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Items: 9

1.

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.

Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G.

J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.

2.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

Mnich SJ, Blanner PM, Hu LG, Shaffer AF, Happa FA, O'Neil S, Ukairo O, Weiss D, Welsh E, Storer C, Mbalaviele G, Ichijo H, Monahan JB, Hardy MM, Eda H.

Int Immunopharmacol. 2010 Oct;10(10):1170-6. doi: 10.1016/j.intimp.2010.06.023. Epub 2010 Jul 6.

PMID:
20609399
3.

A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.

Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ, Schindler JF, South SA, Webb EG, Zhang J, Anderson DR.

J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. doi: 10.1124/jpet.110.166173. Epub 2010 Mar 17.

PMID:
20237073
4.

Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors.

Mnich SJ, Hiebsch RR, Huff RM, Muthian S.

J Pharmacol Exp Ther. 2010 May;333(2):445-53. doi: 10.1124/jpet.109.163998. Epub 2010 Feb 17.

PMID:
20164299
5.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.

Biochem Pharmacol. 2010 May 15;79(10):1445-54. doi: 10.1016/j.bcp.2010.01.003. Epub 2010 Jan 11.

PMID:
20067770
6.

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS' role in disease.

Nemirovskiy OV, Radabaugh MR, Aggarwal P, Funckes-Shippy CL, Mnich SJ, Meyer DM, Sunyer T, Rodney Mathews W, Misko TP.

Nitric Oxide. 2009 May;20(3):150-6. doi: 10.1016/j.niox.2008.12.005. Epub 2008 Dec 25.

PMID:
19146971
7.

Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.

Graneto MJ, Kurumbail RG, Vazquez ML, Shieh HS, Pawlitz JL, Williams JM, Stallings WC, Geng L, Naraian AS, Koszyk FJ, Stealey MA, Xu XD, Weier RM, Hanson GJ, Mourey RJ, Compton RP, Mnich SJ, Anderson GD, Monahan JB, Devraj R.

J Med Chem. 2007 Nov 15;50(23):5712-9. Epub 2007 Oct 19.

PMID:
17948975
8.

Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2.

Mnich SJ, Veenhuizen AW, Monahan JB, Sheehan KC, Lynch KR, Isakson PC, Portanova JP.

J Immunol. 1995 Nov 1;155(9):4437-44.

PMID:
7594605
9.

Evaluation of Misoprostol and Analogs as Inhibitors of T-Cell Activation.

Mnich SJ, Collins PW, Gasiecki AF, Kramer SW, Gregory SA, Portanova JP.

Am J Ther. 1995 Sep;2(9):648-659.

PMID:
11854842

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