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Signal transduction networks during stress combination.

Zandalinas SI, Fritschi FB, Mittler R.

J Exp Bot. 2019 Oct 29. pii: erz486. doi: 10.1093/jxb/erz486. [Epub ahead of print]


Expression of a dominant-negative AtNEET-H89C protein disrupts iron-sulfur metabolism and iron homeostasis in Arabidopsis.

Zandalinas SI, Song L, Sengupta S, McInturf S, Grant DG, Marjault HB, Castro-Guerrero NA, Burks D, Azad RK, Mendoza Cozatl DG, Nechushtai R, Mittler R.

Plant J. 2019 Oct 23. doi: 10.1111/tpj.14581. [Epub ahead of print]


Jasmonic acid is required for plant acclimation to a combination of high light and heat stress.

Balfagón D, Sengupta S, Gómez-Cadenas A, Fritschi FB, Azad R, Mittler R, Zandalinas SI.

Plant Physiol. 2019 Oct 8. pii: pp.00956.2019. doi: 10.1104/pp.19.00956. [Epub ahead of print]


Redox-dependent gating of VDAC by mitoNEET.

Lipper CH, Stofleth JT, Bai F, Sohn YS, Roy S, Mittler R, Nechushtai R, Onuchic JN, Jennings PA.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19924-19929. doi: 10.1073/pnas.1908271116. Epub 2019 Sep 16.


Coordinated and rapid whole-plant systemic stomatal responses.

Devireddy AR, Arbogast J, Mittler R.

New Phytol. 2019 Aug 27. doi: 10.1111/nph.16143. [Epub ahead of print] No abstract available.


Biotechnological Potential of LSD1, EDS1, and PAD4 in the Improvement of Crops and Industrial Plants.

Bernacki MJ, Czarnocka W, Szechyńska-Hebda M, Mittler R, Karpiński S.

Plants (Basel). 2019 Aug 16;8(8). pii: E290. doi: 10.3390/plants8080290. Review.


Whole-Plant Live Imaging of Reactive Oxygen Species.

Fichman Y, Miller G, Mittler R.

Mol Plant. 2019 Sep 2;12(9):1203-1210. doi: 10.1016/j.molp.2019.06.003. Epub 2019 Jun 18.


4-Coumarate 3-hydroxylase in the lignin biosynthesis pathway is a cytosolic ascorbate peroxidase.

Barros J, Escamilla-Trevino L, Song L, Rao X, Serrani-Yarce JC, Palacios MD, Engle N, Choudhury FK, Tschaplinski TJ, Venables BJ, Mittler R, Dixon RA.

Nat Commun. 2019 Apr 30;10(1):1994. doi: 10.1038/s41467-019-10082-7.


The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells.

Iosub-Amir A, Bai F, Sohn YS, Song L, Tamir S, Marjault HB, Mayer G, Karmi O, Jennings PA, Mittler R, Onuchic JN, Friedler A, Nechushtai R.

Chem Sci. 2018 Nov 20;10(3):665-673. doi: 10.1039/c8sc03390k. eCollection 2019 Jan 21.



Rivero RM, Oliver MJ, Mittler R.

Physiol Plant. 2019 Feb;165(2):125-127. doi: 10.1111/ppl.12884. No abstract available.


Identification and characterization of a core set of ROS wave-associated transcripts involved in the systemic acquired acclimation response of Arabidopsis to excess light.

Zandalinas SI, Sengupta S, Burks D, Azad RK, Mittler R.

Plant J. 2019 Apr;98(1):126-141. doi: 10.1111/tpj.14205. Epub 2019 Jan 30.


Rapid Responses to Abiotic Stress: Priming the Landscape for the Signal Transduction Network.

Kollist H, Zandalinas SI, Sengupta S, Nuhkat M, Kangasjärvi J, Mittler R.

Trends Plant Sci. 2019 Jan;24(1):25-37. doi: 10.1016/j.tplants.2018.10.003. Epub 2018 Nov 3. Review.


Local and Systemic Metabolic Responses during Light-Induced Rapid Systemic Signaling.

Choudhury FK, Devireddy AR, Azad RK, Shulaev V, Mittler R.

