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Items: 1 to 50 of 537

1.

Characterization of the Ca2+-coordination structures of L- and T-plastins in combination with their synthetic peptide analogs by FTIR spectroscopy.

Nara M, Morii H, Shimizu T, Shinomiya H, Furuta Y, Miyazono K, Miyakawa T, Tanokura M.

Sci Rep. 2019 Mar 12;9(1):4217. doi: 10.1038/s41598-019-40889-9.

2.

Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).

Sekimata K, Sato T, Sakai N, Watanabe H, Mishima-Tsumagari C, Taguri T, Matsumoto T, Fujii Y, Handa N, Honma T, Tanaka A, Shirouzu M, Yokoyama S, Miyazono K, Hashizume Y, Koyama H.

Chem Pharm Bull (Tokyo). 2019;67(3):224-235. doi: 10.1248/cpb.c18-00598.

3.

Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.

Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R.

Sci Signal. 2019 Feb 26;12(570). pii: eaau8544. doi: 10.1126/scisignal.aau8544.

PMID:
30808819
4.

Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.

Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H.

Cancer Sci. 2019 Feb 9. doi: 10.1111/cas.13968. [Epub ahead of print]

5.

Palbociclib enhances activin-SMAD-induced cytostasis in estrogen receptor-positive breast cancer.

Harada M, Morikawa M, Ozawa T, Kobayashi M, Tamura Y, Takahashi K, Tanabe M, Tada K, Seto Y, Miyazono K, Koinuma D.

Cancer Sci. 2019 Jan;110(1):209-220. doi: 10.1111/cas.13841. Epub 2018 Nov 16.

6.

Structural basis for receptor-regulated SMAD recognition by MAN1.

Miyazono KI, Ohno Y, Wada H, Ito T, Fukatsu Y, Kurisaki A, Asashima M, Tanokura M.

Nucleic Acids Res. 2018 Dec 14;46(22):12139-12153. doi: 10.1093/nar/gky925.

7.

Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.

Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.

Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. doi: 10.1016/j.celrep.2018.07.056.

8.

Intracellular and extracellular TGF-β signaling in cancer: some recent topics.

Miyazono K, Katsuno Y, Koinuma D, Ehata S, Morikawa M.

Front Med. 2018 Aug;12(4):387-411. doi: 10.1007/s11684-018-0646-8. Epub 2018 Jul 24. Review.

PMID:
30043220
9.

Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype.

Kawasaki N, Miwa T, Hokari S, Sakurai T, Ohmori K, Miyauchi K, Miyazono K, Koinuma D.

Cancer Sci. 2018 Jul;109(7):2211-2220. doi: 10.1111/cas.13626. Epub 2018 May 29.

10.

Crystal structure of the novel lesion-specific endonuclease PfuEndoQ from Pyrococcus furiosus.

Miyazono KI, Ishino S, Makita N, Ito T, Ishino Y, Tanokura M.

Nucleic Acids Res. 2018 May 18;46(9):4807-4818. doi: 10.1093/nar/gky261.

11.

Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors.

Miyazono KI, Moriwaki S, Ito T, Kurisaki A, Asashima M, Tanokura M.

Sci Signal. 2018 Mar 27;11(523). pii: eaao7227. doi: 10.1126/scisignal.aao7227.

PMID:
29588413
12.

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells.

Takahashi K, Ehata S, Koinuma D, Morishita Y, Soda M, Mano H, Miyazono K.

Oncogene. 2018 May;37(21):2757-2772. doi: 10.1038/s41388-018-0144-0. Epub 2018 Mar 7.

13.

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.

Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, Morishita Y, Taguchi L, Morikawa M, Heldin CH, Noda T, Ehata S, Miyazono K, Koinuma D.

Cell Discov. 2018 Jan 9;4:1. doi: 10.1038/s41421-017-0001-2. eCollection 2018.

14.

Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-β-dependent and -independent mechanisms.

Nishida J, Miyazono K, Ehata S.

Oncogene. 2018 Apr;37(16):2197-2212. doi: 10.1038/s41388-017-0084-0. Epub 2018 Feb 2.

15.

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.

Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.

Int J Cancer. 2018 Apr 15;142(8):1627-1639. doi: 10.1002/ijc.31179. Epub 2017 Dec 11.

PMID:
29193056
16.

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Sundqvist A, Morikawa M, Ren J, Vasilaki E, Kawasaki N, Kobayashi M, Koinuma D, Aburatani H, Miyazono K, Heldin CH, van Dam H, Ten Dijke P.

Nucleic Acids Res. 2018 Feb 16;46(3):1180-1195. doi: 10.1093/nar/gkx1190.

17.

ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.

Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.

Cell Death Differ. 2017 Dec;24(12):2066-2076. doi: 10.1038/cdd.2017.114. Epub 2017 Jul 28.

