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Caspase-8 restricts natural killer cell accumulation during MCMV Infection.

Feng Y, Daley-Bauer LP, Roback L, Potempa M, Lanier LL, Mocarski ES.

Med Microbiol Immunol. 2019 May 21. doi: 10.1007/s00430-019-00617-6. [Epub ahead of print]


Caspase-8-dependent control of NK- and T cell responses during cytomegalovirus infection.

Feng Y, Daley-Bauer LP, Mocarski ES.

Med Microbiol Immunol. 2019 May 16. doi: 10.1007/s00430-019-00616-7. [Epub ahead of print] Review.


Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles.

Ali M, Roback L, Mocarski ES.

J Biol Chem. 2019 Jan 18;294(3):991-1004. doi: 10.1074/jbc.RA118.004651. Epub 2018 Nov 30.


Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3.

Feng Y, Livingston-Rosanoff D, Roback L, Sundararajan A, Speck SH, Mocarski ES, Daley-Bauer LP.

J Immunol. 2018 Oct 15;201(8):2244-2255. doi: 10.4049/jimmunol.1800110. Epub 2018 Sep 7.


Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1.

Guo H, Gilley RP, Fisher A, Lane R, Landsteiner VJ, Ragan KB, Dovey CM, Carette JE, Upton JW, Mocarski ES, Kaiser WJ.

Cell Death Dis. 2018 Jul 26;9(8):816. doi: 10.1038/s41419-018-0868-3.


Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.

Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES.

Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011.


MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE.

Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7.


Proteasome inhibition blocks necroptosis by attenuating death complex aggregation.

Ali M, Mocarski ES.

Cell Death Dis. 2018 Mar 1;9(3):346. doi: 10.1038/s41419-018-0371-x.


Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3.

Koehler H, Cotsmire S, Langland J, Kibler KV, Kalman D, Upton JW, Mocarski ES, Jacobs BL.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11506-11511. doi: 10.1073/pnas.1700999114. Epub 2017 Oct 9.


Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo.

Suárez NM, Lau B, Kemble GM, Lee R, Mocarski ES, Wilkinson GWG, Adler SP, McVoy MA, Davison AJ.

Virus Genes. 2017 Aug;53(4):650-655. doi: 10.1007/s11262-017-1452-0. Epub 2017 Apr 8.


Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways.

Daley-Bauer LP, Roback L, Crosby LN, McCormick AL, Feng Y, Kaiser WJ, Mocarski ES.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2786-E2795. doi: 10.1073/pnas.1616829114. Epub 2017 Mar 14.


Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming.

Sayed N, Ospino F, Himmati F, Lee J, Chanda P, Mocarski ES, Cooke JP.

Stem Cells. 2017 May;35(5):1197-1207. doi: 10.1002/stem.2607. Epub 2017 Mar 27.


RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S.

Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.


T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.


Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.

Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, Fitzgerald KA, Green DR, Zhang J, Mocarski ES, Alnemri ES.

Nat Commun. 2015 Jun 24;6:7515. doi: 10.1038/ncomms8515.


Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.

Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR.

J Biol Chem. 2015 Aug 14;290(33):20167-84. doi: 10.1074/jbc.M115.652321. Epub 2015 Jun 22.


Manipulation of apoptosis and necroptosis signaling by herpesviruses.

Guo H, Kaiser WJ, Mocarski ES.

Med Microbiol Immunol. 2015 Jun;204(3):439-48. doi: 10.1007/s00430-015-0410-5. Epub 2015 Apr 1. Review.


Necroptosis: The Trojan horse in cell autonomous antiviral host defense.

Mocarski ES, Guo H, Kaiser WJ.

Virology. 2015 May;479-480:160-6. doi: 10.1016/j.virol.2015.03.016. Epub 2015 Mar 24. Review.


Stanley Plotkin: the bright spark of cytomegalovirus vaccines.

Mocarski ES.

