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Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc.

Sourbier C, Ricketts CJ, Liao PJ, Matsumoto S, Wei D, Lang M, Railkar R, Yang Y, Wei MH, Agarwal P, Krishna M, Mitchell JB, Trepel JB, Neckers L, Linehan WM.

Sci Rep. 2019 Dec 5;9(1):18409. doi: 10.1038/s41598-019-55003-2.


Abemaciclib: A multi-functional radiation modifier.

Naz S, Cook JA, Mitchell JB.

Oncotarget. 2019 Feb 8;10(12):1230-1232. doi: 10.18632/oncotarget.26652. eCollection 2019 Feb 8. No abstract available.


Rationale for hypoxia assessment and amelioration for precision therapy and immunotherapy studies.

Dewhirst MW, Mowery YM, Mitchell JB, Cherukuri MK, Secomb TW.

J Clin Invest. 2019 Feb 1;129(2):489-491. doi: 10.1172/JCI126044. Epub 2019 Jan 7. Review. No abstract available.


Imaging Metabolic Processes to Predict Radiation Responses.

Naz S, Kishimoto S, Mitchell JB, Krishna MC.

Semin Radiat Oncol. 2019 Jan;29(1):81-89. doi: 10.1016/j.semradonc.2018.10.004. Review.


Synthesis and evaluation of 13C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized 13C-MRI.

Saito K, Sail D, Yamamoto K, Matsumoto S, Blackman B, Kishimoto S, Brender JR, Swenson RE, Mitchell JB, Krishna MC.

Free Radic Biol Med. 2019 Feb 1;131:18-26. doi: 10.1016/j.freeradbiomed.2018.11.013. Epub 2018 Nov 22.


Effect of ACTN3 Polymorphism on Self-reported Running Times.

Kreutzer A, Martinez CA, Kreutzer M, Stone JD, Mitchell JB, Oliver JM.

J Strength Cond Res. 2019 Jan;33(1):80-88. doi: 10.1519/JSC.0000000000002949.


Effects of oxygen challenging to tissue redox and pO2 status.

Matsumoto KI, Mitchell JB, Krishna MC.

Free Radic Biol Med. 2019 Jan;130:343-347. doi: 10.1016/j.freeradbiomed.2018.10.454. Epub 2018 Nov 2.


Crystal structure evaluation: calculating relative stabilities and other criteria: general discussion.

Addicoat M, Adjiman CS, Arhangelskis M, Beran GJO, Bowskill D, Brandenburg JG, Braun DE, Burger V, Cole J, Cruz-Cabeza AJ, Day GM, Deringer VL, Guo R, Hare A, Helfferich J, Hoja J, Iuzzolino L, Jobbins S, Marom N, McKay D, Mitchell JBO, Mohamed S, Neumann M, Nilsson Lill S, Nyman J, Oganov AR, Piaggi P, Price SL, Reutzel-Edens S, Rietveld I, Ruggiero M, Ryder MR, Sastre G, Schön JC, Taylor C, Tkatchenko A, Tsuzuki S, van den Ende J, Woodley SM, Woollam G, Zhu Q.

Faraday Discuss. 2018 Oct 26;211(0):325-381. doi: 10.1039/C8FD90031K. No abstract available.


A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response.

Takakusagi Y, Naz S, Takakusagi K, Ishima M, Murata H, Ohta K, Miura M, Sugawara F, Sakaguchi K, Kishimoto S, Munasinghe JP, Mitchell JB, Krishna MC.

Cancer Res. 2018 Dec 15;78(24):6828-6837. doi: 10.1158/0008-5472.CAN-18-1654. Epub 2018 Oct 9.


Applications of crystal structure prediction - inorganic and network structures: general discussion.

Burger V, Claeyssens F, Davies DW, Day GM, Dyer MS, Hare A, Li Y, Mellot-Draznieks C, Mitchell JBO, Mohamed S, Oganov AR, Price SL, Ruggiero M, Ryder MR, Sastre G, Schön JC, Spackman P, Woodley SM, Zhu Q.

Faraday Discuss. 2018 Oct 26;211(0):613-642. doi: 10.1039/c8fd90034e. No abstract available.


Applications of crystal structure prediction - organic molecular structures: general discussion.

