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Items: 1 to 50 of 79

1.

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang XM, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N.

Br J Anaesth. 2019 Mar;122(3):350-360. doi: 10.1016/j.bja.2018.10.062. Epub 2018 Dec 28.

2.

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data.

Zhou Y, Fujikura K, Mkrtchian S, Lauschke VM.

Front Pharmacol. 2018 Dec 4;9:1437. doi: 10.3389/fphar.2018.01437. eCollection 2018. Review.

3.

Hypoxia Regulates MicroRNA Expression in the Human Carotid Body.

Mkrtchian S, Lee KL, Kåhlin J, Ebberyd A, Poellinger L, Fagerlund MJ, Eriksson LI.

Adv Exp Med Biol. 2018;1071:25-33. doi: 10.1007/978-3-319-91137-3_3.

PMID:
30357730
4.

An optimized prediction framework to assess the functional impact of pharmacogenetic variants.

Zhou Y, Mkrtchian S, Kumondai M, Hiratsuka M, Lauschke VM.

Pharmacogenomics J. 2019 Apr;19(2):115-126. doi: 10.1038/s41397-018-0044-2. Epub 2018 Sep 12.

5.

Calcium Signaling in Liver Injury and Regeneration.

Oliva-Vilarnau N, Hankeova S, Vorrink SU, Mkrtchian S, Andersson ER, Lauschke VM.

Front Med (Lausanne). 2018 Jul 4;5:192. doi: 10.3389/fmed.2018.00192. eCollection 2018. Review.

6.

Integrating rare genetic variants into pharmacogenetic drug response predictions.

Ingelman-Sundberg M, Mkrtchian S, Zhou Y, Lauschke VM.

Hum Genomics. 2018 May 25;12(1):26. doi: 10.1186/s40246-018-0157-3.

7.

Hypoxia regulates microRNA expression in the human carotid body.

Mkrtchian S, Lee KL, Kåhlin J, Ebberyd A, Poellinger L, Fagerlund MJ, Eriksson LI.

Exp Cell Res. 2017 Mar 15;352(2):412-419. doi: 10.1016/j.yexcr.2017.02.027. Epub 2017 Feb 24.

PMID:
28238835
8.

The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration.

Lauschke VM, Mkrtchian S, Ingelman-Sundberg M.

Biochem Biophys Res Commun. 2017 Jan 15;482(3):399-407. doi: 10.1016/j.bbrc.2016.10.084. Epub 2016 Oct 24. Review.

PMID:
27789285
9.

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.

Lauschke VM, Vorrink SU, Moro SM, Rezayee F, Nordling Å, Hendriks DF, Bell CC, Sison-Young R, Park BK, Goldring CE, Ellis E, Johansson I, Mkrtchian S, Andersson TB, Ingelman-Sundberg M.

Hepatology. 2016 Nov;64(5):1743-1756. doi: 10.1002/hep.28780. Epub 2016 Sep 30.

PMID:
27532775
10.

Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study.

Lodenius Å, Ebberyd A, Hårdemark Cedborg A, Hagel E, Mkrtchian S, Christensson E, Ullman J, Scheinin M, Eriksson LI, Jonsson Fagerlund M.

Anesthesiology. 2016 Oct;125(4):700-15. doi: 10.1097/ALN.0000000000001236.

PMID:
27483127
11.

The CYP2W1 enzyme: regulation, properties and activation of prodrugs.

Guo J, Johansson I, Mkrtchian S, Ingelman-Sundberg M.

Drug Metab Rev. 2016 Aug;48(3):369-78. doi: 10.1080/03602532.2016.1188939. Epub 2016 Jun 3. Review.

PMID:
27257736
12.

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

Bell CC, Hendriks DF, Moro SM, Ellis E, Walsh J, Renblom A, Fredriksson Puigvert L, Dankers AC, Jacobs F, Snoeys J, Sison-Young RL, Jenkins RE, Nordling Å, Mkrtchian S, Park BK, Kitteringham NR, Goldring CE, Lauschke VM, Ingelman-Sundberg M.

