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Mechanisms by Which Obesity Impacts Survival from Acute Lymphoblastic Leukemia.

Orgel E, Sea JL, Mittelman SD.

J Natl Cancer Inst Monogr. 2019 Sep 1;2019(54):152-156. doi: 10.1093/jncimonographs/lgz020.


Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia.

Sea JL, Orgel E, Chen T, Paszkiewicz RL, Krall AS, Oberley MJ, Stiles L, Mittelman SD.

Leuk Lymphoma. 2019 Sep 16:1-9. doi: 10.1080/10428194.2019.1666379. [Epub ahead of print]


Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia.

Mueske NM, Mittelman SD, Wren TAL, Gilsanz V, Orgel E.

Leuk Lymphoma. 2019 Jul 2:1-8. doi: 10.1080/10428194.2019.1623889. [Epub ahead of print]


Central diabetes insipidus associated with refeeding in anorexia nervosa: A case report.

Rosen EL, Thambundit A, Mehler PS, Mittelman SD.

Int J Eat Disord. 2019 Jun;52(6):752-756. doi: 10.1002/eat.23087. Epub 2019 Apr 30.


Proposed endocrine funding priorities for the NICHD strategic plan: expert opinion from the Pediatric Endocrine Society.

Singer K, Katz ML, Mittelman SD; PES Research Affairs Committee.

Pediatr Res. 2019 Aug;86(2):141-143. doi: 10.1038/s41390-019-0401-0. Epub 2019 Apr 17. No abstract available.


Iodine Nutrition in Weaning Infants in the United States.

Fallah R, Du L, Braverman LE, He X, Segura-Harrison M, Yeh MW, Pearce EN, Chiu HK, Mittelman SD, Leung AM.

Thyroid. 2019 Apr;29(4):573-576. doi: 10.1089/thy.2018.0102. Epub 2019 Mar 22.


An addiction-based mobile health weight loss intervention: protocol of a randomized controlled trial.

Vidmar AP, Salvy SJ, Pretlow R, Mittelman SD, Wee CP, Fink C, Steven Fox D, Raymond JK.

Contemp Clin Trials. 2019 Mar;78:11-19. doi: 10.1016/j.cct.2019.01.008. Epub 2019 Jan 14.


Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.

Oliveira FMS, Tran WH, Lesser DJ, Bhatia R, Keens TG, Mittelman SD, Davidson Ward SL, Khoo MCK.

Pediatr Res. 2019 May;85(6):790-798. doi: 10.1038/s41390-018-0226-2. Epub 2018 Nov 12.


Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice.

Tucci J, Alhushki W, Chen T, Sheng X, Kim YM, Mittelman SD.

Cancer Metab. 2018 Nov 1;6:15. doi: 10.1186/s40170-018-0189-0. eCollection 2018.


An addiction model-based mobile health weight loss intervention in adolescents with obesity.

Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittelman SD.

Pediatr Obes. 2019 Feb;14(2):e12464. doi: 10.1111/ijpo.12464. Epub 2018 Aug 16.


Adipocyte metabolism of the chemotherapy daunorubicin.

Mittelman SD, Orgel E.

Oncoscience. 2018 Jun 25;5(5-6):146-147. doi: 10.18632/oncoscience.428. eCollection 2018 May. No abstract available.


Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia.

Prasca S, Carmona R, Ji L, Ko RH, Bhojwani D, Rawlins YA, Mittelman SD, Young G, Orgel E.

Thromb Res. 2018 May;165:44-50. doi: 10.1016/j.thromres.2018.02.150. Epub 2018 Mar 2.


Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention.

Dieli-Conwright CM, Parmentier JH, Sami N, Lee K, Spicer D, Mack WJ, Sattler F, Mittelman SD.

Breast Cancer Res Treat. 2018 Feb;168(1):147-157. doi: 10.1007/s10549-017-4576-y. Epub 2017 Nov 22.


Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin.

Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD.

Mol Cancer Res. 2017 Dec;15(12):1704-1713. doi: 10.1158/1541-7786.MCR-17-0338. Epub 2017 Nov 8.


A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro.

Maggi M, Mittelman SD, Parmentier JH, Colombo G, Meli M, Whitmire JM, Merrell DS, Whitelegge J, Scotti C.

Sci Rep. 2017 Nov 3;7(1):14479. doi: 10.1038/s41598-017-15075-4.


A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia.

Orgel E, Mueske NM, Sposto R, Gilsanz V, Wren TAL, Freyer DR, Butturini AM, Mittelman SD.

Leuk Lymphoma. 2017 Oct;58(10):2370-2378. doi: 10.1080/10428194.2017.1289526. Epub 2017 Feb 20.


Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response.

Sheng X, Tucci J, Parmentier JH, Ji L, Behan JW, Heisterkamp N, Mittelman SD.

Oncotarget. 2016 Nov 8;7(45):73147-73159. doi: 10.18632/oncotarget.12246.


