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Alcohol consumption and vascular disease: other points to consider.

Chen CH, Ferreira JCB, Mochly-Rosen D, Gross ER.

Lancet. 2019 Nov 2;394(10209):1617-1618. doi: 10.1016/S0140-6736(19)31880-X. No abstract available.


Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.

Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW 2nd, Mochly-Rosen D.

Nat Neurosci. 2019 Oct;22(10):1635-1648. doi: 10.1038/s41593-019-0486-0. Epub 2019 Sep 23.


ALDH2 and Cardiovascular Disease.

Chen CH, Ferreira JCB, Mochly-Rosen D.

Adv Exp Med Biol. 2019;1193:53-67. doi: 10.1007/978-981-13-6260-6_3. Review.


Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface.

Raub AG, Hwang S, Horikoshi N, Cunningham AD, Rahighi S, Wakatsuki S, Mochly-Rosen D.

ChemMedChem. 2019 Jul 17;14(14):1321-1324. doi: 10.1002/cmdc.201900341. Epub 2019 Jun 27.


Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes.

Ebert A, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfuss G, Mochly-Rosen D, Wu JC.

Circ Res. 2019 Jun 21;125(1):90-103. doi: 10.1161/CIRCRESAHA.118.313973. Epub 2019 May 20.


Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.

Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D.

J Mol Cell Cardiol. 2019 May;130:160-169. doi: 10.1016/j.yjmcc.2019.04.006. Epub 2019 Apr 11.


A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.

Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D.

Nat Commun. 2019 Jan 18;10(1):329. doi: 10.1038/s41467-018-08276-6.


Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.

Joshi AU, Ebert AE, Haileselassie B, Mochly-Rosen D.

J Mol Cell Cardiol. 2019 Feb;127:125-133. doi: 10.1016/j.yjmcc.2018.12.004. Epub 2018 Dec 11.


Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.

Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz JD, Andreasson KI.

Nat Immunol. 2019 Jan;20(1):50-63. doi: 10.1038/s41590-018-0255-3. Epub 2018 Nov 26.


ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.

Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE.

Cell Chem Biol. 2018 Dec 20;25(12):1456-1469.e6. doi: 10.1016/j.chembiol.2018.09.005. Epub 2018 Oct 4.


Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.

Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D.

Nat Commun. 2018 Oct 2;9(1):4045. doi: 10.1038/s41467-018-06447-z.


Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.

Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D.

Sci Rep. 2018 Sep 19;8(1):14034. doi: 10.1038/s41598-018-32228-1.


Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities.

Kiyuna LA, Albuquerque RPE, Chen CH, Mochly-Rosen D, Ferreira JCB.

Free Radic Biol Med. 2018 Dec;129:155-168. doi: 10.1016/j.freeradbiomed.2018.09.019. Epub 2018 Sep 15. Review.


Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.

Parrish MC, Tan YJ, Grimes KV, Mochly-Rosen D.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:405-421. doi: 10.1146/annurev-pharmtox-010818-021625. Epub 2018 Sep 12.


Structural analysis of clinically relevant pathogenic G6PD variants reveals the importance of tetramerization for G6PD activity.

Cunningham AD, Mochly-Rosen D.

Matters (Zur). 2017 Sep 14;2017. doi: 10.19185/matters.201705000008.


Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases.

Joshi AU, Mochly-Rosen D.

Pharmacol Res. 2018 Dec;138:2-15. doi: 10.1016/j.phrs.2018.08.010. Epub 2018 Aug 23. Review.


Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.

Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6279-6284. doi: 10.1073/pnas.1802184115. Epub 2018 May 24.


MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW 2nd.

Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785.


Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2.

Ueta CB, Campos JC, Albuquerque RPE, Lima VM, Disatnik MH, Sanchez AB, Chen CH, de Medeiros MHG, Yang W, Mochly-Rosen D, Ferreira JCB.

Cardiovasc Res. 2018 Jun 1;114(7):1006-1015. doi: 10.1093/cvr/cvy070.


Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.

Joshi AU, Saw NL, Shamloo M, Mochly-Rosen D.

Oncotarget. 2017 Dec 22;9(5):6128-6143. doi: 10.18632/oncotarget.23640. eCollection 2018 Jan 19.


Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes.

