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Items: 1 to 50 of 291


Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs.

Field CM, Pelletier JF, Mitchison TJ.

Curr Biol. 2019 Jun 17;29(12):1999-2008.e4. doi: 10.1016/j.cub.2019.05.016. Epub 2019 Jun 6.


A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.

Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11444-11453. doi: 10.1073/pnas.1702372116. Epub 2019 May 17.


Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues.

Gasic I, Boswell SA, Mitchison TJ.

PLoS Biol. 2019 Apr 9;17(4):e3000225. doi: 10.1371/journal.pbio.3000225. eCollection 2019 Apr.


Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.

Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.

Elife. 2019 Mar 25;8. pii: e45457. doi: 10.7554/eLife.45457.


Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles.

Shimada K, Mitchison TJ.

Mol Syst Biol. 2019 Feb 19;15(2):e8636. doi: 10.15252/msb.20188636.


A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line.

Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK.

Sci Data. 2019 Feb 19;6:190016. doi: 10.1038/sdata.2019.16.


Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos.

Nguyen T, Mitchison TJ, Wühr M.

Methods Mol Biol. 2019;1920:17-32. doi: 10.1007/978-1-4939-9009-2_2.


Colloid osmotic parameterization and measurement of subcellular crowding.

Mitchison TJ.

Mol Biol Cell. 2019 Jan 15;30(2):173-180. doi: 10.1091/mbc.E18-09-0549. Review.


Site occupancy calibration of taxane pharmacology in live cells and tissues.

Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11406-E11414. doi: 10.1073/pnas.1800047115. Epub 2018 Nov 14.


Autoregulation and repair in microtubule homeostasis.

Gasic I, Mitchison TJ.

Curr Opin Cell Biol. 2019 Feb;56:80-87. doi: 10.1016/ Epub 2018 Nov 8. Review.


A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A.

Nat Commun. 2018 Aug 6;9(1):3116. doi: 10.1038/s41467-018-05036-4.


Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD.

Cell Metab. 2018 May 1;27(5):1067-1080.e5. doi: 10.1016/j.cmet.2018.03.018.


Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.

Wang Y, Li YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ.

Elife. 2018 Mar 12;7. pii: e36414. doi: 10.7554/eLife.36414. No abstract available.


Assembly of Spindles and Asters in Xenopus Egg Extracts.

Field CM, Mitchison TJ.

Cold Spring Harb Protoc. 2018 Jun 1;2018(6). doi: 10.1101/pdb.prot099796.


Spindle-to-Cortex Communication in Cleaving Frog Eggs.

Mitchison TJ, Field CM.

Cold Spring Harb Symp Quant Biol. 2017;82:165-171. doi: 10.1101/sqb.2017.82.033654. Epub 2017 Dec 1.


Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters.

Nguyen PA, Field CM, Mitchison TJ.

Mol Biol Cell. 2018 Feb 1;29(3):304-316. doi: 10.1091/mbc.E17-09-0540. Epub 2017 Nov 29.


Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?

Mitchison TJ, Pineda J, Shi J, Florian S.

Open Biol. 2017 Nov;7(11). pii: 170182. doi: 10.1098/rsob.170182. Review.


Correction: 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells.

Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X.

Elife. 2017 May 4;6. pii: e28212. doi: 10.7554/eLife.28212. No abstract available.


Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation.

Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S.

Mol Biol Cell. 2017 Jul 7;28(14):1975-1983. doi: 10.1091/mbc.E17-03-0171. Epub 2017 May 3.


Vimentin fibers orient traction stress.

Costigliola N, Ding L, Burckhardt CJ, Han SJ, Gutierrez E, Mota A, Groisman A, Mitchison TJ, Danuser G.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):5195-5200. doi: 10.1073/pnas.1614610114. Epub 2017 May 2.


Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin.

Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ.

Mol Biol Cell. 2017 Jun 1;28(11):1444-1456. doi: 10.1091/mbc.E16-12-0860. Epub 2017 Apr 12.


Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic.

Shi J, Mitchison TJ.

Endocr Relat Cancer. 2017 Sep;24(9):T83-T96. doi: 10.1530/ERC-17-0003. Epub 2017 Mar 1. Review.


27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells.

Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X.

Elife. 2017 Feb 28;6. pii: e22911. doi: 10.7554/eLife.22911. Erratum in: Elife. 2017 May 04;6:.


Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis.

Field CM, Pelletier JF, Mitchison TJ.

Methods Cell Biol. 2017;137:395-435. doi: 10.1016/bs.mcb.2016.04.014. Epub 2016 May 9.


Physical basis of large microtubule aster growth.

Ishihara K, Korolev KS, Mitchison TJ.

