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Items: 1 to 50 of 175

1.

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.

Fang R, Uchiyama R, Sakai S, Hara H, Tsutsui H, Suda T, Mitsuyama M, Kawamura I, Tsuchiya K.

Mucosal Immunol. 2019 Sep;12(5):1092-1103. doi: 10.1038/s41385-019-0181-1. Epub 2019 Jul 5.

PMID:
31278375
2.

The Welch Emotional Connection Screen: validation of a brief mother-infant relational health screen.

Hane AA, LaCoursiere JN, Mitsuyama M, Wieman S, Ludwig RJ, Kwon KY, V Browne J, Austin J, M Myers M, Welch MG.

Acta Paediatr. 2019 Apr;108(4):615-625. doi: 10.1111/apa.14483. Epub 2018 Aug 13.

PMID:
29959878
3.

A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.

Kochi Y, Miyashita A, Tsuchiya K, Mitsuyama M, Sekimizu K, Kaito C.

FEMS Microbiol Lett. 2016 Aug;363(15). pii: fnw163. doi: 10.1093/femsle/fnw163. Epub 2016 Jul 3.

PMID:
27377894
4.

Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death.

Hashino M, Tachibana M, Nishida T, Hara H, Tsuchiya K, Mitsuyama M, Watanabe K, Shimizu T, Watarai M.

Front Microbiol. 2015 Oct 16;6:1145. doi: 10.3389/fmicb.2015.01145. eCollection 2015.

5.

Dermal Vγ4(+) γδ T cells possess a migratory potency to the draining lymph nodes and modulate CD8(+) T-cell activity through TNF-α production.

Nakamizo S, Egawa G, Tomura M, Sakai S, Tsuchiya S, Kitoh A, Honda T, Otsuka A, Nakajima S, Dainichi T, Tanizaki H, Mitsuyama M, Sugimoto Y, Kawai K, Yoshikai Y, Miyachi Y, Kabashima K.

J Invest Dermatol. 2015 Apr;135(4):1007-1015. doi: 10.1038/jid.2014.516. Epub 2014 Dec 10.

6.

The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL-18 production in an inflammasome-dependent and -independent manner.

Tsuchiya K, Hara H, Fang R, Hernandez-Cuellar E, Sakai S, Daim S, Chen X, Dewamitta SR, Qu H, Mitsuyama M, Kawamura I.

Eur J Immunol. 2014 Dec;44(12):3696-707. doi: 10.1002/eji.201444673. Epub 2014 Oct 22.

7.

Type I interferon signaling regulates activation of the absent in melanoma 2 inflammasome during Streptococcus pneumoniae infection.

Fang R, Hara H, Sakai S, Hernandez-Cuellar E, Mitsuyama M, Kawamura I, Tsuchiya K.

Infect Immun. 2014 Jun;82(6):2310-7. doi: 10.1128/IAI.01572-14. Epub 2014 Mar 18.

8.

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.

Hara H, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M.

Nat Immunol. 2013 Dec;14(12):1247-55. doi: 10.1038/ni.2749. Epub 2013 Nov 3.

9.

Autoimmune gastro-pancreatitis with anti-protein disulfide isomerase-associated 2 autoantibody in Aire-deficient BALB/cAnN mice.

Kurisaki H, Nagao Y, Nagafuchi S, Mitsuyama M.

PLoS One. 2013 Aug 26;8(8):e73862. doi: 10.1371/journal.pone.0073862. eCollection 2013.

10.

Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b.

Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi T, Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S.

Gene. 2013 Nov 1;530(1):19-25. doi: 10.1016/j.gene.2013.08.015. Epub 2013 Aug 14.

PMID:
23954874
11.

The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation.

Yang R, Xi C, Sita DR, Sakai S, Tsuchiya K, Hara H, Shen Y, Qu H, Fang R, Mitsuyama M, Kawamura I.

Pathog Dis. 2014 Feb;70(1):51-60. doi: 10.1111/2049-632X.12075. Epub 2013 Aug 23.

PMID:
23913588
12.

Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models.

Yokobori N, López B, Geffner L, Sabio y García C, Schierloh P, Barrera L, de la Barrera S, Sakai S, Kawamura I, Mitsuyama M, Ritacco V, Sasiain Mdel C.

Infect Genet Evol. 2013 Jun;16:151-6. doi: 10.1016/j.meegid.2013.01.007. Epub 2013 Jan 24.

PMID:
23352891
13.

Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.

Hernandez-Cuellar E, Tsuchiya K, Hara H, Fang R, Sakai S, Kawamura I, Akira S, Mitsuyama M.

J Immunol. 2012 Dec 1;189(11):5113-7. doi: 10.4049/jimmunol.1202479. Epub 2012 Oct 24.

