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Technological challenges and milestones for writing genomes.

Ostrov N, Beal J, Ellis T, Gordon DB, Karas BJ, Lee HH, Lenaghan SC, Schloss JA, Stracquadanio G, Trefzer A, Bader JS, Church GM, Coelho CM, Efcavitch JW, Güell M, Mitchell LA, Nielsen AAK, Peck B, Smith AC, Stewart CN Jr, Tekotte H.

Science. 2019 Oct 18;366(6463):310-312. doi: 10.1126/science.aay0339. No abstract available.


Sulfur Assimilation Alters Flagellar Function and Modulates the Gene Expression Landscape of Serratia marcescens.

Anderson MT, Mitchell LA, Sintsova A, Rice KA, Mobley HLT.

mSystems. 2019 Aug 6;4(4). pii: e00285-19. doi: 10.1128/mSystems.00285-19.


Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football.

Parivash SN, Goubran M, Mills BD, Rezaii P, Thaler C, Wolman D, Bian W, Mitchell LA, Boldt B, Douglas D, Wilson EW, Choi J, Xie L, Yushkevich PA, DiGiacomo P, Wongsripuemtet J, Parekh M, Fiehler J, Do H, Lopez J, Rosenberg J, Camarillo D, Grant G, Wintermark M, Zeineh M.

J Neurotrauma. 2019 Oct 1;36(19):2762-2773. doi: 10.1089/neu.2018.6357. Epub 2019 Jun 17.


PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models.

Mitchell LA, Yagiz K, Hofacre A, Viaud S, Munday AW, Espinoza FL, Mendoza D, Rodriguez-Aguirre ME, Bergqvist S, Haghighi A, Miner MV, Accomando WP, Burrascano C, Gammon D, Gruber HE, Jolly DJ, Lin AH.

Oncotarget. 2019 Mar 19;10(23):2252-2269. doi: 10.18632/oncotarget.26785. eCollection 2019 Mar 19.


Author Correction: Precise control of SCRaMbLE in synthetic haploid and diploid yeast.

Jia B, Wu Y, Li BZ, Mitchell LA, Liu H, Pan S, Wang J, Zhang HR, Jia N, Li B, Shen M, Xie ZX, Liu D, Cao YX, Li X, Zhou X, Qi H, Boeke JD, Yuan YJ.

Nat Commun. 2019 Feb 14;10(1):839. doi: 10.1038/s41467-019-08474-w.


Citrobacter freundii fitness during bloodstream infection.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT.

Sci Rep. 2018 Aug 7;8(1):11792. doi: 10.1038/s41598-018-30196-0.


Dual-catalytic decarbonylation of fatty acid methyl esters to form olefins.

Fieser ME, Schimler SD, Mitchell LA, Wilborn EG, John A, Hogan LT, Benson B, LaPointe AM, Tolman WB.

Chem Commun (Camb). 2018 Jul 5;54(55):7669-7672. doi: 10.1039/c8cc03823f.


Genomic integrity in the male germ line: evidence in support of the disposable soma hypothesis.

Xavier MJ, Mitchell LA, McEwan KE, Scott RJ, Aitken RJ.

Reproduction. 2018 Sep;156(3):269-282. doi: 10.1530/REP-18-0202. Epub 2018 Jun 19.


In vitro DNA SCRaMbLE.

Wu Y, Zhu RY, Mitchell LA, Ma L, Liu R, Zhao M, Jia B, Xu H, Li YX, Yang ZM, Ma Y, Li X, Liu H, Liu D, Xiao WH, Zhou X, Li BZ, Yuan YJ, Boeke JD.

Nat Commun. 2018 May 22;9(1):1935. doi: 10.1038/s41467-018-03743-6.


Heterozygous diploid and interspecies SCRaMbLEing.

Shen MJ, Wu Y, Yang K, Li Y, Xu H, Zhang H, Li BZ, Li X, Xiao WH, Zhou X, Mitchell LA, Bader JS, Yuan Y, Boeke JD.

Nat Commun. 2018 May 22;9(1):1934. doi: 10.1038/s41467-018-04157-0.


Precise control of SCRaMbLE in synthetic haploid and diploid yeast.

