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Items: 1 to 50 of 75

1.

Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9.

Yazawa R, Nishida Y, Aoyama S, Tanida I, Miyatsuka T, Suzuki L, Himuro M, Haruna H, Takubo N, Shimizu T, Watada H.

Biochem Biophys Res Commun. 2019 Aug 27;516(3):686-692. doi: 10.1016/j.bbrc.2019.06.129. Epub 2019 Jun 26.

PMID:
31253397
2.

Postprandial Plasma Glucagon Kinetics in Type 2 Diabetes Mellitus: Comparison of Immunoassay and Mass Spectrometry.

Katahira T, Kanazawa A, Shinohara M, Koshibu M, Kaga H, Mita T, Tosaka Y, Komiya K, Miyatsuka T, Ikeda F, Azuma K, Takayanagi N, Ogihara T, Ohmura C, Miyachi A, Mieno E, Yamashita S, Watada H.

J Endocr Soc. 2018 Oct 26;3(1):42-51. doi: 10.1210/js.2018-00142. eCollection 2019 Jan 1.

3.

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells.

Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL.

Nat Cell Biol. 2018 Nov;20(11):1267-1277. doi: 10.1038/s41556-018-0216-y. Epub 2018 Oct 22.

4.

Defective autophagy in vascular smooth muscle cells enhances atherosclerotic plaque instability.

Masuyama A, Mita T, Azuma K, Osonoi Y, Nakajima K, Goto H, Nishida Y, Miyatsuka T, Mitsumata M, Watada H.

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1141-1147. doi: 10.1016/j.bbrc.2018.09.192. Epub 2018 Oct 11.

PMID:
30318118
5.

Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors.

Miura M, Miyatsuka T, Katahira T, Sasaki S, Suzuki L, Himuro M, Nishida Y, Fujitani Y, Matsuoka TA, Watada H.

EBioMedicine. 2018 Oct;36:358-366. doi: 10.1016/j.ebiom.2018.09.035. Epub 2018 Sep 25.

6.

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.

Osonoi Y, Mita T, Azuma K, Nakajima K, Masuyama A, Goto H, Nishida Y, Miyatsuka T, Fujitani Y, Koike M, Mitsumata M, Watada H.

Autophagy. 2018;14(11):1991-2006. doi: 10.1080/15548627.2018.1501132. Epub 2018 Aug 10.

7.

Everolimus Directly Suppresses Insulin Secretion Independently of Cell Growth Inhibition.

Suzuki L, Miyatsuka T, Himuro M, Nishio R, Goto H, Uchida T, Nishida Y, Kanazawa A, Watada H.

J Endocr Soc. 2018 May 22;2(7):589-596. doi: 10.1210/js.2017-00475. eCollection 2018 Jul 1.

8.

Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.

Uesato T, Ogihara T, Hara A, Iida H, Miyatsuka T, Fujitani Y, Takeda S, Watada H.

J Endocr Soc. 2018 Jan 30;2(3):207-219. doi: 10.1210/js.2017-00338. eCollection 2018 Mar 1.

9.

Heterogeneity of autophagic status in pancreatic β cells under metabolic stress.

Kamitani M, Miyatsuka T, Miura M, Azuma K, Suzuki L, Himuro M, Katahira T, Nishida Y, Fujitani Y, Watada H.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):328-334. doi: 10.1016/j.bbrc.2018.01.070. Epub 2018 Jan 11.

PMID:
29337057
10.

One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control.

Sato J, Kanazawa A, Hatae C, Makita S, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Watada H.

PLoS One. 2017 Dec 4;12(12):e0188892. doi: 10.1371/journal.pone.0188892. eCollection 2017.

11.

Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.

Honda A, Komiya K, Hara A, Fukunaka A, Suzuki L, Miyatsuka T, Ogihara T, Fujitani Y, Watada H.

Endocr J. 2018 Jan 30;65(1):83-89. doi: 10.1507/endocrj.EJ17-0333. Epub 2017 Oct 4.

12.

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.

Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.

PLoS Genet. 2017 Aug 30;13(8):e1006950. doi: 10.1371/journal.pgen.1006950. eCollection 2017 Aug.

13.

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.

Matsuoka TA, Kawashima S, Miyatsuka T, Sasaki S, Shimo N, Katakami N, Kawamori D, Takebe S, Herrera PL, Kaneto H, Stein R, Shimomura I.

