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Items: 26


Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.

Mittelstadt PR, Taves MD, Ashwell JD.

J Immunol. 2018 Mar 15;200(6):1988-1994. doi: 10.4049/jimmunol.1701328. Epub 2018 Feb 9.


Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12.


Recruitment of calcineurin to the TCR positively regulates T cell activation.

Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD.

Nat Immunol. 2017 Feb;18(2):196-204. doi: 10.1038/ni.3640. Epub 2016 Dec 12.


Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes.

Kugler DG, Flomerfelt FA, Costa DL, Laky K, Kamenyeva O, Mittelstadt PR, Gress RE, Rosshart SP, Rehermann B, Ashwell JD, Sher A, Jankovic D.

J Exp Med. 2016 Dec 12;213(13):3041-3056. Epub 2016 Nov 14.


Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity.

Solano ME, Holmes MC, Mittelstadt PR, Chapman KE, Tolosa E.

Semin Immunopathol. 2016 Nov;38(6):739-763. Epub 2016 Jul 28. Review.


The TBK1-binding domain of optineurin promotes type I interferon responses.

Meena NP, Zhu G, Mittelstadt PR, Giardino Torchia ML, Pourcelot M, Arnoult D, Ashwell JD, Munitic I.

FEBS Lett. 2016 May;590(10):1498-508. doi: 10.1002/1873-3468.12176. Epub 2016 May 4.


Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis.

Li CC, Munitic I, Mittelstadt PR, Castro E, Ashwell JD.

PLoS Biol. 2015 Oct 6;13(10):e1002269. doi: 10.1371/journal.pbio.1002269. eCollection 2015 Oct.


Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.

Presman DM, Ogara MF, Stortz M, Alvarez LD, Pooley JR, Schiltz RL, Grøntved L, Johnson TA, Mittelstadt PR, Ashwell JD, Ganesan S, Burton G, Levi V, Hager GL, Pecci A.

PLoS Biol. 2014 Mar 18;12(3):e1001813. doi: 10.1371/journal.pbio.1001813. eCollection 2014 Mar.


Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.

Guo L, Zheng Z, Ai J, Howatt DA, Mittelstadt PR, Thacker S, Daugherty A, Ashwell JD, Remaley AT, Li XA.

Arterioscler Thromb Vasc Biol. 2014 May;34(5):966-75. doi: 10.1161/ATVBAHA.113.302484. Epub 2014 Mar 6.


CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection.

Kugler DG, Mittelstadt PR, Ashwell JD, Sher A, Jankovic D.

J Exp Med. 2013 Sep 23;210(10):1919-27. doi: 10.1084/jem.20122300. Epub 2013 Aug 26.


Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness.

Mittelstadt PR, Monteiro JP, Ashwell JD.

J Clin Invest. 2012 Jul;122(7):2384-94. doi: 10.1172/JCI63067. Epub 2012 Jun 1.


Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.

Jirmanova L, Giardino Torchia ML, Sarma ND, Mittelstadt PR, Ashwell JD.

Blood. 2011 Sep 22;118(12):3280-9. doi: 10.1182/blood-2011-01-333039. Epub 2011 Jun 28.


T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.

Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD.

J Biol Chem. 2009 Jun 5;284(23):15469-74. doi: 10.1074/jbc.M901004200. Epub 2009 Mar 25.


Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.

Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD.

Blood. 2009 Mar 5;113(10):2229-37. doi: 10.1182/blood-2008-04-153304. Epub 2008 Nov 14.


Activating p38 MAPK: new tricks for an old kinase.

Mittelstadt PR, Salvador JM, Fornace AJ Jr, Ashwell JD.

Cell Cycle. 2005 Sep;4(9):1189-92. Epub 2005 Sep 20. Review.


The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ Jr, Ashwell JD.

Nat Immunol. 2005 Apr;6(4):396-402. Epub 2005 Feb 27.


Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.

Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ Jr, Ashwell JD.

Nat Immunol. 2005 Apr;6(4):390-5. Epub 2005 Feb 27.


Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression.

Mittelstadt PR, Ashwell JD.

Mol Endocrinol. 2003 Aug;17(8):1534-42. Epub 2003 May 15.


Glucocorticoid-inducible genes that regulate T-cell function.

Mittelstadt PR, Galon J, Franchimont D, O'Shea JJ, Ashwell JD.

Ernst Schering Res Found Workshop. 2002;(40):319-39. Review. No abstract available.


HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.

Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD.

J Biol Chem. 2002 May 31;277(22):19482-7. Epub 2002 Mar 21.


Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.

Mittelstadt PR, Ashwell JD.

J Biol Chem. 2001 Aug 3;276(31):29603-10. Epub 2001 Jun 7.


Sequential involvement of NFAT and Egr transcription factors in FasL regulation.

Rengarajan J, Mittelstadt PR, Mages HW, Gerth AJ, Kroczek RA, Ashwell JD, Glimcher LH.

Immunity. 2000 Mar;12(3):293-300.


Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression.

Mittelstadt PR, Ashwell JD.

Mol Cell Biol. 1998 Jul;18(7):3744-51.


Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis.

DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L.

Adv Exp Med Biol. 1994;365:9-22.


Induction of early response genes by cross-linking membrane Ig on B lymphocytes.

Mittelstadt PR, DeFranco AL.

J Immunol. 1993 Jun 1;150(11):4822-32.


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