Effects of exenatide on weight and appetite in overweight adolescents and young adults with Prader-Willi syndrome.

Salehi P, Hsu I, Azen CG, Mittelman SD, Geffner ME, Jeandron D.

Pediatr Obes. 2017 Jun;12(3):221-228. doi: 10.1111/ijpo.12131. Epub 2016 Apr 13.


Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia.

Orgel E, Mueske NM, Wren TA, Gilsanz V, Butturini AM, Freyer DR, Mittelman SD.

Bone. 2016 Apr;85:131-7. doi: 10.1016/j.bone.2016.01.027. Epub 2016 Feb 3.


Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy.

Orgel E, Mueske NM, Sposto R, Gilsanz V, Freyer DR, Mittelman SD.

Leuk Lymphoma. 2018 Jan;59(1):138-145. doi: 10.3109/10428194.2015.1136741. Epub 2016 Jan 27.


Fasting serum blood measures of bone and lipid metabolism in children with myelomeningocele for early detection of cardiovascular and bone fragility risk factors.

Van Speybroeck A, Mueske NM, Mittelman SD, Kremer RK, Ryan DD, Wren TA.

J Spinal Cord Med. 2017 Mar;40(2):193-200. doi: 10.1080/10790268.2015.1101983. Epub 2015 Dec 14.


Increased Abdominal Adiposity in Adolescents and Young Adults With Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.

Kim MS, Ryabets-Lienhard A, Dao-Tran A, Mittelman SD, Gilsanz V, Schrager SM, Geffner ME.

J Clin Endocrinol Metab. 2015 Aug;100(8):E1153-9. doi: 10.1210/jc.2014-4033. Epub 2015 Jun 10.


Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.

Parmentier JH, Maggi M, Tarasco E, Scotti C, Avramis VI, Mittelman SD.

Leuk Res. 2015 Jul;39(7):757-62. doi: 10.1016/j.leukres.2015.04.008. Epub 2015 Apr 22.


Institutional adherence to cardiovascular risk factor screening guidelines for young survivors of acute lymphoblastic leukemia.

Lin MH, Wood JR, Mittelman SD, Freyer DR.

J Pediatr Hematol Oncol. 2015 May;37(4):e253-7. doi: 10.1097/MPH.0000000000000320.


Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics.

Alderete TL, Sattler FR, Richey JM, Allayee H, Mittelman SD, Sheng X, Tucci J, Gyllenhammer LE, Grant EG, Goran MI.

Obesity (Silver Spring). 2015 Mar;23(3):543-51. doi: 10.1002/oby.20991. Epub 2015 Feb 3.


Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia.

Orgel E, Tucci J, Alhushki W, Malvar J, Sposto R, Fu CH, Freyer DR, Abdel-Azim H, Mittelman SD.

Blood. 2014 Dec 18;124(26):3932-8. doi: 10.1182/blood-2014-08-595389. Epub 2014 Oct 27.


A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing.

Huang KE, Mittelman SD, Coates TD, Geffner ME, Wood JC.

J Pediatr Hematol Oncol. 2015 Jan;37(1):54-9. doi: 10.1097/MPH.0000000000000199.


The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia.

Sheng X, Mittelman SD.

Front Pediatr. 2014 Jun 5;2:53. doi: 10.3389/fped.2014.00053. eCollection 2014. Review.


A novel biopsy method to increase yield of subcutaneous abdominal adipose tissue.

Alderete TL, Sattler FR, Sheng X, Tucci J, Mittelman SD, Grant EG, Goran MI.

Int J Obes (Lond). 2015 Jan;39(1):183-6. doi: 10.1038/ijo.2014.90. Epub 2014 May 21.


Activation of adipose tissue macrophages in obese mice does not require lymphocytes.

Behan JW, Ehsanipour EA, Sheng X, Pramanik R, Wang X, Hsieh YT, Kim YM, Mittelman SD.

Obesity (Silver Spring). 2013 Jul;21(7):1380-8. doi: 10.1002/oby.20159. Epub 2013 Jun 11.


Adipocyte differentiation is affected by media height above the cell layer.

Sheng X, Tucci J, Malvar J, Mittelman SD.

Int J Obes (Lond). 2014 Feb;38(2):315-20. doi: 10.1038/ijo.2013.96. Epub 2013 Jun 7.


Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.

Ehsanipour EA, Sheng X, Behan JW, Wang X, Butturini A, Avramis VI, Mittelman SD.

Cancer Res. 2013 May 15;73(10):2998-3006. doi: 10.1158/0008-5472.CAN-12-4402. Epub 2013 Apr 12.


Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy.

Pramanik R, Sheng X, Ichihara B, Heisterkamp N, Mittelman SD.

Leuk Res. 2013 May;37(5):503-9. doi: 10.1016/j.leukres.2012.12.013. Epub 2013 Jan 17.