Plant Physiol. 2018 Dec;178(4):1461-1472. doi: 10.1104/pp.18.01031. Epub 2018 Oct 2.


Rapid accumulation of glutathione during light stress in Arabidopsis.

Choudhury FK, Devireddy AR, Azad RK, Shulaev V, Mittler R.

Plant Cell Physiol. 2018 May 25. doi: 10.1093/pcp/pcy101. [Epub ahead of print]


The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans.

King SD, Gray CF, Song L, Nechushtai R, Gumienny TL, Mittler R, Padilla PA.

Cell Death Differ. 2019 Jan;26(1):162-178. doi: 10.1038/s41418-018-0108-5. Epub 2018 Apr 17.


Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin.

Sengupta S, Nechushtai R, Jennings PA, Onuchic JN, Padilla PA, Azad RK, Mittler R.

Sci Rep. 2018 Mar 19;8(1):4840. doi: 10.1038/s41598-018-23305-6.


Tolerance to Stress Combination in Tomato Plants: New Insights in the Protective Role of Melatonin.

Martinez V, Nieves-Cordones M, Lopez-Delacalle M, Rodenas R, Mestre TC, Garcia-Sanchez F, Rubio F, Nortes PA, Mittler R, Rivero RM.

Molecules. 2018 Feb 28;23(3). pii: E535. doi: 10.3390/molecules23030535.


Coordinating the overall stomatal response of plants: Rapid leaf-to-leaf communication during light stress.

Devireddy AR, Zandalinas SI, Gómez-Cadenas A, Blumwald E, Mittler R.

Sci Signal. 2018 Feb 20;11(518). pii: eaam9514. doi: 10.1126/scisignal.aam9514.


NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer.

Mittler R, Darash-Yahana M, Sohn YS, Bai F, Song L, Cabantchik IZ, Jennings PA, Onuchic JN, Nechushtai R.

Antioxid Redox Signal. 2019 Mar 10;30(8):1083-1095. doi: 10.1089/ars.2018.7502. Epub 2018 Mar 29.


The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease.

Karmi O, Marjault HB, Pesce L, Carloni P, Onuchic JN, Jennings PA, Mittler R, Nechushtai R.

J Biol Inorg Chem. 2018 Jun;23(4):599-612. doi: 10.1007/s00775-018-1538-8. Epub 2018 Feb 12. Review.


Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.

Lipper CH, Karmi O, Sohn YS, Darash-Yahana M, Lammert H, Song L, Liu A, Mittler R, Nechushtai R, Onuchic JN, Jennings PA.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):272-277. doi: 10.1073/pnas.1715842115. Epub 2017 Dec 19.


ROS-induced ROS release in plant and animal cells.

Zandalinas SI, Mittler R.

Free Radic Biol Med. 2018 Jul;122:21-27. doi: 10.1016/j.freeradbiomed.2017.11.028. Epub 2017 Dec 2. Review.


Molecular Dynamics Simulations of the [2Fe-2S] Cluster-Binding Domain of NEET Proteins Reveal Key Molecular Determinants That Induce Their Cluster Transfer/Release.

Pesce L, Calandrini V, Marjault HB, Lipper CH, Rossetti G, Mittler R, Jennings PA, Bauer A, Nechushtai R, Carloni P.

J Phys Chem B. 2017 Nov 30;121(47):10648-10656. doi: 10.1021/acs.jpcb.7b10584. Epub 2017 Nov 16.


Interactions between mitoNEET and NAF-1 in cells.

Karmi O, Holt SH, Song L, Tamir S, Luo Y, Bai F, Adenwalla A, Darash-Yahana M, Sohn YS, Jennings PA, Azad RK, Onuchic JN, Morcos F, Nechushtai R, Mittler R.

PLoS One. 2017 Apr 20;12(4):e0175796. doi: 10.1371/journal.pone.0175796. eCollection 2017.


Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates.

Inupakutika MA, Sengupta S, Nechushtai R, Jennings PA, Onuchic JN, Azad RK, Padilla P, Mittler R.

Sci Rep. 2017 Feb 16;7:42571. doi: 10.1038/srep42571.


Evidence for the Involvement of Electrical, Calcium and ROS Signaling in the Systemic Regulation of Non-Photochemical Quenching and Photosynthesis.

