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Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.

Iglesias N, Paulo JA, Tatarakis A, Wang X, Edwards AL, Bhanu NV, Garcia BA, Haas W, Gygi SP, Moazed D.

Mol Cell. 2020 Jan 2;77(1):51-66.e8. doi: 10.1016/j.molcel.2019.10.018. Epub 2019 Nov 26.


Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.

Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D.

Nature. 2018 Aug;560(7719):504-508. doi: 10.1038/s41586-018-0398-2. Epub 2018 Jul 23.


Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.

Yu R, Wang X, Moazed D.

Nature. 2018 Jun;558(7711):615-619. doi: 10.1038/s41586-018-0239-3. Epub 2018 Jun 20.


Evolving Models of Heterochromatin: From Foci to Liquid Droplets.

Tatarakis A, Behrouzi R, Moazed D.

Mol Cell. 2017 Sep 7;67(5):725-727. doi: 10.1016/j.molcel.2017.08.022.


Silencing repetitive DNA.

Iglesias N, Moazed D.

Elife. 2017 Aug 1;6. pii: e29503. doi: 10.7554/eLife.29503.


Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.

Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D.

Nature. 2017 Jul 27;547(7664):463-467. doi: 10.1038/nature23267. Epub 2017 Jun 22.


DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation.

Wang X, Moazed D.

Science. 2017 Apr 7;356(6333):88-91. doi: 10.1126/science.aaj2114. Epub 2017 Mar 16.


Clr4 specificity and catalytic activity beyond H3K9 methylation.

Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A.

Biochimie. 2017 Apr;135:83-88. doi: 10.1016/j.biochi.2017.01.013. Epub 2017 Jan 29.


A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.

Mathew RS, Tatarakis A, Rudenko A, Johnson-Venkatesh EM, Yang YJ, Murphy EA, Todd TP, Schepers ST, Siuti N, Martorell AJ, Falls WA, Hammack SE, Walsh CA, Tsai LH, Umemori H, Bouton ME, Moazed D.

Elife. 2016 Dec 21;5. pii: e22467. doi: 10.7554/eLife.22467.


Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes.

Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D.

Elife. 2016 Nov 11;5. pii: e17556. doi: 10.7554/eLife.17556.


Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation.

Jain R, Iglesias N, Moazed D.

Mol Cell. 2016 Jul 21;63(2):191-205. doi: 10.1016/j.molcel.2016.05.039. Epub 2016 Jul 7.


CSR-1 Slices a Balance.

Yu R, Moazed D.

Cell. 2016 Apr 7;165(2):267-9. doi: 10.1016/j.cell.2016.03.019.


RNAi and heterochromatin assembly.

Martienssen R, Moazed D.

Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a019323. doi: 10.1101/cshperspect.a019323. Review.


Affinity Pull-Down of Proteins Using Anti-FLAG M2 Agarose Beads.

Gerace E, Moazed D.

Methods Enzymol. 2015;559:99-110. doi: 10.1016/bs.mie.2014.11.010. Epub 2015 May 16.


Affinity Purification of Protein Complexes Using TAP Tags.

Gerace E, Moazed D.

Methods Enzymol. 2015;559:37-52. doi: 10.1016/bs.mie.2014.11.007. Epub 2015 Mar 29.


Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.

Ragunathan K, Jih G, Moazed D.

Science. 2015 Apr 3;348(6230):1258699. doi: 10.1126/science.1258699. Epub 2014 Nov 20.


Small-RNA loading licenses Argonaute for assembly into a transcriptional silencing complex.

Holoch D, Moazed D.

Nat Struct Mol Biol. 2015 Apr;22(4):328-35. doi: 10.1038/nsmb.2979. Epub 2015 Mar 2.


RNA-mediated epigenetic regulation of gene expression.

Holoch D, Moazed D.

Nat Rev Genet. 2015 Feb;16(2):71-84. doi: 10.1038/nrg3863. Epub 2015 Jan 2. Review.


Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED, Braun CR, Gygi SP, Moazed D.

RNA. 2014 Jun;20(6):867-81. doi: 10.1261/rna.044479.114. Epub 2014 Apr 8.


Coimmunoprecipitation of proteins from yeast.

Gerace E, Moazed D.

Methods Enzymol. 2014;541:13-26. doi: 10.1016/B978-0-12-420119-4.00002-1.


Determinants of heterochromatic siRNA biogenesis and function.

Yu R, Jih G, Iglesias N, Moazed D.

Mol Cell. 2014 Jan 23;53(2):262-76. doi: 10.1016/j.molcel.2013.11.014. Epub 2013 Dec 26.


Heterochromatic gene silencing by activator interference and a transcription elongation barrier.

Johnson A, Wu R, Peetz M, Gygi SP, Moazed D.

J Biol Chem. 2013 Oct 4;288(40):28771-82. doi: 10.1074/jbc.M113.460071. Epub 2013 Aug 12.


Cell nucleus.

Heard E, Moazed D.

Curr Opin Cell Biol. 2013 Jun;25(3):279-80. doi: 10.1016/ Epub 2013 Jun 5. No abstract available.


Chromatin: a tail of repression.

Moazed D.

Curr Biol. 2013 May 20;23(10):R456-9. doi: 10.1016/j.cub.2013.04.033.


Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA.

Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8495-500. doi: 10.1073/pnas.1300126110. Epub 2013 May 6.


A piRNA to remember.

Moazed D.

