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Items: 33


Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.

Ablain J, Xu M, Rothschild H, Jordan RC, Mito JK, Daniels BH, Bell CF, Joseph NM, Wu H, Bastian BC, Zon LI, Yeh I.

Science. 2018 Nov 1. pii: eaau6509. doi: 10.1126/science.aau6509. [Epub ahead of print]


Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

McConnell AM, Mito JK, Ablain J, Dang M, Formichella L, Fisher DE, Zon LI.

Dev Biol. 2018 Jun 5. pii: S0012-1606(17)30855-2. doi: 10.1016/j.ydbio.2018.05.026. [Epub ahead of print]


Immunohistochemical Detection and Molecular Characterization of IDH-mutant Sinonasal Undifferentiated Carcinomas.

Mito JK, Bishop JA, Sadow PM, Stelow EB, Faquin WC, Mills SE, Krane JF, French CA, Fletcher CDM, Hornick JL, Sholl LM, Jo VY.

Am J Surg Pathol. 2018 Aug;42(8):1067-1075. doi: 10.1097/PAS.0000000000001064.


SOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens.

Mito JK, Conner JR, Hornick JL, Cibas ES, Qian X.

Cancer Cytopathol. 2018 Mar;126(3):179-189. doi: 10.1002/cncy.21960. Epub 2018 Jan 31.


A modified reporting approach for thyroid FNA in the NIFTP era: A 1-year institutional experience.

Mito JK, Alexander EK, Angell TE, Barletta JA, Nehs MA, Cibas ES, Krane JF.

Cancer Cytopathol. 2017 Nov;125(11):854-864. doi: 10.1002/cncy.21907. Epub 2017 Sep 13.


Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.

Mito JK, Qian X, Doyle LA, Hornick JL, Jo VY.

Am J Clin Pathol. 2017 Aug 1;148(2):179-189. doi: 10.1093/ajcp/aqx060.


Prevalence and significance of HMGA2 expression in oesophageal adenocarcinoma.

Mito JK, Agoston AT, Dal Cin P, Srivastava A.

Histopathology. 2017 Dec;71(6):909-917. doi: 10.1111/his.13310. Epub 2017 Sep 28.


HMGA2 is a specific immunohistochemical marker for pleomorphic adenoma and carcinoma ex-pleomorphic adenoma.

Mito JK, Jo VY, Chiosea SI, Dal Cin P, Krane JF.

Histopathology. 2017 Oct;71(4):511-521. doi: 10.1111/his.13246. Epub 2017 Jul 5.


BRAF V600E is not a consistent feature of myopericytoma.

Mito JK, Jo VY.

J Cutan Pathol. 2016 Dec;43(12):1248-1249. doi: 10.1111/cup.12832. No abstract available.


MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG.

J Clin Invest. 2016 Apr 1;126(4):1606. doi: 10.1172/JCI86573. Epub 2016 Apr 1. No abstract available.


A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG 3rd, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE.

Sci Transl Med. 2016 Jan 6;8(320):320ra4. doi: 10.1126/scitranslmed.aad0293.


MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.

Sachdeva M, Whitley MJ, Mito JK, Ma Y, Lev DC, Cardona DM, Kirsch DG.

Dis Model Mech. 2015 Sep;8(9):1169. doi: 10.1242/dmm.022582. No abstract available.


Myogenic transcription factors regulate pro-metastatic miR-182.

Dodd RD, Sachdeva M, Mito JK, Eward WC, Brigman BE, Ma Y, Dodd L, Kim Y, Lev D, Kirsch DG.

Oncogene. 2016 Apr 7;35(14):1868-75. doi: 10.1038/onc.2015.252. Epub 2015 Aug 3.


MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.

Sachdeva M, Whitley MJ, Mito JK, Ma Y, Lev DC, Cardona DM, Kirsch DG.

Dis Model Mech. 2015 Aug 1;8(8):867-75. doi: 10.1242/dmm.017897. Epub 2015 Jun 4. Erratum in: Dis Model Mech. 2015 Sep;8(9):1169.


A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins.

Mueller JL, Fu HL, Mito JK, Whitley MJ, Chitalia R, Erkanli A, Dodd L, Cardona DM, Geradts J, Willett RM, Kirsch DG, Ramanujam N.

Int J Cancer. 2015 Nov 15;137(10):2403-12. doi: 10.1002/ijc.29611. Epub 2015 Jun 3.


Rescuing dicer defects via inhibition of an anti-dicing nuclease.

Asada K, Canestrari E, Fu X, Li Z, Makowski E, Wu YC, Mito JK, Kirsch DG, Baraban J, Paroo Z.

Cell Rep. 2014 Nov 20;9(4):1471-81.


MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG.