18.

Whole-Body Profiling of Cancer Metastasis with Single-Cell Resolution.

Kubota SI, Takahashi K, Nishida J, Morishita Y, Ehata S, Tainaka K, Miyazono K, Ueda HR.

Cell Rep. 2017 Jul 5;20(1):236-250. doi: 10.1016/j.celrep.2017.06.010.

19.

ZEB1-regulated inflammatory phenotype in breast cancer cells.

Katsura A, Tamura Y, Hokari S, Harada M, Morikawa M, Sakurai T, Takahashi K, Mizutani A, Nishida J, Yokoyama Y, Morishita Y, Murakami T, Ehata S, Miyazono K, Koinuma D.

Mol Oncol. 2017 Sep;11(9):1241-1262. doi: 10.1002/1878-0261.12098. Epub 2017 Jul 11.

20.

Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer.

Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K, Ehata S.

Cancer Res. 2017 Aug 1;77(15):4026-4038. doi: 10.1158/0008-5472.CAN-17-0112. Epub 2017 Jun 13.

21.

RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D.

Oncogene. 2017 Aug 31;36(35):5083. doi: 10.1038/onc.2017.191. Epub 2017 Jun 12.

22.

Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.

Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K.

Oncogene. 2017 Aug 31;36(35):4963-4974. doi: 10.1038/onc.2017.112. Epub 2017 May 1.

PMID:
28459464
23.

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.

Arase M, Tamura Y, Kawasaki N, Isogaya K, Nakaki R, Mizutani A, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.

Sci Rep. 2017 Apr 26;7(1):1166. doi: 10.1038/s41598-017-00973-4.

24.

REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding.

Mizutani H, Sugawara H, Buckle AM, Sangawa T, Miyazono KI, Ohtsuka J, Nagata K, Shojima T, Nosaki S, Xu Y, Wang D, Hu X, Tanokura M, Yura K.

BMC Struct Biol. 2017 Apr 24;17(1):4. doi: 10.1186/s12900-017-0074-z.

25.

Regulation of TGF-β-mediated endothelial-mesenchymal transition by microRNA-27.

Suzuki HI, Katsura A, Mihira H, Horie M, Saito A, Miyazono K.

J Biochem. 2017 May 1;161(5):417-420. doi: 10.1093/jb/mvx017.

26.

Insight into the transition between the open and closed conformations of Thermus thermophilus carboxypeptidase.

Okai M, Yamamura A, Hayakawa K, Tsutsui S, Miyazono KI, Lee WC, Nagata K, Inoue Y, Tanokura M.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):787-793. doi: 10.1016/j.bbrc.2017.01.167. Epub 2017 Feb 2.

PMID:
28161633
27.

Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis.

Akatsu Y, Yoshimatsu Y, Tomizawa T, Takahashi K, Katsura A, Miyazono K, Watabe T.

Cancer Sci. 2017 Jan;108(1):151-155. doi: 10.1111/cas.13103.

28.

Regulation of TGF-β Family Signaling by Inhibitory Smads.

Miyazawa K, Miyazono K.

Cold Spring Harb Perspect Biol. 2017 Mar 1;9(3). pii: a022095. doi: 10.1101/cshperspect.a022095. Review.

29.

Tetrameric structure of the restriction DNA glycosylase R.PabI in complex with nonspecific double-stranded DNA.

Wang D, Miyazono KI, Tanokura M.

Sci Rep. 2016 Oct 12;6:35197. doi: 10.1038/srep35197.

30.

[113th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Special Lecture: TGF-β Family and Internal Medicine].

Miyazono K.

Nihon Naika Gakkai Zasshi. 2016 Sep;105(9):1558-64. Japanese. No abstract available.

PMID:
30169011
31.

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

Vasilaki E, Morikawa M, Koinuma D, Mizutani A, Hirano Y, Ehata S, Sundqvist A, Kawasaki N, Cedervall J, Olsson AK, Aburatani H, Moustakas A, Miyazono K, Heldin CH.

Sci Signal. 2016 Aug 23;9(442):ra84. doi: 10.1126/scisignal.aag3232.

PMID:
27555661
32.

Recent Work on the Nature and Development of Delusions.

Bortolotti L, Miyazono K.

Philos Compass. 2015 Sep;10(9):636-645. Epub 2015 Sep 4.

33.

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology.

Morikawa M, Derynck R, Miyazono K.

Cold Spring Harb Perspect Biol. 2016 May 2;8(5). pii: a021873. doi: 10.1101/cshperspect.a021873. Review.

34.

Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.

Sakai S, Iwata C, Tanaka HY, Cabral H, Morishita Y, Miyazono K, Kano MR.

J Control Release. 2016 May 28;230:109-15. doi: 10.1016/j.jconrel.2016.04.007. Epub 2016 Apr 12.

