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Apparent total tract digestibility, fecal characteristics, and blood parameters of healthy adult dogs fed high fat diets.

Kilburn LR, Allenspach K, Jergens AE, Bourgois-Mochel A, Mochel JP, Serao MCR.

J Anim Sci. 2020 Feb 12. pii: skaa043. doi: 10.1093/jas/skaa043. [Epub ahead of print]


Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs.

Sebbag L, Moody LM, Mochel JP.

Front Pharmacol. 2020 Jan 28;10:1560. doi: 10.3389/fphar.2019.01560. eCollection 2019.


Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter?

Sebbag L, Kirner NS, Allbaugh RA, Reis A, Mochel JP.

Front Vet Sci. 2019 Dec 19;6:457. doi: 10.3389/fvets.2019.00457. eCollection 2019.


Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease.

Atherly T, Rossi G, White R, Seo YJ, Wang C, Ackermann M, Breuer M, Allenspach K, Mochel JP, Jergens AE.

PLoS One. 2019 Dec 30;14(12):e0226780. doi: 10.1371/journal.pone.0226780. eCollection 2019.


In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs.

Musser ML, Mahaffey AL, Fath MA, Buettner GR, Wagner BA, Schneider BK, Seo YJ, Mochel JP, Johannes CM.

Front Vet Sci. 2019 Nov 7;6:385. doi: 10.3389/fvets.2019.00385. eCollection 2019.


Nerve growth factor in dogs: Assessment of two immunoassays and selected ocular parameters following a nicergoline challenge per os.

Sebbag L, Moody LM, Allbaugh RA, Mochel JP.

Vet Ophthalmol. 2020 Jan;23(1):199-204. doi: 10.1111/vop.12723. Epub 2019 Nov 27.


Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs.

Wang J, Schneider BK, Xue J, Sun P, Qiu J, Mochel JP, Cao X.

Front Vet Sci. 2019 Oct 17;6:363. doi: 10.3389/fvets.2019.00363. eCollection 2019.


Re: "Evaluation of Enrofloxacin for Use in Cryopreservation of Zebu Bull (Bos indicus) Semen" by Ishaq et al. (Biopreserv Biobank 2019;[Epub ahead of print]; DOI: 10.1089/bio.2018.0133).

Smith JS, Kreuder AJ, Dowling PM, Dohlman TM, Plummer PJ, Toutain PL, Mochel JP.

Biopreserv Biobank. 2019 Nov 1. doi: 10.1089/bio.2019.0068. [Epub ahead of print] No abstract available.


Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection.

Smith JS, Borts DJ, Slagel CC, Rajewski SM, Bousquet-Melou A, Ferran AA, Plummer PJ, Mochel JP.

Comp Med. 2019 Oct 1;69(5):413-418. doi: 10.30802/AALAS-CM-18-000144. Epub 2019 Oct 3.


Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study.

Klinedinst BS, Pappas C, Le S, Yu S, Wang Q, Wang L, Allenspach-Jorn K, Mochel JP, Willette AA.

Brain Behav Immun. 2019 Nov;82:396-405. doi: 10.1016/j.bbi.2019.09.008. Epub 2019 Sep 9.


Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Dogs and Cats.

Sebbag L, Allbaugh RA, Wehrman RF, Uhl LK, Ben-Shlomo G, Chen T, Mochel JP.

J Ocul Pharmacol Ther. 2019 Nov;35(9):497-502. doi: 10.1089/jop.2019.0038. Epub 2019 Aug 8.


Nonlinear mixed-effects pharmacokinetic modeling of the novel COX-2 selective inhibitor vitacoxib in dogs.

Wang J, Schneider BK, Sun P, Gong X, Qiu J, Li J, Seo YJ, Mochel JP, Cao X.

J Vet Pharmacol Ther. 2019 Sep;42(5):530-540. doi: 10.1111/jvp.12802. Epub 2019 Aug 1.


Histamine-Induced Conjunctivitis and Breakdown of Blood-Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics.

Sebbag L, Allbaugh RA, Weaver A, Seo YJ, Mochel JP.

Front Pharmacol. 2019 Jul 9;10:752. doi: 10.3389/fphar.2019.00752. eCollection 2019.


Clinicopathologic, hemodynamic, and echocardiographic effects of short-term oral administration of anti-inflammatory doses of prednisolone to systemically normal cats.

Khelik IA, Berger DJ, Mochel JP, Seo YJ, Palerme JS, Ware WA, Ward JL.

Am J Vet Res. 2019 Aug;80(8):743-755. doi: 10.2460/ajvr.80.8.743.


Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs.

Jergens AE, Guard BC, Redfern A, Rossi G, Mochel JP, Pilla R, Chandra L, Seo YJ, Steiner JM, Lidbury J, Allenspach K, Suchodolski J.

Front Vet Sci. 2019 Jun 27;6:199. doi: 10.3389/fvets.2019.00199. eCollection 2019.


The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review.

Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP.

