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The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection.

Vornhagen J, Sun Y, Breen P, Forsyth V, Zhao L, Mobley HLT, Bachman MA.

PLoS Pathog. 2019 Aug 26;15(8):e1008010. doi: 10.1371/journal.ppat.1008010. eCollection 2019 Aug.


Sulfur Assimilation Alters Flagellar Function and Modulates the Gene Expression Landscape of Serratia marcescens.

Anderson MT, Mitchell LA, Sintsova A, Rice KA, Mobley HLT.

mSystems. 2019 Aug 6;4(4). pii: e00285-19. doi: 10.1128/mSystems.00285-19.


UTI patients have pre-existing antigen-specific antibody titers against UTI vaccine antigens.

Sarkissian CA, Alteri CJ, Mobley HLT.

Vaccine. 2019 Aug 14;37(35):4937-4946. doi: 10.1016/j.vaccine.2019.07.031. Epub 2019 Jul 15.


Transposon Insertion Site Sequencing in a Urinary Tract Model.

Forsyth VS, Mobley HLT, Armbruster CE.

Methods Mol Biol. 2019;2021:297-337. doi: 10.1007/978-1-4939-9601-8_25.


Vaccination to Protect Against Proteus mirabilis Challenge Utilizing the Ascending Model of Urinary Tract Infection.

Smith SN, Himpsl SD, Mobley HLT.

Methods Mol Biol. 2019;2021:201-215. doi: 10.1007/978-1-4939-9601-8_18.


Using Hemagglutination, Surface Shearing, and Acid Treatment to Study Fimbriae in Proteus mirabilis.

Himpsl SD, Pearson MM, Mobley HLT.

Methods Mol Biol. 2019;2021:109-120. doi: 10.1007/978-1-4939-9601-8_11.


Siderophore Detection Using Chrome Azurol S and Cross-Feeding Assays.

Himpsl SD, Mobley HLT.

Methods Mol Biol. 2019;2021:97-108. doi: 10.1007/978-1-4939-9601-8_10.


Insertional Mutagenesis Protocol for Constructing Single or Sequential Mutations.

Pearson MM, Himpsl SD, Mobley HLT.

Methods Mol Biol. 2019;2021:61-76. doi: 10.1007/978-1-4939-9601-8_7.


Proteus mirabilis Overview.

Mobley HLT.

Methods Mol Biol. 2019;2021:1-4. doi: 10.1007/978-1-4939-9601-8_1.


Flexible Metabolism and Suppression of Latent Enzymes Are Important for Escherichia coli Adaptation to Diverse Environments within the Host.

Alteri CJ, Himpsl SD, Shea AE, Mobley HLT.

J Bacteriol. 2019 Jul 24;201(16). pii: e00181-19. doi: 10.1128/JB.00181-19. Print 2019 Aug 15.


Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection.

Armbruster CE, Forsyth VS, Johnson AO, Smith SN, White AN, Brauer AL, Learman BS, Zhao L, Wu W, Anderson MT, Bachman MA, Mobley HLT.

PLoS Pathog. 2019 Apr 22;15(4):e1007653. doi: 10.1371/journal.ppat.1007653. eCollection 2019 Apr.


CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII.

Waack U, Warnock M, Yee A, Huttinger Z, Smith S, Kumar A, Deroux A, Ginsburg D, Mobley HLT, Lawrence DA, Sandkvist M.

MBio. 2018 Dec 18;9(6). pii: e01606-18. doi: 10.1128/mBio.01606-18.


Cross Talk between MarR-Like Transcription Factors Coordinates the Regulation of Motility in Uropathogenic Escherichia coli.

Luterbach CL, Mobley HLT.

Infect Immun. 2018 Nov 20;86(12). pii: e00338-18. doi: 10.1128/IAI.00338-18. Print 2018 Dec.


Citrobacter freundii fitness during bloodstream infection.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT.

Sci Rep. 2018 Aug 7;8(1):11792. doi: 10.1038/s41598-018-30196-0.


MrpJ Directly Regulates Proteus mirabilis Virulence Factors, Including Fimbriae and Type VI Secretion, during Urinary Tract Infection.

Debnath I, Stringer AM, Smith SN, Bae E, Mobley HLT, Wade JT, Pearson MM.

Infect Immun. 2018 Sep 21;86(10). pii: e00388-18. doi: 10.1128/IAI.00388-18. Print 2018 Oct.


Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age.

Armbruster CE, Smith SN, Mody L, Mobley HLT.

Infect Immun. 2018 Aug 22;86(9). pii: e00327-18. doi: 10.1128/IAI.00327-18. Print 2018 Sep.


The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii.

Crépin S, Ottosen EN, Peters K, Smith SN, Himpsl SD, Vollmer W, Mobley HLT.