Sci Rep. 2016 May 4;6:25187. doi: 10.1038/srep25187.

13.

Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.

Guo J, Thiess S, Johansson I, Mkrtchian S, Ingelman-Sundberg M.

FEBS Lett. 2016 Feb;590(3):330-9. doi: 10.1002/1873-3468.12063. Epub 2016 Feb 2.

14.

Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran.

Neve EP, Köfeler H, Hendriks DF, Nordling Å, Gogvadze V, Mkrtchian S, Näslund E, Ingelman-Sundberg M.

PLoS One. 2015 Sep 17;10(9):e0138487. doi: 10.1371/journal.pone.0138487. eCollection 2015.

15.

The Human Carotid Body Gene Expression and Function in Signaling of Hypoxia and Inflammation.

Kåhlin J, Mkrtchian S, Ebberyd A, Eriksson LI, Fagerlund MJ.

Adv Exp Med Biol. 2015;860:371-7. doi: 10.1007/978-3-319-18440-1_42.

PMID:
26303502
16.

Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.

Choong E, Guo J, Persson A, Virding S, Johansson I, Mkrtchian S, Ingelman-Sundberg M.

PLoS One. 2015 Apr 6;10(4):e0122820. doi: 10.1371/journal.pone.0122820. eCollection 2015.

17.

Targeting unfolded protein response in cancer and diabetes.

Mkrtchian S.

Endocr Relat Cancer. 2015 Jun;22(3):C1-4. doi: 10.1530/ERC-15-0106. Epub 2015 Mar 19.

PMID:
25792543
18.

The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.

Kåhlin J, Mkrtchian S, Ebberyd A, Hammarstedt-Nordenvall L, Nordlander B, Yoshitake T, Kehr J, Prabhakar N, Poellinger L, Fagerlund MJ, Eriksson LI.

Exp Physiol. 2014 Aug;99(8):1089-98. doi: 10.1113/expphysiol.2014.078873. Epub 2014 May 30.

19.

High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase.

Lee MY, Borgiani P, Johansson I, Oteri F, Mkrtchian S, Falconi M, Ingelman-Sundberg M.

Pharmacogenomics J. 2014 Aug;14(4):343-9. doi: 10.1038/tpj.2013.41. Epub 2013 Dec 10.

PMID:
24322786
20.

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

Stenstedt K, Travica S, Guo J, Barragan I, Pors K, Patterson L, Edler D, Mkrtchian S, Johansson I, Ingelman-Sundberg M.

Pharmacogenomics. 2013 Oct;14(13):1615-22. doi: 10.2217/pgs.13.136.

PMID:
24088132
21.

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

Sheldrake HM, Travica S, Johansson I, Loadman PM, Sutherland M, Elsalem L, Illingworth N, Cresswell AJ, Reuillon T, Shnyder SD, Mkrtchian S, Searcey M, Ingelman-Sundberg M, Patterson LH, Pors K.

J Med Chem. 2013 Aug 8;56(15):6273-7. doi: 10.1021/jm4000209. Epub 2013 Jul 26.

PMID:
23844629
22.

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.

Travica S, Pors K, Loadman PM, Shnyder SD, Johansson I, Alandas MN, Sheldrake HM, Mkrtchian S, Patterson LH, Ingelman-Sundberg M.

Clin Cancer Res. 2013 Jun 1;19(11):2952-61. doi: 10.1158/1078-0432.CCR-13-0238. Epub 2013 Apr 15.

23.

The human carotid body transcriptome with focus on oxygen sensing and inflammation--a comparative analysis.

Mkrtchian S, Kåhlin J, Ebberyd A, Gonzalez C, Sanchez D, Balbir A, Kostuk EW, Shirahata M, Fagerlund MJ, Eriksson LI.

