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Items: 1 to 50 of 70

1.

Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers.

Nock S, Höfig C, Harder L, Schomburg L, Brabant G, Mittag J.

Exp Clin Endocrinol Diabetes. 2019 Oct 7. doi: 10.1055/a-1012-8484. [Epub ahead of print]

PMID:
31590191
2.

Fluorescence Correlation Spectroscopy for Particle Sizing in Highly Concentrated Protein Solutions.

Mittag JJ, Jacobs MR, McManus JJ.

Methods Mol Biol. 2019;2039:157-171. doi: 10.1007/978-1-4939-9678-0_12.

PMID:
31342426
3.

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.

Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J.

Cell Rep. 2019 Jun 11;27(11):3385-3400.e3. doi: 10.1016/j.celrep.2019.05.054.

4.

Aortic effects of thyroid hormone in male mice.

Gachkar S, Nock S, Geissler C, Oelkrug R, Johann K, Resch J, Rahman A, Arner A, Kirchner H, Mittag J.

J Mol Endocrinol. 2019 Apr 1;62(3):91-99. doi: 10.1530/JME-18-0217.

PMID:
30608905
5.

Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis.

Krause C, Grohs M, El Gammal A, Wolter S, Lehnert H, Mann O, Mittag J, Kirchner H.

Endocr Connect. 2018 Nov 1. pii: EC-18-0499. doi: 10.1530/EC-18-0499. [Epub ahead of print]

6.

3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines.

Bräunig J, Mergler S, Jyrch S, Hoefig CS, Rosowski M, Mittag J, Biebermann H, Khajavi N.

Front Endocrinol (Lausanne). 2018 Sep 11;9:523. doi: 10.3389/fendo.2018.00523. eCollection 2018.

7.

Peptide Self-Assembly Measured Using Fluorescence Correlation Spectroscopy.

Mittag JJ, Rädler JO, McManus JJ.

Methods Mol Biol. 2018;1777:159-171. doi: 10.1007/978-1-4939-7811-3_8.

PMID:
29744833
8.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM.

Sci Rep. 2018 Apr 12;8(1):5872. doi: 10.1038/s41598-018-24290-6.

9.

In vivo Effects of Repeated Thyronamine Administration in Male C57BL/6J Mice.

Harder L, Schanze N, Sarsenbayeva A, Kugel F, Köhrle J, Schomburg L, Mittag J, Hoefig CS.

Eur Thyroid J. 2018 Jan;7(1):3-12. doi: 10.1159/000481856. Epub 2017 Dec 5.

10.

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor.

Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H.

Front Pharmacol. 2018 Mar 12;9:222. doi: 10.3389/fphar.2018.00222. eCollection 2018.

11.

Effects of sildenafil treatment on thermogenesis and glucose homeostasis in diet-induced obese mice.

Johann K, Reis MC, Harder L, Herrmann B, Gachkar S, Mittag J, Oelkrug R.

Nutr Diabetes. 2018 Mar 13;8(1):9. doi: 10.1038/s41387-018-0026-0.

12.

Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.

Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.

J Neuroendocrinol. 2018 Mar;30(3):e12573. doi: 10.1111/jne.12573.

PMID:
29377458
13.

Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy.

Oelkrug R, Herrmann B, Geissler C, Harder L, Koch C, Lehnert H, Oster H, Kirchner H, Mittag J.

Mol Metab. 2017 Oct;6(10):1126-1136. doi: 10.1016/j.molmet.2017.06.016. Epub 2017 Jul 1.

14.

Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.

Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M.

Nat Commun. 2017 Sep 7;8(1):484. doi: 10.1038/s41467-017-00604-6.

15.

The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system.

Dore R, Levata L, Gachkar S, Jöhren O, Mittag J, Lehnert H, Schulz C.

J Endocrinol. 2017 Nov;235(2):111-122. doi: 10.1530/JOE-17-0151. Epub 2017 Aug 29.

PMID:
28851749
16.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

17.

Impact of plasma protein binding on cargo release by thermosensitive liposomes probed by fluorescence correlation spectroscopy.

Mittag JJ, Kneidl B, Preiβ T, Hossann M, Winter G, Wuttke S, Engelke H, Rädler JO.

Eur J Pharm Biopharm. 2017 Oct;119:215-223. doi: 10.1016/j.ejpb.2017.06.022. Epub 2017 Jun 23.

PMID:
28648864
18.

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.

Fell SM, Li S, Wallis K, Kock A, Surova O, Rraklli V, Höfig CS, Li W, Mittag J, Henriksson MA, Kenchappa RS, Holmberg J, Kogner P, Schlisio S.

Genes Dev. 2017 May 15;31(10):1036-1053. doi: 10.1101/gad.297077.117.

19.

The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice.

Hofmann A, Brunssen C, Peitzsch M, Balyura M, Mittag J, Frenzel A, Jannasch A, Brown NF, Weldon SM, Gueneva-Boucheva KK, Eisenhofer G, Bornstein SR, Morawietz H.

Horm Metab Res. 2017 Jun;49(6):466-471. doi: 10.1055/s-0043-101821. Epub 2017 Apr 20.

