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Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme.

Ohashi R, Martignoni G, Hartmann A, Caliò A, Segala D, Stöhr C, Wach S, Erlmeier F, Weichert W, Autenrieth M, Schraml P, Rupp NJ, Ohe C, Otsuki Y, Kawasaki T, Kobayashi H, Kobayashi K, Miyazaki T, Shibuya H, Usuda H, Umezu H, Fujishima F, Furusato B, Osakabe M, Sugai T, Kuroda N, Tsuzuki T, Nagashima Y, Ajioka Y, Moch H.

Virchows Arch. 2019 Nov 23. doi: 10.1007/s00428-019-02710-w. [Epub ahead of print]


[Eulogy to Prof. Dr. Med. Michael J. Mihatsch : Presentation of the Rudolf Virchow Medal 2019 of the German Society of Pathology].

Moch H.

Pathologe. 2019 Nov 21. doi: 10.1007/s00292-019-00706-6. [Epub ahead of print] German.


Cancer Sample Biobanking at the Next Level: Combining Tissue With Living Cell Repositories to Promote Precision Medicine.

Bolck HA, Pauli C, Göbel E, Mühlbauer K, Dettwiler S, Moch H, Schraml P.

Front Cell Dev Biol. 2019 Oct 22;7:246. doi: 10.3389/fcell.2019.00246. eCollection 2019.


External Validation and Comparison of Prostate Cancer Risk Calculators Incorporating Multiparametric Magnetic Resonance Imaging for Prediction of Clinically Significant Prostate Cancer.

Saba K, Wettstein MS, Lieger L, Hötker AM, Donati OF, Moch H, Ankerst DP, Poyet C, Sulser T, Eberli D, Mortezavi A.

J Urol. 2019 Oct 25:101097JU0000000000000622. doi: 10.1097/JU.0000000000000622. [Epub ahead of print]


Classic Chromophobe Renal Cell Carcinoma Incur a Larger Number of Chromosomal Losses Than Seen in the Eosinophilic Subtype.

Ohashi R, Schraml P, Angori S, Batavia AA, Rupp NJ, Ohe C, Otsuki Y, Kawasaki T, Kobayashi H, Kobayashi K, Miyazaki T, Shibuya H, Usuda H, Umezu H, Fujishima F, Furusato B, Osakabe M, Sugai T, Kuroda N, Tsuzuki T, Nagashima Y, Ajioka Y, Moch H.

Cancers (Basel). 2019 Oct 3;11(10). pii: E1492. doi: 10.3390/cancers11101492.


Molecular characterization and diagnostic criteria of renal cell carcinoma with emphasis on liquid biopsies.

Cimadamore A, Massari F, Santoni M, Mollica V, Di Nunno V, Cheng L, Lopez-Beltran A, Scarpelli M, Montironi R, Moch H.

Expert Rev Mol Diagn. 2019 Sep 11:1-10. doi: 10.1080/14737159.2019.1665510. [Epub ahead of print]


The expression of PD-L1 in salivary gland carcinomas.

Vital D, Ikenberg K, Moch H, Rössle M, Huber GF.

Sci Rep. 2019 Sep 4;9(1):12724. doi: 10.1038/s41598-019-49215-9.


Erratum to "Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma".

Curioni-Fontecedro A, Pitocco R, Schoenewolf NL, Holzmann D, Soldini D, Dummer R, Calvieri S, Moch H, Fitsche A, Mihic-Probst D.

Biomed Res Int. 2019 Jul 22;2019:5256364. doi: 10.1155/2019/5256364. eCollection 2019.


CXCL12 expression is an adverse predictor for disease recurrence in patients with metastatic non-seminomatous testicular germ cell tumors.

Fankhauser CD, Roth L, Grossmann NC, Kranzbühler B, Eberli D, Sulser T, Moch H, Bode PK, Beyer J, Hermanns T.

BMC Cancer. 2019 Aug 14;19(1):802. doi: 10.1186/s12885-019-5961-1.


Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage.

Giovannini S, Weller MC, Repmann S, Moch H, Jiricny J.

Nucleic Acids Res. 2019 Sep 26;47(17):9132-9143. doi: 10.1093/nar/gkz624.


Dataset for the reporting of renal biopsy for tumour: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Delahunt B, Srigley JR, Judge M, Amin M, Billis A, Camparo P, Fleming S, Griffiths D, Lopez-Beltran A, Martignoni G, Moch H, Nacey JN, Zhou M, Evans AJ.

