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Items: 1 to 50 of 52

1.

TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.

Yano W, Yokogawa T, Wakasa T, Yamamura K, Fujioka A, Yoshisue K, Matsushima E, Miyahara S, Miyakoshi H, Taguchi J, Chong KT, Takao Y, Fukuoka M, Matsuo K.

Mol Cancer Ther. 2018 Aug;17(8):1683-1693. doi: 10.1158/1535-7163.MCT-17-0911. Epub 2018 May 10.

2.

Evaluation of the highly sensitive chemiluminescent enzyme immunoassay "Lumipulse HBsAg-HQ" for hepatitis B virus screening.

Deguchi M, Kagita M, Yoshioka N, Tsukamoto H, Takao M, Tahara K, Maeda I, Hidaka Y, Yamauchi S, Kaneko A, Miyakoshi H, Isomura M.

J Clin Lab Anal. 2018 May;32(4):e22334. doi: 10.1002/jcla.22334. Epub 2017 Oct 6.

PMID:
28984383
3.

1,2,3-Triazole-containing uracil derivatives with excellent pharmacokinetics as a novel class of potent human deoxyuridine triphosphatase inhibitors.

Miyakoshi H, Miyahara S, Yokogawa T, Endoh K, Muto T, Yano W, Wakasa T, Ueno H, Chong KT, Taguchi J, Nomura M, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Shuto S, Nagasawa H, Fukuoka M.

J Med Chem. 2012 Jul 26;55(14):6427-37. doi: 10.1021/jm3004174. Epub 2012 Jul 3.

PMID:
22715973
4.

Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy.

Miyahara S, Miyakoshi H, Yokogawa T, Chong KT, Taguchi J, Muto T, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Nomura M, Nagasawa H, Shuto S, Fukuoka M.

J Med Chem. 2012 Jun 14;55(11):5483-96. doi: 10.1021/jm300416h. Epub 2012 May 30.

PMID:
22607122
5.

Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.

Miyakoshi H, Miyahara S, Yokogawa T, Chong KT, Taguchi J, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Nomura M, Shuto S, Nagasawa H, Fukuoka M.

J Med Chem. 2012 Apr 12;55(7):2960-9. doi: 10.1021/jm201627n. Epub 2012 Mar 26.

PMID:
22404301
6.

Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors.

Miyahara S, Miyakoshi H, Yokogawa T, Chong KT, Taguchi J, Muto T, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Nomura M, Nagasawa H, Shuto S, Fukuoka M.

J Med Chem. 2012 Apr 12;55(7):2970-80. doi: 10.1021/jm201628y. Epub 2012 Mar 26.

PMID:
22339362
7.

Analytical evaluation of a high-molecular-weight (HMW) adiponectin chemiluminescent enzyme immunoassay.

Hayama S, Higuchi T, Miyakoshi H, Nakano Y.

Clin Chim Acta. 2010 Dec 14;411(23-24):2073-8. doi: 10.1016/j.cca.2010.09.007. Epub 2010 Sep 16.

PMID:
20837001
8.

Evaluation of APTIMA Combo 2 for cross-reactivity with oropharyngeal Neisseria species and other microorganisms.

Nagasawa Z, Ikeda-Dantsuji Y, Niwa T, Miyakoshi H, Nagayama A.

Clin Chim Acta. 2010 May 2;411(9-10):776-8. doi: 10.1016/j.cca.2010.01.039. Epub 2010 Feb 4. No abstract available.

PMID:
20138032
9.

Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients.

Suzuki F, Miyakoshi H, Kobayashi M, Kumada H.

J Med Virol. 2009 Jan;81(1):27-33. doi: 10.1002/jmv.21339.

PMID:
19031469
10.

Performance of ELISA for specific measurement of high-molecular-weight (HMW) adiponectin.

Tanita T, Miyakoshi H, Nakano Y.

J Immunol Methods. 2008 Apr 20;333(1-2):139-46. doi: 10.1016/j.jim.2008.01.013. Epub 2008 Feb 20.

