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Items: 1 to 50 of 173

1.

Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.

Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM.

FASEB J. 2017 Jul;31(7):2981-2995. doi: 10.1096/fj.201601216R. Epub 2017 Mar 31.

PMID:
28363953

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2.

Differential regulation of T-cell dependent and T-cell independent antibody responses through arginine methyltransferase PRMT1 in vivo.

Hata K, Yanase N, Sudo K, Kiyonari H, Mukumoto Y, Mizuguchi J, Yokosuka T.

FEBS Lett. 2016 Apr;590(8):1200-10. doi: 10.1002/1873-3468.12161. Epub 2016 Apr 8.

PMID:
27013173
Free Article

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3.

Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.

Bauer T, Trump S, Ishaque N, Thürmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm JP, Röder S, Herberth G, Takada E, Mücke O, Winter M, Junge KM, Grützmann K, Rolle-Kampczyk U, Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Geörg C, Stunnenberg HG, Plass C, Rippe K, Mizuguchi J, Herrmann C, Eils R, Lehmann I.

Mol Syst Biol. 2016 Mar 24;12(3):861. doi: 10.15252/msb.20156520.

PMID:
27013061
Free PMC Article

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4.

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis.

Furusawa J, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, Nakae S, Tsuchida A, Matsumoto T, Ema H, Mizuguchi J, Yoshimoto T.

PLoS Pathog. 2016 Mar 18;12(3):e1005507. doi: 10.1371/journal.ppat.1005507. eCollection 2016 Mar.

PMID:
26991425
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5.

Thy28 protects against anti-CD3-mediated thymic cell death in vivo.

Toyota H, Sudo K, Kojima K, Yanase N, Nagao T, Takahashi RH, Iobe H, Kuwabara T, Kakiuchi T, Mizuguchi J.

Apoptosis. 2015 Apr;20(4):444-54. doi: 10.1007/s10495-014-1082-0.

PMID:
25547913

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6.

Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.

Toyota H, Yanase N, Yoshimoto T, Harada M, Kato Y, Mizuguchi J.

Oncol Rep. 2015 Jan;33(1):292-6. doi: 10.3892/or.2014.3603. Epub 2014 Nov 12.

PMID:
25394516

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7.

OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis.

Yanase N, Toyota H, Hata K, Yagyu S, Seki T, Harada M, Kato Y, Mizuguchi J.

Vaccine. 2014 Oct 14;32(45):5918-24. doi: 10.1016/j.vaccine.2014.08.059. Epub 2014 Sep 6.

PMID:
25211769

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8.

Immunosurveillance markers may predict patients who can discontinue imatinib therapy without relapse.

Yoshimoto T, Mizoguchi I, Katagiri S, Tauchi T, Furusawa JI, Chiba Y, Mizuguchi J, Ohyashiki JH, Ohyashiki K.

Oncoimmunology. 2014 May 14;3:e28861. eCollection 2014.

PMID:
25057448
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9.

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.

Hara H, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M.

Nat Immunol. 2013 Dec;14(12):1247-55. doi: 10.1038/ni.2749. Epub 2013 Nov 3.

PMID:
24185614
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10.

IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner.

Chiba Y, Mizoguchi I, Mitobe K, Higuchi K, Nagai H, Nishigori C, Mizuguchi J, Yoshimoto T.

PLoS One. 2013 Oct 14;8(10):e76159. doi: 10.1371/journal.pone.0076159. eCollection 2013.

PMID:
24155891
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11.

Stepwise assembly of fibrinogen is assisted by the endoplasmic reticulum lectin-chaperone system in HepG2 cells.

Tamura T, Arai S, Nagaya H, Mizuguchi J, Wada I.

PLoS One. 2013 Sep 10;8(9):e74580. doi: 10.1371/journal.pone.0074580. eCollection 2013.

PMID:
24040290
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12.

Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases.

Qu N, Xu M, Mizoguchi I, Furusawa J, Kaneko K, Watanabe K, Mizuguchi J, Itoh M, Kawakami Y, Yoshimoto T.

Clin Dev Immunol. 2013;2013:968549. doi: 10.1155/2013/968549. Epub 2013 Jul 14. Review.

PMID:
23956763
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13.

Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.

Takada E, Furuhata M, Nakae S, Ichijo H, Sudo K, Mizuguchi J.

Int Arch Allergy Immunol. 2013;162(2):104-14. doi: 10.1159/000353240. Epub 2013 Jul 31.

PMID:
23921222
Free Article

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14.

Sustained upregulation of effector natural killer cells in chronic myeloid leukemia after discontinuation of imatinib.

Mizoguchi I, Yoshimoto T, Katagiri S, Mizuguchi J, Tauchi T, Kimura Y, Inokuchi K, Ohyashiki JH, Ohyashiki K.

Cancer Sci. 2013 Sep;104(9):1146-53. doi: 10.1111/cas.12216. Epub 2013 Jul 9.

PMID:
23758044
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15.

Arginine methylation regulates antibody responses through modulating cell division and isotype switching in B cells.

Hata K, Mizuguchi J.

Microbiol Immunol. 2013 Mar;57(3):185-92. doi: 10.1111/1348-0421.12019.

PMID:
23278594
Free Article

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16.

IL-27 promotes nitric oxide production induced by LPS through STAT1, NF-κB and MAPKs.

Shimizu M, Ogura K, Mizoguchi I, Chiba Y, Higuchi K, Ohtsuka H, Mizuguchi J, Yoshimoto T.

Immunobiology. 2013 Apr;218(4):628-34. doi: 10.1016/j.imbio.2012.07.028. Epub 2012 Aug 8.

PMID:
22925810

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17.

PKC-δ mediates interferon-α-induced apoptosis through c-Jun NH₂-terminal kinase activation.

Yanase N, Hayashida M, Kanetaka-Naka Y, Hoshika A, Mizuguchi J.

BMC Cell Biol. 2012 Mar 21;13:7. doi: 10.1186/1471-2121-13-7.

PMID:
22435755
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18.

Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells.

Toyota H, Jiang XZ, Asakura H, Mizuguchi J.

Cell Mol Biol Lett. 2012 Mar;17(1):36-48. doi: 10.2478/s11658-011-0034-8. Epub 2011 Dec 2.

PMID:
22139584
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19.

Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.

Koh CY, Kumar S, Kazimirova M, Nuttall PA, Radhakrishnan UP, Kim S, Jagadeeswaran P, Imamura T, Mizuguchi J, Iwanaga S, Swaminathan K, Kini RM.

PLoS One. 2011;6(10):e26367. doi: 10.1371/journal.pone.0026367. Epub 2011 Oct 28.

PMID:
22053189
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20.

Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.

Xu M, Morishima N, Mizoguchi I, Chiba Y, Fujita K, Kuroda M, Iwakura Y, Cua DJ, Yasutomo K, Mizuguchi J, Yoshimoto T.

Eur J Immunol. 2011 Oct;41(10):2828-39. doi: 10.1002/eji.201141291. Epub 2011 Aug 31.

PMID:
21953641
Free Article

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21.

IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3.

Kamiya S, Okumura M, Chiba Y, Fukawa T, Nakamura C, Nimura N, Mizuguchi J, Wada S, Yoshimoto T.

Immunol Lett. 2011 Jul;138(1):47-53. doi: 10.1016/j.imlet.2011.02.022. Epub 2011 Mar 29.

PMID:
21453726

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22.

Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27.

Xu M, Mizoguchi I, Morishima N, Chiba Y, Mizuguchi J, Yoshimoto T.

Clin Dev Immunol. 2010;2010. pii: 832454. doi: 10.1155/2010/832454. Epub 2010 Sep 14. Review.

PMID:
20885915
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23.

Enhanced T cell-independent antibody responses in c-Jun N-terminal kinase 2 (JNK2)-deficient B cells following stimulation with CpG-1826 and anti-IgM.

Cao Y, Takada E, Hata K, Sudo K, Furuhata M, Mizuguchi J.

Immunol Lett. 2010 Aug 16;132(1-2):38-44.

PMID:
20665951

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24.

Interleukins and cancer immunotherapy.

Yoshimoto T, Morishima N, Okumura M, Chiba Y, Xu M, Mizuguchi J.

Immunotherapy. 2009 Sep;1(5):825-44. doi: 10.2217/imt.09.46. Review.

