Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 160


High-potency ligands for DREADD imaging and activation in rodents and monkeys.

Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M.

Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z.


Linoleic acid in diets of mice increases total endocannabinoid levels in bowel and liver: modification by dietary glucose.

Ghosh S, O'Connell JF, Carlson OD, González-Mariscal I, Kim Y, Moaddel R, Ghosh P, Egan JM.

Obes Sci Pract. 2019 Jul 16;5(4):383-394. doi: 10.1002/osp4.344. eCollection 2019 Aug.


Tetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia.

Semba RD, Moaddel R, Zhang P, Ramsden CE, Ferrucci L.

Med Hypotheses. 2019 Jun;127:142-149. doi: 10.1016/j.mehy.2019.04.015. Epub 2019 Apr 17.


Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging.

Ubaida-Mohien C, Gonzalez-Freire M, Lyashkov A, Moaddel R, Chia CW, Simonsick EM, Sen R, Ferrucci L.

Front Physiol. 2019 Mar 26;10:312. doi: 10.3389/fphys.2019.00312. eCollection 2019.


(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.

Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD.

Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13.


Elevated Plasma Growth and Differentiation Factor-15 is Associated with Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.

Semba RD, Gonzalez-Freire M, Tanaka T, Biancotto A, Zhang P, Shardell M, Moaddel R, Ferrucci L; CHI Consortium.

J Gerontol A Biol Sci Med Sci. 2019 Mar 15. pii: glz071. doi: 10.1093/gerona/glz071. [Epub ahead of print]


(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.

Zanos P, Highland JN, Stewart BW, Georgiou P, Jenne CE, Lovett J, Morris PJ, Thomas CJ, Moaddel R, Zarate CA Jr, Gould TD.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6441-6450. doi: 10.1073/pnas.1819540116. Epub 2019 Mar 13.


Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Demarest TG, Truong GTD, Lovett J, Mohanty JG, Mattison JA, Mattson MP, Ferrucci L, Bohr VA, Moaddel R.

Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019. Epub 2019 Feb 27.


Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.

Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA Jr, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5160-5169. doi: 10.1073/pnas.1816071116. Epub 2019 Feb 22.


Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging.

Semba RD, Zhang P, Adelnia F, Sun K, Gonzalez-Freire M, Salem N Jr, Brennan N, Spencer RG, Fishbein K, Khadeer M, Shardell M, Moaddel R, Ferrucci L.

Aging Cell. 2019 Apr;18(2):e12915. doi: 10.1111/acel.12915. Epub 2019 Feb 4.


Rapid screening and identification of monoamine oxidase-A inhibitors from Corydalis Rhizome using enzyme-immobilized magnetic beads based method.

Zhang Y, Wang Q, Liu R, Zhou H, Crommen J, Moaddel R, Jiang Z, Zhang T.

J Chromatogr A. 2019 May 10;1592:1-8. doi: 10.1016/j.chroma.2019.01.062. Epub 2019 Jan 24.


Serum lipids in adults with late age-related macular degeneration: a case-control study.

Semba RD, Moaddel R, Cotch MF, Jonasson F, Eiriksdottir G, Harris TB, Launer LJ, Sun K, Klein R, Schaumberg DA, Jónsson P, Gudnason V, Ferrucci L.

Lipids Health Dis. 2019 Jan 8;18(1):7. doi: 10.1186/s12944-018-0954-7.


Editorial for Sergio and Sandor.

Barbas C, Chankvetadze B, Furlanetto S, Haginaka J, Li S, Moaddel R, Veuthey JL.

J Pharm Biomed Anal. 2019 Feb 20;165:410. doi: 10.1016/j.jpba.2018.11.037. Epub 2018 Nov 17. No abstract available.


Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine.

Highland JN, Morris PJ, Zanos P, Lovett J, Ghosh S, Wang AQ, Zarate CA Jr, Thomas CJ, Moaddel R, Gould TD.

J Psychopharmacol. 2018 Nov 29:269881118812095. doi: 10.1177/0269881118812095. [Epub ahead of print]


Relationship of Circulating Growth and Differentiation Factors 8 and 11 and Their Antagonists as Measured Using Liquid Chromatography-Tandem Mass Spectrometry With Age and Skeletal Muscle Strength in Healthy Adults.

Semba RD, Zhang P, Zhu M, Fabbri E, Gonzalez-Freire M, Carlson OD, Moaddel R, Tanaka T, Egan JM, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):129-136. doi: 10.1093/gerona/gly255.


Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.

Moaddel R, Shardell M, Khadeer M, Lovett J, Kadriu B, Ravichandran S, Morris PJ, Yuan P, Thomas CJ, Gould TD, Ferrucci L, Zarate CA.

Psychopharmacology (Berl). 2018 Oct;235(10):3017-3030. doi: 10.1007/s00213-018-4992-7. Epub 2018 Aug 16.


Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products.