Diabetes. 2017 May;66(5):1293-1300. doi: 10.2337/db16-0887. Epub 2017 Feb 21.

14.

Efficacy and Safety of Vildagliptin as an Add-On Therapy in Inadequately Controlled Type 2 Diabetes Patients Treated With Basal Insulin.

Saito D, Kanazawa A, Shigihara N, Sato F, Uchida T, Sato J, Goto H, Miyatsuka T, Ikeda F, Ogihara T, Ohmura C, Watada H.

J Clin Med Res. 2017 Mar;9(3):193-199. doi: 10.14740/jocmr2874w. Epub 2017 Jan 25.

15.

Preserving expression of Pdx1 improves β-cell failure in diabetic mice.

Yamamoto Y, Miyatsuka T, Sasaki S, Miyashita K, Kubo F, Shimo N, Takebe S, Watada H, Kaneto H, Matsuoka TA, Shimomura I.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):418-424. doi: 10.1016/j.bbrc.2016.12.128. Epub 2016 Dec 23.

PMID:
28017717
16.

Golgi membrane-associated degradation pathway in yeast and mammals.

Yamaguchi H, Arakawa S, Kanaseki T, Miyatsuka T, Fujitani Y, Watada H, Tsujimoto Y, Shimizu S.

EMBO J. 2016 Sep 15;35(18):1991-2007. doi: 10.15252/embj.201593191. Epub 2016 Aug 10.

17.

A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control.

Sato J, Kanazawa A, Makita S, Hatae C, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Takeno K, Shimada S, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Fujitani Y, Watada H.

Clin Nutr. 2017 Aug;36(4):992-1000. doi: 10.1016/j.clnu.2016.07.003. Epub 2016 Jul 18.

PMID:
27472929
18.

Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice.

Kubo F, Miyatsuka T, Sasaki S, Takahara M, Yamamoto Y, Shimo N, Watada H, Kaneto H, Gannon M, Matsuoka TA, Shimomura I.

Biochem Biophys Res Commun. 2016 Feb 26;471(1):68-74. doi: 10.1016/j.bbrc.2016.01.177. Epub 2016 Feb 4.

19.

Chronology of endocrine differentiation and beta-cell neogenesis.

Miyatsuka T.

Endocr J. 2016;63(3):205-11. doi: 10.1507/endocrj.EJ15-0601. Epub 2015 Nov 27. Review.

20.

Short-term selective alleviation of glucotoxicity and lipotoxicity ameliorates the suppressed expression of key β-cell factors under diabetic conditions.

Shimo N, Matsuoka TA, Miyatsuka T, Takebe S, Tochino Y, Takahara M, Kaneto H, Shimomura I.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):948-54. doi: 10.1016/j.bbrc.2015.10.038. Epub 2015 Oct 20.

PMID:
26471305
21.

Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice.

Sasaki S, Miyatsuka T, Matsuoka TA, Takahara M, Yamamoto Y, Yasuda T, Kaneto H, Fujitani Y, German MS, Akiyama H, Watada H, Shimomura I.

Diabetologia. 2015 Nov;58(11):2582-91. doi: 10.1007/s00125-015-3728-z. Epub 2015 Aug 20.

PMID:
26290048
22.

Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.

Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93. doi: 10.1073/pnas.1319378112. Epub 2015 Feb 18.

23.

Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo.

Matsuoka TA, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki J, Gannon M, Stein R, Shimomura I.

J Biol Chem. 2015 Mar 20;290(12):7647-57. doi: 10.1074/jbc.M114.595579. Epub 2015 Feb 2.

24.

Case of aniridia with a heterozygous PAX6 mutation in which the glucagon response to arginine was evaluated.

Osawa S, Yasuda T, Kaneto H, Shimo N, Yamamoto Y, Kawamori D, Miyatsuka T, Matsuoka TA, Shimomura I.

J Diabetes Investig. 2015 Jan;6(1):105-6. doi: 10.1111/jdi.12251. Epub 2015 Jan 1. No abstract available.

25.

Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients.

Shimo N, Yasuda T, Kaneto H, Katakami N, Kuroda A, Sakamoto F, Takahara M, Irie Y, Horikawa K, Miyashita K, Miyatsuka T, Yoshiuchi K, Kawamori D, Sakamoto K, Matsuoka TA, Kosugi K, Shimomura I, Matsuhisa M.

