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Items: 1 to 50 of 106

1.

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague.

Tao P, Mahalingam M, Zhu J, Moayeri M, Sha J, Lawrence WS, Leppla SH, Chopra AK, Rao VB.

MBio. 2018 Oct 16;9(5). pii: e01926-18. doi: 10.1128/mBio.01926-18.

2.

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

Amaral EP, Riteau N, Moayeri M, Maier N, Mayer-Barber KD, Pereira RM, Lage SL, Kubler A, Bishai WR, D'Império-Lima MR, Sher A, Andrade BB.

Front Immunol. 2018 Jun 21;9:1427. doi: 10.3389/fimmu.2018.01427. eCollection 2018.

3.

Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species.

Vrentas CE, Schaut RG, Boggiatto PM, Olsen SC, Sutterwala FS, Moayeri M.

Vet Immunol Immunopathol. 2018 Jul;201:49-56. doi: 10.1016/j.vetimm.2018.05.008. Epub 2018 May 21.

PMID:
29914682
4.

Small molecule inhibitors of anthrax edema factor.

Jiao GS, Kim S, Moayeri M, Thai A, Cregar-Hernandez L, McKasson L, O'Malley S, Leppla SH, Johnson AT.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):134-139. doi: 10.1016/j.bmcl.2017.11.040. Epub 2017 Nov 24.

PMID:
29198864
5.

Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support.

Suffredini DA, Cui X, Jaswal D, Remy KE, Li Y, Sun J, Solomon SB, Fitz Y, Moayeri M, Leppla S, Eichacker PQ.

Intensive Care Med Exp. 2017 Oct 23;5(1):48. doi: 10.1186/s40635-017-0159-9.

6.

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.

Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E.

PLoS Pathog. 2017 Sep 25;13(9):e1006603. doi: 10.1371/journal.ppat.1006603. eCollection 2017 Sep.

7.

Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

Suffredini DA, Li Y, Xu W, Moayeri M, Leppla S, Fitz Y, Cui X, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H946-H958. doi: 10.1152/ajpheart.00285.2017. Epub 2017 Sep 8.

8.

A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis.

Tao P, Mahalingam M, Zhu J, Moayeri M, Kirtley ML, Fitts EC, Andersson JA, Lawrence WS, Leppla SH, Chopra AK, Rao VB.

Front Immunol. 2017 Jun 26;8:687. doi: 10.3389/fimmu.2017.00687. eCollection 2017.

9.

Assessment of validity and reliability of Drug Hypersensitivity Quality of Life Questionnaire: The Dutch experience.

Moayeri M, Van Os-Medendorp H, Baiardini I, Röckmann H.

Eur Ann Allergy Clin Immunol. 2017 May;49(3):129-134.

10.

In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1.

Keefer AB, Asare EK, Pomerantsev AP, Moayeri M, Martens C, Porcella SF, Gottesman S, Leppla SH, Vrentas CE.

BMC Microbiol. 2017 Mar 14;17(1):63. doi: 10.1186/s12866-017-0973-y.

11.

Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review.

Moayeri M, Heida KY, Franx A, Spiering W, de Laat MW, Oudijk MA.

Arch Gynecol Obstet. 2017 Feb;295(2):313-323. doi: 10.1007/s00404-016-4216-5. Epub 2016 Nov 2. Review.

12.

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection.

Vrentas CE, Moayeri M, Keefer AB, Greaney AJ, Tremblay J, O'Mard D, Leppla SH, Shoemaker CB.

J Biol Chem. 2016 Oct 7;291(41):21596-21606. Epub 2016 Aug 18.

13.

Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

Li Y, Cui X, Xu W, Ohanjanian L, Sampath-Kumar H, Suffredini D, Moayeri M, Leppla S, Fitz Y, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H781-93. doi: 10.1152/ajpheart.00163.2016. Epub 2016 Jul 22.

14.

The Effect of Preimplantation Genetic Screening on Implantation Rate in Women over 35 Years of Age.

Moayeri M, Saeidi H, Modarresi MH, Hashemi M.

Cell J. 2016 Spring;18(1):13-20. Epub 2016 Apr 4.

15.

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice.

Moayeri M, Tremblay JM, Debatis M, Dmitriev IP, Kashentseva EA, Yeh AJ, Cheung GY, Curiel DT, Leppla S, Shoemaker CB.

Clin Vaccine Immunol. 2016 Jan 6;23(3):213-8. doi: 10.1128/CVI.00611-15.

16.

Bacterial Exotoxins and the Inflammasome.

Greaney AJ, Leppla SH, Moayeri M.

Front Immunol. 2015 Nov 10;6:570. doi: 10.3389/fimmu.2015.00570. eCollection 2015. Review.

17.

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.

Greaney AJ, Maier NK, Leppla SH, Moayeri M.

