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Phase separation in biology and disease-a symposium report.

Cable J, Brangwynne C, Seydoux G, Cowburn D, Pappu RV, Castañeda CA, Berchowitz LE, Chen Z, Jonikas M, Dernburg A, Mittag T, Fawzi NL.

Ann N Y Acad Sci. 2019 Jun 14. doi: 10.1111/nyas.14126. [Epub ahead of print]


Dwelling at membranes promotes decisive signaling.

Martin EW, Mittag T.

Science. 2019 Mar 8;363(6431):1036-1037. doi: 10.1126/science.aaw6434. No abstract available.


Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.

Alberti S, Gladfelter A, Mittag T.

Cell. 2019 Jan 24;176(3):419-434. doi: 10.1016/j.cell.2018.12.035. Review.


Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.

Bouchard JJ, Otero JH, Scott DC, Szulc E, Martin EW, Sabri N, Granata D, Marzahn MR, Lindorff-Larsen K, Salvatella X, Schulman BA, Mittag T.

Mol Cell. 2018 Oct 4;72(1):19-36.e8. doi: 10.1016/j.molcel.2018.08.027. Epub 2018 Sep 20.


Multiple Modes of Protein-Protein Interactions Promote RNP Granule Assembly.

Mittag T, Parker R.

J Mol Biol. 2018 Nov 2;430(23):4636-4649. doi: 10.1016/j.jmb.2018.08.005. Epub 2018 Aug 9. Review.


Protein quality and miRNA slicing get into phase.

Mittag T, Fawzi NL.

Nat Cell Biol. 2018 Jun;20(6):635-637. doi: 10.1038/s41556-018-0113-4. No abstract available.


Protein Phase Separation: A New Phase in Cell Biology.

Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M.

Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27. Review.


Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions.

Martin EW, Mittag T.

Biochemistry. 2018 May 1;57(17):2478-2487. doi: 10.1021/acs.biochem.8b00008. Epub 2018 Mar 16.


A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL.

EMBO J. 2018 Mar 1;37(5). pii: e97452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.


TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, Murray ME, Kato M, Fryer JD, Petrucelli L, Zinman L, Weintraub S, Mesulam M, Keith J, Zivkovic SA, Hirsch-Reinshagen V, Roos RP, Züchner S, Graff-Radford NR, Petersen RC, Caselli RJ, Wszolek ZK, Finger E, Lippa C, Lacomis D, Stewart H, Dickson DW, Kim HJ, Rogaeva E, Bigio E, Boylan KB, Taylor JP, Rademakers R.

Neuron. 2017 Aug 16;95(4):808-816.e9. doi: 10.1016/j.neuron.2017.07.025.


An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase.

Csizmok V, Orlicky S, Cheng J, Song J, Bah A, Delgoshaie N, Lin H, Mittag T, Sicheri F, Chan HS, Tyers M, Forman-Kay JD.

Nat Commun. 2017 Jan 3;8:13943. doi: 10.1038/ncomms13943.


Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation.

Martin EW, Holehouse AS, Grace CR, Hughes A, Pappu RV, Mittag T.

J Am Chem Soc. 2016 Nov 30;138(47):15323-15335. Epub 2016 Nov 17.


Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.

Marzahn MR, Marada S, Lee J, Nourse A, Kenrick S, Zhao H, Ben-Nissan G, Kolaitis RM, Peters JL, Pounds S, Errington WJ, Privé GG, Taylor JP, Sharon M, Schuck P, Ogden SK, Mittag T.

EMBO J. 2016 Jun 15;35(12):1254-75. doi: 10.15252/embj.201593169. Epub 2016 May 23.


Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.

Pierce WK, Grace CR, Lee J, Nourse A, Marzahn MR, Watson ER, High AA, Peng J, Schulman BA, Mittag T.

J Mol Biol. 2016 Mar 27;428(6):1256-1271. doi: 10.1016/j.jmb.2015.10.002. Epub 2015 Oct 22.


Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.

Molliex A, Temirov J, Lee J, Coughlin M, Kanagaraj AP, Kim HJ, Mittag T, Taylor JP.

Cell. 2015 Sep 24;163(1):123-33. doi: 10.1016/j.cell.2015.09.015.


Dimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chains.

Feige MJ, Behnke J, Mittag T, Hendershot LM.

J Biol Chem. 2015 Oct 30;290(44):26821-31. doi: 10.1074/jbc.M115.689471. Epub 2015 Sep 23.


Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a protocol for a systematic review and network meta-analysis of primary prevention trials.

Schwingshackl L, Hoffmann G, Buijsse B, Mittag T, Stelmach-Mardas M, Boeing H, Gottschald M, Dietrich S, Arregui M, Dias S.

Syst Rev. 2015 Mar 26;4:34. doi: 10.1186/s13643-015-0029-z.


Protein disorder: wagging a tail at ubiquitin.

Mittag T, Marzahn MR.

Nat Chem Biol. 2015 Jan;11(1):7-8. doi: 10.1038/nchembio.1716. Epub 2014 Dec 17. No abstract available.


Short aggregation-prone peptide detectives: finding proteins and truths about aggregation.

Mittag T, Marzahn MR.

J Mol Biol. 2015 Jan 30;427(2):221-4. doi: 10.1016/j.jmb.2014.10.017. Epub 2014 Nov 1. No abstract available.


Association between water consumption and body weight outcomes in children and adolescents: a systematic review.

Muckelbauer R, Barbosa CL, Mittag T, Burkhardt K, Mikelaishvili N, Müller-Nordhorn J.

Obesity (Silver Spring). 2014 Dec;22(12):2462-75. doi: 10.1002/oby.20911. Review.


Oral microbiome link to neurodegeneration in glaucoma.

Astafurov K, Elhawy E, Ren L, Dong CQ, Igboin C, Hyman L, Griffen A, Mittag T, Danias J.

PLoS One. 2014 Sep 2;9(9):e104416. doi: 10.1371/journal.pone.0104416. eCollection 2014.


The cytoplasmic domain of the T-cell receptor zeta subunit does not form disordered dimers.

Nourse A, Mittag T.

J Mol Biol. 2014 Jan 9;426(1):62-70. doi: 10.1016/j.jmb.2013.09.036. Epub 2013 Oct 10.


From sequence and forces to structure, function, and evolution of intrinsically disordered proteins.

Forman-Kay JD, Mittag T.

Structure. 2013 Sep 3;21(9):1492-9. doi: 10.1016/j.str.2013.08.001.


Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

Duda DM, Olszewski JL, Tron AE, Hammel M, Lambert LJ, Waddell MB, Mittag T, DeCaprio JA, Schulman BA.

Mol Cell. 2012 Aug 10;47(3):371-82. doi: 10.1016/j.molcel.2012.05.044. Epub 2012 Jun 28.


Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.

Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3287-92. doi: 10.1073/pnas.1116455109. Epub 2012 Feb 10.


Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone.

Andreasen M, Nielsen SB, Mittag T, Bjerring M, Nielsen JT, Zhang S, Nielsen EH, Jeppesen M, Christiansen G, Besenbacher F, Dong M, Nielsen NC, Skrydstrup T, Otzen DE.

Biochim Biophys Acta. 2012 Feb;1824(2):274-85. doi: 10.1016/j.bbapap.2011.10.014. Epub 2011 Oct 29.


Gene expression changes in steroid-induced IOP elevation in bovine trabecular meshwork.

Danias J, Gerometta R, Ge Y, Ren L, Panagis L, Mittag TW, Candia OA, Podos SM.

Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8636-45. doi: 10.1167/iovs.11-7563.


Retinal gene expression changes related to IOP exposure and axonal loss in DBA/2J mice.

Panagis L, Zhao X, Ge Y, Ren L, Mittag TW, Danias J.

Invest Ophthalmol Vis Sci. 2011 Oct 3;52(11):7807-16. doi: 10.1167/iovs.10-7063.


Further studies toward the stereocontrolled synthesis of silicon-containing peptide mimics.

Hernández D, Lindsay KB, Nielsen L, Mittag T, Bjerglund K, Friis S, Mose R, Skrydstrup T.

J Org Chem. 2010 May 21;75(10):3283-93. doi: 10.1021/jo100301n.


Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase.

Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD.

Structure. 2010 Mar 14;18(4):494-506. doi: 10.1016/j.str.2010.01.020.


Synthesis of a ketomethylene isostere of the fibrillating peptide SNNFGAILSS.

Mittag T, Otzen DE, Nielsen NC, Skrydstrup T.

J Org Chem. 2009 Oct 16;74(20):7955-7. doi: 10.1021/jo901466b.


Gene expression changes in areas of focal loss of retinal ganglion cells in the retina of DBA/2J mice.