Zhao YM, Wang LH, Luo SF, Wang QQ, Moaddel R, Zhang TT, Jiang ZJ.

J Chromatogr A. 2018 Sep 21;1568:123-130. doi: 10.1016/j.chroma.2018.07.031. Epub 2018 Jul 6.


Plasma proteomic signature of age in healthy humans.

Tanaka T, Biancotto A, Moaddel R, Moore AZ, Gonzalez-Freire M, Aon MA, Candia J, Zhang P, Cheung F, Fantoni G; CHI consortium, Semba RD, Ferrucci L.

Aging Cell. 2018 Oct;17(5):e12799. doi: 10.1111/acel.12799. Epub 2018 Jul 11.


Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults.

Semba RD, Gonzalez-Freire M, Moaddel R, Sun K, Fabbri E, Zhang P, Carlson OD, Khadeer M, Chia CW, Salem N Jr, Ferrucci L.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3331-3339. doi: 10.1210/jc.2018-00480.


Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD.

Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Review. Erratum in: Pharmacol Rev. 2018 Oct;70(4):879.


Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging.

Gonzalez-Freire M, Moaddel R, Sun K, Fabbri E, Zhang P, Khadeer M, Salem N Jr, Ferrucci L, Semba RD.

J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):62-67. doi: 10.1093/gerona/gly100.


Searching for a mitochondrial root to the decline in muscle function with ageing.

Gonzalez-Freire M, Adelnia F, Moaddel R, Ferrucci L.

J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):435-440. doi: 10.1002/jcsm.12313. Epub 2018 May 18.


Natural polyphenols as sirtuin 6 modulators.

Rahnasto-Rilla M, Tyni J, Huovinen M, Jarho E, Kulikowicz T, Ravichandran S, A Bohr V, Ferrucci L, Lahtela-Kakkonen M, Moaddel R.

Sci Rep. 2018 Mar 7;8(1):4163. doi: 10.1038/s41598-018-22388-5.


Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects.

Nugent AC, Ballard ED, Gould TD, Park LT, Moaddel R, Brutsche NE, Zarate CA Jr.

Mol Psychiatry. 2019 Jul;24(7):1040-1052. doi: 10.1038/s41380-018-0028-2. Epub 2018 Feb 27.


In honour of the 60th birthday of Professor Bezhan Chankvetadze.

Barbas C, Görög S, Haginaka J, Moaddel R, Pinzauti S.

J Pharm Biomed Anal. 2018 Jan 5;147:1. doi: 10.1016/j.jpba.2017.10.008. No abstract available.


Low serum ω-3 and ω-6 polyunsaturated fatty acids and other metabolites are associated with poor linear growth in young children from rural Malawi.

Semba RD, Trehan I, Li X, Salem N Jr, Moaddel R, Ordiz MI, Maleta KM, Kraemer K, Manary MJ.

Am J Clin Nutr. 2017 Dec;106(6):1490-1499. doi: 10.3945/ajcn.117.164384. Epub 2017 Oct 25.


Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease.

Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB.

J Crohns Colitis. 2017 Oct 27;11(11):1369-1380. doi: 10.1093/ecco-jcc/jjx096.


Correction to "Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites".

Morris PJ, Moaddel R, Zanos P, Moore CE, Gould TD, Zarate CA Jr, Thomas CJ.

Org Lett. 2017 Oct 6;19(19):5494. doi: 10.1021/acs.orglett.7b02839. Epub 2017 Sep 21. No abstract available.


Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites.

Morris PJ, Moaddel R, Zanos P, Moore CE, Gould TD, Zarate CA Jr, Thomas CJ.

Org Lett. 2017 Sep 1;19(17):4572-4575. doi: 10.1021/acs.orglett.7b02177. Epub 2017 Aug 22. Erratum in: Org Lett. 2017 Oct 6;19(19):5494.


Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.


Zanos et al. reply.

Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KSS, Fang Y, Huang XP, Mayo CL, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA, Gould TD.

Nature. 2017 Jun 21;546(7659):E4-E5. doi: 10.1038/nature22085. No abstract available.


The Identification of a SIRT6 Activator from Brown Algae Fucus distichus.

Rahnasto-Rilla MK, McLoughlin P, Kulikowicz T, Doyle M, Bohr VA, Lahtela-Kakkonen M, Ferrucci L, Hayes M, Moaddel R.

Mar Drugs. 2017 Jun 21;15(6). pii: E190. doi: 10.3390/md15060190.


A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes.

Semba RD, Zhang P, Zhu M, Fabbri E, Gonzalez-Freire M, Moaddel R, Geng-Spyropoulos M, Ferrucci L.

Proteomics. 2017 Aug;17(15-16). doi: 10.1002/pmic.201600232.


Development and characterization of mitochondrial membrane affinity chromatography columns derived from skeletal muscle and platelets for the study of mitochondrial transmembrane proteins.

