, Winter AL, Stuebner KM, Yoon U, Wilk VL, Borgatti A, Augustin LB, Modiano JF, Saltzman DA.

Vet Med Sci. 2016 Jun 6;2(3):179-190. doi: 10.1002/vms3.32. eCollection 2016 Aug.

21.

Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cure.

Anderson KL, Modiano JF.

Vet Sci. 2015 Dec;2(4):363-387. Epub 2015 Oct 19.

22.

Anti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous Diabetes.

Kim JH, Furrow E, Ritt MG, Utz PJ, Robinson WH, Yu L, Eckert A, Stuebner K, O'Brien TD, Steinman L, Modiano JF.

PLoS One. 2016 Mar 31;11(3):e0152397. doi: 10.1371/journal.pone.0152397. eCollection 2016.

24.

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives.

Kim JH, Graef AJ, Dickerson EB, Modiano JF.

Vet Sci. 2015 Nov 6;2(4):388-405. doi: 10.3390/vetsci2040388. Review.

25.

Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma.

Scott MC, Sarver AL, Tomiyasu H, Cornax I, Van Etten J, Varshney J, O'Sullivan MG, Subramanian S, Modiano JF.

J Biol Chem. 2015 Nov 20;290(47):28070-83. doi: 10.1074/jbc.M115.679696. Epub 2015 Sep 16.

26.

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background.

Elvers I, Turner-Maier J, Swofford R, Koltookian M, Johnson J, Stewart C, Zhang CZ, Schumacher SE, Beroukhim R, Rosenberg M, Thomas R, Mauceli E, Getz G, Palma FD, Modiano JF, Breen M, Lindblad-Toh K, Alföldi J.

Genome Res. 2015 Nov;25(11):1634-45. doi: 10.1101/gr.194449.115. Epub 2015 Sep 16.

27.

Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.

Im KS, Graef AJ, Breen M, Lindblad-Toh K, Modiano JF, Kim JH.

Vet Comp Oncol. 2017 Jun;15(2):315-327. doi: 10.1111/vco.12165. Epub 2015 Sep 3. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.

PMID:
26337509
28.

Mesenchymal stromal cells inhibit murine syngeneic anti-tumor immune responses by attenuating inflammation and reorganizing the tumor microenvironment.

Modiano JF, Lindborg BA, McElmurry RT, Lewellen M, Forster CL, Zamora EA, Schaack J, Bellgrau D, O'Brien TD, Tolar J.

Cancer Immunol Immunother. 2015 Nov;64(11):1449-60. doi: 10.1007/s00262-015-1749-6. Epub 2015 Aug 7.

29.

Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma.

Rodriguez AM, Graef AJ, LeVine DN, Cohen IR, Modiano JF, Kim JH.

J Vet Intern Med. 2015 Jul-Aug;29(4):1088-97. doi: 10.1111/jvim.13570. Epub 2015 Jun 25.

30.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA.

Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11.

31.

Stimulation with Concanavalin-A Induces IL-17 Production by Canine Peripheral T Cells.

Ritt MG, Lindborg BA, O'Brien TD, Bisignano J, Modiano JF.

Vet Sci. 2015 Apr 10;2(2):43-51. doi: 10.3390/vetsci2020043.

32.

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.

Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K.

PLoS Genet. 2015 Feb 2;11(2):e1004922. doi: 10.1371/journal.pgen.1004922. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 May;11(5):e1005339.

33.

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

May SL, Zhou Q, Lewellen M, Carter CM, Coffey D, Highfill SL, Bucher CM, Matise I, Morse HC 3rd, O'Sullivan MG, Schutten M, Johnson C, Bellgrau D, Blazar BR, Modiano JF.

PLoS One. 2014 Jun 19;9(6):e100629. doi: 10.1371/journal.pone.0100629. eCollection 2014.

34.

Development of a novel anti-canine CD20 monoclonal antibody with diagnostic and therapeutic potential.

Ito D, Brewer S, Modiano JF, Beall MJ.

Leuk Lymphoma. 2015 Jan;56(1):219-25. doi: 10.3109/10428194.2014.914193. Epub 2014 Jun 16.

35.

Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications.

Ito D, Frantz AM, Modiano JF.

Vet Immunol Immunopathol. 2014 Jun 15;159(3-4):192-201. doi: 10.1016/j.vetimm.2014.02.016. Epub 2014 Feb 24. Review.

36.

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma.

Thomas R, Borst L, Rotroff D, Motsinger-Reif A, Lindblad-Toh K, Modiano JF, Breen M.

Chromosome Res. 2014 Sep;22(3):305-19. doi: 10.1007/s10577-014-9406-z. Epub 2014 Mar 6.

37.

Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment.