Elife. 2016 Nov 28;5. pii: e19145. doi: 10.7554/eLife.19145.


The balbiani body and the concept of physiological amyloids.

Boke E, Mitchison TJ.

Cell Cycle. 2017 Jan 17;16(2):153-154. doi: 10.1080/15384101.2016.1241605. Epub 2016 Oct 13. No abstract available.


Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response.

Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R.

Sci Rep. 2016 Sep 9;6:32985. doi: 10.1038/srep32985.


Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9810-5. doi: 10.1073/pnas.1606862113. Epub 2016 Aug 15.


Amyloid-like Self-Assembly of a Cellular Compartment.

Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ.

Cell. 2016 Jul 28;166(3):637-650. doi: 10.1016/j.cell.2016.06.051.


Anti-Microtubule Drugs.

Florian S, Mitchison TJ.

Methods Mol Biol. 2016;1413:403-21. doi: 10.1007/978-1-4939-3542-0_25. Review.


Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts.

Groen AC, Mitchison TJ.

Methods Mol Biol. 2016;1413:35-45. doi: 10.1007/978-1-4939-3542-0_3.


Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells.

Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU.

ACS Chem Biol. 2016 Jun 17;11(6):1544-51. doi: 10.1021/acschembio.6b00203. Epub 2016 Apr 28.


Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis.

Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S.

J Cell Biol. 2015 Nov 23;211(4):757-63. doi: 10.1083/jcb.201505058.


The Nuclear Proteome of a Vertebrate.

Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP.

Curr Biol. 2015 Oct 19;25(20):2663-71. doi: 10.1016/j.cub.2015.08.047. Epub 2015 Oct 1.


Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs.

Field CM, Groen AC, Nguyen PA, Mitchison TJ.

Mol Biol Cell. 2015 Oct 15;26(20):3628-40. doi: 10.1091/mbc.E15-04-0233. Epub 2015 Aug 26.


Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ.

Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741c. No abstract available.


Size Scaling of Microtubule Assemblies in Early Xenopus Embryos.

Mitchison TJ, Ishihara K, Nguyen P, Wühr M.

Cold Spring Harb Perspect Biol. 2015 Aug 10;7(10):a019182. doi: 10.1101/cshperspect.a019182. Review.


Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins.

Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M.

Methods Cell Biol. 2015;128:223-241. doi: 10.1016/bs.mcb.2015.01.007. Epub 2015 Apr 8.


In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.

Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ.

Nat Methods. 2015 Jun;12(6):577-85. doi: 10.1038/nmeth.3363. Epub 2015 Apr 13.


Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages.

Krukenberg KA, Kim S, Tan ES, Maliga Z, Mitchison TJ.

Chem Biol. 2015 Apr 23;22(4):446-452. doi: 10.1016/j.chembiol.2015.03.007. Epub 2015 Apr 9.


Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ.

Nat Chem Biol. 2015 Mar;11(3):235. doi: 10.1038/nchembio0315-235d. No abstract available.


Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis.

Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA.

EMBO J. 2015 Jan 13;34(2):251-65. doi: 10.15252/embj.201385162. Epub 2014 Dec 4.


Microtubule nucleation remote from centrosomes may explain how asters span large cells.

Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17715-22. doi: 10.1073/pnas.1418796111. Epub 2014 Dec 2.


Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R.

Sci Transl Med. 2014 Nov 5;6(261):261ra152. doi: 10.1126/scitranslmed.3009318.


Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ.

Nat Chem Biol. 2014 Dec;10(12):1043-8. doi: 10.1038/nchembio.1661. Epub 2014 Oct 26. Erratum in: Nat Chem Biol. 2015 Mar;11(3):235. Nat Chem Biol. 2015 Sep;11(9):741.


Spatial organization of cytokinesis signaling reconstituted in a cell-free system.

Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ.

Science. 2014 Oct 10;346(6206):244-7. doi: 10.1126/science.1256773.


Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics.

Choi PJ, Mitchison TJ.

Integr Biol (Camb). 2014 Dec;6(12):1153-61. doi: 10.1039/c4ib00096j. Epub 2014 Sep 17.


Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines.

Krukenberg KA, Jiang R, Steen JA, Mitchison TJ.

Cell Rep. 2014 Sep 25;8(6):1808-1818. doi: 10.1016/j.celrep.2014.08.009. Epub 2014 Sep 4.


Organization of early frog embryos by chemical waves emanating from centrosomes.

Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130454. doi: 10.1098/rstb.2013.0454. Review.


The engine of microtubule dynamics comes into focus.

Mitchison TJ.

Cell. 2014 May 22;157(5):1008-10. doi: 10.1016/j.cell.2014.05.001.

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