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Dataset for the reporting of carcinoma of renal tubular origin: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Delahunt B, Srigley JR, Judge MJ, Amin MB, Billis A, Camparo P, Evans AJ, Fleming S, Griffiths D, Lopez-Beltran A, Martignoni G, Moch H, Nacey JN, Zhou M.

Histopathology. 2018 Oct 16. doi: 10.1111/his.13754. [Epub ahead of print] Review.


Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - Clinical associations in NSCLC patients of the ETOP Lungscape cohort.

Rulle U, Tsourti Z, Casanova R, Deml KF, Verbeken E, Thunnissen E, Warth A, Cheney R, Sejda A, Speel EJ, Madsen LB, Nonaka D, Navarro A, Sansano I, Marchetti A, Finn SP, Monkhorst K, Kerr KM, Haberecker M, Wu C, Zygoura P, Kammler R, Geiger T, Gendreau S, Schulze K, Vrugt B, Wild P, Moch H, Weder W, Ciftlik AT, Dafni U, Peters S, Bubendorf L, Stahel RA, Soltermann A.

J Thorac Oncol. 2018 Sep 18. pii: S1556-0864(18)33053-3. doi: 10.1016/j.jtho.2018.08.2034. [Epub ahead of print]


Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma.

Velagapudi S, Schraml P, Yalcinkaya M, Bolck HA, Rohrer L, Moch H, von Eckardstein A.

J Lipid Res. 2018 Nov;59(11):2188-2201. doi: 10.1194/jlr.M083311. Epub 2018 Sep 1.


A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.

Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA.

Mod Pathol. 2018 Aug 23. doi: 10.1038/s41379-018-0110-y. [Epub ahead of print]


Advancing synoptic cancer reports beyond English: the University of Bern/PathoLink approach.

Banz Y, Berezowska S, de Leval L, Rubbia-Brandt L, Tolnay M, Moch H, Perren A, Hewer E.

Virchows Arch. 2018 Nov;473(5):655-656. doi: 10.1007/s00428-018-2431-0. Epub 2018 Aug 7. No abstract available.


The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading.

Vital D, Ikenberg K, Moch H, Roessle M, Huber GF.

Laryngoscope Investig Otolaryngol. 2018 Apr 19;3(3):182-190. doi: 10.1002/lio2.160. eCollection 2018 Jun.


Cancer of unknown primary-Epidemiological trends and relevance of comprehensive genomic profiling.

Binder C, Matthes KL, Korol D, Rohrmann S, Moch H.

Cancer Med. 2018 Sep;7(9):4814-4824. doi: 10.1002/cam4.1689. Epub 2018 Jul 17.


Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists.

Williamson SR, Rao P, Hes O, Epstein JI, Smith SC, Picken MM, Zhou M, Tretiakova MS, Tickoo SK, Chen YB, Reuter VE, Fleming S, Maclean FM, Gupta NS, Kuroda N, Delahunt B, Mehra R, Przybycin CG, Cheng L, Eble JN, Grignon DJ, Moch H, Lopez JI, Kunju LP, Tamboli P, Srigley JR, Amin MB, Martignoni G, Hirsch MS, Bonsib SM, Trpkov K.

Am J Surg Pathol. 2018 Sep;42(9):1253-1261. doi: 10.1097/PAS.0000000000001087.


Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report.

Tuma J, Moch H, Stuckmann G, Gysel W, Serra AL.

BMC Nephrol. 2018 May 30;19(1):123. doi: 10.1186/s12882-018-0919-0.


Multi-laboratory proficiency testing of clinical cancer genomic profiling by next-generation sequencing.

Zhong Q, Wagner U, Kurt H, Molinari F, Cathomas G, Komminoth P, Barman-Aksözen J, Schneider-Yin X, Rey JP, Vassella E, Rogel U, Diebold J, McKee T, Jochum W, Kashofer K, Hofman P, Zischka M, Moch H, Rechsteiner M, Wild PJ.

Pathol Res Pract. 2018 Jul;214(7):957-963. doi: 10.1016/j.prp.2018.05.020. Epub 2018 May 22.


Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors.

Visentin M, Torozi A, Gai Z, Häusler S, Li C, Hiller C, Schraml PH, Moch H, Kullak-Ublick GA.

Drug Metab Dispos. 2018 Aug;46(8):1129-1136. doi: 10.1124/dmd.118.081091. Epub 2018 May 24.


Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model.

Keller N, Andreoni F, Reiber C, Luethi-Schaller H, Schuepbach RA, Moch H, Marques Maggio E, Zinkernagel AS.

Am J Pathol. 2018 Jul;188(7):1517-1523. doi: 10.1016/j.ajpath.2018.03.009. Epub 2018 Apr 22.


Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study.

Gramatzki D, Roth P, Rushing EJ, Weller J, Andratschke N, Hofer S, Korol D, Regli L, Pangalu A, Pless M, Oberle J, Bernays R, Moch H, Rohrmann S, Weller M.

Ann Oncol. 2018 Jun 1;29(6):1431-1436. doi: 10.1093/annonc/mdy106.


Targeted next-generation-sequencing for reliable detection of targetable rearrangements in lung adenocarcinoma-a single center retrospective study.

Velizheva NP, Rechsteiner MP, Valtcheva N, Freiberger SN, Wong CE, Vrugt B, Zhong Q, Wagner U, Moch H, Hillinger S, Schmitt-Opitz I, Soltermann A, Wild PJ, Tischler V.

Pathol Res Pract. 2018 Apr;214(4):572-578. doi: 10.1016/j.prp.2018.02.001. Epub 2018 Feb 16.


Comprehensive immunohistochemical analysis of PD-L1 shows scarce expression in castration-resistant prostate cancer.

Fankhauser CD, Schüffler PJ, Gillessen S, Omlin A, Rupp NJ, Rueschoff JH, Hermanns T, Poyet C, Sulser T, Moch H, Wild PJ.

Oncotarget. 2017 Dec 4;9(12):10284-10293. doi: 10.18632/oncotarget.22888. eCollection 2018 Feb 13.


Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.

Nat Med. 2018 May;24(4):463-473. doi: 10.1038/nm.4494. Epub 2018 Mar 12.


PD-L1 is a positive prognostic factor in squamous cell carcinoma of the nasal vestibule.

Vital D, Holzmann D, Huber GF, Moch H, Morand GB, Ikenberg K.

Rhinology. 2018 Sep 1;56(3):255-260. doi: 10.4193/Rhin17.215.


Morphological clues to the appropriate recognition of hereditary renal neoplasms.

Moch H, Ohashi R, Gandhi JS, Amin MB.

Semin Diagn Pathol. 2018 May;35(3):184-192. doi: 10.1053/j.semdp.2018.01.005. Epub 2018 Feb 14. Review.


Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

Rechsteiner M, Dedes K, Fink D, Pestalozzi B, Sobottka B, Moch H, Wild P, Varga Z.

J Cancer Res Clin Oncol. 2018 May;144(5):865-874. doi: 10.1007/s00432-018-2609-5. Epub 2018 Feb 17.


Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer.

Posch F, Silina K, Leibl S, Mündlein A, Moch H, Siebenhüner A, Samaras P, Riedl J, Stotz M, Szkandera J, Stöger H, Pichler M, Stupp R, van den Broek M, Schraml P, Gerger A, Petrausch U, Winder T.

Oncoimmunology. 2017 Dec 18;7(2):e1378844. doi: 10.1080/2162402X.2017.1378844. eCollection 2018.


Biomarker discovery for renal cancer stem cells.

Corrò C, Moch H.

J Pathol Clin Res. 2018 Jan 17;4(1):3-18. doi: 10.1002/cjp2.91. eCollection 2018 Jan. Review.


Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma.

Siliņa K, Soltermann A, Attar FM, Casanova R, Uckeley ZM, Thut H, Wandres M, Isajevs S, Cheng P, Curioni-Fontecedro A, Foukas P, Levesque MP, Moch H, Linē A, van den Broek M.