Mol Microbiol. 2018 Sep;109(6):745-762. doi: 10.1111/mmi.14000. Epub 2018 Sep 28.


TosR-Mediated Regulation of Adhesins and Biofilm Formation in Uropathogenic Escherichia coli.

Luterbach CL, Forsyth VS, Engstrom MD, Mobley HLT.

mSphere. 2018 May 16;3(3). pii: e00222-18. doi: 10.1128/mSphere.00222-18. eCollection 2018 May-Jun.


Rapid Growth of Uropathogenic Escherichia coli during Human Urinary Tract Infection.

Forsyth VS, Armbruster CE, Smith SN, Pirani A, Springman AC, Walters MS, Nielubowicz GR, Himpsl SD, Snitkin ES, Mobley HLT.

MBio. 2018 Mar 6;9(2). pii: e00186-18. doi: 10.1128/mBio.00186-18.


Distinct Signature of Oxylipid Mediators of Inflammation during Infection and Asymptomatic Colonization by E. coli in the Urinary Bladder.

Packiriswamy N, Gandy J, Smith SN, Mobley HLT, Sordillo LM, Subashchandrabose S.

Mediators Inflamm. 2017;2017:4207928. doi: 10.1155/2017/4207928. Epub 2017 Dec 27.


Pathogenesis of Proteus mirabilis Infection.

Armbruster CE, Mobley HLT, Pearson MM.

EcoSal Plus. 2018 Feb;8(1). doi: 10.1128/ecosalplus.ESP-0009-2017. Review.


Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections.

Dbeibo L, van Rensburg JJ, Smith SN, Fortney KR, Gangaiah D, Gao H, Marzoa J, Liu Y, Mobley HLT, Spinola SM.

Infect Immun. 2018 Feb 20;86(3). pii: e00798-17. doi: 10.1128/IAI.00798-17. Print 2018 Mar.


Role of Ethanolamine Utilization Genes in Host Colonization during Urinary Tract Infection.

Sintsova A, Smith S, Subashchandrabose S, Mobley HL.

Infect Immun. 2018 Feb 20;86(3). pii: e00542-17. doi: 10.1128/IAI.00542-17. Print 2018 Mar.


Subtle variation within conserved effector operon gene products contributes to T6SS-mediated killing and immunity.

Alteri CJ, Himpsl SD, Zhu K, Hershey HL, Musili N, Miller JE, Mobley HLT.

PLoS Pathog. 2017 Nov 20;13(11):e1006729. doi: 10.1371/journal.ppat.1006729. eCollection 2017 Nov.


Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.

Mike LA, Tripathi A, Blankenship CM, Saluk A, Schultz PJ, Tamayo-Castillo G, Sherman DH, Mobley HLT.

Chem Commun (Camb). 2017 Nov 28;53(95):12778-12781. doi: 10.1039/c7cc07732g.


Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors.

Waack U, Johnson TL, Chedid K, Xi C, Simmons LA, Mobley HLT, Sandkvist M.

Front Cell Infect Microbiol. 2017 Aug 28;7:380. doi: 10.3389/fcimb.2017.00380. eCollection 2017.


Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirements.

Armbruster CE, Forsyth-DeOrnellas V, Johnson AO, Smith SN, Zhao L, Wu W, Mobley HLT.

PLoS Pathog. 2017 Jun 14;13(6):e1006434. doi: 10.1371/journal.ppat.1006434. eCollection 2017 Jun.


Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity.

Anderson MT, Mitchell LA, Mobley HLT.

J Bacteriol. 2017 Jul 25;199(16). pii: e00159-17. doi: 10.1128/JB.00159-17. Print 2017 Aug 15.


Capsule Production and Glucose Metabolism Dictate Fitness during Serratia marcescens Bacteremia.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT.

MBio. 2017 May 23;8(3). pii: e00740-17. doi: 10.1128/mBio.00740-17.


The Pathogenic Potential of Proteus mirabilis Is Enhanced by Other Uropathogens during Polymicrobial Urinary Tract Infection.

Armbruster CE, Smith SN, Johnson AO, DeOrnellas V, Eaton KA, Yep A, Mody L, Wu W, Mobley HLT.

Infect Immun. 2017 Jan 26;85(2). pii: e00808-16. doi: 10.1128/IAI.00808-16. Print 2017 Feb.


How Often Do Clinically Diagnosed Catheter-Associated Urinary Tract Infections in Nursing Homes Meet Standardized Criteria?

Armbruster CE, Prenovost K, Mobley HL, Mody L.

J Am Geriatr Soc. 2017 Feb;65(2):395-401. doi: 10.1111/jgs.14533. Epub 2016 Nov 14.


Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection.