Singh NS, Habicht KL, Moaddel R, Shimmo R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jun 15;1055-1056:144-148. doi: 10.1016/j.jchromb.2017.04.022. Epub 2017 Apr 13.


Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP.

J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1703-1709. doi: 10.1093/gerona/glx041.


Environmental Enteric Dysfunction is Associated with Carnitine Deficiency and Altered Fatty Acid Oxidation.

Semba RD, Trehan I, Li X, Moaddel R, Ordiz MI, Maleta KM, Kraemer K, Shardell M, Ferrucci L, Manary M.

EBioMedicine. 2017 Mar;17:57-66. doi: 10.1016/j.ebiom.2017.01.026. Epub 2017 Jan 18.


Targeted proteomics of cannabinoid receptor CB1 and the CB1b isoform.

Ghosh S, González-Mariscal I, Egan JM, Moaddel R.

J Pharm Biomed Anal. 2017 Sep 10;144:154-158. doi: 10.1016/j.jpba.2016.11.003. Epub 2016 Nov 11.


A robotic protocol for high-throughput processing of samples for selected reaction monitoring assays.

Zhu M, Zhang P, Geng-Spyropoulos M, Moaddel R, Semba RD, Ferrucci L.

Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600339. Epub 2016 Dec 23.


Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

Zanos P, Moaddel R, Morris PJ, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD.

Biol Psychiatry. 2017 Apr 15;81(8):e69-e71. doi: 10.1016/j.biopsych.2016.08.039. Epub 2016 Sep 30. No abstract available.


Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition.

Di Giovanni V, Bourdon C, Wang DX, Seshadri S, Senga E, Versloot CJ, Voskuijl W, Semba RD, Trehan I, Moaddel R, Ordiz MI, Zhang L, Parkinson J, Manary MJ, Bandsma RH.

J Nutr. 2016 Dec;146(12):2436-2444. Epub 2016 Nov 2.



Chankvetadze B, Görög S, Haginaka J, Moaddel R, Pinzauti S.

J Pharm Biomed Anal. 2016 Oct 25;130:1-2. doi: 10.1016/j.jpba.2016.09.012. No abstract available.


Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism.

González-Mariscal I, Krzysik-Walker SM, Doyle ME, Liu QR, Cimbro R, Santa-Cruz Calvo S, Ghosh S, Cieśla Ł, Moaddel R, Carlson OD, Witek RP, O'Connell JF, Egan JM.

Sci Rep. 2016 Sep 19;6:33302. doi: 10.1038/srep33302.


Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.

Semba RD, Trehan I, Gonzalez-Freire M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ.

Adv Nutr. 2016 Sep 15;7(5):853-65. doi: 10.3945/an.116.013276. Print 2016 Sep.


Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers.

Asher GN, Xie Y, Moaddel R, Sanghvi M, Dossou KS, Kashuba AD, Sandler RS, Hawke RL.

J Clin Pharmacol. 2017 Feb;57(2):185-193. doi: 10.1002/jcph.806. Epub 2016 Sep 6.


Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters.

Can A, Zanos P, Moaddel R, Kang HJ, Dossou KS, Wainer IW, Cheer JF, Frost DO, Huang XP, Gould TD.

J Pharmacol Exp Ther. 2016 Oct;359(1):159-70. doi: 10.1124/jpet.116.235838. Epub 2016 Jul 28.


Comparison of analytical techniques for the identification of bioactive compounds from natural products.

Cieśla Ł, Moaddel R.

Nat Prod Rep. 2016 Oct 28;33(10):1131-45. doi: 10.1039/c6np00016a. Epub 2016 Jul 1. Review.


Environmental Enteric Dysfunction Is Associated With Altered Bile Acid Metabolism.

Semba RD, Gonzalez-Freire M, Moaddel R, Trehan I, Maleta KM, Khadeer M, Ordiz MI, Ferrucci L, Manary MJ.

J Pediatr Gastroenterol Nutr. 2017 Apr;64(4):536-540. doi: 10.1097/MPG.0000000000001313.


Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays.

de Moraes MC, Cardoso CL, Seidl C, Moaddel R, Cass QB.

Curr Pharm Des. 2016;22(39):5976-5987. Review.


Metabolic alterations in children with environmental enteric dysfunction.

Semba RD, Shardell M, Trehan I, Moaddel R, Maleta KM, Ordiz MI, Kraemer K, Khadeer M, Ferrucci L, Manary MJ.

Sci Rep. 2016 Jun 13;6:28009. doi: 10.1038/srep28009.


The association of serum choline with linear growth failure in young children from rural Malawi.

Semba RD, Zhang P, Gonzalez-Freire M, Moaddel R, Trehan I, Maleta KM, Ordiz MI, Ferrucci L, Manary MJ.

Am J Clin Nutr. 2016 Jul;104(1):191-7. doi: 10.3945/ajcn.115.129684. Epub 2016 Jun 8.

Supplemental Content

Loading ...
Support Center