Diabetes Res Clin Pract. 2014 Nov;106(2):e41-3. doi: 10.1016/j.diabres.2014.08.005. Epub 2014 Aug 12.

PMID:
25287616
26.

Menin determines K-RAS proliferative outputs in endocrine cells.

Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS.

J Clin Invest. 2014 Sep;124(9):4093-101. doi: 10.1172/JCI69004. Epub 2014 Aug 18.

27.

Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.

Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.

J Clin Invest. 2014 Aug;124(8):3634-44. doi: 10.1172/JCI69866. Epub 2014 Jul 18.

28.

Chronological analysis with fluorescent timer reveals unique features of newly generated β-cells.

Miyatsuka T, Matsuoka TA, Sasaki S, Kubo F, Shimomura I, Watada H, German MS, Hara M.

Diabetes. 2014 Oct;63(10):3388-93. doi: 10.2337/db13-1312. Epub 2014 May 16.

29.

Sequential introduction and dosage balance of defined transcription factors affect reprogramming efficiency from pancreatic duct cells into insulin-producing cells.

Miyashita K, Miyatsuka T, Matsuoka TA, Sasaki S, Takebe S, Yasuda T, Watada H, Kaneto H, Shimomura I.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):514-9. doi: 10.1016/j.bbrc.2014.01.083. Epub 2014 Jan 25.

PMID:
24472553
30.

A novel function of Onecut1 protein as a negative regulator of MafA gene expression.

Yamamoto K, Matsuoka TA, Kawashima S, Takebe S, Kubo F, Miyatsuka T, Kaneto H, Shimomura I.

J Biol Chem. 2013 Jul 26;288(30):21648-58. doi: 10.1074/jbc.M113.481424. Epub 2013 Jun 17. Erratum in: J Biol Chem. 2013 Oct 25;288(43):31298. Kubo, Noriyo [corrected to Kubo, Fumiyo].

31.

Serum vitamin D levels are decreased in patients without remission of Graves' disease.

Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F, Miyatsuka T, Kitamura T, Katakami N, Kawamori D, Otsuki M, Matsuoka TA, Kaneto H, Shimomura I.

Endocrine. 2013 Feb;43(1):230-2. doi: 10.1007/s12020-012-9789-6. Epub 2012 Sep 15. No abstract available.

32.

Large adrenal ganglioneuroma.

Sasaki S, Yasuda T, Kaneto H, Otsuki M, Tabuchi Y, Fujita Y, Kubo F, Tsuji M, Fujisawa K, Kasami R, Kitamura T, Miyatsuka T, Katakami N, Kawamori D, Matsuoka TA, Imagawa A, Shimomura I.

Intern Med. 2012;51(17):2365-70. Epub 2012 Sep 1.

33.

Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease.

Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F, Miyatsuka T, Kitamura T, Katakami N, Kawamori D, Otsuki M, Matsuoka TA, Kaneto H, Shimomura I.

Endocrine. 2012 Dec;42(3):739-41. doi: 10.1007/s12020-012-9679-y. Epub 2012 May 1. No abstract available.

34.

Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.

Miyatsuka T, Kosaka Y, Kim H, German MS.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):185-90. doi: 10.1073/pnas.1004842108. Epub 2010 Dec 20.

35.

Efficacy of occasional self-monitoring of postprandial blood glucose levels in type 2 diabetic patients without insulin therapy.

Shiraiwa T, Takahara M, Kaneto H, Miyatsuka T, Yamamoto K, Yoshiuchi K, Sakamoto K, Matsuoka TA, Matsuhisa M, Yamasaki Y, Shimomura I.

Diabetes Res Clin Pract. 2010 Dec;90(3):e91-2. doi: 10.1016/j.diabres.2010.09.022. Epub 2010 Oct 27. No abstract available.

PMID:
21030103
36.

Serotonin regulates pancreatic beta cell mass during pregnancy.

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS.

Nat Med. 2010 Jul;16(7):804-8. doi: 10.1038/nm.2173. Epub 2010 Jun 27.

37.

Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.

Matsuoka TA, Kaneto H, Miyatsuka T, Yamamoto T, Yamamoto K, Kato K, Shimomura I, Stein R, Matsuhisa M.