J Physiol. 2012 Aug 15;590(16):3807-19. doi: 10.1113/jphysiol.2012.231084. Epub 2012 May 21.

24.

The ligands of estrogen receptor α regulate cytochrome P4502C9 (CYP2C9) expression.

Mwinyi J, Cavaco I, Yurdakok B, Mkrtchian S, Ingelman-Sundberg M.

J Pharmacol Exp Ther. 2011 Jul;338(1):302-9. doi: 10.1124/jpet.110.175075. Epub 2011 Apr 14.

PMID:
21493749
25.

ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.

Farmaki E, Mkrtchian S, Papazian I, Papavassiliou AG, Kiaris H.

Biochim Biophys Acta. 2011 Jun;1813(6):1165-71. doi: 10.1016/j.bbamcr.2011.03.003. Epub 2011 Mar 22.

26.

The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia.

Fagerlund MJ, Kåhlin J, Ebberyd A, Schulte G, Mkrtchian S, Eriksson LI.

Anesthesiology. 2010 Dec;113(6):1270-9. doi: 10.1097/ALN.0b013e3181fac061.

PMID:
20980909
27.

Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity.

Gomez A, Nekvindova J, Travica S, Lee MY, Johansson I, Edler D, Mkrtchian S, Ingelman-Sundberg M.

Mol Pharmacol. 2010 Dec;78(6):1004-11. doi: 10.1124/mol.110.067652. Epub 2010 Aug 30.

PMID:
20805301
28.

Regulation of CYP2C19 expression by estrogen receptor α: implications for estrogen-dependent inhibition of drug metabolism.

Mwinyi J, Cavaco I, Pedersen RS, Persson A, Burkhardt S, Mkrtchian S, Ingelman-Sundberg M.

Mol Pharmacol. 2010 Nov;78(5):886-94. doi: 10.1124/mol.110.065540. Epub 2010 Jul 30.

PMID:
20675569
29.

The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.

Mwinyi J, Hofmann Y, Pedersen RS, Nekvindová J, Cavaco I, Mkrtchian S, Ingelman-Sundberg M.

Life Sci. 2010 May 8;86(19-20):699-706. doi: 10.1016/j.lfs.2010.02.021. Epub 2010 Mar 4.

PMID:
20206639
30.

Regulated increase in folding capacity prevents unfolded protein stress in the ER.

Christis C, Fullaondo A, Schildknegt D, Mkrtchian S, Heck AJ, Braakman I.

J Cell Sci. 2010 Mar 1;123(Pt 5):787-94. doi: 10.1242/jcs.041111. Epub 2010 Feb 9.

31.

New insights into the regulation of CYP2C9 gene expression: the role of the transcription factor GATA-4.

Mwinyi J, Nekvindová J, Cavaco I, Hofmann Y, Pedersen RS, Landman E, Mkrtchian S, Ingelman-Sundberg M.

Drug Metab Dispos. 2010 Mar;38(3):415-21. doi: 10.1124/dmd.109.029405. Epub 2009 Dec 7.

PMID:
19995889
32.

The C-terminal domain of ERp29 mediates polyomavirus binding, unfolding, and infection.

Rainey-Barger EK, Mkrtchian S, Tsai B.

J Virol. 2009 Feb;83(3):1483-91. doi: 10.1128/JVI.02057-08. Epub 2008 Nov 19.

33.

ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts.

Mkrtchian S, Baryshev M, Sargsyan E, Chatzistamou I, Volakaki AA, Chaviaras N, Pafiti A, Triantafyllou A, Kiaris H.

Mol Carcinog. 2008 Nov;47(11):886-92. doi: 10.1002/mc.20444.

PMID:
18395818
34.

Expression of CYP2W1 in colon tumors: regulation by gene methylation.

Gomez A, Karlgren M, Edler D, Bernal ML, Mkrtchian S, Ingelman-Sundberg M.

Pharmacogenomics. 2007 Oct;8(10):1315-25.

PMID:
17979506
35.

