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Citrobacter freundii fitness during bloodstream infection.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT.

Sci Rep. 2018 Aug 7;8(1):11792. doi: 10.1038/s41598-018-30196-0.


MrpJ Directly Regulates Proteus mirabilis Virulence Factors Including Fimbriae and Type VI Secretion During Urinary Tract Infection.

Debnath I, Stringer AM, Smith SN, Bae E, Mobley HLT, Wade JT, Pearson MM.

Infect Immun. 2018 Aug 6. pii: IAI.00388-18. doi: 10.1128/IAI.00388-18. [Epub ahead of print]


Urine cytokine and chemokine levels predict urinary tract infection severity independent of uropathogen, urine bacterial burden, host genetics, and host age.

Armbruster CE, Smith SN, Mody L, Mobley HLT.

Infect Immun. 2018 Jun 11. pii: IAI.00327-18. doi: 10.1128/IAI.00327-18. [Epub ahead of print]


The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii.

Crépin S, Ottosen EN, Peters K, Smith SN, Himpsl SD, Vollmer W, Mobley HLT.

Mol Microbiol. 2018 Jun 8. doi: 10.1111/mmi.14000. [Epub ahead of print]


TosR-Mediated Regulation of Adhesins and Biofilm Formation in Uropathogenic Escherichia coli.

Luterbach CL, Forsyth VS, Engstrom MD, Mobley HLT.

mSphere. 2018 May 16;3(3). pii: e00222-18. doi: 10.1128/mSphere.00222-18. eCollection 2018 May-Jun.


Rapid Growth of Uropathogenic Escherichia coli during Human Urinary Tract Infection.

Forsyth VS, Armbruster CE, Smith SN, Pirani A, Springman AC, Walters MS, Nielubowicz GR, Himpsl SD, Snitkin ES, Mobley HLT.

MBio. 2018 Mar 6;9(2). pii: e00186-18. doi: 10.1128/mBio.00186-18.


Distinct Signature of Oxylipid Mediators of Inflammation during Infection and Asymptomatic Colonization by E. coli in the Urinary Bladder.

Packiriswamy N, Gandy J, Smith SN, Mobley HLT, Sordillo LM, Subashchandrabose S.

Mediators Inflamm. 2017;2017:4207928. doi: 10.1155/2017/4207928. Epub 2017 Dec 27.


Pathogenesis of Proteus mirabilis Infection.

Armbruster CE, Mobley HLT, Pearson MM.

EcoSal Plus. 2018 Feb;8(1). doi: 10.1128/ecosalplus.ESP-0009-2017.


Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections.

Dbeibo L, van Rensburg JJ, Smith SN, Fortney KR, Gangaiah D, Gao H, Marzoa J, Liu Y, Mobley HLT, Spinola SM.

Infect Immun. 2018 Feb 20;86(3). pii: e00798-17. doi: 10.1128/IAI.00798-17. Print 2018 Mar.


Role of Ethanolamine Utilization Genes in Host Colonization during Urinary Tract Infection.

Sintsova A, Smith S, Subashchandrabose S, Mobley HL.

Infect Immun. 2018 Feb 20;86(3). pii: e00542-17. doi: 10.1128/IAI.00542-17. Print 2018 Mar.


Subtle variation within conserved effector operon gene products contributes to T6SS-mediated killing and immunity.

Alteri CJ, Himpsl SD, Zhu K, Hershey HL, Musili N, Miller JE, Mobley HLT.

PLoS Pathog. 2017 Nov 20;13(11):e1006729. doi: 10.1371/journal.ppat.1006729. eCollection 2017 Nov.


Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.

Mike LA, Tripathi A, Blankenship CM, Saluk A, Schultz PJ, Tamayo-Castillo G, Sherman DH, Mobley HLT.

Chem Commun (Camb). 2017 Nov 28;53(95):12778-12781. doi: 10.1039/c7cc07732g.


Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors.

Waack U, Johnson TL, Chedid K, Xi C, Simmons LA, Mobley HLT, Sandkvist M.

Front Cell Infect Microbiol. 2017 Aug 28;7:380. doi: 10.3389/fcimb.2017.00380. eCollection 2017.


Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirements.

Armbruster CE, Forsyth-DeOrnellas V, Johnson AO, Smith SN, Zhao L, Wu W, Mobley HLT.

PLoS Pathog. 2017 Jun 14;13(6):e1006434. doi: 10.1371/journal.ppat.1006434. eCollection 2017 Jun.


Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity.

Anderson MT, Mitchell LA, Mobley HLT.

J Bacteriol. 2017 Jul 25;199(16). pii: e00159-17. doi: 10.1128/JB.00159-17. Print 2017 Aug 15.


Capsule Production and Glucose Metabolism Dictate Fitness during Serratia marcescens Bacteremia.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT.

MBio. 2017 May 23;8(3). pii: e00740-17. doi: 10.1128/mBio.00740-17.