Mike LA, Smith SN, Sumner CA, Eaton KA, Mobley HL.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13468-13473. Epub 2016 Nov 7.


Editorial: Infection and immunity research at the University of Maryland, Baltimore.

Kaper JB, Flajnik MF, Mobley HL.

Pathog Dis. 2016 Nov;74(8). pii: ftw100. Epub 2016 Oct 4. No abstract available.


Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection.

Subashchandrabose S, Smith S, DeOrnellas V, Crepin S, Kole M, Zahdeh C, Mobley HL.

mSphere. 2015 Nov 4;1(1). pii: e00013-15. doi: 10.1128/mSphere.00013-15. eCollection 2016 Jan-Feb.


The Versatile Type VI Secretion System.

Alteri CJ, Mobley HL.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0026-2015. Review.


Measuring Escherichia coli Gene Expression during Human Urinary Tract Infections.

Mobley HL.

Pathogens. 2016 Jan 15;5(1). pii: E7. doi: 10.3390/pathogens5010007.


Development of a Vaccine against Escherichia coli Urinary Tract Infections.

Mobley HL, Alteri CJ.

Pathogens. 2015 Dec 31;5(1). pii: E1. doi: 10.3390/pathogens5010001.


Virulence and Fitness Determinants of Uropathogenic Escherichia coli.

Subashchandrabose S, Mobley HLT.

Microbiol Spectr. 2015 Aug;3(4). doi: 10.1128/microbiolspec.UTI-0015-2012. Review.


Host Characteristics and Bacterial Traits Predict Experimental Virulence for Escherichia coli Bloodstream Isolates From Patients With Urosepsis.

Johnson JR, Porter S, Johnston B, Kuskowski MA, Spurbeck RR, Mobley HL, Williamson DA.

Open Forum Infect Dis. 2015 Jun 6;2(3):ofv083. doi: 10.1093/ofid/ofv083. eCollection 2015 Sep.


Metabolism and Fitness of Urinary Tract Pathogens.

Alteri CJ, Mobley HLT.

Microbiol Spectr. 2015 Jun;3(3). doi: 10.1128/microbiolspec.MBP-0016-2015.


Genome-Wide Identification of Klebsiella pneumoniae Fitness Genes during Lung Infection.

Bachman MA, Breen P, Deornellas V, Mu Q, Zhao L, Wu W, Cavalcoli JD, Mobley HL.

MBio. 2015 Jun 9;6(3):e00775. doi: 10.1128/mBio.00775-15.


Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G.

Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.


Back to the metal age: battle for metals at the host-pathogen interface during urinary tract infection.

Subashchandrabose S, Mobley HL.

Metallomics. 2015 Jun;7(6):935-42. doi: 10.1039/c4mt00329b. Review.


Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection.

Buckles EL, Luterbach CL, Wang X, Lockatell CV, Johnson DE, Mobley HL, Donnenberg MS.

Pathog Dis. 2015 Jun;73(4). pii: ftv014. doi: 10.1093/femspd/ftv014. Epub 2015 Feb 11.


Blocking yersiniabactin import attenuates extraintestinal pathogenic Escherichia coli in cystitis and pyelonephritis and represents a novel target to prevent urinary tract infection.

Brumbaugh AR, Smith SN, Subashchandrabose S, Himpsl SD, Hazen TH, Rasko DA, Mobley HL.

Infect Immun. 2015 Apr;83(4):1443-50. doi: 10.1128/IAI.02904-14. Epub 2015 Jan 26.


Preferential use of central metabolism in vivo reveals a nutritional basis for polymicrobial infection.

Alteri CJ, Himpsl SD, Mobley HL.

PLoS Pathog. 2015 Jan 8;11(1):e1004601. doi: 10.1371/journal.ppat.1004601. eCollection 2015 Jan.


Host-specific induction of Escherichia coli fitness genes during human urinary tract infection.

Subashchandrabose S, Hazen TH, Brumbaugh AR, Himpsl SD, Smith SN, Ernst RD, Rasko DA, Mobley HL.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18327-32. doi: 10.1073/pnas.1415959112. Epub 2014 Dec 8.


Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection.

Steigedal M, Marstad A, Haug M, Damås JK, Strong RK, Roberts PL, Himpsl SD, Stapleton A, Hooton TM, Mobley HL, Hawn TR, Flo TH.

J Immunol. 2014 Dec 15;193(12):6081-9. doi: 10.4049/jimmunol.1401528. Epub 2014 Nov 14.


Arginine promotes Proteus mirabilis motility and fitness by contributing to conservation of the proton gradient and proton motive force.

Armbruster CE, Hodges SA, Smith SN, Alteri CJ, Mobley HL.

Microbiologyopen. 2014 Oct;3(5):630-41. doi: 10.1002/mbo3.194. Epub 2014 Aug 7.

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