PMID:
18304569
11.

A case of refractory hypothyroidism requiring daily intravenous thyroxine.

Nagaoka T, Miyakoshi H, Takamura T, Nagai Y, Matsushita S, Kaneko S, Kobayashi K.

J Int Med Res. 2002 Jul-Aug;30(4):463-5.

PMID:
12235934
13.

Improvement of cardiac function after treatment with octreotide followed by trans-sphenoidal surgery in an acromegalic patient who presented with congestive heart failure.

Shimakura A, Miyakoshi H, Ohkuwa H, Kitabayashi M, Komai T, Hisada A, Aoki K, Sakagami S, Kobayashi K, Takata S.

Jpn Heart J. 2002 Jan;43(1):69-77.

14.

Inhaled insulin in type 1 diabetes.

Nagaoka T, Miyakoshi H.

Lancet. 2001 Jun 16;357(9272):1979. No abstract available.

PMID:
11729843
15.

Rules on originality need to be clearly set out.

Nagaoka T, Miyakoshi H.

Nature. 2001 Oct 4;413(6855):453. No abstract available.

PMID:
11586323
16.

Cavernous sinus syndrome associated with nonsecretory myeloma.

Kyoda K, Nakamura S, Takeshima M, Matano S, Masuda S, Matsuda T, Miyakoshi H.

Intern Med. 1999 Dec;38(12):988-90.

17.

Clinical analysis and TPO levels in three patients with refractory thrombocytopenia.

Kyoda K, Nakamura S, Takeshima M, Okumura H, Ohtake S, Matsuda T, Miyakoshi H.

Am J Hematol. 1999 Oct;62(2):103-5.

18.

A very rare case of continuous ambulatory peritoneal dialysis peritonitis caused by Anisakis larva.

Ohta M, Ikeda K, Miyakoshi H, Nishide K, Horigami T, Akao T, Yamagishi S, Hirano S.

Am J Gastroenterol. 1995 Oct;90(10):1902-3. No abstract available.

PMID:
7572931
19.

Development and usefulness of the gelatin-particle-agglutination test for titration of antibodies against diphtheria, pertussis and tetanus toxins.

Miyamura K, Sadahiro S, Konda T, Takahashi M, Fujino R, Nishimura Y, Miyakoshi H, Horiuchi K, Furuya Y, Kubota T, et al.

Jpn J Med Sci Biol. 1995 Feb;48(1):49-59.

PMID:
7666594
20.

An adult case of neurohypophyseal ectopy presenting ACTH deficiency and partial GH deficiency.

Takamura T, Ohsawa K, Nishimura Y, Yamagishi S, Komatsu Y, Iwata A, Osada S, Nagai Y, Miyakoshi H, Kobayashi K.

Endocr J. 1995 Feb;42(1):83-8.

21.

Low NK syndrome and its relationship to chronic fatigue syndrome.

Aoki T, Miyakoshi H, Usuda Y, Herberman RB.

Clin Immunol Immunopathol. 1993 Dec;69(3):253-65. Review. No abstract available.

PMID:
8242898
23.

[Detection of antibodies against HIV-1 and HIV-2 using "new antigens"].

Miyakoshi H.

Nihon Rinsho. 1993 Sep;51 Suppl:279-83. Japanese. No abstract available.

PMID:
7505848
24.

[Studies on thyroid hormone autoantibody in two euthyroid cases with spuriously high value of serum free triiodothyronine].

Yamagishi S, Miyakoshi H, Nagai Y, Ohsawa K, Kobayashi K.

Nihon Naibunpi Gakkai Zasshi. 1992 Nov 20;68(11):1205-14. Japanese.

PMID:
1468596
25.

Characterization of the insulin resistance in liver cirrhosis: a comparison with non-insulin dependent diabetes mellitus.

Miyamoto I, Miyakoshi H, Nagai Y, Ohsawa K, Nishimura Y, Noto Y, Kobayashi K.