Białasek M, Górecka M, Mittler R, Karpiński S.

Plant Cell Physiol. 2017 Feb 10. doi: 10.1093/pcp/pcw232. [Epub ahead of print]


Orchestrating rapid long-distance signaling in plants with Ca2+ , ROS and electrical signals.

Choi WG, Miller G, Wallace I, Harper J, Mittler R, Gilroy S.

Plant J. 2017 May;90(4):698-707. doi: 10.1111/tpj.13492. Epub 2017 Mar 30.


Plant adaptations to the combination of drought and high temperatures.

Zandalinas SI, Mittler R, Balfagón D, Arbona V, Gómez-Cadenas A.

Physiol Plant. 2018 Jan;162(1):2-12. doi: 10.1111/ppl.12540. Epub 2017 Feb 22. Review.


The evolution of reactive oxygen species metabolism.

Inupakutika MA, Sengupta S, Devireddy AR, Azad RK, Mittler R.

J Exp Bot. 2016 Nov;67(21):5933-5943. Epub 2016 Oct 14. Review.


Reactive oxygen species, abiotic stress and stress combination.

Choudhury FK, Rivero RM, Blumwald E, Mittler R.

Plant J. 2017 Jun;90(5):856-867. doi: 10.1111/tpj.13299. Epub 2016 Nov 1. Review.


ROS Are Good.

Mittler R.

Trends Plant Sci. 2017 Jan;22(1):11-19. doi: 10.1016/j.tplants.2016.08.002. Epub 2016 Sep 23. Review.


Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.

Darash-Yahana M, Pozniak Y, Lu M, Sohn YS, Karmi O, Tamir S, Bai F, Song L, Jennings PA, Pikarsky E, Geiger T, Onuchic JN, Mittler R, Nechushtai R.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10890-5. doi: 10.1073/pnas.1612736113. Epub 2016 Sep 12.


Corrigendum: Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.

Bohannon C, Powers R, Satyabhama L, Cui A, Tipton C, Michaeli M, Skountzou I, Mittler RS, Kleinstein SH, Mehr R, Lee FE, Sanz I, Jacob J.

Nat Commun. 2016 Aug 16;7:12687. doi: 10.1038/ncomms12687. No abstract available.


ABA is required for the accumulation of APX1 and MBF1c during a combination of water deficit and heat stress.

Zandalinas SI, Balfagón D, Arbona V, Gómez-Cadenas A, Inupakutika MA, Mittler R.

J Exp Bot. 2016 Oct;67(18):5381-5390. Epub 2016 Aug 6.


GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome.

Danielpur L, Sohn YS, Karmi O, Fogel C, Zinger A, Abu-Libdeh A, Israeli T, Riahi Y, Pappo O, Birk R, Zangen DH, Mittler R, Cabantchik ZI, Cerasi E, Nechushtai R, Leibowitz G.

J Clin Endocrinol Metab. 2016 Oct;101(10):3592-3599. Epub 2016 Jul 26.


Recent Progress in Understanding the Role of Reactive Oxygen Species in Plant Cell Signaling.

Dietz KJ, Mittler R, Noctor G.

Plant Physiol. 2016 Jul;171(3):1535-9. doi: 10.1104/pp.16.00938. No abstract available.


Accumulation of Flavonols over Hydroxycinnamic Acids Favors Oxidative Damage Protection under Abiotic Stress.

Martinez V, Mestre TC, Rubio F, Girones-Vilaplana A, Moreno DA, Mittler R, Rivero RM.

Front Plant Sci. 2016 Jun 15;7:838. doi: 10.3389/fpls.2016.00838. eCollection 2016.


Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.

Bohannon C, Powers R, Satyabhama L, Cui A, Tipton C, Michaeli M, Skountzou I, Mittler RS, Kleinstein SH, Mehr R, Lee FE, Sanz I, Jacob J.

Nat Commun. 2016 Jun 7;7:11826. doi: 10.1038/ncomms11826. Erratum in: Nat Commun. 2016 Aug 16;7:12687. Lee, Francis Eun-Hyung [Lee, Frances Eun-Hyung].


ROS, Calcium, and Electric Signals: Key Mediators of Rapid Systemic Signaling in Plants.