Cell. 2012 Apr 27;149(3):512-4. doi: 10.1016/j.cell.2012.04.008.


RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery.

Holoch D, Moazed D.

Genes Dev. 2012 Apr 15;26(8):741-5. doi: 10.1101/gad.191155.112.


Mechanisms for the inheritance of chromatin states.

Moazed D.

Cell. 2011 Aug 19;146(4):510-8. doi: 10.1016/j.cell.2011.07.013.


Chromatin affinity-precipitation using a small metabolic molecule: its application to analysis of O-acetyl-ADP-ribose.

Tung SY, Hong JY, Walz T, Moazed D, Liou GG.

Cell Mol Life Sci. 2012 Feb;69(4):641-50. doi: 10.1007/s00018-011-0771-x. Epub 2011 Jul 28.


Autoregulation of convergent RNAi genes in fission yeast.

Gullerova M, Moazed D, Proudfoot NJ.

Genes Dev. 2011 Mar 15;25(6):556-68. doi: 10.1101/gad.618611. Epub 2011 Feb 28.


Histone demethylation and timely DNA replication.

Gerace EL, Moazed D.

Mol Cell. 2010 Dec 10;40(5):683-4. doi: 10.1016/j.molcel.2010.11.036.


The methyltransferase activity of Clr4Suv39h triggers RNAi independently of histone H3K9 methylation.

Gerace EL, Halic M, Moazed D.

Mol Cell. 2010 Aug 13;39(3):360-72. doi: 10.1016/j.molcel.2010.07.017.


The nuclear envelope in genome organization, expression and stability.

Mekhail K, Moazed D.

Nat Rev Mol Cell Biol. 2010 May;11(5):317-28. doi: 10.1038/nrm2894. Review.


Dicer-independent primal RNAs trigger RNAi and heterochromatin formation.

Halic M, Moazed D.

Cell. 2010 Feb 19;140(4):504-16. doi: 10.1016/j.cell.2010.01.019.


Molecular biology. Rejoice--RNAi for yeast.

Moazed D.

Science. 2009 Oct 23;326(5952):533-4. doi: 10.1126/science.1182102. No abstract available.


22G-RNAs in transposon silencing and centromere function.

Halic M, Moazed D.

Mol Cell. 2009 Oct 23;36(2):170-1. doi: 10.1016/j.molcel.2009.10.010.


Reconstitution of heterochromatin-dependent transcriptional gene silencing.

Johnson A, Li G, Sikorski TW, Buratowski S, Woodcock CL, Moazed D.

Mol Cell. 2009 Sep 24;35(6):769-81. doi: 10.1016/j.molcel.2009.07.030.


Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling.

Sinha M, Watanabe S, Johnson A, Moazed D, Peterson CL.

Cell. 2009 Sep 18;138(6):1109-21. doi: 10.1016/j.cell.2009.07.013.


Transposon silencing by piRNAs.

Halic M, Moazed D.

Cell. 2009 Sep 18;138(6):1058-60. doi: 10.1016/j.cell.2009.08.030.


An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.

Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D.

Mol Cell. 2009 Apr 24;34(2):155-67. doi: 10.1016/j.molcel.2009.02.032.


Regulation of Spo12 phosphorylation and its essential role in the FEAR network.

Tomson BN, Rahal R, Reiser V, Monje-Casas F, Mekhail K, Moazed D, Amon A.

Curr Biol. 2009 Mar 24;19(6):449-60. doi: 10.1016/j.cub.2009.02.024. Epub 2009 Mar 5.


Small RNAs in transcriptional gene silencing and genome defence.

Moazed D.

Nature. 2009 Jan 22;457(7228):413-20. doi: 10.1038/nature07756. Review.


HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR, Hong EJ, Li X, Gerber S, Denison C, Gygi S, Moazed D.

Mol Cell. 2008 Dec 26;32(6):778-90. doi: 10.1016/j.molcel.2008.10.026.


Role for perinuclear chromosome tethering in maintenance of genome stability.

Mekhail K, Seebacher J, Gygi SP, Moazed D.

Nature. 2008 Dec 4;456(7222):667-70. doi: 10.1038/nature07460. Epub 2008 Nov 9.


Epigenomics: a roadmap, but to where?

Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K.

Science. 2008 Oct 3;322(5898):43-4. doi: 10.1126/science.322.5898.43b. No abstract available.


Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.

Buchberger JR, Onishi M, Li G, Seebacher J, Rudner AD, Gygi SP, Moazed D.

Mol Cell Biol. 2008 Nov;28(22):6903-18. doi: 10.1128/MCB.01210-08. Epub 2008 Sep 15.


TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway.

B├╝hler M, Spies N, Bartel DP, Moazed D.

Nat Struct Mol Biol. 2008 Oct;15(10):1015-23. doi: 10.1038/nsmb.1481. Epub 2008 Sep 7.


siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription.

Iida T, Nakayama J, Moazed D.

Mol Cell. 2008 Jul 25;31(2):178-89. doi: 10.1016/j.molcel.2008.07.003.


Regulation of SIRT6 protein levels by nutrient availability.

Kanfi Y, Shalman R, Peshti V, Pilosof SN, Gozlan YM, Pearson KJ, Lerrer B, Moazed D, Marine JC, de Cabo R, Cohen HY.

FEBS Lett. 2008 Mar 5;582(5):543-8. doi: 10.1016/j.febslet.2008.01.019. Epub 2008 Jan 31.

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