J Clin Pathol. 2019 Sep;72(9):573-578. doi: 10.1136/jclinpath-2019-205959. Epub 2019 Jul 12. Review.


Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation.

Srigley JR, Delahunt B, Samaratunga H, Billis A, Cheng L, Clouston D, Evans A, Furusato B, Kench J, Leite K, MacLennan G, Moch H, Pan CC, Rioux-Leclercq N, Ro J, Shanks J, Shen S, Tsuzuki T, Varma M, Wheeler T, Yaxley J, Egevad L.

Pathology. 2019 Aug;51(5):463-473. doi: 10.1016/j.pathol.2019.05.001. Epub 2019 Jul 3. Review.


Tracing Clonal Dynamics Reveals that Two- and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma.

Bolck HA, Corrò C, Kahraman A, von Teichman A, Toussaint NC, Kuipers J, Chiovaro F, Koelzer VH, Pauli C, Moritz W, Bode PK, Rechsteiner M, Beerenwinkel N, Schraml P, Moch H.

Eur Urol Focus. 2019 Jun 29. pii: S2405-4569(19)30164-6. doi: 10.1016/j.euf.2019.06.009. [Epub ahead of print]


MiRNAs Are Involved in Tall Cell Morphology in Papillary Thyroid Carcinoma.

Boos LA, Schmitt A, Moch H, Komminoth P, Simillion C, Marinoni I, Nikiforov YE, Nikiforova MN, Perren A, Dettmer MS.

Cancers (Basel). 2019 Jun 25;11(6). pii: E885. doi: 10.3390/cancers11060885.


Allele Loss and Reduced Expression of CYCLOPS Genes is a Characteristic Feature of Chromophobe Renal Cell Carcinoma.

Ohashi R, Schraml P, Batavia A, Angori S, Simmler P, Rupp N, Ajioka Y, Oliva E, Moch H.

Transl Oncol. 2019 Sep;12(9):1131-1137. doi: 10.1016/j.tranon.2019.05.005. Epub 2019 Jun 11.


Extensive Histological Sampling following Focal Therapy of Clinically Significant Prostate Cancer with High Intensity Focused Ultrasound.

Mortezavi A, Krauter J, Gu A, Sonderer J, Bruhin J, Reeve KA, Held L, Donati OF, Rupp NJ, Moch H, Sulser T, Eberli D.

J Urol. 2019 Oct;202(4):717-724. doi: 10.1097/JU.0000000000000298. Epub 2019 Sep 6.


Eight autopsy cases of melanoma brain metastases showing angiotropism and pericytic mimicry. Implications for extravascular migratory metastasis.

Rodewald AK, Rushing EJ, Kirschenbaum D, Mangana J, Mittmann C, Moch H, Lugassy C, Barnhill RL, Mihic-Probst D.

J Cutan Pathol. 2019 Aug;46(8):570-578. doi: 10.1111/cup.13465. Epub 2019 Apr 16.


IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer.

Corrò C, Healy ME, Engler S, Bodenmiller B, Li Z, Schraml P, Weber A, Frew IJ, Rechsteiner M, Moch H.

J Pathol. 2019 Jul;248(3):377-389. doi: 10.1002/path.5267. Epub 2019 Apr 11.


Specific immune cell and lymphatic vessel signatures identified by image analysis in renal cancer.

Schraml P, Athelogou M, Hermanns T, Huss R, Moch H.

Mod Pathol. 2019 Jul;32(7):1042-1052. doi: 10.1038/s41379-019-0214-z. Epub 2019 Feb 8.


Histological and molecular characterization of TFEB-rearranged renal cell carcinomas.

Wyvekens N, Rechsteiner M, Fritz C, Wagner U, Tchinda J, Wenzel C, Kuithan F, Horn LC, Moch H.

Virchows Arch. 2019 May;474(5):625-631. doi: 10.1007/s00428-019-02526-8. Epub 2019 Jan 31.


Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.

Bihr S, Ohashi R, Moore AL, Rüschoff JH, Beisel C, Hermanns T, Mischo A, Corrò C, Beyer J, Beerenwinkel N, Moch H, Schraml P.

Neoplasia. 2019 Feb;21(2):247-256. doi: 10.1016/j.neo.2018.12.006. Epub 2019 Jan 16.


Clear cell renal cell carcinoma with wild-type von Hippel-Lindau gene: a non-existent or new tumour entity?

Batavia AA, Schraml P, Moch H.

Histopathology. 2019 Jan;74(1):60-67. doi: 10.1111/his.13749. Review.


Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma.

