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Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications.

Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, Weiss DJ, Zheng L, Giebel B, Lim SK.

J Extracell Vesicles. 2019 Apr 29;8(1):1609206. doi: 10.1080/20013078.2019.1609206. eCollection 2019.


Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension?

Willis GR, Fernandez-Gonzalez A, Reis M, Mitsialis SA, Kourembanas S.

Int J Mol Sci. 2018 Aug 27;19(9). pii: E2534. doi: 10.3390/ijms19092534. Review.


PPARĪ³ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation.

Legchenko E, Chouvarine P, Borchert P, Fernandez-Gonzalez A, Snay E, Meier M, Maegel L, Mitsialis SA, Rog-Zielinska EA, Kourembanas S, Jonigk D, Hansmann G.

Sci Transl Med. 2018 Apr 25;10(438). pii: eaao0303. doi: 10.1126/scitranslmed.aao0303.


Reply to Muraca et al.: Exosome Treatment of Bronchopulmonary Dysplasia: How Pure Should Your Exosome Preparation Be?

Mitsialis SA, Willis GR, Fernandez-Gonzalez A, Kourembanas S.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):970. doi: 10.1164/rccm.201710-2066LE. No abstract available.


Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency.

Willis GR, Kourembanas S, Mitsialis SA.

Front Cardiovasc Med. 2017 Oct 9;4:63. doi: 10.3389/fcvm.2017.00063. eCollection 2017.


"Good things come in small packages": application of exosome-based therapeutics in neonatal lung injury.

Willis GR, Mitsialis SA, Kourembanas S.

Pediatr Res. 2018 Jan;83(1-2):298-307. doi: 10.1038/pr.2017.256. Epub 2017 Nov 22. Review.


Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation.

Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S.

Am J Respir Crit Care Med. 2018 Jan 1;197(1):104-116. doi: 10.1164/rccm.201705-0925OC.


Therapeutic Applications of Extracellular Vesicles: Perspectives from Newborn Medicine.

Willis GR, Kourembanas S, Mitsialis SA.

Methods Mol Biol. 2017;1660:409-432. doi: 10.1007/978-1-4939-7253-1_34. Review.


Stem cell-based therapies for the newborn lung and brain: Possibilities and challenges.

Mitsialis SA, Kourembanas S.

Semin Perinatol. 2016 Apr;40(3):138-51. doi: 10.1053/j.semperi.2015.12.002. Epub 2016 Jan 15. Review.


Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice.

Cruz FF, Borg ZD, Goodwin M, Sokocevic D, Wagner DE, Coffey A, Antunes M, Robinson KL, Mitsialis SA, Kourembanas S, Thane K, Hoffman AM, McKenna DH, Rocco PR, Weiss DJ.

Stem Cells Transl Med. 2015 Nov;4(11):1302-16. doi: 10.5966/sctm.2014-0280. Epub 2015 Sep 16.


The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up.

Vitali SH, Hansmann G, Rose C, Fernandez-Gonzalez A, Scheid A, Mitsialis SA, Kourembanas S.

Pulm Circ. 2014 Dec;4(4):619-29. doi: 10.1086/678508.


An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells.

Hale A, Lee C, Annis S, Min PK, Pande R, Creager MA, Julian CG, Moore LG, Mitsialis SA, Hwang SJ, Kourembanas S, Chan SY.

Biochim Biophys Acta. 2014 Nov;1843(11):2528-42. doi: 10.1016/j.bbamcr.2014.06.012. Epub 2014 Jun 28.


Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension.

Xiao Y, Christou H, Liu L, Visner G, Mitsialis SA, Kourembanas S, Liu H.

Am J Respir Crit Care Med. 2013 Aug 15;188(4):482-91. doi: 10.1164/rccm.201304-0700OC.


Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension.

Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, Sdrimas K, Fernandez-Gonzalez A, Kourembanas S.

Circulation. 2012 Nov 27;126(22):2601-11. doi: 10.1161/CIRCULATIONAHA.112.114173. Epub 2012 Oct 31.


Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension.

Hansmann G, Fernandez-Gonzalez A, Aslam M, Vitali SH, Martin T, Mitsialis SA, Kourembanas S.

Pulm Circ. 2012 Apr-Jun;2(2):170-81. doi: 10.4103/2045-8932.97603.


Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.

Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L875-90. doi: 10.1152/ajplung.00293.2011. Epub 2012 Jan 27.


Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension.

Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S.

Circulation. 2011 May 10;123(18):1986-95. doi: 10.1161/CIRCULATIONAHA.110.978627. Epub 2011 Apr 25.


Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension.

Liang OD, Mitsialis SA, Chang MS, Vergadi E, Lee C, Aslam M, Fernandez-Gonzalez A, Liu X, Baveja R, Kourembanas S.

Stem Cells. 2011 Jan;29(1):99-107. doi: 10.1002/stem.548.


Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease.

Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S.