PMID:
20636026

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25.

A double-edged sword in B-cell-targeted therapy for inflammatory diseases.

Mizuguchi J.

Expert Rev Clin Immunol. 2009 May;5(3):283-90. doi: 10.1586/eci.09.11.

PMID:
20477006

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26.

A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes.

Morishima N, Mizoguchi I, Okumura M, Chiba Y, Xu M, Shimizu M, Matsui M, Mizuguchi J, Yoshimoto T.

J Biomed Biotechnol. 2010;2010:605483. doi: 10.1155/2010/605483. Epub 2010 Apr 29. Review.

PMID:
20454646
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27.

6-{5-Amino-3-tert-butyl-4-[(E)-(3-methyl-1,2,4-thiadiazol-5-yl)diazen-yl]-1H-pyrazol-1-yl}-1,3,5-triazine-2,4(1H,3H)-dione-1-methyl-pyrrolidin-2-one-water (1/1/1).

Shibata H, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 27;66(Pt 4):o944-5. doi: 10.1107/S1600536810010871.

PMID:
21580749
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28.

(2,6-Bis{5-amino-3-tert-butyl-4-[(3-methyl-1,2,4-thia-diazol-5-yl)diazen-yl]-1H-pyrazol-1-yl}-4-oxo-1,4-dihydro-1,3,5-triazin-1-ido)methanol(phenol)sodium phenol tetra-solvate.

Shibata H, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 27;66(Pt 4):m463-4. doi: 10.1107/S160053681001086X.

PMID:
21580548
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29.

Enhancement in thermal stability and resistance to denaturants of lipase encapsulated in mesoporous silica with alkyltrimethylammonium (CTAB).

Itoh T, Ishii R, Matsuura S, Mizuguchi J, Hamakawa S, Hanaoka TA, Tsunoda T, Mizukami F.

Colloids Surf B Biointerfaces. 2010 Feb 1;75(2):478-82. doi: 10.1016/j.colsurfb.2009.09.022. Epub 2009 Sep 23.

PMID:
19854031

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30.

Tumor necrosis factor-related apoptosis-inducing ligand induces apoptotic cell death through c-Jun NH2-terminal kinase activation in squamous cell carcinoma cells.

Noutomi T, Itoh M, Toyota H, Takada E, Mizuguchi J.

Oncol Rep. 2009 Nov;22(5):1169-72.

PMID:
19787236

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31.

Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin.

Furuhata M, Takada E, Noguchi T, Ichijo H, Mizuguchi J.

Exp Cell Res. 2009 Dec 10;315(20):3467-76. doi: 10.1016/j.yexcr.2009.09.007. Epub 2009 Sep 18.

PMID:
19766627

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32.

TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23.

Morishima N, Mizoguchi I, Takeda K, Mizuguchi J, Yoshimoto T.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):105-10. doi: 10.1016/j.bbrc.2009.05.140. Epub 2009 Jun 6.

PMID:
19501566

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33.

Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinasein the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one.

Takasaki A, Hanyu H, Iwamoto T, Shirato K, Izumi R, Toyota H, Mizuguchi J, Miyazawa K, Tomoda A.

Mol Med Rep. 2009 Mar-Apr;2(2):199-203. doi: 10.3892/mmr_00000084.

PMID:
21475813

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34.

A redetermination of 2-(6-diethyl-amino-3-diethyl-iminio-3H-xanthen-9-yl)benzoate-ethyl gallate (1/1) at room temperature.

Mizuguchi J, Sato K.

Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 6;65(Pt 4):o701-2. doi: 10.1107/S160053680900751X.

PMID:
21582440
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35.

2-(4-Hydroxy-phenyl-sulfon-yl)phenol.

Sato K, Shima H, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 28;65(Pt 2):o391. doi: 10.1107/S160053680900258X.

PMID:
21581986
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36.

Benzyl-tributyl-ammonium 6,7-dihydroxy-naphthalene-2-sulfonate.

Uta K, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 17;65(Pt 2):o323. doi: 10.1107/S160053680900018X.

PMID:
21581928
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37.

Benzyl-tributyl-ammonium 4,6-dihydroxy-naphthalene-2-sulfonate.