Diabetes. 2010 Jul;59(7):1709-20. doi: 10.2337/db08-0693. Epub 2010 Apr 27.

38.

Rfx6 directs islet formation and insulin production in mice and humans.

Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Désir J, Vanden Eijnden S, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS.

Nature. 2010 Feb 11;463(7282):775-80. doi: 10.1038/nature08748.

39.

Chronology of islet differentiation revealed by temporal cell labeling.

Miyatsuka T, Li Z, German MS.

Diabetes. 2009 Aug;58(8):1863-8. doi: 10.2337/db09-0390. Epub 2009 May 28.

40.

Role of copper ion in the pathogenesis of type 2 diabetes.

Tanaka A, Kaneto H, Miyatsuka T, Yamamoto K, Yoshiuchi K, Yamasaki Y, Shimomura I, Matsuoka TA, Matsuhisa M.

Endocr J. 2009;56(5):699-706. Epub 2009 May 20.

41.

Role of MafA in pancreatic beta-cells.

Kaneto H, Matsuoka TA, Kawashima S, Yamamoto K, Kato K, Miyatsuka T, Katakami N, Matsuhisa M.

Adv Drug Deliv Rev. 2009 Jul 2;61(7-8):489-96. doi: 10.1016/j.addr.2008.12.015. Epub 2009 Apr 22. Review.

PMID:
19393272
42.

Transcription factors as therapeutic targets for diabetes.

Miyatsuka T, Matsuoka TA, Kaneto H.

Expert Opin Ther Targets. 2008 Nov;12(11):1431-42. doi: 10.1517/14728222.12.11.1431 .

PMID:
18851698
43.

PDX-1 functions as a master factor in the pancreas.

Kaneto H, Matsuoka TA, Miyatsuka T, Kawamori D, Katakami N, Yamasaki Y, Matsuhisa M.

Front Biosci. 2008 May 1;13:6406-20. Review.

PMID:
18508668
44.

Signals from the neural crest regulate beta-cell mass in the pancreas.

Nekrep N, Wang J, Miyatsuka T, German MS.

Development. 2008 Jun;135(12):2151-60. doi: 10.1242/dev.015859.

45.

Pleiotropic Roles of PDX-1 in the Pancreas.

Kaneto H, Miyatsuka T, Kawamori D, Matsuoka TA.

Rev Diabet Stud. 2007 Winter;4(4):209-25. doi: 10.1900/RDS.2007.4.209. Epub 2008 Feb 10.

46.

Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes.

Kaneto H, Matsuoka TA, Katakami N, Kawamori D, Miyatsuka T, Yoshiuchi K, Yasuda T, Sakamoto K, Yamasaki Y, Matsuhisa M.

Curr Mol Med. 2007 Nov;7(7):674-86. Review.

PMID:
18045145
47.

PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function.

Kaneto H, Miyatsuka T, Kawamori D, Yamamoto K, Kato K, Shiraiwa T, Katakami N, Yamasaki Y, Matsuhisa M, Matsuoka TA.

Endocr J. 2008 May;55(2):235-52. Epub 2007 Oct 15. Review.

48.

Tissue-specific deletion of c-Jun in the pancreas has limited effects on pancreas formation.

Yamamoto K, Miyatsuka T, Tanaka A, Toyoda S, Kato K, Shiraiwa T, Fujitani Y, Yamasaki Y, Hori M, Matsuhisa M, Matsuoka TA, Kaneto H.

Biochem Biophys Res Commun. 2007 Nov 30;363(4):908-14. Epub 2007 Sep 24.

PMID:
17920562
49.

Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III.

Miyatsuka T, Matsuoka TA, Shiraiwa T, Yamamoto T, Kojima I, Kaneto H.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):905-9. Epub 2007 Aug 24.

PMID:
17803961
50.

Establishment of a non-invasive mouse reporter model for monitoring in vivo pdx-1 promoter activity.

Shiraiwa T, Kaneto H, Miyatsuka T, Kato K, Yamamoto K, Kawashima A, Kajimoto Y, Matsuoka TA, Matsuhisa M, Yamasaki Y, Fujitani Y.

Biochem Biophys Res Commun. 2007 Sep 28;361(3):739-44. Epub 2007 Jul 27.

PMID:
17678877

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