J Clin Invest. 2014 Oct;124(10):4305-19. doi: 10.1172/JCI77116. Epub 2014 Sep 2. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1606.


Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.

Blum JM, Añó L, Li Z, Van Mater D, Bennett BD, Sachdeva M, Lagutina I, Zhang M, Mito JK, Dodd LG, Cardona DM, Dodd RD, Williams N, Ma Y, Lepper C, Linardic CM, Mukherjee S, Grosveld GC, Fan CM, Kirsch DG.

Cell Rep. 2013 Nov 27;5(4):933-40. doi: 10.1016/j.celrep.2013.10.020. Epub 2013 Nov 14.


Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma.

Fu HL, Mueller JL, Javid MP, Mito JK, Kirsch DG, Ramanujam N, Brown JQ.

PLoS One. 2013 Jul 23;8(7):e68868. doi: 10.1371/journal.pone.0068868. Print 2013.


NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.

Dodd RD, Mito JK, Eward WC, Chitalia R, Sachdeva M, Ma Y, Barretina J, Dodd L, Kirsch DG.

Mol Cancer Ther. 2013 Sep;12(9):1906-17. doi: 10.1158/1535-7163.MCT-13-0189. Epub 2013 Jul 15.


Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins.

Mueller JL, Harmany ZT, Mito JK, Kennedy SA, Kim Y, Dodd L, Geradts J, Kirsch DG, Willett RM, Brown JQ, Ramanujam N.

PLoS One. 2013 Jun 18;8(6):e66198. doi: 10.1371/journal.pone.0066198. Print 2013.


Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents.

Cuneo KC, Mito JK, Javid MP, Ferrer JM, Kim Y, Lee WD, Bawendi MG, Brigman BE, Kirsch DG.

Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):136-42. doi: 10.1016/j.ijrobp.2012.12.007. Epub 2013 Feb 4.


A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.

Eward WC, Mito JK, Eward CA, Carter JE, Ferrer JM, Kirsch DG, Brigman BE.

Clin Orthop Relat Res. 2013 Mar;471(3):834-42. doi: 10.1007/s11999-012-2560-8.


Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.

Mito JK, Min HD, Ma Y, Carter JE, Brigman BE, Dodd L, Dankort D, McMahon M, Kirsch DG.

J Pathol. 2013 Jan;229(1):132-40. doi: 10.1002/path.4099. Epub 2012 Nov 20.


Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma.

Kim S, Dodd RD, Mito JK, Ma Y, Kim Y, Riedel RF, Kirsch DG.

Sarcoma. 2012;2012:680708. doi: 10.1155/2012/680708. Epub 2012 Apr 29.


Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.

Mito JK, Ferrer JM, Brigman BE, Lee CL, Dodd RD, Eward WC, Marshall LF, Cuneo KC, Carter JE, Ramasunder S, Kim Y, Lee WD, Griffith LG, Bawendi MG, Kirsch DG.

Cancer. 2012 Nov 1;118(21):5320-30. doi: 10.1002/cncr.27458. Epub 2012 Mar 21.


Animal models of soft-tissue sarcoma.

Dodd RD, Mito JK, Kirsch DG.

Dis Model Mech. 2010 Sep-Oct;3(9-10):557-66. doi: 10.1242/dmm.005223. Epub 2010 Aug 16. Review.


Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens.

Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR.

Blood. 2010 May 13;115(19):3869-78. doi: 10.1182/blood-2009-10-248997. Epub 2010 Jan 13.


Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.

Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG.

PLoS One. 2009 Nov 30;4(11):e8075. doi: 10.1371/journal.pone.0008075.


C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.

Tykodi SS, Fujii N, Vigneron N, Lu SM, Mito JK, Miranda MX, Chou J, Voong LN, Thompson JA, Sandmaier BM, Cresswell P, Van den Eynde B, Riddell SR, Warren EH.

Clin Cancer Res. 2008 Aug 15;14(16):5260-9. doi: 10.1158/1078-0432.CCR-08-0028.


DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells.

Rosinski KV, Fujii N, Mito JK, Koo KK, Xuereb SM, Sala-Torra O, Gibbs JS, Radich JP, Akatsuka Y, Van den Eynde BJ, Riddell SR, Warren EH.

Blood. 2008 May 1;111(9):4817-26. doi: 10.1182/blood-2007-06-096313. Epub 2008 Feb 25.


An antigen produced by splicing of noncontiguous peptides in the reverse order.

Warren EH, Vigneron NJ, Gavin MA, Coulie PG, Stroobant V, Dalet A, Tykodi SS, Xuereb SM, Mito JK, Riddell SR, Van den Eynde BJ.

Science. 2006 Sep 8;313(5792):1444-7.


The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL.

Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH.

Blood. 2006 May 1;107(9):3779-86. Epub 2006 Jan 3.

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