The links between insulin resistance, diabetes, and cancer.

Orgel E, Mittelman SD.

Curr Diab Rep. 2013 Apr;13(2):213-22. doi: 10.1007/s11892-012-0356-6. Review.


Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males.

Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SD, Khoo MC, Davidson Ward SL.

Pediatr Res. 2012 Sep;72(3):293-8. doi: 10.1038/pr.2012.73. Epub 2012 Jun 5.


Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone.

Antony R, Sheng X, Ehsanipour EA, Ng E, Pramanik R, Klemm L, Ichihara B, Mittelman SD.

Leuk Res. 2012 May;36(5):591-3. doi: 10.1016/j.leukres.2012.01.011. Epub 2012 Feb 16.


Pituitary iron and volume predict hypogonadism in transfusional iron overload.

Noetzli LJ, Panigrahy A, Mittelman SD, Hyderi A, Dongelyan A, Coates TD, Wood JC.

Am J Hematol. 2012 Feb;87(2):167-71. doi: 10.1002/ajh.22247. Epub 2011 Dec 27.


Pancreatic iron and glucose dysregulation in thalassemia major.

Noetzli LJ, Mittelman SD, Watanabe RM, Coates TD, Wood JC.

Am J Hematol. 2012 Feb;87(2):155-60. doi: 10.1002/ajh.22223. Epub 2011 Nov 24.


A longitudinal assessment of lipids in youth with type 1 diabetes.

Reh CM, Mittelman SD, Wee CP, Shah AC, Kaufman FR, Wood JR.

Pediatr Diabetes. 2011 Jun;12(4 Pt 2):365-71. doi: 10.1111/j.1399-5448.2010.00733.x. Epub 2011 Mar 11.


Autonomic and metabolic effects of OSA in childhood obesity.

Oliveira FM, Tran WH, Lesser D, Bhatia R, Ortega R, Mittelman SD, Keens TG, Davidson Ward SL, Khoo MC.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:6134-7. doi: 10.1109/IEMBS.2010.5627789.


Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models.

Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD.

Cancer Prev Res (Phila). 2010 Oct;3(10):1259-64. doi: 10.1158/1940-6207.CAPR-10-0087. Epub 2010 Sep 7.


Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY.

Mittelman SD, Klier K, Braun S, Azen C, Geffner ME, Buchanan TA.

Obesity (Silver Spring). 2010 May;18(5):918-25. doi: 10.1038/oby.2009.499. Epub 2010 Jan 21.


Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice.

Behan JW, Avramis VI, Yun JP, Louie SG, Mittelman SD.

Pharmacol Res. 2010 May;61(5):385-90. doi: 10.1016/j.phrs.2010.01.007. Epub 2010 Jan 18.


Adiposity predicts carotid intima-media thickness in healthy children and adolescents.

Mittelman SD, Gilsanz P, Mo AO, Wood J, Dorey F, Gilsanz V.

J Pediatr. 2010 Apr;156(4):592-7.e2. doi: 10.1016/j.jpeds.2009.10.014. Epub 2009 Dec 14.


Adipocytes impair leukemia treatment in mice.

Behan JW, Yun JP, Proektor MP, Ehsanipour EA, Arutyunyan A, Moses AS, Avramis VI, Louie SG, Butturini A, Heisterkamp N, Mittelman SD.

Cancer Res. 2009 Oct 1;69(19):7867-74. doi: 10.1158/0008-5472.CAN-09-0800. Epub 2009 Sep 22.


Reciprocal relations of subcutaneous and visceral fat to bone structure and strength.

Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD.

J Clin Endocrinol Metab. 2009 Sep;94(9):3387-93. doi: 10.1210/jc.2008-2422. Epub 2009 Jun 16.


Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults.

Di Iorgi N, Mittelman SD, Gilsanz V.

Int J Obes (Lond). 2008 Dec;32(12):1854-60. doi: 10.1038/ijo.2008.170. Epub 2008 Oct 7.


Reciprocal relation between marrow adiposity and the amount of bone in the axial and appendicular skeleton of young adults.

Di Iorgi N, Rosol M, Mittelman SD, Gilsanz V.

J Clin Endocrinol Metab. 2008 Jun;93(6):2281-6. doi: 10.1210/jc.2007-2691. Epub 2008 Apr 1.


Relationship of highly sensitive C-reactive protein and lipid levels in adolescents with type 1 diabetes mellitus.

Karantza MV, Mittelman SD, Dorey F, Samie S, Kaiserman K, Halvorson M, Kaufman FR.

Pediatr Diabetes. 2008 Apr;9(2):122-6. Epub 2007 Nov 23.


Fat mass is not beneficial to bone in adolescents and young adults.

Janicka A, Wren TA, Sanchez MM, Dorey F, Kim PS, Mittelman SD, Gilsanz V.

J Clin Endocrinol Metab. 2007 Jan;92(1):143-7. Epub 2006 Oct 17.


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