Jia B, Wu Y, Li BZ, Mitchell LA, Liu H, Pan S, Wang J, Zhang HR, Jia N, Li B, Shen M, Xie ZX, Liu D, Cao YX, Li X, Zhou X, Qi H, Boeke JD, Yuan YJ.

Nat Commun. 2018 May 22;9(1):1933. doi: 10.1038/s41467-018-03084-4. Erratum in: Nat Commun. 2019 Feb 14;10(1):839.


L-SCRaMbLE as a tool for light-controlled Cre-mediated recombination in yeast.

Hochrein L, Mitchell LA, Schulz K, Messerschmidt K, Mueller-Roeber B.

Nat Commun. 2018 May 22;9(1):1931. doi: 10.1038/s41467-017-02208-6.


Asymmetric Hearing Loss Prompting MRI Referral in a Military Population: Redefining Audiometric Criteria.

Tolisano AM, Burgos RM, Lustik MB, Mitchell LA, Littlefield PD.

Otolaryngol Head Neck Surg. 2018 Apr;158(4):695-701. doi: 10.1177/0194599818756300. Epub 2018 Feb 6.


A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models.

Yagiz K, Rodriguez-Aguirre ME, Lopez Espinoza F, Montellano TT, Mendoza D, Mitchell LA, Ibanez CE, Kasahara N, Gruber HE, Jolly DJ, Robbins JM.

Mol Ther Oncolytics. 2017 Dec 5;8:14-26. doi: 10.1016/j.omto.2017.12.001. eCollection 2018 Mar 30.


Coupling Yeast Golden Gate and VEGAS for Efficient Assembly of the Violacein Pathway in Saccharomyces cerevisiae.

Chuang J, Boeke JD, Mitchell LA.

Methods Mol Biol. 2018;1671:211-225. doi: 10.1007/978-1-4939-7295-1_14.


Rapid and Efficient CRISPR/Cas9-Based Mating-Type Switching of Saccharomyces cerevisiae.

Xie ZX, Mitchell LA, Liu HM, Li BZ, Liu D, Agmon N, Wu Y, Li X, Zhou X, Li B, Xiao WH, Ding MZ, Wang Y, Yuan YJ, Boeke JD.

G3 (Bethesda). 2018 Jan 4;8(1):173-183. doi: 10.1534/g3.117.300347.


Synthetic genome engineering gets infectious.

Mitchell LA, Ellis T.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11006-11008. doi: 10.1073/pnas.1715365114. Epub 2017 Oct 9. No abstract available.


Feasibility of transthoracic echocardiographic imaging in non-sedated ovine subjects using a commercial restraint device.

Colpitts ME, Phillion RC, Malinowski M, Coleman RA, Mitchell LA, Malone AB, Eberhart LL, Sanders RA, Langholz DE.

Lab Anim. 2018 Apr;52(2):196-199. doi: 10.1177/0023677217736553. Epub 2017 Oct 23.


Mechanistic Insights into the Alternating Copolymerization of Epoxides and Cyclic Anhydrides Using a (Salph)AlCl and Iminium Salt Catalytic System.

Fieser ME, Sanford MJ, Mitchell LA, Dunbar CR, Mandal M, Van Zee NJ, Urness DM, Cramer CJ, Coates GW, Tolman WB.

J Am Chem Soc. 2017 Oct 25;139(42):15222-15231. doi: 10.1021/jacs.7b09079. Epub 2017 Oct 6.


Crystal structures of the three closely related compounds: bis-[(1H-tetra-zol-5-yl)meth-yl]nitramide, tri-amino-guanidinium 5-({[(1H-tetra-zol-5-yl)meth-yl](nitro)-amino}-meth-yl)tetra-zol-1-ide, and di-ammonium bis-[(tetra-zol-1-id-5-yl)meth-yl]nitramide monohydrate.

Mitchell LA, Imler GH, Parrish DA, Deschamps JR, Leonard PW, Chavez DE.

Acta Crystallogr E Crystallogr Commun. 2017 Jun 20;73(Pt 7):1056-1061. doi: 10.1107/S2056989017008817. eCollection 2017 Jul 1.


Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity.

Anderson MT, Mitchell LA, Mobley HLT.

J Bacteriol. 2017 Jul 25;199(16). pii: e00159-17. doi: 10.1128/JB.00159-17. Print 2017 Aug 15.


Capsule Production and Glucose Metabolism Dictate Fitness during Serratia marcescens Bacteremia.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT.

mBio. 2017 May 23;8(3). pii: e00740-17. doi: 10.1128/mBio.00740-17.


Ammonia Oxide as a Building Block for High-Performance and Insensitive Energetic Materials.

Tang Y, Mitchell LA, Imler GH, Parrish DA, Shreeve JM.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5894-5898. doi: 10.1002/anie.201702285. Epub 2017 Apr 24.


Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model.

Mitchell LA, Lopez Espinoza F, Mendoza D, Kato Y, Inagaki A, Hiraoka K, Kasahara N, Gruber HE, Jolly DJ, Robbins JM.

Neuro Oncol. 2017 Jul 1;19(7):930-939. doi: 10.1093/neuonc/nox037.


Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity.

Hiraoka K, Inagaki A, Kato Y, Huang TT, Mitchell LA, Kamijima S, Takahashi M, Matsumoto H, Hacke K, Kruse CA, Ostertag D, Robbins JM, Gruber HE, Jolly DJ, Kasahara N.

Neuro Oncol. 2017 Jul 1;19(7):918-929. doi: 10.1093/neuonc/nox038.


Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions†.

Katen AL, Sipilä P, Mitchell LA, Stanger SJ, Nixon B, Roman SD.

Biol Reprod. 2017 Apr 1;96(4):921-935. doi: 10.1093/biolre/iox021.


Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro.

Lin AH, Twitty CG, Burnett R, Hofacre A, Mitchell LA, Espinoza FL, Gruber HE, Jolly DJ.

Mol Ther Nucleic Acids. 2017 Mar 17;6:221-232. doi: 10.1016/j.omtn.2016.11.007. Epub 2016 Dec 10.


Design of a synthetic yeast genome.

Richardson SM, Mitchell LA, Stracquadanio G, Yang K, Dymond JS, DiCarlo JE, Lee D, Huang CL, Chandrasegaran S, Cai Y, Boeke JD, Bader JS.

Science. 2017 Mar 10;355(6329):1040-1044. doi: 10.1126/science.aaf4557.


Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond.

Mitchell LA, Wang A, Stracquadanio G, Kuang Z, Wang X, Yang K, Richardson S, Martin JA, Zhao Y, Walker R, Luo Y, Dai H, Dong K, Tang Z, Yang Y, Cai Y, Heguy A, Ueberheide B, Fenyö D, Dai J, Bader JS, Boeke JD.

Science. 2017 Mar 10;355(6329). pii: eaaf4831. doi: 10.1126/science.aaf4831.


Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome.

Shen Y, Wang Y, Chen T, Gao F, Gong J, Abramczyk D, Walker R, Zhao H, Chen S, Liu W, Luo Y, Müller CA, Paul-Dubois-Taine A, Alver B, Stracquadanio G, Mitchell LA, Luo Z, Fan Y, Zhou B, Wen B, Tan F, Wang Y, Zi J, Xie Z, Li B, Yang K, Richardson SM, Jiang H, French CE, Nieduszynski CA, Koszul R, Marston AL, Yuan Y, Wang J, Bader JS, Dai J, Boeke JD, Xu X, Cai Y, Yang H.

Science. 2017 Mar 10;355(6329). pii: eaaf4791. doi: 10.1126/science.aaf4791.


Bug mapping and fitness testing of chemically synthesized chromosome X.

Wu Y, Li BZ, Zhao M, Mitchell LA, Xie ZX, Lin QH, Wang X, Xiao WH, Wang Y, Zhou X, Liu H, Li X, Ding MZ, Liu D, Zhang L, Liu BL, Wu XL, Li FF, Dong XT, Jia B, Zhang WZ, Jiang GZ, Liu Y, Bai X, Song TQ, Chen Y, Zhou SJ, Zhu RY, Gao F, Kuang Z, Wang X, Shen M, Yang K, Stracquadanio G, Richardson SM, Lin Y, Wang L, Walker R, Luo Y, Ma PS, Yang H, Cai Y, Dai J, Bader JS, Boeke JD, Yuan YJ.