Uta K, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 17;65(Pt 2):o322. doi: 10.1107/S1600536809000415.

PMID:
21581927
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38.

Benzyl-tributyl-ammonium 7-hydroxy-naphthalene-1-sulfonate.

Sato Y, Uta K, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 17;65(Pt 2):o321. doi: 10.1107/S1600536809001056.

PMID:
21581926
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39.

Benzyl-tributyl-ammonium 4-hydroxy-naphthalene-2-sulfonate.

Uta K, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 17;65(Pt 2):o320. doi: 10.1107/S1600536809000178.

PMID:
21581925
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40.

Benzyl-tributyl-ammonium 6-hydroxy-naphthalene-2-sulfonate.

Uta K, Sato Y, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 17;65(Pt 2):o319. doi: 10.1107/S1600536809001329.

PMID:
21581924
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41.

Antiproliferative activity of IL-27 on melanoma.

Yoshimoto T, Morishima N, Mizoguchi I, Shimizu M, Nagai H, Oniki S, Oka M, Nishigori C, Mizuguchi J.

J Immunol. 2008 May 15;180(10):6527-35.

PMID:
18453571
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42.

c-Jun NH2-terminal kinase (JNK)-dependent nuclear translocation of apoptosis-inducing factor (AIF) following engagement of membrane immunoglobulin on WEHI-231 B lymphoma cells.

Takada E, Hata K, Mizuguchi J.

J Cell Biochem. 2008 Aug 1;104(5):1927-36. doi: 10.1002/jcb.21764.

PMID:
18384124

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43.

STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production.

Owaki T, Asakawa M, Morishima N, Mizoguchi I, Fukai F, Takeda K, Mizuguchi J, Yoshimoto T.

J Immunol. 2008 Mar 1;180(5):2903-11.

PMID:
18292512
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44.

Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one.

Shirato K, Imaizumi K, Miyazawa K, Takasaki A, Mizuguchi J, Che XF, Akiyama S, Tomoda A.

Biol Pharm Bull. 2008 Jan;31(1):62-7.

PMID:
18175943
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45.

A low-temperature phase of the 1:1 complex of 2-(6-diethylamino-3-diethyl-iminio-3H-xanthen-9-yl)benzoate with ethyl gallate at 93 K.

Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 7;64(Pt 7):o1238-9. doi: 10.1107/S1600536808016528.

PMID:
21202875
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46.

Poly[tris{μ(2)-4-[4-(di-methyl-amino)-phenyl-diazenyl]benzene-sulfonato}tri-dioxane-tri-sodium(I)].

Sato K, Shibata H, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2008 Mar 29;64(Pt 4):m586-7. doi: 10.1107/S1600536808008015.

PMID:
21202034
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47.

Poly[bis-(acetone-κO)bis-{μ(3)-1-[(5-chloro-2-oxidophenyl)diazenyl]-2-naphtholato-κO:O,O':O'}-sodium(I)-chromium(III)].

Ito S, Sato Y, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 11;64(Pt 2):m333-4. doi: 10.1107/S1600536808000433.

PMID:
21201299
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48.

Erratum: Diacetonitrile-tetra-kis{μ(2)-3-anilinocarbonyl-1-[(5-chloro-2-oxidophen-yl)diazen-yl]-2-naphtholato}tetra-aqua-diiron(III)disodium(I) dihydrate. Corrigendum.

Sato Y, Uta K, Mizuguchi J.

Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 30;64(Pt 2):e14. doi: 10.1107/S1600536808002869.

PMID:
21201243
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49.

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

Seita J, Asakawa M, Ooehara J, Takayanagi S, Morita Y, Watanabe N, Fujita K, Kudo M, Mizuguchi J, Ema H, Nakauchi H, Yoshimoto T.

Blood. 2008 Feb 15;111(4):1903-12. Epub 2007 Nov 27.

PMID:
18042804

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50.

c-Jun-NH2-terminal kinase potentiates apoptotic cell death in response to carboplatin in B lymphoma cells.

Takada E, Hata K, Mizuguchi J.

Cancer Chemother Pharmacol. 2008 Sep;62(4):569-76. Epub 2007 Nov 17.

PMID:
18026729

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