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Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice.

Achyut BR, Zhang H, Angara K, Mivechi NF, Arbab AS, Ko L.

Cancer Lett. 2020 Feb 12;476:57-66. doi: 10.1016/j.canlet.2020.02.005. [Epub ahead of print]


HSF1-Mediated Control of Cellular Energy Metabolism and mTORC1 Activation Drive Acute T-Cell Lymphoblastic Leukemia Progression.

Eroglu B, Pang J, Jin X, Xi C, Moskophidis D, Mivechi NF.

Mol Cancer Res. 2019 Nov 19. doi: 10.1158/1541-7786.MCR-19-0217. [Epub ahead of print]


Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.

Jin X, Qiao A, Moskophidis D, Mivechi NF.

Mol Cell Biol. 2018 Aug 28;38(18). pii: e00095-18. doi: 10.1128/MCB.00095-18. Print 2018 Sep 15.


Targeted Deletion of Hsf1, 2, and 4 Genes in Mice.

Jin X, Eroglu B, Moskophidis D, Mivechi NF.

Methods Mol Biol. 2018;1709:1-22. doi: 10.1007/978-1-4939-7477-1_1.


Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis.

Zhang L, Wang Y, Rashid MH, Liu M, Angara K, Mivechi NF, Maihle NJ, Arbab AS, Ko L.

Oncotarget. 2017 May 25;8(31):51591-51607. doi: 10.18632/oncotarget.18196. eCollection 2017 Aug 1.


WITHDRAWN: Abrogation of heat shock factor 1 (Hsf1) phosphorylation deregulates its activity and lowers activation threshold, leading to obesity in mice.

Jin X, Qiao A, Moskophidis D, Mivechi NF.

J Biol Chem. 2017 Jul 19. pii: jbc.M117.789354. doi: 10.1074/jbc.M117.789354. [Epub ahead of print]


The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis.

Qiao A, Jin X, Pang J, Moskophidis D, Mivechi NF.

J Cell Biol. 2017 Mar 6;216(3):723-741. doi: 10.1083/jcb.201607091. Epub 2017 Feb 9.


GT198 Expression Defines Mutant Tumor Stroma in Human Breast Cancer.

Yang Z, Peng M, Cheng L, Jones K, Maihle NJ, Mivechi NF, Ko L.

Am J Pathol. 2016 May;186(5):1340-50. doi: 10.1016/j.ajpath.2016.01.006. Epub 2016 Mar 18. Erratum in: Am J Pathol. 2016 Aug;186(8):2236.


Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells.

Sharma BK, Kolhe R, Black SM, Keller JR, Mivechi NF, Satyanarayana A.

FASEB J. 2016 Jan;30(1):262-75. doi: 10.1096/fj.15-277749. Epub 2015 Sep 1.


Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury.

Eroglu B, Kimbler DE, Pang J, Choi J, Moskophidis D, Yanasak N, Dhandapani KM, Mivechi NF.

J Neurochem. 2014 Sep;130(5):626-41. doi: 10.1111/jnc.12781. Epub 2014 Jul 4.


An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.

Eroglu B, Min JN, Zhang Y, Szurek E, Moskophidis D, Eroglu A, Mivechi NF.

Dev Biol. 2014 Feb 15;386(2):448-60. doi: 10.1016/j.ydbio.2013.12.038. Epub 2013 Dec 28.


Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma.

Hong Y, Peng Y, Guo ZS, Guevara-Patino J, Pang J, Butterfield LH, Mivechi NF, Munn DH, Bartlett DL, He Y.

Hepatology. 2014 Apr;59(4):1448-58. doi: 10.1002/hep.26893. Epub 2014 Feb 18.


Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations.

Peng M, Zhang H, Jaafar L, Risinger JI, Huang S, Mivechi NF, Ko L.

J Biol Chem. 2013 Nov 15;288(46):33387-97. doi: 10.1074/jbc.M113.485581. Epub 2013 Oct 4.


GT198 Splice Variants Display Dominant-Negative Activities and Are Induced by Inactivating Mutations.

Peng M, Yang Z, Zhang H, Jaafar L, Wang G, Liu M, Flores-Rozas H, Xu J, Mivechi NF, Ko L.

Genes Cancer. 2013 Jan;4(1-2):26-38. doi: 10.1177/1947601913486345.


Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers.

Peng M, Bakker JL, Dicioccio RA, Gille JJ, Zhao H, Odunsi K, Sucheston L, Jaafar L, Mivechi NF, Waisfisz Q, Ko L.

Genes Cancer. 2013 Jan;4(1-2):15-25. doi: 10.1177/1947601913486344.


Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.

Xi C, Hu Y, Buckhaults P, Moskophidis D, Mivechi NF.

J Biol Chem. 2012 Oct 12;287(42):35646-57. doi: 10.1074/jbc.M112.377481. Epub 2012 Jul 30.


The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma.

Wu J, Li J, Salcedo R, Mivechi NF, Trinchieri G, Horuzsko A.

Cancer Res. 2012 Aug 15;72(16):3977-86. doi: 10.1158/0008-5472.CAN-12-0938. Epub 2012 Jun 19.