Endocrinol Jpn. 1992 Oct;39(5):421-9.

26.

Improvement of simultaneous detection of antibodies to Gag and envelope antigens of human T-lymphotropic virus type I by western immunoblot assay.

Miyakoshi H, Sugimoto M, Igarashi H, Honda H, Fujino R, Mizukoshi M.

J Clin Microbiol. 1992 Oct;30(10):2555-9.

27.

[A case of pseudohypoparathyroidism (PHP) type II associated with Bartter's syndrome--restoration of phosphaturic response to parathyroid hormone (PTH) by treatment for hypopotassemia].

Bando Y, Miyakoshi H, Nagaoka T, Ohsawa K, Kobayashi K.

Nihon Naibunpi Gakkai Zasshi. 1992 Jul 20;68(7):676-87. Japanese.

PMID:
1516722
28.

Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome.

Nagai Y, Miyakoshi H, Ohsawa K, Ieki Y, Takamura T, Kobayashi K.

Endocrinol Jpn. 1992 Feb;39(1):129-32.

29.

Exacerbation of hypothyroidism following tumor necrosis factor-alpha infusion.

Miyakoshi H, Ohsawa K, Yokoyama H, Nagai Y, Ieki Y, Bando YI, Kobayashi K.

Intern Med. 1992 Feb;31(2):200-3.

30.

[The frequency and mechanisms of urolithiasis in acromegaly].

Ieki Y, Miyakoshi H, Nagai Y, Bando Y, Usuda R, Miyamoto I, Ohsawa K, Kobayashi K.

Nihon Naibunpi Gakkai Zasshi. 1991 Jul 20;67(7):755-63. Japanese.

PMID:
1889513
31.

Improvement of gelatin particle agglutination test for detection of anti-HTLV-I antibody.

Fujino R, Kawato K, Ikeda M, Miyakoshi H, Mizukoshi M, Imai J.

Jpn J Cancer Res. 1991 Apr;82(4):367-70.

32.

Cyclosporine A (CyA)-induced decrease of serum gonadotropin levels in a case of Klinefelter's syndrome.

Nagai Y, Miyakoshi H, Ieki Y, Bando Y, Usuda R, Miyamoto I, Ohsawa K, Yokoyama H, Tomosugi N, Kobayashi K.

Nihon Naibunpi Gakkai Zasshi. 1991 Jan 20;67(1):33-41.

PMID:
1901551
33.

Giant cavernous hemangioma of the liver and multiple primary malignant tumors in a patient with suspected familial inhibition of natural killer cell activity--a case report.

Tomiyama T, Uchida K, Yoshida K, Muto T, Saito H, Nemoto K, Inoue Z, Morita T, Miyakoshi H, Tamura K, et al.

Jpn J Surg. 1989 Mar;19(2):216-22.

PMID:
2724721
34.

Low natural killer syndrome: clinical and immunologic features.

Aoki T, Usuda Y, Miyakoshi H, Tamura K, Herberman RB.

Nat Immun Cell Growth Regul. 1987;6(3):116-28.

PMID:
2442602
35.

[Thyrotoxicosis preceded by hypothyroidism in a case of chronic thyroiditis with Graves' ophthalmopathy].

Yamamoto T, Ohsawa K, Nishimura Y, Sanada A, Miyakoshi H, Noto Y, Hattori N.

Nihon Naika Gakkai Zasshi. 1985 Oct;74(10):1414-9. Japanese. No abstract available.

PMID:
3841550
36.

Detection of antibodies to HTLV-I and -III in sera from Japanese hemophiliacs.

Abe T, Kinoshita T, Matsuda J, Ryu T, Ting RC, Aoki T, Robert-Guroff M, Miyakoshi H, Gallo RC.

Cancer Res. 1985 Sep;45(9 Suppl):4621s-4623s.

37.