Cancer Res. 2018 Mar 1;78(5):1308-1320. doi: 10.1158/0008-5472.CAN-17-1987. Epub 2017 Dec 26.


NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.


[Establishment of a living biobank : Improved guidance of precision cancer care with in vitro and in vivo cancer models].

Pauli C, Moch H, Rubin MA.

Pathologe. 2017 Nov;38(Suppl 2):160-168. doi: 10.1007/s00292-017-0346-1. Review. German.


Neue und vielversprechende molekulare Therapieoptionen in verschiedenen Subtypen des Nierenzellkarzinoms.

Rupp NJ, Mischo A, Moch H.

Ther Umsch. 2017 Sep;74(4):171-179. doi: 10.1024/0040-5930/a000901. Review. German. No abstract available.


A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A.

Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010.


Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.

Bogowicz M, Riesterer O, Ikenberg K, Stieb S, Moch H, Studer G, Guckenberger M, Tanadini-Lang S.

Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):921-928. doi: 10.1016/j.ijrobp.2017.06.002. Epub 2017 Jun 15.


Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.

Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP.

Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14.


[Clinical autopsies in Switzerland : A status report].

Rodewald AK, Bode P, Cathomas G, Moch H.

Pathologe. 2017 Sep;38(5):416-421. doi: 10.1007/s00292-017-0323-8. Review. German.


SOX2 Gene Amplification and Overexpression is Linked to HPV-positive Vulvar Carcinomas.

Gut A, Moch H, Choschzick M.

Int J Gynecol Pathol. 2018 Jan;37(1):68-73. doi: 10.1097/PGP.0000000000000388.


The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule.

Vital D, Huber GF, Holzmann D, Moch H, Ikenberg K.

Eur Arch Otorhinolaryngol. 2017 Sep;274(9):3503-3512. doi: 10.1007/s00405-017-4659-8. Epub 2017 Jul 1.


Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.

Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ.

Nat Med. 2017 Jul;23(7):869-877. doi: 10.1038/nm.4343. Epub 2017 May 29.


Circulating Tumor Cells: A Reliable Biomarker for Prostate Cancer Treatment Assessment?

Ciccarese C, Montironi R, Fiorentino M, Martignoni G, Brunelli M, Iacovelli R, Lopez-Beltran A, Cheng L, Scarpelli M, Moch H, Tortora G, Massari F.

Curr Drug Metab. 2017;18(8):692-699. doi: 10.2174/1389200218666170518163549. Review.


Urinary Biomarkers for Prostate Cancer.

Giunchi F, Ciccarese C, Montironi R, Scarpelli M, Lopez-Beltran A, Cheng L, Moch H, Massari F, Fiorentino M.

Curr Drug Metab. 2017 Oct 16;18(8):723-726. doi: 10.2174/1389200218666170518161140. Review.


Targeting the Programmed Cell Death-1 Pathway in Genitourinary Tumors: Current Progress and Future Perspectives.

Mann SA, Lopez-Beltran A, Massari F, Pili R, Fiorentino M, Koch MO, Kaimakliotis HZ, Wang L, Scarpelli M, Ciccarese C, Moch H, Montironi R, Cheng L.

Curr Drug Metab. 2017 Oct 16;18(8):700-711. doi: 10.2174/1389200218666170518162500. Review.


Mirna Expression in Bladder Cancer and Their Potential Role in Clinical Practice.

Blanca A, Cheng L, Montironi R, Moch H, Massari F, Fiorentino M, Raspollini MR, Scarpelli M, Lopez-Beltran A.

Curr Drug Metab. 2017 Oct 16;18(8):712-722. doi: 10.2174/1389200218666170518164507. Review.


An Immune Atlas of Clear Cell Renal Cell Carcinoma.

Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe'er D, Bodenmiller B.

Cell. 2017 May 4;169(4):736-749.e18. doi: 10.1016/j.cell.2017.04.016.


Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death.

Mortezavi A, Salemi S, Rupp NJ, Rüschoff JH, Hermanns T, Poyet C, Randazzo M, Simon HU, Moch H, Sulser T, Wild P, Eberli D.