PMID:
28427090
20.

3-Iodothyronamine Induces Tail Vasodilation Through Central Action in Male Mice.

Gachkar S, Oelkrug R, Martinez-Sanchez N, Rial-Pensado E, Warner A, Hoefig CS, López M, Mittag J.

Endocrinology. 2017 Jun 1;158(6):1977-1984. doi: 10.1210/en.2016-1951.

PMID:
28368510
21.

Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism.

Aponte-Santamaría C, Lippok S, Mittag JJ, Obser T, Schneppenheim R, Baldauf C, Gräter F, Budde U, Rädler JO.

Biophys J. 2017 Jan 10;112(1):57-65. doi: 10.1016/j.bpj.2016.11.3202.

22.

Understanding the Kinetics of Protein-Nanoparticle Corona Formation.

Vilanova O, Mittag JJ, Kelly PM, Milani S, Dawson KA, Rädler JO, Franzese G.

ACS Nano. 2016 Dec 27;10(12):10842-10850. doi: 10.1021/acsnano.6b04858. Epub 2016 Nov 16.

23.

Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes.

Hofmann A, Peitzsch M, Brunssen C, Mittag J, Jannasch A, Frenzel A, Brown N, Weldon SM, Eisenhofer G, Bornstein SR, Morawietz H.

Horm Metab Res. 2017 Jan;49(1):43-49. doi: 10.1055/s-0042-116157. Epub 2016 Nov 3.

PMID:
27813053
24.

3-Iodothyronamine Decreases Expression of Genes Involved in Iodide Metabolism in Mouse Thyroids and Inhibits Iodide Uptake in PCCL3 Thyrocytes.

Schanze N, Jacobi SF, Rijntjes E, Mergler S, Del Olmo M, Hoefig CS, Khajavi N, Lehmphul I, Biebermann H, Mittag J, Köhrle J.

Thyroid. 2017 Jan;27(1):11-22. doi: 10.1089/thy.2016.0182. Epub 2016 Dec 21.

PMID:
27788620
25.

Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats.

Hofmann A, Brunssen C, Peitzsch M, Martin M, Mittag J, Jannasch A, Engelmann F, Brown NF, Weldon SM, Huber J, Streicher R, Deussen A, Eisenhofer G, Bornstein SR, Morawietz H.

Endocrinology. 2016 Oct;157(10):3844-3855. Epub 2016 Aug 15.

PMID:
27526033
26.

Positive correlation of thyroid hormones and serum copper in children with congenital hypothyroidism.

Blasig S, Kühnen P, Schuette A, Blankenstein O, Mittag J, Schomburg L.

J Trace Elem Med Biol. 2016 Sep;37:90-95. doi: 10.1016/j.jtemb.2016.05.007. Epub 2016 May 24.

PMID:
27267969
27.

Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice.

Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J.

Endocrinology. 2016 Jul;157(7):2957-67. doi: 10.1210/en.2016-1095. Epub 2016 May 4.

PMID:
27145010
28.

Quantitative thermophoretic study of disease-related protein aggregates.

Wolff M, Mittag JJ, Herling TW, Genst ED, Dobson CM, Knowles TP, Braun D, Buell AK.

Sci Rep. 2016 Mar 17;6:22829. doi: 10.1038/srep22829.

29.

Leptin Raises Defended Body Temperature without Activating Thermogenesis.

Fischer AW, Hoefig CS, Abreu-Vieira G, de Jong JMA, Petrovic N, Mittag J, Cannon B, Nedergaard J.

Cell Rep. 2016 Feb 23;14(7):1621-1631. doi: 10.1016/j.celrep.2016.01.041. Epub 2016 Feb 11.

30.

Knockout of GH3 genes in the moss Physcomitrella patens leads to increased IAA levels at elevated temperature and in darkness.

Mittag J, Gabrielyan A, Ludwig-Müller J.

Plant Physiol Biochem. 2015 Dec;97:339-49. doi: 10.1016/j.plaphy.2015.10.013. Epub 2015 Oct 21.

PMID:
26520677
31.

Breaking BAT: can browning create a better white?

Warner A, Mittag J.

J Endocrinol. 2016 Jan;228(1):R19-29. doi: 10.1530/JOE-15-0408. Epub 2015 Oct 8. Review.

PMID:
26450134
32.

Biosynthesis of 3-Iodothyronamine From T4 in Murine Intestinal Tissue.

Hoefig CS, Wuensch T, Rijntjes E, Lehmphul I, Daniel H, Schweizer U, Mittag J, Köhrle J.

Endocrinology. 2015 Nov;156(11):4356-64. doi: 10.1210/en.2014-1499. Epub 2015 Sep 8.

PMID:
26348473
33.

Thyroid hormone drives the expression of mouse carbonic anhydrase Car4 in kidney, lung and brain.

Vujovic M, Dudazy-Gralla S, Hård J, Solsjö P, Warner A, Vennström B, Mittag J.

Mol Cell Endocrinol. 2015 Nov 15;416:19-26. doi: 10.1016/j.mce.2015.08.017. Epub 2015 Aug 28.

