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Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF.

Biomedicines. 2018 Aug 28;6(3). pii: E90. doi: 10.3390/biomedicines6030090.


Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.


Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter.

Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5203. doi: 10.1002/anie.201803138. No abstract available.


A complicated complex: Ion channels, voltage sensing, cell membranes and peptide inhibitors.

Zhang AH, Sharma G, Undheim EAB, Jia X, Mobli M.

Neurosci Lett. 2018 Jul 13;679:35-47. doi: 10.1016/j.neulet.2018.04.030. Epub 2018 Apr 21. Review.


Structural insights into the mechanism of inhibition of AHAS by herbicides.

Lonhienne T, Garcia MD, Pierens G, Mobli M, Nouwens A, Guddat LW.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1945-E1954. doi: 10.1073/pnas.1714392115. Epub 2018 Feb 13.


Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B.

Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31.


Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24.


Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.

Franke B, James AM, Mobli M, Colgrave ML, Mylne JS, Rosengren KJ.

J Biol Chem. 2017 Jul 28;292(30):12398-12411. doi: 10.1074/jbc.M117.776955. Epub 2017 May 23.


Modulation of Ion Channels by Cysteine-Rich Peptides: From Sequence to Structure.

Mobli M, Undheim EAB, Rash LD.

Adv Pharmacol. 2017;79:199-223. doi: 10.1016/bs.apha.2017.03.001. Epub 2017 Apr 24.


The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD.

Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0.


Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20.


The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M.

PLoS One. 2017 Mar 16;12(3):e0173551. doi: 10.1371/journal.pone.0173551. eCollection 2017.


A non-uniform sampling approach enables studies of dilute and unstable proteins.

Miljenović T, Jia X, Lavrencic P, Kobe B, Mobli M.

J Biomol NMR. 2017 Jun;68(2):119-127. doi: 10.1007/s10858-017-0091-z. Epub 2017 Feb 10.


NaV1.7 as a pain target - From gene to pharmacology.

Vetter I, Deuis JR, Mueller A, Israel MR, Starobova H, Zhang A, Rash LD, Mobli M.

Pharmacol Ther. 2017 Apr;172:73-100. doi: 10.1016/j.pharmthera.2016.11.015. Epub 2016 Dec 2. Review. No abstract available.


The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins.

Casey LW, Lavrencic P, Bentham AR, Cesari S, Ericsson DJ, Croll T, Turk D, Anderson PA, Mark AE, Dodds PN, Mobli M, Kobe B, Williams SJ.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12856-12861. doi: 10.1073/pnas.1609922113. Epub 2016 Oct 17.


Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data.

Mohanty B, Williams ML, Doak BC, Vazirani M, Ilyichova O, Wang G, Bermel W, Simpson JS, Chalmers DK, King GF, Mobli M, Scanlon MJ.

J Biomol NMR. 2016 Nov;66(3):195-208. Epub 2016 Oct 24.


Correction: Sparse sampling methods in multidimensional NMR.

Mobli M, Maciejewski MW, Schuyler AD, Stern AS, Hoch JC.

Phys Chem Chem Phys. 2016 Jul 28;18(28):19482. doi: 10.1039/c6cp90157c. Epub 2016 Jul 1.


Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides.

Undheim EA, Mobli M, King GF.

Bioessays. 2016 Jun;38(6):539-48. doi: 10.1002/bies.201500165. Epub 2016 May 11. Review.


Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I.

J Biol Chem. 2016 May 27;291(22):11829-42. doi: 10.1074/jbc.M116.721662. Epub 2016 Mar 29.


Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers.

Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF.

J Pept Sci. 2016 May;22(5):280-9. doi: 10.1002/psc.2857. Epub 2016 Feb 22.


Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.

Klint JK, Chin YK, Mobli M.

Mol Pharmacol. 2015 Dec;88(6):1002-10. doi: 10.1124/mol.115.100784. Epub 2015 Oct 1.


Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Saez NJ, Deplazes E, Cristofori-Armstrong B, Chassagnon IR, Lin X, Mobli M, Mark AE, Rash LD, King GF.

Br J Pharmacol. 2015 Oct;172(20):4985-95. doi: 10.1111/bph.13267. Epub 2015 Sep 22.


Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators.

Undheim EA, Grimm LL, Low CF, Morgenstern D, Herzig V, Zobel-Thropp P, Pineda SS, Habib R, Dziemborowicz S, Fry BG, Nicholson GM, Binford GJ, Mobli M, King GF.

Structure. 2015 Jul 7;23(7):1283-92. doi: 10.1016/j.str.2015.05.003. Epub 2015 Jun 11.


Reducing seed dependent variability of non-uniformly sampled multidimensional NMR data.

Mobli M.

J Magn Reson. 2015 Jul;256:60-69. doi: 10.1016/j.jmr.2015.04.003. Epub 2015 Apr 25.


Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.

Nogueira ML, Sforça ML, Chin YK, Mobli M, Handler A, Gorbatyuk VY, Robson SA, King GF, Gueiros-Filho FJ, Zeri AC.

Biomol NMR Assign. 2015 Oct;9(2):387-91. doi: 10.1007/s12104-015-9615-1. Epub 2015 May 13.


Solution structure of the RNA-binding cold-shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition.

Sawyer AL, Landsberg MJ, Ross IL, Kruse O, Mobli M, Hankamer B.