Regulation of embryonic stem cell pluripotency by heat shock protein 90.

Bradley E, Bieberich E, Mivechi NF, Tangpisuthipongsa D, Wang G.

Stem Cells. 2012 Aug;30(8):1624-33. doi: 10.1002/stem.1143.


Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo.

Jin X, Eroglu B, Cho W, Yamaguchi Y, Moskophidis D, Mivechi NF.

Mol Cancer Res. 2012 Apr;10(4):523-34. doi: 10.1158/1541-7786.MCR-11-0530. Epub 2012 Feb 21.


Targeted deletion of Hsf1, 2, and 4 genes in mice.

Jin X, Eroglu B, Moskophidis D, Mivechi NF.

Methods Mol Biol. 2011;787:1-20. doi: 10.1007/978-1-61779-295-3_1.


Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L).

Hu Y, Mivechi NF.

J Biol Chem. 2011 Sep 9;286(36):31397-408. doi: 10.1074/jbc.M111.255851. Epub 2011 Jul 22.


Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.

Jin X, Moskophidis D, Mivechi NF.

Cell Metab. 2011 Jul 6;14(1):91-103. doi: 10.1016/j.cmet.2011.03.025.


Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.

Eroglu B, Moskophidis D, Mivechi NF.

Mol Cell Biol. 2010 Oct;30(19):4626-43. doi: 10.1128/MCB.01493-09. Epub 2010 Aug 2.


Heat shock factor 1 deficiency via its downstream target gene alphaB-crystallin (Hspb5) impairs p53 degradation.

Jin X, Moskophidis D, Hu Y, Phillips A, Mivechi NF.

J Cell Biochem. 2009 Jun 1;107(3):504-15. doi: 10.1002/jcb.22151.


Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.

Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D.

Genesis. 2007 Aug;45(8):487-501.


Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice.

Homma S, Jin X, Wang G, Tu N, Min J, Yanasak N, Mivechi NF.

J Neurosci. 2007 Jul 25;27(30):7974-86.


Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors.

Min JN, Huang L, Zimonjic DB, Moskophidis D, Mivechi NF.

Oncogene. 2007 Aug 2;26(35):5086-97. Epub 2007 Feb 19.


Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.

Min JN, Zhang Y, Moskophidis D, Mivechi NF.

Genesis. 2004 Dec;40(4):205-17.


Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility.

Wang G, Ying Z, Jin X, Tu N, Zhang Y, Phillips M, Moskophidis D, Mivechi NF.

Genesis. 2004 Feb;38(2):66-80.


HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo.

Hu Y, Mivechi NF.

J Biol Chem. 2003 May 9;278(19):17299-306. Epub 2003 Mar 5.


Heat shock factor-4 (HSF-4a) is a repressor of HSF-1 mediated transcription.

Zhang Y, Frejtag W, Dai R, Mivechi NF.

J Cell Biochem. 2001;82(4):692-703.


Suppression of heat shock transcription factor HSF1 in zebrafish causes heat-induced apoptosis.

Wang G, Huang H, Dai R, Lee KY, Lin S, Mivechi NF.

Genesis. 2001 Jul;30(3):195-7. No abstract available.


Heat shock factor-4 (HSF-4a) represses basal transcription through interaction with TFIIF.

Frejtag W, Zhang Y, Dai R, Anderson MG, Mivechi NF.

J Biol Chem. 2001 May 4;276(18):14685-94. Epub 2001 Feb 2.


Role of ERK activation in growth and erythroid differentiation of K562 cells.

Woessmann W, Mivechi NF.

Exp Cell Res. 2001 Apr 1;264(2):193-200.


c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.

Dai R, Frejtag W, He B, Zhang Y, Mivechi NF.

J Biol Chem. 2000 Jun 16;275(24):18210-8.


An essential role for mitogen-activated protein kinases, ERKs, in preventing heat-induced cell death.

Woessmann W, Meng YH, Mivechi NF.

J Cell Biochem. 1999 Sep 15;74(4):648-62.


DNA-dependent protein kinase protects against heat-induced apoptosis.

Nueda A, Hudson F, Mivechi NF, Dynan WS.

J Biol Chem. 1999 May 21;274(21):14988-96.


Structural organization and promoter analysis of murine heat shock transcription factor-1 gene.

Zhang Y, Koushik S, Dai R, Mivechi NF.

J Biol Chem. 1998 Dec 4;273(49):32514-21.


Analysis of the phosphorylation of human heat shock transcription factor-1 by MAP kinase family members.

Kim J, Nueda A, Meng YH, Dynan WS, Mivechi NF.

J Cell Biochem. 1997 Oct 1;67(1):43-54.


Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation.

Bergeron M, Mivechi NF, Giaccia AJ, Giffard RG.

Neurol Res. 1996 Feb;18(1):64-72.


Over-expression of HSP-70 protects astrocytes from combined oxygen-glucose deprivation.

Papadopoulos MC, Sun XY, Cao J, Mivechi NF, Giffard RG.

Neuroreport. 1996 Jan 31;7(2):429-32.


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