J Leukoc Biol. 2016 Jan;99(1):189-99. doi: 10.1189/jlb.3A0415-155RR. Epub 2015 Aug 12.

18.

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.

Andrade BB, Pavan Kumar N, Amaral EP, Riteau N, Mayer-Barber KD, Tosh KW, Maier N, Conceição EL, Kubler A, Sridhar R, Banurekha VV, Jawahar MS, Barbosa T, Manganiello VC, Moss J, Fontana JR, Marciano BE, Sampaio EP, Olivier KN, Holland SM, Jackson SH, Moayeri M, Leppla S, Sereti I, Barber DL, Nutman TB, Babu S, Sher A.

J Immunol. 2015 Sep 15;195(6):2763-73. doi: 10.4049/jimmunol.1500942. Epub 2015 Aug 12.

19.

Anthrax Pathogenesis.

Moayeri M, Leppla SH, Vrentas C, Pomerantsev AP, Liu S.

Annu Rev Microbiol. 2015;69:185-208. doi: 10.1146/annurev-micro-091014-104523. Epub 2015 Jul 16. Review.

PMID:
26195305
20.

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines.

Remy KE, Cui X, Li Y, Sun J, Solomon SB, Fitz Y, Barochia AV, Al-Hamad M, Moayeri M, Leppla SH, Eichacker PQ.

Intensive Care Med Exp. 2015 Dec;3(1):9. doi: 10.1186/s40635-015-0043-4. Epub 2015 Feb 28.

21.

The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.

Maier NK, Leppla SH, Moayeri M.

J Immunol. 2015 Mar 15;194(6):2776-85. doi: 10.4049/jimmunol.1401611. Epub 2015 Feb 13.

22.

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.

Moayeri M, Leysath CE, Tremblay JM, Vrentas C, Crown D, Leppla SH, Shoemaker CB.

J Biol Chem. 2015 Mar 6;290(10):6584-95. doi: 10.1074/jbc.M114.627943. Epub 2015 Jan 6.

23.

Anthrax lethal and edema toxins in anthrax pathogenesis.

Liu S, Moayeri M, Leppla SH.

Trends Microbiol. 2014 Jun;22(6):317-25. doi: 10.1016/j.tim.2014.02.012. Epub 2014 Mar 27. Review.

24.

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.

Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M.

PLoS Pathog. 2014 Mar 13;10(3):e1003927. doi: 10.1371/journal.ppat.1003927. eCollection 2014 Mar.

25.

NLRP1a expression in Srebp-1a-deficient mice.

Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL.

Cell Metab. 2014 Mar 4;19(3):345-6. doi: 10.1016/j.cmet.2014.02.002. No abstract available.

26.

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.

Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME.

MBio. 2014 Feb 18;5(1). pii: e01117-13. doi: 10.1128/mBio.01117-13.

27.

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.

Maier NK, Crown D, Liu J, Leppla SH, Moayeri M.

J Immunol. 2014 Jan 15;192(2):763-70. doi: 10.4049/jimmunol.1301434. Epub 2013 Dec 13.

28.

Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin.

Abrami L, Brandi L, Moayeri M, Brown MJ, Krantz BA, Leppla SH, van der Goot FG.

Cell Rep. 2013 Nov 27;5(4):986-96. doi: 10.1016/j.celrep.2013.10.019. Epub 2013 Nov 14.

29.

Anthrax edema factor toxicity is strongly mediated by the N-end rule.

Leysath CE, Phillips DD, Crown D, Fattah RJ, Moayeri M, Leppla SH.

PLoS One. 2013 Aug 28;8(8):e74474. doi: 10.1371/journal.pone.0074474. eCollection 2013.

30.

Key tissue targets responsible for anthrax-toxin-induced lethality.

Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH.

Nature. 2013 Sep 5;501(7465):63-8. doi: 10.1038/nature12510. Epub 2013 Aug 28.

31.

Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.

Moayeri M, Crown D, Jiao GS, Kim S, Johnson A, Leysath C, Leppla SH.

Antimicrob Agents Chemother. 2013 Sep;57(9):4139-45. doi: 10.1128/AAC.00941-13. Epub 2013 Jun 17.

32.

Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.

D'Agnillo F, Williams MC, Moayeri M, Warfel JM.

PLoS One. 2013 Apr 23;8(4):e62576. doi: 10.1371/journal.pone.0062576. Print 2013.

33.

Transcriptional analysis of the three Nlrp1 paralogs in mice.

Sastalla I, Crown D, Masters SL, McKenzie A, Leppla SH, Moayeri M.

BMC Genomics. 2013 Mar 18;14:188. doi: 10.1186/1471-2164-14-188.

34.

Prolonged ceftriaxone-induced immune thrombocytopenia due to impaired drug clearance: a case report.

Jacquot C, Moayeri M, Kim B, Shugarts S, Lynch KL, Leavitt AD.