Deshwal S, Forkink M, Hu CH, Buonincontri G, Antonucci S, Di Sante M, Murphy MP, Paolocci N, Mochly-Rosen D, Krieg T, Di Lisa F, Kaludercic N.

Cell Death Differ. 2018 Sep;25(9):1671-1685. doi: 10.1038/s41418-018-0071-1. Epub 2018 Feb 19.


Transcriptome analysis and prognosis of ALDH isoforms in human cancer.

Chang PM, Chen CH, Yeh CC, Lu HJ, Liu TT, Chen MH, Liu CY, Wu ATH, Yang MH, Tai SK, Mochly-Rosen D, Huang CF.

Sci Rep. 2018 Feb 9;8(1):2713. doi: 10.1038/s41598-018-21123-4.


Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D.

EMBO Mol Med. 2018 Mar;10(3). pii: e8166. doi: 10.15252/emmm.201708166.


Human Chitotriosidase Does Not Catabolize Hyaluronan.

Danielson B, Chen CH, Kaber G, Mochly-Rosen D, Grimes K, Stern R, Bollyky PL.

Int J Biol Macromol. 2018 Apr 1;109:629-633. doi: 10.1016/j.ijbiomac.2017.11.181. Epub 2017 Dec 13.


Thiophene bridged aldehydes (TBAs) image ALDH activity in cells via modulation of intramolecular charge transfer.

Maity S, Sadlowski CM, George Lin JM, Chen CH, Peng LH, Lee ES, Vegesna GK, Lee C, Kim SH, Mochly-Rosen D, Kumar S, Murthy N.

Chem Sci. 2017 Oct 1;8(10):7143-7151. doi: 10.1039/c7sc03017g. Epub 2017 Aug 24.


Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Alcohol Consumption are Associated With Asymptomatic Cardiac Remodeling and Subclinical Systolic Dysfunction in Large Community-Dwelling Asians.

Hung CL, Chang SC, Chang SH, Chi PC, Lai YJ, Wang SW, Wu YJ, Yeh HI, Lin SJ, Chen CH, Mochly-Rosen D, Wang LY; MAGNET Study Investigator.

Alcohol Alcohol. 2017 Nov 1;52(6):638-646. doi: 10.1093/alcalc/agx049.


Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor.

Kim J, Shin JH, Chen CH, Cruz L, Farnebo L, Yang J, Borges P, Kang G, Mochly-Rosen D, Sunwoo JB.

Oncotarget. 2017 Apr 10;8(32):52345-52356. doi: 10.18632/oncotarget.17017. eCollection 2017 Aug 8.


Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure.

Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, Ferreira JCB.

Autophagy. 2017 Aug 3;13(8):1304-1317. doi: 10.1080/15548627.2017.1325062.


Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment.

Kim J, Chen CH, Yang J, Mochly-Rosen D.

J Biomed Sci. 2017 May 22;24(1):33. doi: 10.1186/s12929-017-0338-8.


The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.

Chen CH, Joshi AU, Mochly-Rosen D.

Acta Neurol Taiwan. 2016 Dec 15;25(4):111-123. Review.


Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.

Cunningham AD, Colavin A, Huang KC, Mochly-Rosen D.

Cell Rep. 2017 Mar 14;18(11):2592-2599. doi: 10.1016/j.celrep.2017.02.048.


Corrigendum: Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

Qvit N, Kornfeld OS, Mochly-Rosen D.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2236. doi: 10.1002/anie.201700072. No abstract available.


Peptides and peptidomimetics as regulators of protein-protein interactions.

Cunningham AD, Qvit N, Mochly-Rosen D.

Curr Opin Struct Biol. 2017 Jun;44:59-66. doi: 10.1016/ Epub 2017 Jan 4. Review.


Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites.

Nene A, Chen CH, Disatnik MH, Cruz L, Mochly-Rosen D.

J Biomed Sci. 2017 Jan 5;24(1):3. doi: 10.1186/s12929-016-0312-x.


Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.

Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironomobe N, Motoda C, Oda N, Chayama K, Chen CH, Gross ER, Mochly-Rosen D, Kihara Y.

J Biomed Sci. 2016 Dec 7;23(1):89.


Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities.