Front Aging Neurosci. 2019 Jun 18;11:130. doi: 10.3389/fnagi.2019.00130. eCollection 2019. Review.


Effects of experimentally induced respiratory disease on the pharmacokinetics and tissue residues of tulathromycin in meat goats.

Smith JS, Mochel JP, Borts DJ, Griffith RW.

J Vet Pharmacol Ther. 2019 Jul;42(4):420-429. doi: 10.1111/jvp.12764. Epub 2019 Jun 10.


Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy.

Kathrani A, Lezcano V, Hall EJ, Jergens AE, Seo YJ, Mochel JP, Atherly T, Allenspach K.

PLoS One. 2019 Jun 10;14(6):e0218218. doi: 10.1371/journal.pone.0218218. eCollection 2019.


Interleukin-13 and interleukin-33 mRNA are underexpressed in the duodenal mucosa of German Shepherd dogs with chronic enteropathy.

Kathrani A, Lezcano V, Hall EJ, Jergens AE, Seo YJ, Mochel JP, Atherly T, Allenspach K.

J Vet Intern Med. 2019 Jul;33(4):1660-1668. doi: 10.1111/jvim.15544. Epub 2019 Jun 6.


Paper spray high-resolution accurate mass spectrometry for quantitation of voriconazole in equine tears.

Lerch M, Allbaugh RA, Sebbag L, Mochel JP, Weller P, Borts DJ.

Anal Bioanal Chem. 2019 Aug;411(20):5187-5196. doi: 10.1007/s00216-019-01898-9. Epub 2019 May 23.


Tear Fluid Pharmacokinetics Following Oral Prednisone Administration in Dogs With and Without Conjunctivitis.

Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP.

J Ocul Pharmacol Ther. 2019 Jul/Aug;35(6):341-349. doi: 10.1089/jop.2019.0020. Epub 2019 May 9.


Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer.

Schneider BK, Boyer A, Ciccolini J, Barlesi F, Wang K, Benzekry S, Mochel JP.

CPT Pharmacometrics Syst Pharmacol. 2019 Aug;8(8):577-586. doi: 10.1002/psp4.12415. Epub 2019 May 9.


Derivation of adult canine intestinal organoids for translational research in gastroenterology.

Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois-Mochel A, Yuan W, Kimber M, Qi Y, Wang Q, Wannemuehler M, Ellinwood NM, Snella E, Martin M, Skala M, Meyerholz D, Estes M, Fernandez-Zapico ME, Jergens AE, Mochel JP, Allenspach K.

BMC Biol. 2019 Apr 11;17(1):33. doi: 10.1186/s12915-019-0652-6.


CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies.

Mochel JP, Ekker SC, Johannes CM, Jergens AE, Allenspach K, Bourgois-Mochel A, Knouse M, Benzekry S, Wierson W, LeBlanc AK, Kenderian SS.

AAPS J. 2019 Apr 8;21(3):50. doi: 10.1208/s12248-019-0322-1.


Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease.

Allenspach KA, Mochel JP, Du Y, Priestnall SL, Moore F, Slayter M, Rodrigues A, Ackermann M, Krockenberger M, Mansell J; WSAVA GI Standardization Working Group, Luckschander N, Wang C, Suchodolski J, Berghoff N, Jergens AE.

Vet Pathol. 2019 May;56(3):435-443. doi: 10.1177/0300985818813090. Epub 2018 Dec 18.


Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation.

Mochel JP, Teng CH, Peyrou M, Giraudel J, Danhof M, Rigel DF.

Eur J Pharm Sci. 2019 Feb 1;128:103-111. doi: 10.1016/j.ejps.2018.11.037. Epub 2018 Nov 30.


Relative Oral Bioavailability of Two Amoxicillin-Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study.

Moczarnik J, Berger DJ, Noxon JO, LeVine DN, Lin Z, Coetzee JF, Mochel JP.

J Am Anim Hosp Assoc. 2019 Jan/Feb;55(1):14-22. doi: 10.5326/JAAHA-MS-6872. Epub 2018 Nov 14.


Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes).

Uhl LK, Saito A, Iwashita H, Maggs DJ, Mochel JP, Sebbag L.

J Feline Med Surg. 2019 Oct;21(10):944-950. doi: 10.1177/1098612X18810867. Epub 2018 Nov 12.


Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs.

Berger EP, Johannes CM, Jergens AE, Allenspach K, Powers BE, Du Y, Mochel JP, Fox LE, Musser ML.

J Vet Intern Med. 2018 Nov;32(6):2045-2053. doi: 10.1111/jvim.15335. Epub 2018 Oct 11.


Comparative plasma and interstitial fluid pharmacokinetics and tissue residues of ceftiofur crystalline-free acid in cattle with induced coliform mastitis.

Gorden PJ, Ydstie JA, Kleinhenz MD, Brick TA, Smith JS, Griffith RW, Wulf LW, Rajewski SM, Zhang M, Sidhu PK, Mochel JP, Coetzee JF.