Kim JH, Frantz AM, Anderson KL, Graef AJ, Scott MC, Robinson S, Sharkey LC, O'Brien TD, Dickerson EB, Modiano JF.

Exp Cell Res. 2014 Apr 15;323(1):155-64. doi: 10.1016/j.yexcr.2014.02.020. Epub 2014 Feb 25. Erratum in: Exp Cell Res. 2018 Oct 1;371(1):299.

38.

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.

Gorden BH, Kim JH, Sarver AL, Frantz AM, Breen M, Lindblad-Toh K, O'Brien TD, Sharkey LC, Modiano JF, Dickerson EB.

Am J Pathol. 2014 Apr;184(4):985-995. doi: 10.1016/j.ajpath.2013.12.025. Epub 2014 Feb 11.

39.

Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.

London CA, Bernabe LF, Barnard S, Kisseberth WC, Borgatti A, Henson M, Wilson H, Jensen K, Ito D, Modiano JF, Bear MD, Pennell ML, Saint-Martin JR, McCauley D, Kauffman M, Shacham S.

PLoS One. 2014 Feb 4;9(2):e87585. doi: 10.1371/journal.pone.0087585. eCollection 2014.

40.

Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility.

McAloney CA, Silverstein KA, Modiano JF, Bagchi A.

BMC Vet Res. 2014 Jan 14;10:20. doi: 10.1186/1746-6148-10-20.

41.

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.

Karlsson EK, Sigurdsson S, Ivansson E, Thomas R, Elvers I, Wright J, Howald C, Tonomura N, Perloski M, Swofford R, Biagi T, Fryc S, Anderson N, Courtay-Cahen C, Youell L, Ricketts SL, Mandlebaum S, Rivera P, von Euler H, Kisseberth WC, London CA, Lander ES, Couto G, Comstock K, Starkey MP, Modiano JF, Breen M, Lindblad-Toh K.

Genome Biol. 2013 Dec 12;14(12):R132. doi: 10.1186/gb-2013-14-12-r132.

42.

Isolation and characterization of canine natural killer cells.

Michael HT, Ito D, McCullar V, Zhang B, Miller JS, Modiano JF.

Vet Immunol Immunopathol. 2013 Sep 15;155(3):211-7. doi: 10.1016/j.vetimm.2013.06.013. Epub 2013 Jun 28.

43.

Molecular characterization of canine BCR-ABL-positive chronic myelomonocytic leukemia before and after chemotherapy.

Culver S, Ito D, Borst L, Bell JS, Modiano JF, Breen M.

Vet Clin Pathol. 2013 Sep;42(3):314-22. doi: 10.1111/vcp.12055. Epub 2013 Jun 25.

44.

Parenchymal signal intensity in 3-T body MRI of dogs with hematopoietic neoplasia.

Feeney DA, Sharkey LC, Steward SM, Bahr KL, Henson MS, Ito D, O'Brien TD, Jessen CR, Husbands BD, Borgatti A, Modiano JF.

Comp Med. 2013 Apr;63(2):174-82.

45.

Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma.

Stiles JM, Amaya C, Rains S, Diaz D, Pham R, Battiste J, Modiano JF, Kokta V, Boucheron LE, Mitchell DC, Bryan BA.

PLoS One. 2013;8(3):e60021. doi: 10.1371/journal.pone.0060021. Epub 2013 Mar 28.

46.

Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors.

Schappa JT, Frantz AM, Gorden BH, Dickerson EB, Vallera DA, Modiano JF.

Int J Cancer. 2013 Oct 15;133(8):1936-44. doi: 10.1002/ijc.28187. Epub 2013 Apr 25.

47.

Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors.

Cannon CM, Pozniak J, Scott MC, Ito D, Gorden BH, Graef AJ, Modiano JF.

Vet Comp Oncol. 2015 Mar;13(1):48-59. doi: 10.1111/vco.12018. Epub 2013 Feb 15.

48.

Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.

Wells JW, Evans CH, Scott MC, Rütgen BC, O'Brien TD, Modiano JF, Cvetkovic G, Tepic S.

PLoS One. 2013;8(1):e54464. doi: 10.1371/journal.pone.0054464. Epub 2013 Jan 24.

49.

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.

Sarver AL, Thayanithy V, Scott MC, Cleton-Jansen AM, Hogendoorn PC, Modiano JF, Subramanian S.

Orphanet J Rare Dis. 2013 Jan 11;8:7. doi: 10.1186/1750-1172-8-7.

50.

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations.

Angstadt AY, Thayanithy V, Subramanian S, Modiano JF, Breen M.

Cancer Genet. 2012 Nov;205(11):572-87. doi: 10.1016/j.cancergen.2012.09.005. Epub 2012 Nov 6.

PMID:
23137772

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