Am J Respir Crit Care Med. 2009 Dec 1;180(11):1122-30. doi: 10.1164/rccm.200902-0242OC. Epub 2009 Aug 27.


Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S.

PLoS One. 2009 Jun 19;4(6):e5978. doi: 10.1371/journal.pone.0005978.


Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype.

Fernandez-Gonzalez A, Kourembanas S, Wyatt TA, Mitsialis SA.

Am J Respir Cell Mol Biol. 2009 Mar;40(3):305-13. doi: 10.1165/rcmb.2008-0102OC. Epub 2008 Sep 5.


Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.

Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA.

Circulation. 2008 Apr 22;117(16):2114-22. doi: 10.1161/CIRCULATIONAHA.107.716241. Epub 2008 Apr 7.


The role of heme oxygenase-1 in pulmonary disease.

Fredenburgh LE, Perrella MA, Mitsialis SA.

Am J Respir Cell Mol Biol. 2007 Feb;36(2):158-65. Epub 2006 Sep 15. Review.


Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1.

Wu X, Chang MS, Mitsialis SA, Kourembanas S.

Circ Res. 2006 Aug 4;99(3):240-7. Epub 2006 Jul 13.


Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin.

Vitali SH, Mitsialis SA, Christou H, Fernandez-Gonzalez A, Liu X, Kourembanas S.

Chest. 2005 Dec;128(6 Suppl):578S-579S. No abstract available.


Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells.

Christou H, Bailey N, Kluger MS, Mitsialis SA, Kourembanas S.

Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2647-52. Epub 2005 Jan 28.


Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways.

Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S.

FASEB J. 2004 Jul;18(10):1090-2. Epub 2004 May 7.


Effect of heme oxygenase-1 overexpression in two models of lung inflammation.

Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S.

Exp Biol Med (Maywood). 2003 May;228(5):442-6.


Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia.

Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S.

Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8798-803. Epub 2001 Jul 10.


Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.

Minamino T, Mitsialis SA, Kourembanas S.

Mol Cell Biol. 2001 May;21(10):3336-42.


Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells.

Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S.

J Biol Chem. 1997 Dec 26;272(52):32804-9.


Retinoic acid alters the expression of pattern-related genes in the developing rat lung.

Cardoso WV, Mitsialis SA, Brody JS, Williams MC.

Dev Dyn. 1996 Sep;207(1):47-59.


Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro.

Cardoso WV, Williams MC, Mitsialis SA, Joyce-Brady M, Rishi AK, Brody JS.

Am J Respir Cell Mol Biol. 1995 May;12(5):464-76.


Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors.

Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA.

Cell Mol Biol Res. 1995;41(3):147-54.


Regulation of renal rK1-kallikrein in spontaneously hypertensive rats.

Goud HD, Oza NB, Mitsialis SA, Levinsky NG.

Ren Physiol Biochem. 1993 May-Jun;16(3):125-30.


DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle.

Christianson AM, King DL, Hatzivassiliou E, Casas JE, Hallenbeck PL, Nikodem VM, Mitsialis SA, Kafatos FC.

Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11503-7.


A short 5'-flanking DNA region is sufficient for developmentally correct expression of moth chorion genes in Drosophila.

Mitsialis SA, Spoerel N, Leviten M, Kafatos FC.

Proc Natl Acad Sci U S A. 1987 Nov;84(22):7987-91.


Developmental control and evolution in the chorion gene families of insects.

Kafatos FC, Spoerel N, Mitsialis SA, Nguyen HT, Romano C, Lingappa JR, Mariani BD, Rodakis GC, Lecanidou R, Tsitilou SG.

Adv Genet. 1987;24:223-42. Review. No abstract available.


Regulatory elements controlling chorion gene expression are conserved between flies and moths.

Mitsialis SA, Kafatos FC.

Nature. 1985 Oct 3-9;317(6036):453-6.


Studies on the developmentally regulated expression and amplification of insect chorion genes.

Kafatos FC, Mitsialis SA, Spoerel N, Mariani B, Lingappa JR, Delidakis C.

Cold Spring Harb Symp Quant Biol. 1985;50:537-47. No abstract available.


Studies on the structure and organization of avian sarcoma proviruses in the rat XC cell line.

Mitsialis SA, Katz RA, Svoboda J, Guntaka RV.

J Gen Virol. 1983 Sep;64 (Pt 9):1885-93.


Studies on the methylation of avian sarcoma proviruses in permissive and non-permissive cells.

Katz RA, Mitsialis SA, Guntaka RV.

J Gen Virol. 1983 Feb;64 (Pt 2):429-35.


An avian tumor virus promoter directs expression of plasmid genes in Escherichia coli.

Mitsialis SA, Young JF, Palese P, Guntaka RV.

Gene. 1981 Dec;16(1-3):217-25.


Binding of Escherichia coli RNA polymerase to a specific site located near the 3'-end of the avaian sarcoma virus genome.

Guntaka RV, Rao PY, Katz RA, Mitsialis SA.

Biochim Biophys Acta. 1980 May 30;607(3):457-69.


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