Oncotarget. 2017 May 9;8(19):31765-31774. doi: 10.18632/oncotarget.15986.


p16INK4a : A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule.

Vital D, Holzmann D, Huber GF, Soyka MB, Moch H, Zimmermann DR, Ikenberg K.

Head Neck. 2017 Jul;39(7):1392-1398. doi: 10.1002/hed.24767. Epub 2017 Mar 28.


Morphoproteomic Characterization of Lung Squamous Cell Carcinoma Fragmentation, a Histological Marker of Increased Tumor Invasiveness.

Casanova R, Xia D, Rulle U, Nanni P, Grossmann J, Vrugt B, Wettstein R, Ballester R, Astolfo A, Weder W, Moch H, Stampanoni M, Beck AH, Soltermann A.

Cancer Res. 2017 May 15;77(10):2585-2593. doi: 10.1158/0008-5472.CAN-16-2363. Epub 2017 Mar 31. Erratum in: Cancer Res. 2018 Feb 1;78(3):841.


Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists.

Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE, Cheng L, Kunju LP, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, Gupta NS.

Hum Pathol. 2017 May;63:149-156. doi: 10.1016/j.humpath.2017.03.004. Epub 2017 Mar 14.


A curated collection of tissue microarray images and clinical outcome data of prostate cancer patients.

Zhong Q, Guo T, Rechsteiner M, Rüschoff JH, Rupp N, Fankhauser C, Saba K, Mortezavi A, Poyet C, Hermanns T, Zhu Y, Moch H, Aebersold R, Wild PJ.

Sci Data. 2017 Mar 14;4:170014. doi: 10.1038/sdata.2017.14.


Detecting circulating tumor DNA in renal cancer: An open challenge.

Corrò C, Hejhal T, Poyet C, Sulser T, Hermanns T, Winder T, Prager G, Wild PJ, Frew I, Moch H, Rechsteiner M.

Exp Mol Pathol. 2017 Apr;102(2):255-261. doi: 10.1016/j.yexmp.2017.02.009. Epub 2017 Feb 23.


Prominent Oncogenic Roles of EVI1 in Breast Carcinoma.

Wang H, Schaefer T, Konantz M, Braun M, Varga Z, Paczulla AM, Reich S, Jacob F, Perner S, Moch H, Fehm TN, Kanz L, Schulze-Osthoff K, Lengerke C.

Cancer Res. 2017 Apr 15;77(8):2148-2160. doi: 10.1158/0008-5472.CAN-16-0593. Epub 2017 Feb 16.


Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report.

Valtcheva N, Lang FM, Noske A, Samartzis EP, Schmidt AM, Bellini E, Fink D, Moch H, Rechsteiner M, Dedes KJ, Wild PJ.

BMC Cancer. 2017 Jan 19;17(1):66. doi: 10.1186/s12885-017-3054-6.


Prognostic Role of Preoperative Serum Lipid Levels in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer.

Wettstein MS, Saba K, Umbehr MH, Murtola TJ, Fankhauser CD, Adank JP, Hofmann M, Sulser T, Hermanns T, Moch H, Wild P, Poyet C.

Prostate. 2017 Apr;77(5):549-556. doi: 10.1002/pros.23296. Epub 2017 Jan 17.


Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.

Brandt S, Samartzis EP, Zimmermann AK, Fink D, Moch H, Noske A, Dedes KJ.

BMC Cancer. 2017 Jan 10;17(1):44. doi: 10.1186/s12885-016-3026-2.


VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.

Razafinjatovo CF, Stiehl D, Deininger E, Rechsteiner M, Moch H, Schraml P.

Oncotarget. 2017 Feb 7;8(6):10199-10212. doi: 10.18632/oncotarget.14372.


Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers.

Hofmann AL, Behr J, Singer J, Kuipers J, Beisel C, Schraml P, Moch H, Beerenwinkel N.

BMC Bioinformatics. 2017 Jan 3;18(1):8. doi: 10.1186/s12859-016-1417-7.

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