Calcium-regulating peptide hormones and blood electrolytic balance in chronic heart failure.

Arakelyan KP, Sahakyan YA, Hayrapetyan LR, Khudaverdyan DN, Ingelman-Sundberg M, Mkrtchian S, Ter-Markosyan AS.

Regul Pept. 2007 Aug 16;142(3):95-100. Epub 2007 Feb 16.

PMID:
17368822
36.

Dimerization of ERp29, a PDI-like protein, is essential for its diverse functions.

Rainey-Barger EK, Mkrtchian S, Tsai B.

Mol Biol Cell. 2007 Apr;18(4):1253-60. Epub 2007 Jan 31.

37.

Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma.

Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, Mkrtchian S, Koutselini H.

Am J Dermatopathol. 2006 Oct;28(5):410-2.

PMID:
17012915
38.

ERp29, an unusual redox-inactive member of the thioredoxin family.

Mkrtchian S, Sandalova T.

Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):325-37. Review.

PMID:
16677078
39.

ERp29 is an essential endoplasmic reticulum factor regulating secretion of thyroglobulin.

Baryshev M, Sargsyan E, Mkrtchian S.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):617-24. Epub 2005 Dec 19.

PMID:
16380091
40.

ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding.

Magnuson B, Rainey EK, Benjamin T, Baryshev M, Mkrtchian S, Tsai B.

Mol Cell. 2005 Oct 28;20(2):289-300.

41.

The physiological unfolded protein response in the thyroid epithelial cells.

Sargsyan E, Baryshev M, Mkrtchian S.

Biochem Biophys Res Commun. 2004 Sep 17;322(2):570-6.

PMID:
15325268
42.

Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism.

Baryshev M, Sargsyan E, Wallin G, Lejnieks A, Furudate S, Hishinuma A, Mkrtchian S.

J Mol Endocrinol. 2004 Jun;32(3):903-20.

PMID:
15171721
43.

Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly.

Gavrilovich Zgoda V, Arison B, Mkrtchian S, Ingelman-Sundberg M, Correia MA.

Arch Biochem Biophys. 2002 Dec 1;408(1):58-68.

PMID:
12485603
44.

Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29.

Sargsyan E, Baryshev M, Backlund M, Sharipo A, Mkrtchian S.

Gene. 2002 Feb 20;285(1-2):127-39.

PMID:
12039039
45.

Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex.

Sargsyan E, Baryshev M, Szekely L, Sharipo A, Mkrtchian S.

J Biol Chem. 2002 May 10;277(19):17009-15. Epub 2002 Mar 7.

46.

Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer.

Liepinsh E, Baryshev M, Sharipo A, Ingelman-Sundberg M, Otting G, Mkrtchian S.

Structure. 2001 Jun;9(6):457-71.

47.

Oligomerization properties of ERp29, an endoplasmic reticulum stress protein.

Mkrtchian S, Baryshev M, Matvijenko O, Sharipo A, Sandalova T, Schneider G, Ingelman-Sundberg M.

FEBS Lett. 1998 Jul 24;431(3):322-6. Erratum in: FEBS Lett 1998 Aug 21;433(3):335. Mkrtchiana S [corrected to Mkrtchian S].

48.

A stress-inducible rat liver endoplasmic reticulum protein, ERp29.

Mkrtchian S, Fang C, Hellman U, Ingelman-Sundberg M.

Eur J Biochem. 1998 Jan 15;251(1-2):304-13.

49.

Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells.

Backlund M, Johansson I, Mkrtchian S, Ingelman-Sundberg M.

J Biol Chem. 1997 Dec 12;272(50):31755-63.

50.

Combination of direct DNA sequencing with degenerate primer-mediated PCR and 5'-/3'-RACE to screen novel cDNA sequences.

Fang C, Mkrtchian S, Ingelman-Sundberg M.

Biotechniques. 1997 Jul;23(1):52, 54, 56, 58. No abstract available.

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