14.

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.

Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK.

Blood. 2012 Aug 9;120(6):1299-308. doi: 10.1182/blood-2012-03-417881. Epub 2012 Jun 21.

PMID:
22723549
15.

Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability.

Yamamoto T, Hara H, Tsuchiya K, Sakai S, Fang R, Matsuura M, Nomura T, Sato F, Mitsuyama M, Kawamura I.

Infect Immun. 2012 Jul;80(7):2323-32. doi: 10.1128/IAI.06162-11. Epub 2012 Apr 16.

16.

Evasion of human innate immunity without antagonizing TLR4 by mutant Salmonella enterica serovar Typhimurium having penta-acylated lipid A.

Matsuura M, Kawasaki K, Kawahara K, Mitsuyama M.

Innate Immun. 2012 Oct;18(5):764-73. Epub 2012 Mar 14.

17.

HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines.

Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, Utsunomiya A, Mitsuyama M, Matsuoka M.

Blood. 2012 Jan 12;119(2):434-44. doi: 10.1182/blood-2011-05-357459. Epub 2011 Nov 28.

18.

Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.

Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, Dewamitta SR, Xu Y, Qu H, Alnemri ES, Mitsuyama M.

J Immunol. 2011 Nov 1;187(9):4890-9. doi: 10.4049/jimmunol.1100381. Epub 2011 Sep 28.

19.

Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.

Daim S, Kawamura I, Tsuchiya K, Hara H, Kurenuma T, Shen Y, Dewamitta SR, Sakai S, Nomura T, Qu H, Mitsuyama M.

J Med Microbiol. 2011 May;60(Pt 5):582-91. doi: 10.1099/jmm.0.026047-0. Epub 2011 Jan 13.

PMID:
21233299
20.

PD-1-PD-L1 pathway impairs T(h)1 immune response in the late stage of infection with Mycobacterium bovis bacillus Calmette-Guérin.

Sakai S, Kawamura I, Okazaki T, Tsuchiya K, Uchiyama R, Mitsuyama M.

Int Immunol. 2010 Dec;22(12):915-25. doi: 10.1093/intimm/dxq446. Epub 2010 Nov 3.

PMID:
21047981
21.

Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes.

Tsuchiya K, Hara H, Kawamura I, Nomura T, Yamamoto T, Daim S, Dewamitta SR, Shen Y, Fang R, Mitsuyama M.

J Immunol. 2010 Jul 15;185(2):1186-95. doi: 10.4049/jimmunol.1001058. Epub 2010 Jun 21.

22.

Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.

Shen Y, Kawamura I, Nomura T, Tsuchiya K, Hara H, Dewamitta SR, Sakai S, Qu H, Daim S, Yamamoto T, Mitsuyama M.

Infect Immun. 2010 Jun;78(6):2857-67. doi: 10.1128/IAI.01138-09. Epub 2010 Apr 5.

23.

Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation.

Emoto M, Yoshida T, Fukuda T, Kawamura I, Mitsuyama M, Kita E, Hurwitz R, Kaufmann SH, Emoto Y.

Infect Immun. 2010 Jun;78(6):2667-76. doi: 10.1128/IAI.01441-09. Epub 2010 Mar 29.

24.

Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes.

Dewamitta SR, Nomura T, Kawamura I, Hara H, Tsuchiya K, Kurenuma T, Shen Y, Daim S, Yamamoto T, Qu H, Sakai S, Xu Y, Mitsuyama M.

Infect Immun. 2010 May;78(5):1884-94. doi: 10.1128/IAI.01143-09. Epub 2010 Mar 1.

25.

[Mechanism for the induction of host immune response by virulence factors of Listeria monocytogenes].

Mitsuyama M.

Nihon Saikingaku Zasshi. 2009 Dec;64(2-4):365-76. Review. Japanese. No abstract available.

26.

The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages.

Kurenuma T, Kawamura I, Hara H, Uchiyama R, Daim S, Dewamitta SR, Sakai S, Tsuchiya K, Nomura T, Mitsuyama M.

Infect Immun. 2009 Sep;77(9):3992-4001. doi: 10.1128/IAI.00015-09. Epub 2009 Jul 13.

27.

Kyoto University graduate school of medicine: tradition and modernity harmonized.

Mitsuyama M.

J Mol Med (Berl). 2009 Oct;87(10):1009-13. doi: 10.1007/s00109-009-0487-7. Epub 2009 Jun 3. No abstract available.

PMID:
19495569
28.

[Survival strategy of intracellular bacteria in macrophages].

Tsuchiya K, Kawamura I, Mitsuyama M.