Biochem J. 2015 Jul 1;469(1):97-106. doi: 10.1042/BJ20150217. Epub 2015 Apr 28.


Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF.

Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.


α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.

Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF.

J Am Chem Soc. 2015 Mar 11;137(9):3209-12. doi: 10.1021/jacs.5b00244. Epub 2015 Mar 3.


RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.

Ma C, Mobli M, Yang X, Keller AN, King GF, Lewis PJ.

Nucleic Acids Res. 2015 Mar 11;43(5):2829-40. doi: 10.1093/nar/gkv108. Epub 2015 Feb 17.


Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna.

Mobli M, Qaraaty M, Amin G, Haririan I, Hajimahmoodi M, Rahimi R.

Arch Gynecol Obstet. 2015 Jul;292(1):21-35. doi: 10.1007/s00404-015-3629-x. Epub 2015 Jan 31. Review.


The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.

Bende NS, Dziemborowicz S, Herzig V, Ramanujam V, Brown GW, Bosmans F, Nicholson GM, King GF, Mobli M.

FEBS J. 2015 Mar;282(5):904-20. doi: 10.1111/febs.13189. Epub 2015 Jan 23.


Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR.

Mobli M, Hoch JC.

Prog Nucl Magn Reson Spectrosc. 2014 Nov;83:21-41. doi: 10.1016/j.pnmrs.2014.09.002. Epub 2014 Oct 13. Review. Erratum in: Prog Nucl Magn Reson Spectrosc. 2015 Apr;86-87;80.


Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide.

Wang G, MacRaild CA, Mohanty B, Mobli M, Cowieson NP, Anders RF, Simpson JS, McGowan S, Norton RS, Scanlon MJ.

PLoS One. 2014 Oct 24;9(10):e109674. doi: 10.1371/journal.pone.0109674. eCollection 2014.


Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.

Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD.

J Med Chem. 2014 Nov 13;57(21):9195-203. doi: 10.1021/jm501400p. Epub 2014 Nov 4.


A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.

Bende NS, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Wagner J, Nicholson GM, King GF, Bosmans F.

Nat Commun. 2014 Jul 11;5:4350. doi: 10.1038/ncomms5350.


Non-uniform sampling in EPR--optimizing data acquisition for HYSCORE spectroscopy.

Nakka KK, Tesiram YA, Brereton IM, Mobli M, Harmer JR.

Phys Chem Chem Phys. 2014 Aug 21;16(31):16378-82. doi: 10.1039/c4cp02172j.


Effect of myrtle fruit syrup on abnormal uterine bleeding: a randomized double-blind, placebo-controlled pilot study.

Qaraaty M, Kamali SH, Dabaghian FH, Zafarghandi N, Mokaberinejad R, Mobli M, Amin G, Naseri M, Kamalinejad M, Amin M, Ghaseminejad A, HosseiniKhabiri SJ, Talei D.

Daru. 2014 Jun 2;22:45. doi: 10.1186/2008-2231-22-45.


Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6.

Bobby R, Robustelli P, Kralicek AV, Mobli M, King GF, Grötzinger J, Dingley AJ.

FEBS J. 2014 May;281(10):2471-83. doi: 10.1111/febs.12800. Epub 2014 Apr 28.


Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl.

Dekan Z, Mobli M, Pennington MW, Fung E, Nemeth E, Alewood PF.

Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2931-4. doi: 10.1002/anie.201310103. Epub 2014 Feb 7.


Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.

Klint JK, Berecki G, Durek T, Mobli M, Knapp O, King GF, Adams DJ, Alewood PF, Rash LD.

Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19.


A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN.

Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.


Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain.

de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF.

Nat Commun. 2014;5:3165. doi: 10.1038/ncomms4165.


Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology.

Bozorgi M, Memariani Z, Mobli M, Salehi Surmaghi MH, Shams-Ardekani MR, Rahimi R.

ScientificWorldJournal. 2013 Dec 15;2013:219815. doi: 10.1155/2013/219815. eCollection 2013. Review.


Solution structure, membrane interactions, and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni.

Jia X, Schulte L, Loukas A, Pickering D, Pearson M, Mobli M, Jones A, Rosengren KJ, Daly NL, Gobert GN, Jones MK, Craik DJ, Mulvenna J.

J Biol Chem. 2014 Mar 7;289(10):7151-63. doi: 10.1074/jbc.M113.531558. Epub 2014 Jan 15.


Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR.

Hoch JC, Maciejewski MW, Mobli M, Schuyler AD, Stern AS.

Acc Chem Res. 2014 Feb 18;47(2):708-17. doi: 10.1021/ar400244v. Epub 2014 Jan 9.


Measuring interactions of FERM domain-containing sorting Nexin proteins with endosomal lipids and cargo molecules.

Ghai R, Mobli M, Collins BM.

Methods Enzymol. 2014;534:331-49. doi: 10.1016/B978-0-12-397926-1.00019-6.


Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2.

Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T.

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1017-20. doi: 10.1002/anie.201308898. Epub 2013 Dec 9.


Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter.

Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12020-3. doi: 10.1002/anie.201304660. Epub 2013 Sep 24. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2018 May 4;57(19):5203.


Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula.

Hardy MC, Daly NL, Mobli M, Morales RA, King GF.

PLoS One. 2013 Sep 11;8(9):e73136. doi: 10.1371/journal.pone.0073136. eCollection 2013.

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