PMID:
26319697
34.

Physcomitrella patens auxin conjugate synthetase (GH3) double knockout mutants are more resistant to Pythium infection than wild type.

Mittag J, Šola I, Rusak G, Ludwig-Müller J.

J Plant Physiol. 2015 Jul 1;183:75-83. doi: 10.1016/j.jplph.2015.05.015. Epub 2015 Jun 9.

PMID:
26102574
35.

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Hoefig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.

J Mol Endocrinol. 2015 Jun;54(3):205-16. doi: 10.1530/JME-15-0003. Epub 2015 Apr 15.

PMID:
25878061
36.

3-Iodothyroacetic acid lacks thermoregulatory and cardiovascular effects in vivo.

Hoefig CS, Jacobi SF, Warner A, Harder L, Schanze N, Vennström B, Mittag J.

Br J Pharmacol. 2015 Jul;172(13):3426-33. doi: 10.1111/bph.13131. Epub 2015 Jun 9.

37.

Brown fat and vascular heat dissipation: The new cautionary tail.

Warner A, Mittag J.

Adipocyte. 2014 Jul 1;3(3):221-3. doi: 10.4161/adip.28815. Epub 2014 Apr 9.

38.

Simultaneous measurement of a range of particle sizes during Aβ1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy.

Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ.

Biochem Biophys Res Commun. 2014 May 30;448(2):195-9. doi: 10.1016/j.bbrc.2014.04.088. Epub 2014 Apr 24.

PMID:
24769478
39.

Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1.

Warner A, Rahman A, Solsjö P, Gottschling K, Davis B, Vennström B, Arner A, Mittag J.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16241-6. doi: 10.1073/pnas.1310300110. Epub 2013 Sep 17.

40.

Identification of thyroid hormone response elements in vivo using mice expressing a tagged thyroid hormone receptor α1.

Dudazy-Gralla S, Nordström K, Hofmann PJ, Meseh DA, Schomburg L, Vennström B, Mittag J.

Biosci Rep. 2013 Mar 13;33(2):e00027. doi: 10.1042/BSR20120124.

41.

Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions.

Mittag J, Lyons DJ, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B.

J Clin Invest. 2013 Jan;123(1):509-16. doi: 10.1172/JCI65252. Epub 2012 Dec 21.

42.

Thyroid hormone and the central control of homeostasis.

Warner A, Mittag J.

J Mol Endocrinol. 2012 Jun 26;49(1):R29-35. doi: 10.1530/JME-12-0068. Print 2012 Aug. Review.

PMID:
22586142
43.

Serum copper as a novel biomarker for resistance to thyroid hormone.

Mittag J, Behrends T, Nordström K, Anselmo J, Vennström B, Schomburg L.

Biochem J. 2012 Apr 1;443(1):103-9. doi: 10.1042/BJ20111817.

PMID:
22220593
44.

TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia.

Müller K, Führer D, Mittag J, Klöting N, Blüher M, Weiss RE, Many MC, Schmid KW, Krohn K.

Mol Endocrinol. 2011 Nov;25(11):1867-79. doi: 10.1210/me.2011-0065. Epub 2011 Oct 6.

45.

Thyroid hormones regulate selenoprotein expression and selenium status in mice.

Mittag J, Behrends T, Hoefig CS, Vennström B, Schomburg L.

PLoS One. 2010 Sep 22;5(9):e12931. doi: 10.1371/journal.pone.0012931.

46.

The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.

Wallis K, Dudazy S, van Hogerlinden M, Nordström K, Mittag J, Vennström B.

Mol Endocrinol. 2010 Oct;24(10):1904-16. doi: 10.1210/me.2010-0175. Epub 2010 Aug 25.

47.

Adaptations of the autonomous nervous system controlling heart rate are impaired by a mutant thyroid hormone receptor-alpha1.

Mittag J, Davis B, Vujovic M, Arner A, Vennström B.

Endocrinology. 2010 May;151(5):2388-95. doi: 10.1210/en.2009-1201. Epub 2010 Mar 12.

PMID:
20228172
48.

Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice.

Trajkovic-Arsic M, Visser TJ, Darras VM, Friesema EC, Schlott B, Mittag J, Bauer K, Heuer H.

Endocrinology. 2010 Feb;151(2):802-9. doi: 10.1210/en.2009-1053. Epub 2009 Dec 8.

PMID:
19996182
49.

Analysis of hypertrophic thyrotrophs in pituitaries of athyroid Pax8-/- mice.

Mittag J, Friedrichsen S, Strube A, Heuer H, Bauer K.

Endocrinology. 2009 Sep;150(9):4443-9. doi: 10.1210/en.2009-0327. Epub 2009 May 28.

PMID:
19477936
50.

Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism.

Vujovic M, Nordström K, Gauthier K, Flamant F, Visser TJ, Vennström B, Mittag J.

Endocrinology. 2009 Jun;150(6):2940-7. doi: 10.1210/en.2008-1085. Epub 2009 Mar 12.

PMID:
19282388

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