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Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni.

Min K, An DR, Yoon HJ, Rana N, Park JS, Kim J, Lee M, Hesek D, Ryu S, Kim BM, Mobashery S, Suh SW, Lee HH.

Nat Commun. 2020 Jan 23;11(1):458. doi: 10.1038/s41467-019-13934-4.


Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation.

Mahasenan KV, Batuecas MT, De Benedetti S, Kim C, Rana N, Lee M, Hesek D, Fisher JF, Sanz-Aparicio J, Hermoso JA, Mobashery S.

ACS Chem Biol. 2020 Jan 17;15(1):189-196. doi: 10.1021/acschembio.9b00754. Epub 2020 Jan 7.


Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division.

Alcorlo M, Dik DA, De Benedetti S, Mahasenan KV, Lee M, Domínguez-Gil T, Hesek D, Lastochkin E, López D, Boggess B, Mobashery S, Hermoso JA.

Nat Commun. 2019 Dec 5;10(1):5567. doi: 10.1038/s41467-019-13354-4.


Constructing and deconstructing the bacterial cell wall.

Fisher JF, Mobashery S.

Protein Sci. 2019 Oct 6. doi: 10.1002/pro.3737. [Epub ahead of print] Review.


Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9.

Nguyen TT, Jones JI, Wolter WR, Pérez RL, Schroeder VA, Champion MM, Hesek D, Lee M, Suckow MA, Mobashery S, Chang M.

Wound Repair Regen. 2019 Nov 17. doi: 10.1111/wrr.12782. [Epub ahead of print]


Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials.

Ceballos S, Kim C, Qian Y, Mobashery S, Chang M, Torres C.

Antimicrob Agents Chemother. 2019 Dec 20;64(1). pii: e01344-19. doi: 10.1128/AAC.01344-19. Print 2019 Dec 20.


Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus.

Speri E, Kim C, De Benedetti S, Qian Y, Lastochkin E, Fishovitz J, Fisher JF, Mobashery S.

ACS Med Chem Lett. 2019 Jul 1;10(8):1148-1153. doi: 10.1021/acsmedchemlett.9b00169. eCollection 2019 Aug 8.


The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May.


Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA).

Speri E, Fishovitz J, Mobashery S.

Medchemcomm. 2018 Oct 30;9(12):2008-2016. doi: 10.1039/c8md00479j. eCollection 2018 Dec 1.


Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics.

Dik DA, Madukoma CS, Tomoshige S, Kim C, Lastochkin E, Boggess WC, Fisher JF, Shrout JD, Mobashery S.

ACS Chem Biol. 2019 Feb 15;14(2):296-303. doi: 10.1021/acschembio.8b01025. Epub 2019 Jan 18.


MMP-9 inhibitors impair learning in spontaneously hypertensive rats.

Raz L, Yang Y, Thompson J, Hobson S, Pesko J, Mobashery S, Chang M, Rosenberg G.

PLoS One. 2018 Dec 11;13(12):e0208357. doi: 10.1371/journal.pone.0208357. eCollection 2018.


A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.

Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S.

Biochemistry. 2018 Oct 23;57(42):6090-6098. doi: 10.1021/acs.biochem.8b00800. Epub 2018 Oct 10.


A positive positive to negative.

Fisher JF, Mobashery S.

Nat Chem. 2018 Oct;10(10):998-1000. doi: 10.1038/s41557-018-0148-y. No abstract available.


Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

Nguyen TT, Ding D, Wolter WR, Pérez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, Chang M.

J Med Chem. 2018 Oct 11;61(19):8825-8837. doi: 10.1021/acs.jmedchem.8b01005. Epub 2018 Sep 27.


In Search of Selectivity in Inhibition of ADAM10.

Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2018 Jun 11;9(7):708-713. doi: 10.1021/acsmedchemlett.8b00163. eCollection 2018 Jul 12.


Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.

Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S, Chang M.