Med Microbiol Immunol. 2015 Jun;204(3):243-5. doi: 10.1007/s00430-015-0392-3. Epub 2015 Mar 20. No abstract available.


Suppression of RIP3-dependent necroptosis by human cytomegalovirus.

Omoto S, Guo H, Talekar GR, Roback L, Kaiser WJ, Mocarski ES.

J Biol Chem. 2015 May 1;290(18):11635-48. doi: 10.1074/jbc.M115.646042. Epub 2015 Mar 16.


The A, B, Cs of herpesvirus capsids.

Tandon R, Mocarski ES, Conway JF.

Viruses. 2015 Feb 26;7(3):899-914. doi: 10.3390/v7030899. Review.


Herpes simplex virus suppresses necroptosis in human cells.

Guo H, Omoto S, Harris PA, Finger JN, Bertin J, Gough PJ, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2015 Feb 11;17(2):243-51. doi: 10.1016/j.chom.2015.01.003.


The immunological underpinnings of vaccinations to prevent cytomegalovirus disease.

McCormick AL, Mocarski ES.

Cell Mol Immunol. 2015 Mar;12(2):170-9. doi: 10.1038/cmi.2014.120. Epub 2014 Dec 29. Review.


RIP3 induces apoptosis independent of pronecrotic kinase activity.

Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, Casillas LN, Haile PA, Sehon CA, Marquis RW, Upton J, Daley-Bauer LP, Roback L, Ramia N, Dovey CM, Carette JE, Chan FK, Bertin J, Gough PJ, Mocarski ES, Kaiser WJ.

Mol Cell. 2014 Nov 20;56(4):481-95. doi: 10.1016/j.molcel.2014.10.021. Epub 2014 Nov 20.


TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.


Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.

Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA.

J Immunol. 2014 Sep 1;193(5):2519-2530. doi: 10.4049/jimmunol.1400276. Epub 2014 Jul 25.


Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ.

J Immunol. 2014 Jun 15;192(12):5476-80. doi: 10.4049/jimmunol.1400499. Epub 2014 May 12.


RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7753-8. doi: 10.1073/pnas.1401857111. Epub 2014 May 12.


Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. doi: 10.1073/pnas.1403477111. Epub 2014 May 5.


Cytomegalovirus hijacks CX3CR1(hi) patrolling monocytes as immune-privileged vehicles for dissemination in mice.

Daley-Bauer LP, Roback LJ, Wynn GM, Mocarski ES.

Cell Host Microbe. 2014 Mar 12;15(3):351-62. doi: 10.1016/j.chom.2014.02.002.


True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity.

Mocarski ES, Kaiser WJ, Livingston-Rosanoff D, Upton JW, Daley-Bauer LP.

J Immunol. 2014 Mar 1;192(5):2019-26. doi: 10.4049/jimmunol.1302426. Review.


Highly acidic C-terminal region of cytomegalovirus pUL96 determines its functions during virus maturation independently of a direct pp150 interaction.

Brechtel TM, Mocarski ES, Tandon R.

J Virol. 2014 Apr;88(8):4493-503. doi: 10.1128/JVI.03784-13. Epub 2014 Feb 5.


Transcription of true late (γ2) cytomegalovirus genes requires UL92 function that is conserved among beta- and gammaherpesviruses.

Omoto S, Mocarski ES.

J Virol. 2014 Jan;88(1):120-30. doi: 10.1128/JVI.02983-13. Epub 2013 Oct 16.


Priorities for CMV vaccine development.

Krause PR, Bialek SR, Boppana SB, Griffiths PD, Laughlin CA, Ljungman P, Mocarski ES, Pass RF, Read JS, Schleiss MR, Plotkin SA.

Vaccine. 2013 Dec 17;32(1):4-10. doi: 10.1016/j.vaccine.2013.09.042. Epub 2013 Oct 13. Review.


Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells.

Antonopoulos C, El Sanadi C, Kaiser WJ, Mocarski ES, Dubyak GR.