J Vet Pharmacol Ther. 2018 Dec;41(6):848-860. doi: 10.1111/jvp.12688. Epub 2018 Jul 4.


Adverse reactions to fentanyl transdermal patches in calves: a preliminary clinical and pharmacokinetic study.

Smith JS, Mochel JP, Borts DJ, Lewis KA, Coetzee JF.

Vet Anaesth Analg. 2018 Jul;45(4):575-580. doi: 10.1016/j.vaa.2018.02.009. Epub 2018 Apr 11.


Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.

Martinez MN, Gehring R, Mochel JP, Pade D, Pelligand L.

J Vet Pharmacol Ther. 2018 Aug;41(4):E68-E76. doi: 10.1111/jvp.12666. Epub 2018 May 28. Review.


Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats.

Sebbag L, Showman L, McDowell EM, Perera A, Mochel JP.

J Ocul Pharmacol Ther. 2018 Jul/Aug;34(6):452-459. doi: 10.1089/jop.2018.0008. Epub 2018 Apr 30.


Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation.

Smith JS, Coetzee JF, Fisher IWG, Borts DJ, Mochel JP.

J Vet Pharmacol Ther. 2018 Aug;41(4):555-561. doi: 10.1111/jvp.12501. Epub 2018 Mar 30.


Effects of short-term anti-inflammatory glucocorticoid treatment on clinicopathologic, echocardiographic, and hemodynamic variables in systemically healthy dogs.

Masters AK, Berger DJ, Ware WA, Langenfeld NR, Coetzee JF, Mochel JPM, Ward JL.

Am J Vet Res. 2018 Apr;79(4):411-423. doi: 10.2460/ajvr.79.4.411.


Effect of tear collection on lacrimal total protein content in dogs and cats: a comparison between Schirmer strips and ophthalmic sponges.

Sebbag L, McDowell EM, Hepner PM, Mochel JP.

BMC Vet Res. 2018 Mar 1;14(1):61. doi: 10.1186/s12917-018-1390-7.


Comparison of milk and plasma pharmacokinetics of meloxicam in postpartum versus mid-lactation Holstein cows.

Gorden PJ, Burchard M, Ydstie JA, Kleinhenz MD, Wulf LW, Rajewski SJ, Wang C, Gehring R, Mochel JP, Coetzee JF.

J Vet Pharmacol Ther. 2018 Jun;41(3):463-468. doi: 10.1111/jvp.12488. Epub 2018 Feb 11.


Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences.

Mochel JP, Tyden E, Hellmann K, Vendrig JC, Şenel S, Dencker L, Cristina RT, Linden H, Schmerold I.

J Vet Pharmacol Ther. 2018 Jun;41(3):378-383. doi: 10.1111/jvp.12472. Epub 2017 Dec 20.


Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research.

Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martín MG, Allenspach K.

AAPS J. 2017 Dec 12;20(1):17. doi: 10.1208/s12248-017-0178-1. Review.


Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics.

Bon C, Toutain PL, Concordet D, Gehring R, Martin-Jimenez T, Smith J, Pelligand L, Martinez M, Whittem T, Riviere JE, Mochel JP.

J Vet Pharmacol Ther. 2018 Apr;41(2):171-183. doi: 10.1111/jvp.12473. Epub 2017 Dec 11. Review.


Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative.

Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel JP.

CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):65-68. doi: 10.1002/psp4.12262. Epub 2017 Nov 27.


Tear fluid collection in dogs and cats using ophthalmic sponges.

Sebbag L, Harrington DM, Mochel JP.

Vet Ophthalmol. 2018 May;21(3):249-254. doi: 10.1111/vop.12502. Epub 2017 Aug 27.


Multiple comparison procedure and modeling: a versatile tool for evaluating dose-response relationships in veterinary pharmacology - a case study with furosemide.

Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP.

J Vet Pharmacol Ther. 2016 Dec;39(6):539-546. doi: 10.1111/jvp.12313. Epub 2016 May 11.


Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats.

Pelligand L, Soubret A, King JN, Elliott J, Mochel JP.

CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635. doi: 10.1002/psp4.12141. Epub 2016 Oct 22.


Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment.

Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE.

J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. doi: 10.1111/jvp.12311. Epub 2016 Apr 17. Review.


Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned?

Mochel JP, Danhof M.

Rev Physiol Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Review.


Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs.

Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M.

Pharm Res. 2015 Jun;32(6):1931-46. doi: 10.1007/s11095-014-1587-9. Epub 2014 Dec 2.


Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs.

Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel JM, Danhof M.

Chronobiol Int. 2014 Jun;31(5):715-30. doi: 10.3109/07420528.2014.897711. Epub 2014 Mar 21.


Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology.

Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M.

Chronobiol Int. 2013 Nov;30(9):1144-59. doi: 10.3109/07420528.2013.807275. Epub 2013 Aug 9.


Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis.

Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel JM.

Res Vet Sci. 2013 Oct;95(2):580-7. doi: 10.1016/j.rvsc.2013.04.021. Epub 2013 May 31.


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