Ueta CB, Gomes KS, Ribeiro MA, Mochly-Rosen D, Ferreira JC.

Pharmacol Res. 2017 Jan;115:96-106. doi: 10.1016/j.phrs.2016.11.016. Epub 2016 Nov 19. Review.


Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

Qvit N, Kornfeld OS, Mochly-Rosen D.

Angew Chem Int Ed Engl. 2016 Dec 12;55(50):15672-15679. doi: 10.1002/anie.201605429. Epub 2016 Nov 17. Erratum in: Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2236.


Peptidomimetic therapeutics: scientific approaches and opportunities.

Qvit N, Rubin SJS, Urban TJ, Mochly-Rosen D, Gross ER.

Drug Discov Today. 2017 Feb;22(2):454-462. doi: 10.1016/j.drudis.2016.11.003. Epub 2016 Nov 14. Review.


Potential biomarkers to follow the progression and treatment response of Huntington's disease.

Disatnik MH, Joshi AU, Saw NL, Shamloo M, Leavitt BR, Qi X, Mochly-Rosen D.

J Exp Med. 2016 Nov 14;213(12):2655-2669. Epub 2016 Nov 7.


Correcting mitochondrial fusion by manipulating mitofusin conformations.

Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II.

Nature. 2016 Dec 1;540(7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24.


Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.

Hurt CM, Lu Y, Stary CM, Piplani H, Small BA, Urban TJ, Qvit N, Gross GJ, Mochly-Rosen D, Gross ER.

J Am Heart Assoc. 2016 Sep 26;5(9). pii: e003774.


Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.

Van Wassenhove LD, Mochly-Rosen D, Weinberg KI.

Mol Genet Metab. 2016 Sep;119(1-2):28-36. doi: 10.1016/j.ymgme.2016.07.004. Epub 2016 Jul 15. Review.


In Vivo Post-Cardiac Arrest Myocardial Dysfunction Is Supported by Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2.

Woods C, Shang C, Taghavi F, Downey P, Zalewski A, Rubio GR, Liu J, Homburger JR, Grunwald Z, Qi W, Bollensdorff C, Thanaporn P, Ali A, Riemer K, Kohl P, Mochly-Rosen D, Gerstenfeld E, Large S, Ali Z, Ashley E.

Circulation. 2016 Sep 27;134(13):961-977. doi: 10.1161/CIRCULATIONAHA.116.021618. Epub 2016 Aug 31.


PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation.

Yu YH, Liao PR, Guo CJ, Chen CH, Mochly-Rosen D, Chuang LM.

PLoS One. 2016 Aug 30;11(8):e0161993. doi: 10.1371/journal.pone.0161993. eCollection 2016.


VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.

Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X.

Nat Commun. 2016 Aug 26;7:12646. doi: 10.1038/ncomms12646.


Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus.

Cunningham AD, Hwang S, Mochly-Rosen D.

Clin Perinatol. 2016 Jun;43(2):341-54. doi: 10.1016/j.clp.2016.01.010. Epub 2016 Feb 28. Review.


Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo.

Qvit N, Disatnik MH, Sho E, Mochly-Rosen D.

J Am Chem Soc. 2016 Jun 22;138(24):7626-35. doi: 10.1021/jacs.6b02724. Epub 2016 Jun 8.


The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.

Joshi AU, Kornfeld OS, Mochly-Rosen D.

Cell Calcium. 2016 Sep;60(3):218-34. doi: 10.1016/j.ceca.2016.04.010. Epub 2016 May 7. Review.


Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death.

Qvit N, Joshi AU, Cunningham AD, Ferreira JC, Mochly-Rosen D.

J Biol Chem. 2016 Jun 24;291(26):13608-21. doi: 10.1074/jbc.M115.711630. Epub 2016 Apr 27.


Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors.

Qvit N, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang LA, Baron LA, Teh-Poot C, Martínez-Vega P, Ramirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, Gozzo FC, Torrecilhas AC, Manso Alves MJ, Jardim A, Momar N, Dumonteil E, Mochly-Rosen D.

Int J Parasitol Drugs Drug Resist. 2016 Feb 12;6(1):74-84. doi: 10.1016/j.ijpddr.2016.02.003. eCollection 2016 Apr.

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