Morand GB, Ikenberg K, Vital DG, Cardona I, Moch H, Stoeckli SJ, Huber GF.

Head Neck. 2019 Apr;41(4):950-958. doi: 10.1002/hed.25532. Epub 2018 Dec 18.


Data set for the reporting of carcinoma of renal tubular origin: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Delahunt B, Srigley JR, Judge MJ, Amin MB, Billis A, Camparo P, Evans AJ, Fleming S, Griffiths DF, Lopez-Beltran A, Martignoni G, Moch H, Nacey JN, Zhou M.

Histopathology. 2019 Feb;74(3):377-390. doi: 10.1111/his.13754. Review.


Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry - Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort.

Rulle U, Tsourti Z, Casanova R, Deml KF, Verbeken E, Thunnissen E, Warth A, Cheney R, Sejda A, Speel EJ, Madsen LB, Nonaka D, Navarro A, Sansano I, Marchetti A, Finn SP, Monkhorst K, Kerr KM, Haberecker M, Wu C, Zygoura P, Kammler R, Geiger T, Gendreau S, Schulze K, Vrugt B, Wild P, Moch H, Weder W, Ciftlik AT, Dafni U, Peters S, Bubendorf L, Stahel RA, Soltermann A.

J Thorac Oncol. 2018 Dec;13(12):1851-1863. doi: 10.1016/j.jtho.2018.08.2034. Epub 2018 Sep 18.


Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma.

Velagapudi S, Schraml P, Yalcinkaya M, Bolck HA, Rohrer L, Moch H, von Eckardstein A.

J Lipid Res. 2018 Nov;59(11):2188-2201. doi: 10.1194/jlr.M083311. Epub 2018 Sep 1.


A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.

Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA.

Mod Pathol. 2018 Dec;31(12):1770-1786. doi: 10.1038/s41379-018-0110-y. Epub 2018 Aug 23.


Advancing synoptic cancer reports beyond English: the University of Bern/PathoLink approach.

Banz Y, Berezowska S, de Leval L, Rubbia-Brandt L, Tolnay M, Moch H, Perren A, Hewer E.

Virchows Arch. 2018 Nov;473(5):655-656. doi: 10.1007/s00428-018-2431-0. Epub 2018 Aug 7. No abstract available.


The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading.

Vital D, Ikenberg K, Moch H, Roessle M, Huber GF.

Laryngoscope Investig Otolaryngol. 2018 Apr 19;3(3):182-190. doi: 10.1002/lio2.160. eCollection 2018 Jun.


Cancer of unknown primary-Epidemiological trends and relevance of comprehensive genomic profiling.

Binder C, Matthes KL, Korol D, Rohrmann S, Moch H.

Cancer Med. 2018 Sep;7(9):4814-4824. doi: 10.1002/cam4.1689. Epub 2018 Jul 17.


Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists.

Williamson SR, Rao P, Hes O, Epstein JI, Smith SC, Picken MM, Zhou M, Tretiakova MS, Tickoo SK, Chen YB, Reuter VE, Fleming S, Maclean FM, Gupta NS, Kuroda N, Delahunt B, Mehra R, Przybycin CG, Cheng L, Eble JN, Grignon DJ, Moch H, Lopez JI, Kunju LP, Tamboli P, Srigley JR, Amin MB, Martignoni G, Hirsch MS, Bonsib SM, Trpkov K.

Am J Surg Pathol. 2018 Sep;42(9):1253-1261. doi: 10.1097/PAS.0000000000001087.


Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report.

Tuma J, Moch H, Stuckmann G, Gysel W, Serra AL.

BMC Nephrol. 2018 May 30;19(1):123. doi: 10.1186/s12882-018-0919-0.


Multi-laboratory proficiency testing of clinical cancer genomic profiling by next-generation sequencing.

Zhong Q, Wagner U, Kurt H, Molinari F, Cathomas G, Komminoth P, Barman-Aksözen J, Schneider-Yin X, Rey JP, Vassella E, Rogel U, Diebold J, McKee T, Jochum W, Kashofer K, Hofman P, Zischka M, Moch H, Rechsteiner M, Wild PJ.

Pathol Res Pract. 2018 Jul;214(7):957-963. doi: 10.1016/j.prp.2018.05.020. Epub 2018 May 22.


Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors.

Visentin M, Torozi A, Gai Z, Häusler S, Li C, Hiller C, Schraml PH, Moch H, Kullak-Ublick GA.

Drug Metab Dispos. 2018 Aug;46(8):1129-1136. doi: 10.1124/dmd.118.081091. Epub 2018 May 24.


Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model.

Keller N, Andreoni F, Reiber C, Luethi-Schaller H, Schuepbach RA, Moch H, Marques Maggio E, Zinkernagel AS.

Am J Pathol. 2018 Jul;188(7):1517-1523. doi: 10.1016/j.ajpath.2018.03.009. Epub 2018 Apr 22.


Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study.

Gramatzki D, Roth P, Rushing EJ, Weller J, Andratschke N, Hofer S, Korol D, Regli L, Pangalu A, Pless M, Oberle J, Bernays R, Moch H, Rohrmann S, Weller M.

Ann Oncol. 2018 Jun 1;29(6):1431-1436. doi: 10.1093/annonc/mdy106.


Targeted next-generation-sequencing for reliable detection of targetable rearrangements in lung adenocarcinoma-a single center retrospective study.

Velizheva NP, Rechsteiner MP, Valtcheva N, Freiberger SN, Wong CE, Vrugt B, Zhong Q, Wagner U, Moch H, Hillinger S, Schmitt-Opitz I, Soltermann A, Wild PJ, Tischler V.

Pathol Res Pract. 2018 Apr;214(4):572-578. doi: 10.1016/j.prp.2018.02.001. Epub 2018 Feb 16.


Comprehensive immunohistochemical analysis of PD-L1 shows scarce expression in castration-resistant prostate cancer.

Fankhauser CD, Schüffler PJ, Gillessen S, Omlin A, Rupp NJ, Rueschoff JH, Hermanns T, Poyet C, Sulser T, Moch H, Wild PJ.

Oncotarget. 2017 Dec 4;9(12):10284-10293. doi: 10.18632/oncotarget.22888. eCollection 2018 Feb 13.


Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.

Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K.

Nat Med. 2018 May;24(4):463-473. doi: 10.1038/nm.4494. Epub 2018 Mar 12.


PD-L1 is a positive prognostic factor in squamous cell carcinoma of the nasal vestibule.

Vital D, Holzmann D, Huber GF, Moch H, Morand GB, Ikenberg K.

Rhinology. 2018 Sep 1;56(3):255-260. doi: 10.4193/Rhin17.215.


Morphological clues to the appropriate recognition of hereditary renal neoplasms.

Moch H, Ohashi R, Gandhi JS, Amin MB.

Semin Diagn Pathol. 2018 May;35(3):184-192. doi: 10.1053/j.semdp.2018.01.005. Epub 2018 Feb 14. Review.


Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

Rechsteiner M, Dedes K, Fink D, Pestalozzi B, Sobottka B, Moch H, Wild P, Varga Z.

J Cancer Res Clin Oncol. 2018 May;144(5):865-874. doi: 10.1007/s00432-018-2609-5. Epub 2018 Feb 17.


Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer.

Posch F, Silina K, Leibl S, Mündlein A, Moch H, Siebenhüner A, Samaras P, Riedl J, Stotz M, Szkandera J, Stöger H, Pichler M, Stupp R, van den Broek M, Schraml P, Gerger A, Petrausch U, Winder T.

Oncoimmunology. 2017 Dec 18;7(2):e1378844. doi: 10.1080/2162402X.2017.1378844. eCollection 2018.


Biomarker discovery for renal cancer stem cells.

Corrò C, Moch H.

J Pathol Clin Res. 2018 Jan 17;4(1):3-18. doi: 10.1002/cjp2.91. eCollection 2018 Jan. Review.


Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma.

Siliņa K, Soltermann A, Attar FM, Casanova R, Uckeley ZM, Thut H, Wandres M, Isajevs S, Cheng P, Curioni-Fontecedro A, Foukas P, Levesque MP, Moch H, Linē A, van den Broek M.

Cancer Res. 2018 Mar 1;78(5):1308-1320. doi: 10.1158/0008-5472.CAN-17-1987. Epub 2017 Dec 26.


NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.


[Establishment of a living biobank : Improved guidance of precision cancer care with in vitro and in vivo cancer models].

Pauli C, Moch H, Rubin MA.

Pathologe. 2017 Nov;38(Suppl 2):160-168. doi: 10.1007/s00292-017-0346-1. Review. German.


Neue und vielversprechende molekulare Therapieoptionen in verschiedenen Subtypen des Nierenzellkarzinoms.

Rupp NJ, Mischo A, Moch H.

Ther Umsch. 2017 Sep;74(4):171-179. doi: 10.1024/0040-5930/a000901. Review. German. No abstract available.


A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A.

Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010.

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