The Pathogenic Potential of Proteus mirabilis Is Enhanced by Other Uropathogens during Polymicrobial Urinary Tract Infection.

Armbruster CE, Smith SN, Johnson AO, DeOrnellas V, Eaton KA, Yep A, Mody L, Wu W, Mobley HL.

Infect Immun. 2017 Jan 26;85(2). pii: e00808-16. doi: 10.1128/IAI.00808-16. Print 2017 Feb.


How Often Do Clinically Diagnosed Catheter-Associated Urinary Tract Infections in Nursing Homes Meet Standardized Criteria?

Armbruster CE, Prenovost K, Mobley HL, Mody L.

J Am Geriatr Soc. 2017 Feb;65(2):395-401. doi: 10.1111/jgs.14533. Epub 2016 Nov 14.


Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection.

Mike LA, Smith SN, Sumner CA, Eaton KA, Mobley HL.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13468-13473. Epub 2016 Nov 7.


Editorial: Infection and immunity research at the University of Maryland, Baltimore.

Kaper JB, Flajnik MF, Mobley HL.

Pathog Dis. 2016 Nov;74(8). pii: ftw100. Epub 2016 Oct 4. No abstract available.


Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection.

Subashchandrabose S, Smith S, DeOrnellas V, Crepin S, Kole M, Zahdeh C, Mobley HL.

mSphere. 2015 Nov 4;1(1). pii: e00013-15. doi: 10.1128/mSphere.00013-15. eCollection 2016 Jan-Feb.


The Versatile Type VI Secretion System.

Alteri CJ, Mobley HL.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0026-2015. Review.


Measuring Escherichia coli Gene Expression during Human Urinary Tract Infections.

Mobley HL.

Pathogens. 2016 Jan 15;5(1). pii: E7. doi: 10.3390/pathogens5010007.


Development of a Vaccine against Escherichia coli Urinary Tract Infections.

Mobley HL, Alteri CJ.

Pathogens. 2015 Dec 31;5(1). pii: E1. doi: 10.3390/pathogens5010001.


Virulence and Fitness Determinants of Uropathogenic Escherichia coli.

Subashchandrabose S, Mobley HLT.

Microbiol Spectr. 2015 Aug;3(4). doi: 10.1128/microbiolspec.UTI-0015-2012. Review.


Host Characteristics and Bacterial Traits Predict Experimental Virulence for Escherichia coli Bloodstream Isolates From Patients With Urosepsis.

Johnson JR, Porter S, Johnston B, Kuskowski MA, Spurbeck RR, Mobley HL, Williamson DA.

Open Forum Infect Dis. 2015 Jun 6;2(3):ofv083. doi: 10.1093/ofid/ofv083. eCollection 2015 Sep.


Metabolism and Fitness of Urinary Tract Pathogens.

Alteri CJ, Mobley HLT.

Microbiol Spectr. 2015 Jun;3(3). doi: 10.1128/microbiolspec.MBP-0016-2015.


Genome-Wide Identification of Klebsiella pneumoniae Fitness Genes during Lung Infection.

Bachman MA, Breen P, Deornellas V, Mu Q, Zhao L, Wu W, Cavalcoli JD, Mobley HL.

MBio. 2015 Jun 9;6(3):e00775. doi: 10.1128/mBio.00775-15.


Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G.

Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.


Back to the metal age: battle for metals at the host-pathogen interface during urinary tract infection.

Subashchandrabose S, Mobley HL.

Metallomics. 2015 Jun;7(6):935-42. doi: 10.1039/c4mt00329b. Review.


Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection.

Buckles EL, Luterbach CL, Wang X, Lockatell CV, Johnson DE, Mobley HL, Donnenberg MS.

Pathog Dis. 2015 Jun;73(4). pii: ftv014. doi: 10.1093/femspd/ftv014. Epub 2015 Feb 11.


Blocking yersiniabactin import attenuates extraintestinal pathogenic Escherichia coli in cystitis and pyelonephritis and represents a novel target to prevent urinary tract infection.

Brumbaugh AR, Smith SN, Subashchandrabose S, Himpsl SD, Hazen TH, Rasko DA, Mobley HL.

Infect Immun. 2015 Apr;83(4):1443-50. doi: 10.1128/IAI.02904-14. Epub 2015 Jan 26.


Preferential use of central metabolism in vivo reveals a nutritional basis for polymicrobial infection.

Alteri CJ, Himpsl SD, Mobley HL.

PLoS Pathog. 2015 Jan 8;11(1):e1004601. doi: 10.1371/journal.ppat.1004601. eCollection 2015 Jan.


Host-specific induction of Escherichia coli fitness genes during human urinary tract infection.

Subashchandrabose S, Hazen TH, Brumbaugh AR, Himpsl SD, Smith SN, Ernst RD, Rasko DA, Mobley HL.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18327-32. doi: 10.1073/pnas.1415959112. Epub 2014 Dec 8.


Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection.