Science. 2017 Mar 10;355(6329). pii: eaaf4706. doi: 10.1126/science.aaf4706.


"Perfect" designer chromosome V and behavior of a ring derivative.

Xie ZX, Li BZ, Mitchell LA, Wu Y, Qi X, Jin Z, Jia B, Wang X, Zeng BX, Liu HM, Wu XL, Feng Q, Zhang WZ, Liu W, Ding MZ, Li X, Zhao GR, Qiao JJ, Cheng JS, Zhao M, Kuang Z, Wang X, Martin JA, Stracquadanio G, Yang K, Bai X, Zhao J, Hu ML, Lin QH, Zhang WQ, Shen MH, Chen S, Su W, Wang EX, Guo R, Zhai F, Guo XJ, Du HX, Zhu JQ, Song TQ, Dai JJ, Li FF, Jiang GZ, Han SL, Liu SY, Yu ZC, Yang XN, Chen K, Hu C, Li DS, Jia N, Liu Y, Wang LT, Wang S, Wei XT, Fu MQ, Qu LM, Xin SY, Liu T, Tian KR, Li XN, Zhang JH, Song LX, Liu JG, Lv JF, Xu H, Tao R, Wang Y, Zhang TT, Deng YX, Wang YR, Li T, Ye GX, Xu XR, Xia ZB, Zhang W, Yang SL, Liu YL, Ding WQ, Liu ZN, Zhu JQ, Liu NZ, Walker R, Luo Y, Wang Y, Shen Y, Yang H, Cai Y, Ma PS, Zhang CT, Bader JS, Boeke JD, Yuan YJ.

Science. 2017 Mar 10;355(6329). pii: eaaf4704. doi: 10.1126/science.aaf4704.


3D organization of synthetic and scrambled chromosomes.

Mercy G, Mozziconacci J, Scolari VF, Yang K, Zhao G, Thierry A, Luo Y, Mitchell LA, Shen M, Shen Y, Walker R, Zhang W, Wu Y, Xie ZX, Luo Z, Cai Y, Dai J, Yang H, Yuan YJ, Boeke JD, Bader JS, Muller H, Koszul R.

Science. 2017 Mar 10;355(6329). pii: eaaf4597. doi: 10.1126/science.aaf4597.


Engineering the ribosomal DNA in a megabase synthetic chromosome.

Zhang W, Zhao G, Luo Z, Lin Y, Wang L, Guo Y, Wang A, Jiang S, Jiang Q, Gong J, Wang Y, Hou S, Huang J, Li T, Qin Y, Dong J, Qin Q, Zhang J, Zou X, He X, Zhao L, Xiao Y, Xu M, Cheng E, Huang N, Zhou T, Shen Y, Walker R, Luo Y, Kuang Z, Mitchell LA, Yang K, Richardson SM, Wu Y, Li BZ, Yuan YJ, Yang H, Lin J, Chen GQ, Wu Q, Bader JS, Cai Y, Boeke JD, Dai J.

Science. 2017 Mar 10;355(6329). pii: eaaf3981. doi: 10.1126/science.aaf3981.


Preference-based disease-specific health-related quality of life instrument for glaucoma: a mixed methods study protocol.

Muratov S, Podbielski DW, Jack SM, Ahmed II, Mitchell LA, Baltaziak M, Xie F.

BMJ Open. 2016 Nov 8;6(11):e012732. doi: 10.1136/bmjopen-2016-012732.


Comparative Study of Various Pyrazole-based Anions: A Promising Family of Ionic Derivatives as Insensitive Energetic Materials.

Yin P, Mitchell LA, Parrish DA, Shreeve JM.

Chem Asian J. 2017 Feb 1;12(3):378-384. doi: 10.1002/asia.201601615. Epub 2017 Jan 9.


Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic treatment.

Liu TT, Achrol AS, Mitchell LA, Rodriguez SA, Feroze A, Iv M, Kim C, Chaudhary N, Gevaert O, Stuart JM, Harsh GR, Chang SD, Rubin DL.