J Immunol. 2013 Nov 1;191(9):4789-803. doi: 10.4049/jimmunol.1300645. Epub 2013 Sep 27.


Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES.

J Biol Chem. 2013 Oct 25;288(43):31268-79. doi: 10.1074/jbc.M113.462341. Epub 2013 Sep 9.


Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.

Long AB, Kaiser WJ, Mocarski ES, Caspary T.

Cell Death Differ. 2013 Nov;20(11):1510-20. doi: 10.1038/cdd.2013.97. Epub 2013 Jul 26.


Natural antisense transcripts of UL123 packaged in human cytomegalovirus virions.

Yang CQ, Miao LF, Pan X, Wu CC, Rayner S, Mocarski ES, Ye HQ, Luo MH.

Arch Virol. 2014 Jan;159(1):147-51. doi: 10.1007/s00705-013-1793-5. Epub 2013 Jul 25.


Viral modulation of programmed necrosis.

Kaiser WJ, Upton JW, Mocarski ES.

Curr Opin Virol. 2013 Jun;3(3):296-306. doi: 10.1016/j.coviro.2013.05.019. Epub 2013 Jun 15. Review.


Cytomegalovirus UL91 is essential for transcription of viral true late (γ2) genes.

Omoto S, Mocarski ES.

J Virol. 2013 Aug;87(15):8651-64. doi: 10.1128/JVI.01052-13. Epub 2013 May 29.


The need and challenges for development of an Epstein-Barr virus vaccine.

Cohen JI, Mocarski ES, Raab-Traub N, Corey L, Nabel GJ.

Vaccine. 2013 Apr 18;31 Suppl 2:B194-6. doi: 10.1016/j.vaccine.2012.09.041. Review.


Gene products of the embedded m41/m41.1 locus of murine cytomegalovirus differentially influence replication and pathogenesis.

Crosby LN, McCormick AL, Mocarski ES.

Virology. 2013 Feb 20;436(2):274-83. doi: 10.1016/j.virol.2012.12.002. Epub 2013 Jan 5.


Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway.

McCormick AL, Roback L, Wynn G, Mocarski ES.

Virology. 2013 Jan 20;435(2):250-7. doi: 10.1016/j.virol.2012.08.042. Epub 2012 Nov 14.


Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.

Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E.

J Immunol. 2012 Dec 15;189(12):5508-12. doi: 10.4049/jimmunol.1202121. Epub 2012 Nov 9.


Activation of innate immunity is required for efficient nuclear reprogramming.

Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski ES, Pera RR, Yakubov E, Cooke JP.

Cell. 2012 Oct 26;151(3):547-58. doi: 10.1016/j.cell.2012.09.034.


Antiviral T cell response triggers cytomegalovirus hepatitis in mice.

Livingston-Rosanoff D, Daley-Bauer LP, Garcia A, McCormick AL, Huang J, Mocarski ES.

J Virol. 2012 Dec;86(23):12879-90. doi: 10.1128/JVI.01752-12. Epub 2012 Sep 19.


Mechanisms modulating immune clearance during human cytomegalovirus latency.

Slobedman B, Mocarski ES.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14291-2. doi: 10.1073/pnas.1212245109. Epub 2012 Sep 4. No abstract available.


Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes.

Daley-Bauer LP, Wynn GM, Mocarski ES.

Immunity. 2012 Jul 27;37(1):122-33. doi: 10.1016/j.immuni.2012.04.014.


Viral and host control of cytomegalovirus maturation.

Tandon R, Mocarski ES.

Trends Microbiol. 2012 Aug;20(8):392-401. doi: 10.1016/j.tim.2012.04.008. Epub 2012 May 23. Review.


DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

Upton JW, Kaiser WJ, Mocarski ES.

Cell Host Microbe. 2012 Mar 15;11(3):290-7. doi: 10.1016/j.chom.2012.01.016.

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