PMID:
27080571
35.

RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D.

Oncogene. 2016 Sep 22;35(38):5000-9. doi: 10.1038/onc.2016.35. Epub 2016 Feb 29. Erratum in: Oncogene. 2017 Jun 12;:.

36.

Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer.

Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T, Mano H.

Cancer Res. 2016 Apr 1;76(7):1814-24. doi: 10.1158/0008-5472.CAN-14-3816. Epub 2016 Feb 26.

37.

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

Hosoya H, Dobroff AS, Driessen WH, Cristini V, Brinker LM, Staquicini FI, Cardó-Vila M, D'Angelo S, Ferrara F, Proneth B, Lin YS, Dunphy DR, Dogra P, Melancon MP, Stafford RJ, Miyazono K, Gelovani JG, Kataoka K, Brinker CJ, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1877-82. doi: 10.1073/pnas.1525796113. Epub 2016 Feb 2.

38.

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.

Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K.

Stem Cell Reports. 2016 Jan 12;6(1):64-73. doi: 10.1016/j.stemcr.2015.12.004.

39.

Mechanisms of action of bone morphogenetic proteins in cancer.

Davis H, Raja E, Miyazono K, Tsubakihara Y, Moustakas A.

Cytokine Growth Factor Rev. 2016 Feb;27:81-92. doi: 10.1016/j.cytogfr.2015.11.009. Epub 2015 Nov 24. Review.

PMID:
26678814
40.

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β.

Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y, Miyazono K.

Genes Cells. 2016 Jan;21(1):99-116. doi: 10.1111/gtc.12323. Epub 2015 Dec 10.

41.

The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.

Mizutani A, Koinuma D, Seimiya H, Miyazono K.

Oncogene. 2016 Jul 7;35(27):3514-23. doi: 10.1038/onc.2015.412. Epub 2015 Nov 2.

42.

Epigenomic Regulation of Smad1 Signaling During Cellular Senescence Induced by Ras Activation.

Kaneda A, Nonaka A, Fujita T, Yamanaka R, Fujimoto M, Miyazono K, Aburatani H.

Methods Mol Biol. 2016;1344:341-53. doi: 10.1007/978-1-4939-2966-5_22.

PMID:
26520136
43.

[A case of a simple ulcer associated with ulcerative colitis that demonstrated a good clinical response to infliximab].

Kishi M, Sou S, Ishihara H, Terabe H, Yasaka M, Kuhara K, Takeda T, Shimokoube M, Morimitsu Y, Miyazono K.

Nihon Shokakibyo Gakkai Zasshi. 2015;112(9):1682-8. doi: 10.11405/nisshoshi.112.1682. Japanese.

PMID:
26346358
44.

A clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines.

Sugimoto K, Suzuki HI, Fujimura T, Ono A, Kaga N, Isobe Y, Sasaki M, Taka H, Miyazono K, Komatsu N.

Cancer Sci. 2015 Nov;106(11):1534-43. doi: 10.1111/cas.12807. Epub 2015 Oct 16.

45.

Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I.

Miyazono K, Ishino S, Tsutsumi K, Ito T, Ishino Y, Tanokura M.

Nucleic Acids Res. 2015 Aug 18;43(14):7122-36. doi: 10.1093/nar/gkv654. Epub 2015 Jul 2.

46.

Small-RNA asymmetry is directly driven by mammalian Argonautes.

Suzuki HI, Katsura A, Yasuda T, Ueno T, Mano H, Sugimoto K, Miyazono K.

Nat Struct Mol Biol. 2015 Jul;22(7):512-21. doi: 10.1038/nsmb.3050. Epub 2015 Jun 22.

PMID:
26098316
47.

A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B.

Suzuki HI, Katsura A, Miyazono K.

Cancer Sci. 2015 Sep;106(9):1174-81. doi: 10.1111/cas.12721. Epub 2015 Jul 14.

48.

Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs.

Ihida-Stansbury K, Ames J, Chokshi M, Aiad N, Sanyal S, Kawabata KC, Levental I, Sundararaghavan HG, Burdick JA, Janmey P, Miyazono K, Wells RG, Jones PL.

Pulm Circ. 2015 Jun;5(2):382-97. doi: 10.1086/681272.

49.

Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1.

Hoshino Y, Nishida J, Katsuno Y, Koinuma D, Aoki T, Kokudo N, Miyazono K, Ehata S.

Am J Pathol. 2015 May;185(5):1457-70. doi: 10.1016/j.ajpath.2015.01.011. Epub 2015 Mar 11.

PMID:
25769430
50.

Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis.

Kimura J, Ichii O, Miyazono K, Nakamura T, Horino T, Otsuka-Kanazawa S, Kon Y.

Sci Rep. 2014 Dec 3;4:7290. doi: 10.1038/srep07290.

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