Transfusion. 2013 Nov;53(11):2715-21. doi: 10.1111/trf.12138. Epub 2013 Mar 3.

PMID:
23451879
35.

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors.

Phillips DD, Fattah RJ, Crown D, Zhang Y, Liu S, Moayeri M, Fischer ER, Hansen BT, Ghirlando R, Nestorovich EM, Wein AN, Simons L, Leppla SH, Leysath CE.

J Biol Chem. 2013 Mar 29;288(13):9058-65. doi: 10.1074/jbc.M113.452110. Epub 2013 Feb 7.

36.

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages.

Hellmich KA, Levinsohn JL, Fattah R, Newman ZL, Maier N, Sastalla I, Liu S, Leppla SH, Moayeri M.

PLoS One. 2012;7(11):e49741. doi: 10.1371/journal.pone.0049741. Epub 2012 Nov 12.

37.

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.

38.

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.

Levinsohn JL, Newman ZL, Hellmich KA, Fattah R, Getz MA, Liu S, Sastalla I, Leppla SH, Moayeri M.

PLoS Pathog. 2012;8(3):e1002638. doi: 10.1371/journal.ppat.1002638. Epub 2012 Mar 29.

39.

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.

Jiao GS, Kim S, Moayeri M, Crown D, Thai A, Cregar-Hernandez L, McKasson L, Sankaran B, Lehrer A, Wong T, Johns L, Margosiak SA, Leppla SH, Johnson AT.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2242-6. doi: 10.1016/j.bmcl.2012.01.095. Epub 2012 Feb 1.

40.

Anthrax and the inflammasome.

Moayeri M, Sastalla I, Leppla SH.

Microbes Infect. 2012 May;14(5):392-400. doi: 10.1016/j.micinf.2011.12.005. Epub 2011 Dec 17. Review.

41.

Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis.

Bellanti JA, Lin FY, Chu C, Shiloach J, Leppla SH, Benavides GA, Karpas A, Moayeri M, Guo C, Robbins JB, Schneerson R.

Clin Vaccine Immunol. 2012 Feb;19(2):140-5. doi: 10.1128/CVI.05556-11. Epub 2011 Dec 21.

42.

Anthrax edema toxin impairs clearance in mice.

Sastalla I, Tang S, Crown D, Liu S, Eckhaus MA, Hewlett IK, Leppla SH, Moayeri M.

Infect Immun. 2012 Feb;80(2):529-38. doi: 10.1128/IAI.05947-11. Epub 2011 Nov 21.

43.

Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis.

Okugawa S, Moayeri M, Pomerantsev AP, Sastalla I, Crown D, Gupta PK, Leppla SH.

Mol Microbiol. 2012 Jan;83(1):96-109. doi: 10.1111/j.1365-2958.2011.07915.x. Epub 2011 Nov 22.

44.

Monoclonal antibody therapies against anthrax.

Chen Z, Moayeri M, Purcell R.

Toxins (Basel). 2011 Aug;3(8):1004-19. doi: 10.3390/toxins3081004. Epub 2011 Aug 15. Review.

45.

Mouse monoclonal antibodies to anthrax edema factor protect against infection.

Leysath CE, Chen KH, Moayeri M, Crown D, Fattah R, Chen Z, Das SR, Purcell RH, Leppla SH.

Infect Immun. 2011 Nov;79(11):4609-16. doi: 10.1128/IAI.05314-11. Epub 2011 Sep 12.

46.

A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins.

Pomerantsev AP, Pomerantseva OM, Moayeri M, Fattah R, Tallant C, Leppla SH.

Protein Expr Purif. 2011 Nov;80(1):80-90. doi: 10.1016/j.pep.2011.05.016. Epub 2011 Aug 7.

47.

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.

Altaweel L, Chen Z, Moayeri M, Cui X, Li Y, Su J, Fitz Y, Johnson S, Leppla SH, Purcell R, Eichacker PQ.

Crit Care Med. 2011 Jun;39(6):1439-47. doi: 10.1097/CCM.0b013e3182120691.

48.

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.

Kim S, Jiao GS, Moayeri M, Crown D, Cregar-Hernandez L, McKasson L, Margosiak SA, Leppla SH, Johnson AT.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2030-3. doi: 10.1016/j.bmcl.2011.02.010. Epub 2011 Feb 18.

49.

Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.

Hicks CW, Li Y, Okugawa S, Solomon SB, Moayeri M, Leppla SH, Mohanty A, Subramanian GM, Mignone TS, Fitz Y, Cui X, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H1108-18. doi: 10.1152/ajpheart.01128.2010. Epub 2011 Jan 7.

50.

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.

Moayeri M, Crown D, Newman ZL, Okugawa S, Eckhaus M, Cataisson C, Liu S, Sastalla I, Leppla SH.

PLoS Pathog. 2010 Dec 9;6(12):e1001222. doi: 10.1371/journal.ppat.1001222.

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