Steigedal M, Marstad A, Haug M, Damås JK, Strong RK, Roberts PL, Himpsl SD, Stapleton A, Hooton TM, Mobley HL, Hawn TR, Flo TH.

J Immunol. 2014 Dec 15;193(12):6081-9. doi: 10.4049/jimmunol.1401528. Epub 2014 Nov 14.


Arginine promotes Proteus mirabilis motility and fitness by contributing to conservation of the proton gradient and proton motive force.

Armbruster CE, Hodges SA, Smith SN, Alteri CJ, Mobley HL.

Microbiologyopen. 2014 Oct;3(5):630-41. doi: 10.1002/mbo3.194. Epub 2014 Aug 7.


PafR, a novel transcription regulator, is important for pathogenesis in uropathogenic Escherichia coli.

Baum M, Watad M, Smith SN, Alteri CJ, Gordon N, Rosenshine I, Mobley HL, Amster-Choder O.

Infect Immun. 2014 Oct;82(10):4241-52. doi: 10.1128/IAI.00086-14. Epub 2014 Jul 28.


SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains.

Nesta B, Valeri M, Spagnuolo A, Rosini R, Mora M, Donato P, Alteri CJ, Del Vecchio M, Buccato S, Pezzicoli A, Bertoldi I, Buzzigoli L, Tuscano G, Falduto M, Rippa V, Ashhab Y, Bensi G, Fontana MR, Seib KL, Mobley HL, Pizza M, Soriani M, Serino L.

PLoS Pathog. 2014 May 8;10(5):e1004124. doi: 10.1371/journal.ppat.1004124. eCollection 2014 May. Erratum in: PLoS Pathog. 2015 Mar;11(3):e1004773.


Inhibitors of TonB function identified by a high-throughput screen for inhibitors of iron acquisition in uropathogenic Escherichia coli CFT073.

Yep A, McQuade T, Kirchhoff P, Larsen M, Mobley HL.

MBio. 2014 Feb 25;5(2):e01089-13. doi: 10.1128/mBio.01089-13.


Genome-wide detection of fitness genes in uropathogenic Escherichia coli during systemic infection.

Subashchandrabose S, Smith SN, Spurbeck RR, Kole MM, Mobley HL.

PLoS Pathog. 2013;9(12):e1003788. doi: 10.1371/journal.ppat.1003788. Epub 2013 Dec 5.


Increased incidence of urolithiasis and bacteremia during Proteus mirabilis and Providencia stuartii coinfection due to synergistic induction of urease activity.

Armbruster CE, Smith SN, Yep A, Mobley HL.

J Infect Dis. 2014 May 15;209(10):1524-32. doi: 10.1093/infdis/jit663. Epub 2013 Nov 26.


Multicellular bacteria deploy the type VI secretion system to preemptively strike neighboring cells.

Alteri CJ, Himpsl SD, Pickens SR, Lindner JR, Zora JS, Miller JE, Arno PD, Straight SW, Mobley HL.

PLoS Pathog. 2013;9(9):e1003608. doi: 10.1371/journal.ppat.1003608. Epub 2013 Sep 5.


Draft genome sequences of five recent human uropathogenic Escherichia coli isolates.

Subashchandrabose S, Hazen TH, Rasko DA, Mobley HL.

Pathog Dis. 2013 Oct;69(1):66-70. Epub 2013 Oct 1.


Immunization with the yersiniabactin receptor, FyuA, protects against pyelonephritis in a murine model of urinary tract infection.

Brumbaugh AR, Smith SN, Mobley HL.

Infect Immun. 2013 Sep;81(9):3309-16. doi: 10.1128/IAI.00470-13. Epub 2013 Jun 24.


The multifunctional protein YdiV represses P fimbria-mediated adherence in uropathogenic Escherichia coli.

Spurbeck RR, Alteri CJ, Himpsl SD, Mobley HL.

J Bacteriol. 2013 Jul;195(14):3156-64. doi: 10.1128/JB.02254-12. Epub 2013 May 10.


A phyletically rare gene promotes the niche-specific fitness of an E. coli pathogen during bacteremia.

Wiles TJ, Norton JP, Smith SN, Lewis AJ, Mobley HL, Casjens SR, Mulvey MA.

PLoS Pathog. 2013 Feb;9(2):e1003175. doi: 10.1371/journal.ppat.1003175. Epub 2013 Feb 14.


Initiation of swarming motility by Proteus mirabilis occurs in response to specific cues present in urine and requires excess L-glutamine.

Armbruster CE, Hodges SA, Mobley HL.

J Bacteriol. 2013 Mar;195(6):1305-19. doi: 10.1128/JB.02136-12. Epub 2013 Jan 11.


Anaerobic respiration using a complete oxidative TCA cycle drives multicellular swarming in Proteus mirabilis.

Alteri CJ, Himpsl SD, Engstrom MD, Mobley HL.

MBio. 2012 Oct 30;3(6). pii: e00365-12. doi: 10.1128/mBio.00365-12.

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