Gilroy S, Białasek M, Suzuki N, Górecka M, Devireddy AR, Karpiński S, Mittler R.

Plant Physiol. 2016 Jul;171(3):1606-15. doi: 10.1104/pp.16.00434. Epub 2016 May 10. No abstract available.


Humoral and Cell-Mediated Immune Responses to Alternate Booster Schedules of Anthrax Vaccine Adsorbed in Humans.

Quinn CP, Sabourin CL, Schiffer JM, Niemuth NA, Semenova VA, Li H, Rudge TL, Brys AM, Mittler RS, Ibegbu CC, Wrammert J, Ahmed R, Parker SD, Babcock J, Keitel W, Poland GA, Keyserling HL, El Sahly H, Jacobson RM, Marano N, Plikaytis BD, Wright JG.

Clin Vaccine Immunol. 2016 Apr 4;23(4):326-38. doi: 10.1128/CVI.00696-15. Print 2016 Apr.


ABA Is Required for Plant Acclimation to a Combination of Salt and Heat Stress.

Suzuki N, Bassil E, Hamilton JS, Inupakutika MA, Zandalinas SI, Tripathy D, Luo Y, Dion E, Fukui G, Kumazaki A, Nakano R, Rivero RM, Verbeck GF, Azad RK, Blumwald E, Mittler R.

PLoS One. 2016 Jan 29;11(1):e0147625. doi: 10.1371/journal.pone.0147625. eCollection 2016.


Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells.

Holt SH, Darash-Yahana M, Sohn YS, Song L, Karmi O, Tamir S, Michaeli D, Luo Y, Paddock ML, Jennings PA, Onuchic JN, Azad RK, Pikarsky E, Cabantchik IZ, Nechushtai R, Mittler R.

J Cell Sci. 2016 Jan 1;129(1):155-65. doi: 10.1242/jcs.178293. Epub 2015 Nov 30.


Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis.

Lipper CH, Paddock ML, Onuchic JN, Mittler R, Nechushtai R, Jennings PA.

PLoS One. 2015 Oct 8;10(10):e0139699. doi: 10.1371/journal.pone.0139699. eCollection 2015.


Ultra-fast alterations in mRNA levels uncover multiple players in light stress acclimation in plants.

Suzuki N, Devireddy AR, Inupakutika MA, Baxter A, Miller G, Song L, Shulaev E, Azad RK, Shulaev V, Mittler R.

Plant J. 2015 Nov;84(4):760-72. doi: 10.1111/tpj.13039.


The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.

Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis EA, Jennings PA, Onuchic JN, Mittler R, Nechushtai R.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3698-703. doi: 10.1073/pnas.1502960112. Epub 2015 Mar 11.


The roles of ROS and ABA in systemic acquired acclimation.

Mittler R, Blumwald E.

Plant Cell. 2015 Jan;27(1):64-70. doi: 10.1105/tpc.114.133090. Epub 2015 Jan 20. Review.


Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.

Tamir S, Paddock ML, Darash-Yahana-Baram M, Holt SH, Sohn YS, Agranat L, Michaeli D, Stofleth JT, Lipper CH, Morcos F, Cabantchik IZ, Onuchic JN, Jennings PA, Mittler R, Nechushtai R.

Biochim Biophys Acta. 2015 Jun;1853(6):1294-315. doi: 10.1016/j.bbamcr.2014.10.014. Epub 2014 Oct 23. Review.


Interview with Ron Mittler.

Mittler R.

Trends Plant Sci. 2014 Oct;19(10):611-2. doi: 10.1016/j.tplants.2014.07.009. Epub 2014 Aug 19. No abstract available.


A tidal wave of signals: calcium and ROS at the forefront of rapid systemic signaling.

Gilroy S, Suzuki N, Miller G, Choi WG, Toyota M, Devireddy AR, Mittler R.

Trends Plant Sci. 2014 Oct;19(10):623-30. doi: 10.1016/j.tplants.2014.06.013. Epub 2014 Jul 23.


A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.

Tamir S, Eisenberg-Domovich Y, Conlan AR, Stofleth JT, Lipper CH, Paddock ML, Mittler R, Jennings PA, Livnah O, Nechushtai R.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1572-8. doi: 10.1107/S1399004714005458. Epub 2014 May 23.

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