Tanpakushitsu Kakusan Koso. 2009 Jun;54(8 Suppl):996-1001. Review. Japanese. No abstract available.

PMID:
21089530
29.
30.

Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation.

Shoma S, Tsuchiya K, Kawamura I, Nomura T, Hara H, Uchiyama R, Daim S, Mitsuyama M.

Infect Immun. 2008 Apr;76(4):1547-57. doi: 10.1128/IAI.01269-07. Epub 2008 Jan 14.

31.

New computer-based cognitive function test for the elderly.

Tamura T, Tshji M, Higashi Y, Sekine M, Kohdabashi A, Fujimoto T, Mitsuyama M.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:692-4.

PMID:
17946417
32.

Sustained-release form of basic fibroblast growth factor prevents catheter-related bacterial invasion in mice.

Hirose K, Marui A, Arai Y, Fujita M, Nomura T, Mitsuyama M, Tabata Y, Komeda M.

Interact Cardiovasc Thorac Surg. 2005 Dec;4(6):526-30. Epub 2005 Sep 15.

PMID:
17670475
33.

A novel approach to reduce catheter-related infection using sustained-release basic fibroblast growth factor for tissue regeneration in mice.

Hirose K, Marui A, Arai Y, Nomura T, Kaneda K, Kimura Y, Ikeda T, Fujita M, Mitsuyama M, Tabata Y, Komeda M.

Heart Vessels. 2007 Jul;22(4):261-7. Epub 2007 Jul 20.

PMID:
17653521
34.

Tuberculosis: vaccine and drug development.

Mitsuyama M, McMurray DN.

Tuberculosis (Edinb). 2007 Aug;87 Suppl 1:S10-3. Epub 2007 Jul 9. Review. No abstract available.

PMID:
17616481
35.

RD1 region in mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitochondrial membrane damage and ATP depletion.

Kaku T, Kawamura I, Uchiyama R, Kurenuma T, Mitsuyama M.

FEMS Microbiol Lett. 2007 Sep;274(2):189-95. Epub 2007 Jul 4.

36.
38.

Involvement of caspase-9 in the inhibition of necrosis of RAW 264 cells infected with Mycobacterium tuberculosis.

Uchiyama R, Kawamura I, Fujimura T, Kawanishi M, Tsuchiya K, Tominaga T, Kaku T, Fukasawa Y, Sakai S, Nomura T, Mitsuyama M.

Infect Immun. 2007 Jun;75(6):2894-902. Epub 2007 Apr 2.

39.
40.

Sustained-release vancomycin sheet may help to prevent prosthetic graft methicillin-resistant Staphylococcus aureus infection.

Hirose K, Marui A, Arai Y, Nomura T, Inoue S, Kaneda K, Kamitani T, Fujita M, Mitsuyama M, Tabata Y, Komeda M.

J Vasc Surg. 2006 Aug;44(2):377-82.

41.
42.

Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice.

Yamamoto K, Kawamura I, Tominaga T, Nomura T, Ito J, Mitsuyama M.

Clin Exp Immunol. 2006 Jun;144(3):475-84.

43.

Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans.

Nakamura K, Miyagi K, Koguchi Y, Kinjo Y, Uezu K, Kinjo T, Akamine M, Fujita J, Kawamura I, Mitsuyama M, Adachi Y, Ohno N, Takeda K, Akira S, Miyazato A, Kaku M, Kawakami K.

FEMS Immunol Med Microbiol. 2006 Jun;47(1):148-54.

44.

Dependence of the lethal effect of pore-forming haemolysins of Gram-positive bacteria on cytolytic activity.

Watanabe I, Nomura T, Tominaga T, Yamamoto K, Kohda C, Kawamura I, Mitsuyama M.

J Med Microbiol. 2006 May;55(Pt 5):505-10.

PMID:
16585635
45.
46.
47.

Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b.

Fukasawa Y, Kawamura I, Uchiyama R, Yamamoto K, Kaku T, Tominaga T, Nomura T, Ichiyama S, Ezaki T, Mitsuyama M.

Infect Immun. 2005 Oct;73(10):7051-5.

48.
49.

Microvascular response in the periosteum following mucoperiosteal flap surgery in dogs: 3-dimensional observation of an angiogenic process.

Nobuto T, Suwa F, Kono T, Hatakeyama Y, Honjou N, Shirai T, Mitsuyama M, Imai H.

J Periodontol. 2005 Aug;76(8):1339-45.

PMID:
16101367
50.

Involvement of the virulence gene products of Yersinia enterocolitica in the immune response of infected mice.

Takeuchi O, Suzuki T, Kawamura I, Kobayashi N, Takizawa-Hashimoto A, Mitsuyama M.

FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):321-9.

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