Eur J Pharmacol. 2018 Sep 5;834:77-83. doi: 10.1016/j.ejphar.2018.07.014. Epub 2018 Jul 19.


Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice.

Chen S, Chen Z, Cui J, McCrary ML, Song H, Mobashery S, Chang M, Gu Z.

eNeuro. 2018 Jun 27;5(3). pii: ENEURO.0391-17.2018. doi: 10.1523/ENEURO.0391-17.2018. eCollection 2018 May-Jun.


Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria.

Ceballos S, Kim C, Ding D, Mobashery S, Chang M, Torres C.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00453-18. doi: 10.1128/AAC.00453-18. Print 2018 Aug.


Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.

Dik DA, Fisher JF, Mobashery S.

Chem Rev. 2018 Jun 27;118(12):5952-5984. doi: 10.1021/acs.chemrev.8b00277. Epub 2018 May 30. Review.


Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics.

Tomoshige S, Dik DA, Akabane-Nakata M, Madukoma CS, Fisher JF, Shrout JD, Mobashery S.

ACS Infect Dis. 2018 Jun 8;4(6):860-867. doi: 10.1021/acsinfecdis.8b00105. Epub 2018 May 7.


Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa.

Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4393-4398. doi: 10.1073/pnas.1801298115. Epub 2018 Apr 9.


Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S.

Sci Rep. 2018 Mar 7;8(1):4110. doi: 10.1038/s41598-018-22527-y.


Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives.

Kim C, Hesek D, Lee M, Mobashery S.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):642-645. doi: 10.1016/j.bmcl.2018.01.028. Epub 2018 Jan 31.


Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.

Bernardo-García N, Mahasenan KV, Batuecas MT, Lee M, Hesek D, Petráčková D, Doubravová L, Branny P, Mobashery S, Hermoso JA.

ACS Chem Biol. 2018 Mar 16;13(3):694-702. doi: 10.1021/acschembio.7b00817. Epub 2018 Jan 30.


Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol.

Lee M, Hesek D, Zajíček J, Fisher JF, Mobashery S.

Chem Commun (Camb). 2017 Nov 28;53(95):12774-12777. doi: 10.1039/c7cc06781j.


X-ray Structure of Catenated Lytic Transglycosylase SltB1.

Domínguez-Gil T, Molina R, Dik DA, Spink E, Mobashery S, Hermoso JA.

Biochemistry. 2017 Dec 5;56(48):6317-6320. doi: 10.1021/acs.biochem.7b00932. Epub 2017 Nov 16.


Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.

Testero SA, Granados C, Fernández D, Gallego P, Covaleda G, Reverter D, Vendrell J, Avilés FX, Pallarès I, Mobashery S.

ACS Med Chem Lett. 2017 Sep 22;8(10):1122-1127. doi: 10.1021/acsmedchemlett.7b00346. eCollection 2017 Oct 12.


Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster.

Horsman ME, Marous DR, Li R, Oliver RA, Byun B, Emrich SJ, Boggess B, Townsend CA, Mobashery S.

ACS Chem Biol. 2017 Oct 20;12(10):2552-2557. doi: 10.1021/acschembio.7b00687. Epub 2017 Sep 26.


Lytic transglycosylases: concinnity in concision of the bacterial cell wall.

Dik DA, Marous DR, Fisher JF, Mobashery S.

Crit Rev Biochem Mol Biol. 2017 Oct;52(5):503-542. doi: 10.1080/10409238.2017.1337705. Epub 2017 Jun 23. Review.


Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2017 May 1;8(6):654-659. doi: 10.1021/acsmedchemlett.7b00130. eCollection 2017 Jun 8.


Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Walls.

Lee M, Hesek D, Lastochkin E, Dik DA, Boggess B, Mobashery S.

Chembiochem. 2017 Sep 5;18(17):1696-1702. doi: 10.1002/cbic.201700293. Epub 2017 Jul 25.


Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.

Acebrón I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 May 24;139(20):6795-6798. doi: 10.1021/jacs.7b01626. Epub 2017 May 10.


From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa.

Lee M, Hesek D, Dik DA, Fishovitz J, Lastochkin E, Boggess B, Fisher JF, Mobashery S.

Angew Chem Int Ed Engl. 2017 Mar 1;56(10):2735-2739. doi: 10.1002/anie.201611279. Epub 2017 Jan 27.


Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2017 Feb 8;139(5):2102-2110. doi: 10.1021/jacs.6b12565. Epub 2017 Jan 27.


Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity.

Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF.

Structure. 2017 Feb 7;25(2):295-304. doi: 10.1016/j.str.2016.12.007. Epub 2017 Jan 12.


Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.

Dik DA, Domínguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, Boggess B, Hellman LM, Fisher JF, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 Feb 1;139(4):1448-1451. doi: 10.1021/jacs.6b12819. Epub 2017 Jan 17.


Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S.

ACS Chem Biol. 2016 Oct 21;11(10):2936. Epub 2016 Sep 6. No abstract available.


The oxadiazole antibacterials.

Janardhanan J, Chang M, Mobashery S.

Curr Opin Microbiol. 2016 Oct;33:13-17. doi: 10.1016/j.mib.2016.05.009. Epub 2016 May 27. Review.


Endless Resistance. Endless Antibiotics?

Fisher JF, Mobashery S.

Medchemcomm. 2016 Jan 1;7(1):37-49. Epub 2015 Nov 3.


Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori.

An DR, Im HN, Jang JY, Kim HS, Kim J, Yoon HJ, Hesek D, Lee M, Mobashery S, Kim SJ, Suh SW.

PLoS One. 2016 Oct 6;11(10):e0164243. doi: 10.1371/journal.pone.0164243. eCollection 2016.


Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance.

Lee M, Dhar S, De Benedetti S, Hesek D, Boggess B, Blázquez B, Mathee K, Mobashery S.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12568. doi: 10.1002/anie.201608482. No abstract available.


Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules.

Boudreau MA, Fishovitz J, Llarrull LI, Xiao Q, Mobashery S.

ACS Infect Dis. 2015 Oct 9;1(10):454-9. doi: 10.1021/acsinfecdis.5b00086. Epub 2015 Aug 24.


Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa.

Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA.

Structure. 2016 Oct 4;24(10):1729-1741. doi: 10.1016/j.str.2016.07.019. Epub 2016 Sep 8.


Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae.

Schaub RE, Chan YA, Lee M, Hesek D, Mobashery S, Dillard JP.

Mol Microbiol. 2016 Dec;102(5):865-881. doi: 10.1111/mmi.13496. Epub 2016 Sep 26.


Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M.

ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. Epub 2016 Aug 25.


In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.

Janardhanan J, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5581-8. doi: 10.1128/AAC.00787-16. Print 2016 Sep.


Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria.

Rivera I, Molina R, Lee M, Mobashery S, Hermoso JA.

Microb Drug Resist. 2016 Sep;22(6):470-6. doi: 10.1089/mdr.2016.0083. Epub 2016 Jun 21. Review.


The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.

Sandalova T, Lee M, Henriques-Normark B, Hesek D, Mobashery S, Mellroth P, Achour A.

Mol Microbiol. 2016 Sep;101(6):954-67. doi: 10.1111/mmi.13435. Epub 2016 Jul 5.


Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance.

Lee M, Dhar S, De Benedetti S, Hesek D, Boggess B, Blázquez B, Mathee K, Mobashery S.

Angew Chem Int Ed Engl. 2016 Jun 6;55(24):6882-6. doi: 10.1002/anie.201601693. Epub 2016 Apr 25. Erratum in: Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12568.


β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.

Fisher JF, Mobashery S.

Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a025221. doi: 10.1101/cshperspect.a025221. Review.

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