Seroepidemiology of human T-lymphotropic retrovirus type I (HTLV-I) in residents of Niigata Prefecture, Japan. Comparative studies by indirect immunofluorescence microscopy and enzyme-linked immunosorbent assay.

Aoki T, Miyakoshi H, Koide H, Yoshida T, Ishikawa H, Sugisaki Y, Mizukoshi M, Tamura K, Misawa H, Hamada C, et al.

Int J Cancer. 1985 Mar 15;35(3):301-6.

PMID:
2982747
38.

Immune status of leukemia patients.

Kaneko Y, Miyakoshi H, Aoyagi Y, Aoki T.

Haematol Blood Transfus. 1985;29:200-3. No abstract available.

PMID:
3861482
39.

Roles of HTLV-I p19 and natural antibody to HTLV-I in host immune responses.

Aoki T, Hamada C, Ohno S, Miyakoshi H, Kaneko Y, Robert-Guroff M, Ting RC, Gallo RC.

Haematol Blood Transfus. 1985;29:342-4. No abstract available.

PMID:
2993130
40.

Antibodies to HTLV I and III in sera from two Japanese patients, one with possible pre-AIDS.

Aoki T, Miyakoshi H, Usuda Y, Chermann JC, Barré-Sinoussi F, Ting RC, Gallo RC.

Lancet. 1984 Oct 20;2(8408):936-7. No abstract available.

PMID:
6148658
41.

Impaired plasma cyclic AMP response to exogenous glucagon in acute liver injury.

Miyakoshi H, Noda Y, Uchida S, Tanaka N, Noto Y, Kato Y, Kawai K, Hayakawa H, Kobayashi K, Hattori N.

J Clin Gastroenterol. 1984 Aug;6(4):337-42.

PMID:
6090530
42.
43.

Location of human T-cell leukemia virus (HTLV) p19 antigen on virus-producing cells.

Aoki T, Hamada C, Ohno S, Miyakoshi H, Koide H, Robert-Guroff M, Ting RC, Gallo RC.

Int J Cancer. 1984 Feb 15;33(2):161-5.

PMID:
6319298
45.
46.

[Characteristic clinical features of adult T-cell leukemia in Sado Island].

Aoyagi Y, Takahashi M, Aoki S, Shinada S, Hattori A, Shibata A, Nemoto K, Tsukada T, Miyakoshi H, Koide H, et al.

Rinsho Ketsueki. 1983 Oct;24(10):1321-30. Japanese. No abstract available.

PMID:
6323786
47.

High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient.

Sarin PS, Aoki T, Shibata A, Ohnishi Y, Aoyagi Y, Miyakoshi H, Emura I, Kalyanaraman VS, Robert-Guroff M, Popovic M, Sarngadharan M, Nowell PC, Gallo RC.

Proc Natl Acad Sci U S A. 1983 Apr;80(8):2370-4.

48.

Immunological effects of 1alpha-hydroxycholecalciferol (1alpha-OH-D3) and its metabolites.

Miyakoshi H, Aoki T, Hirasawa Y.

Clin Nephrol. 1981 Sep;16(3):119-25.

PMID:
6895354
49.

[Treatment of renovascular hypertension with percutaneous transluminal angioplasty (author's transl)].

Takabatake T, Yamamoto Y, Takemori Y, Maekawa M, Ohta H, Arai S, Nomura G, Hattori N, Matsui O, Miyakoshi H, Koshiyama K.

Nihon Jinzo Gakkai Shi. 1981 Apr;23(4):479-98. Japanese. No abstract available.

PMID:
6460130
50.

[The response of plasma cyclic AMP to exogenous glucagon as a marker for severity in acute liver injury (author's transl)].

Miyakoshi H, Noda Y, Tanaka N, Noto Y, Kato Y, Hayakawa H, Kobayashi K, Hattori N.

Nihon Shokakibyo Gakkai Zasshi. 1980 Oct;77(10):1596-603. Japanese. No abstract available.

PMID:
6256563

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