Panagis L, Zhao X, Ge Y, Ren L, Mittag TW, Danias J.

Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2024-34. doi: 10.1167/iovs.09-3560. Epub 2009 Sep 8.


Protein dynamics and conformational disorder in molecular recognition.

Mittag T, Kay LE, Forman-Kay JD.

J Mol Recognit. 2010 Mar-Apr;23(2):105-16. doi: 10.1002/jmr.961. Review. Erratum in: J Mol Recognit. 2010 Mar;23(2):258.


Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.

Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17772-7. doi: 10.1073/pnas.0809222105. Epub 2008 Nov 13.


Comparison of anterior segment structures in two rat glaucoma models: an ultrasound biomicroscopic study.

Nissirios N, Chanis R, Johnson E, Morrison J, Cepurna WO, Jia L, Mittag T, Danias J.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2478-82. doi: 10.1167/iovs.07-0965.


Direct entry to peptidyl ketones via SmI2-mediated C-C bond formation with readily accessible N-peptidyl oxazolidinones.

Mittag T, Christensen KL, Lindsay KB, Nielsen NC, Skrydstrup T.

J Org Chem. 2008 Feb 1;73(3):1088-92. doi: 10.1021/jo702286b. Epub 2007 Dec 29.


Effect of 15-keto latanoprost on intraocular pressure and aqueous humor dynamics in monkey eyes.

Wang RF, Gagliuso DJ, Mittag TW, Podos SM.

Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4143-7.


Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity.

Borg M, Mittag T, Pawson T, Tyers M, Forman-Kay JD, Chan HS.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9650-5. Epub 2007 May 23.


Ceruloplasmin upregulation in retina of murine and human glaucomatous eyes.

Stasi K, Nagel D, Yang X, Ren L, Mittag T, Danias J.

Invest Ophthalmol Vis Sci. 2007 Feb;48(2):727-32.


Atomic-level characterization of disordered protein ensembles.

Mittag T, Forman-Kay JD.

Curr Opin Struct Biol. 2007 Feb;17(1):3-14. Epub 2007 Jan 23. Review.


Noninvasive determination of intraocular pressure (IOP) in nonsedated mice of 5 different inbred strains.

Nissirios N, Goldblum D, Rohrer K, Mittag T, Danias J.

J Glaucoma. 2007 Jan;16(1):57-61.


Apoptotic retinal ganglion cell death in the DBA/2 mouse model of glaucoma.

Reichstein D, Ren L, Filippopoulos T, Mittag T, Danias J.

Exp Eye Res. 2007 Jan;84(1):13-21. Epub 2006 Oct 30.


Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding.

Mittag T, Franzoni L, Cavazzini D, Schaffhausen B, Rossi GL, Günther UL.

J Am Chem Soc. 2006 Aug 2;128(30):9844-8.


Topographic and morphologic analyses of retinal ganglion cell loss in old DBA/2NNia mice.

Filippopoulos T, Danias J, Chen B, Podos SM, Mittag TW.

Invest Ophthalmol Vis Sci. 2006 May;47(5):1968-74.


Conformational switches modulate protein interactions in peptide antibiotic synthetases.

Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V.

Science. 2006 Apr 14;312(5771):273-6.


Predictability and limitations of non-invasive murine tonometry: comparison of two devices.

Filippopoulos T, Matsubara A, Danias J, Huang W, Dobberfuhl A, Ren L, Mittag T, Miller JW, Grosskreutz CL.

Exp Eye Res. 2006 Jul;83(1):194-201. Epub 2006 Mar 24.


Vascular changes in the posterior eye segment of secondary angle-closure glaucoma: cause or consequence?

May CA, Mittag T.

Graefes Arch Clin Exp Ophthalmol. 2006 Nov;244(11):1505-11. Epub 2006 Mar 21.


Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes.

Stasi K, Nagel D, Yang X, Wang RF, Ren L, Podos SM, Mittag T, Danias J.

Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1024-9.


Characterization of retinal damage in the episcleral vein cauterization rat glaucoma model.

Danias J, Shen F, Kavalarakis M, Chen B, Goldblum D, Lee K, Zamora MF, Su Y, Brodie SE, Podos SM, Mittag T.

Exp Eye Res. 2006 Feb;82(2):219-28. Epub 2005 Aug 16. Erratum in: Exp Eye Res. 2006 Oct;83(4):1002. Brodie, Scott E [added].

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