Neuro Oncol. 2017 Jul 1;19(7):997-1007. doi: 10.1093/neuonc/now270.


Why So Slow? Mechanistic Insights from Studies of a Poor Catalyst for Polymerization of ε-Caprolactone.

Stasiw DE, Mandal M, Neisen BD, Mitchell LA, Cramer CJ, Tolman WB.

Inorg Chem. 2017 Jan 17;56(2):725-728. doi: 10.1021/acs.inorgchem.6b02849. Epub 2016 Dec 22.


Non-faith-based arguments against physician-assisted suicide and euthanasia.

Sulmasy DP, Travaline JM, Mitchell LA, Ely EW.

Linacre Q. 2016 Aug;83(3):246-257.


Energetic N-Nitramino/N-Oxyl-Functionalized Pyrazoles with Versatile π-π Stacking: Structure-Property Relationships of High-Performance Energetic Materials.

Yin P, Mitchell LA, Parrish DA, Shreeve JM.

Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14409-14411. doi: 10.1002/anie.201608499. Epub 2016 Oct 20.


Phenyl substitution of cationic bis-cyclometalated iridium(iii) complexes for iTMC-LEECs.

Suhr KJ, Bastatas LD, Shen Y, Mitchell LA, Frazier GA, Taylor DW, Slinker JD, Holliday BJ.

Dalton Trans. 2016 Nov 28;45(44):17807-17823. Epub 2016 Oct 24.


3,6-Dinitropyrazolo[4,3-c]pyrazole-Based Multipurpose Energetic Materials through Versatile N-Functionalization Strategies.

Yin P, Zhang J, Mitchell LA, Parrish DA, Shreeve JM.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12895-7. doi: 10.1002/anie.201606894. Epub 2016 Sep 15.


Electrophilic iodination: a gateway to high iodine compounds and energetic materials.

Chand D, He C, Mitchell LA, Parrish DA, Shreeve JM.

Dalton Trans. 2016 Sep 21;45(35):13827-33. doi: 10.1039/c6dt02438f. Epub 2016 Aug 11.


Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions.

Schlingmann B, Overgaard CE, Molina SA, Lynn KS, Mitchell LA, Dorsainvil White S, Mattheyses AL, Guidot DM, Capaldo CT, Koval M.

Nat Commun. 2016 Jul 25;7:12276. doi: 10.1038/ncomms12276.


Small Cation-Based High-Performance Energetic Nitraminofurazanates.

Tang Y, He C, Mitchell LA, Parrish DA, Shreeve JM.

Chemistry. 2016 Aug 8;22(33):11846-53. doi: 10.1002/chem.201602171. Epub 2016 Jun 29.


Correction: From FOX-7 to H-FOX to insensitive energetic materials with hypergolic properties.

Dharavath S, Mitchell LA, Parrish DA, Shreeve JM.

Chem Commun (Camb). 2016 Jun 21;52(52):8168.


Energetic aminated-azole assemblies from intramolecular and intermolecular N-HO and N-HN hydrogen bonds.

He C, Yin P, Mitchell LA, Parrish DA, Shreeve JM.

Chem Commun (Camb). 2016 Jun 21;52(52):8123-6. doi: 10.1039/c6cc03833f.


Energetic Salts Based on 3,5-Bis(dinitromethyl)-1,2,4-triazole Monoanion and Dianion: Controllable Preparation, Characterization, and High Performance.

Zhang J, Dharavath S, Mitchell LA, Parrish DA, Shreeve JM.

J Am Chem Soc. 2016 Jun 22;138(24):7500-3. doi: 10.1021/jacs.6b03819. Epub 2016 Jun 10.


GENOME ENGINEERING. The Genome Project-Write.

Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.

Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. Epub 2016 Jun 2. No abstract available.


Mono- and diiodo-1,2,3-triazoles and their mono nitro derivatives.

Chand D, He C, Hooper JP, Mitchell LA, Parrish DA, Shreeve JM.

Dalton Trans. 2016 Jun 21;45(23):9684-8. doi: 10.1039/c6dt01731b. Epub 2016 May 26.


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