Adjiman CS, Brandenburg JG, Braun DE, Cole J, Collins C, Cooper AI, Cruz-Cabeza AJ, Day GM, Dudek M, Hare A, Iuzzolino L, McKay D, Mitchell JBO, Mohamed S, Neelamraju S, Neumann M, Nilsson Lill S, Nyman J, Oganov AR, Price SL, Pulido A, Reutzel-Edens S, Rietveld I, Ruggiero MT, Schön JC, Tsuzuki S, van den Ende J, Woollam G, Zhu Q.

Faraday Discuss. 2018 Oct 26;211(0):493-539. doi: 10.1039/c8fd90032a. No abstract available.


Behavioral immune system activity predicts downregulation of chronic basal inflammation.

Gassen J, Prokosch ML, Makhanova A, Eimerbrink MJ, White JD, Proffitt Leyva RP, Peterman JL, Nicolas SC, Reynolds TA, Maner JK, McNulty JK, Eckel LA, Nikonova L, Brinkworth JF, Phillips MD, Mitchell JB, Boehm GW, Hill SE.

PLoS One. 2018 Sep 20;13(9):e0203961. doi: 10.1371/journal.pone.0203961. eCollection 2018.


Modelling of ultraviolet light inactivation kinetics of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, Clostridium difficile spores and murine norovirus on fomite surfaces.

Mitchell JB, Sifuentes LY, Wissler A, Abd-Elmaksoud S, Lopez GU, Gerba CP.

J Appl Microbiol. 2019 Jan;126(1):58-67. doi: 10.1111/jam.14103. Epub 2018 Oct 25.


Artificial intelligence in pharmaceutical research and development.

Mitchell JB.

Future Med Chem. 2018 Jul 1;10(13):1529-1531. doi: 10.4155/fmc-2018-0158. Epub 2018 Jul 3. No abstract available.


Co-imaging of the tumor oxygenation and metabolism using electron paramagnetic resonance imaging and 13-C hyperpolarized magnetic resonance imaging before and after irradiation.

Matsuo M, Kawai T, Kishimoto S, Saito K, Munasinghe J, Devasahayam N, Mitchell JB, Krishna MC.

Oncotarget. 2018 May 18;9(38):25089-25100. doi: 10.18632/oncotarget.25317. eCollection 2018 May 18.


Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.

Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC.

Cancer Res. 2018 Jul 15;78(14):3783-3792. doi: 10.1158/0008-5472.CAN-18-0491. Epub 2018 May 23.


Operando Atomic Force Microscopy Reveals Mechanics of Structural Water Driven Battery-to-Pseudocapacitor Transition.

Wang R, Mitchell JB, Gao Q, Tsai WY, Boyd S, Pharr M, Balke N, Augustyn V.

ACS Nano. 2018 Jun 26;12(6):6032-6039. doi: 10.1021/acsnano.8b02273. Epub 2018 May 21.


Abemaciclib, a Selective CDK4/6 Inhibitor, Enhances the Radiosensitivity of Non-Small Cell Lung Cancer In Vitro and In Vivo.

Naz S, Sowers A, Choudhuri R, Wissler M, Gamson J, Mathias A, Cook JA, Mitchell JB.

Clin Cancer Res. 2018 Aug 15;24(16):3994-4005. doi: 10.1158/1078-0432.CCR-17-3575. Epub 2018 May 1.


Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications.

Enomoto A, Qian C, Devasahayam N, Kishimoto S, Oshima N, Blackman B, Swenson RE, Mitchell JB, Koretsky AP, Krishna MC.

Magn Reson Med. 2018 Nov;80(5):2288-2298. doi: 10.1002/mrm.27185. Epub 2018 Mar 30.


Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.

Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE.

Clin Cancer Res. 2018 Jul 1;24(13):3137-3148. doi: 10.1158/1078-0432.CCR-17-1957. Epub 2018 Mar 29.


Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.

Cook JA, Naz S, Anver MR, Sowers AL, Fabre K, Krishna MC, Mitchell JB.

Radiat Res. 2018 May;189(5):490-496. doi: 10.1667/RR14987.1. Epub 2018 Mar 12.


PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation.

Morisada M, Clavijo PE, Moore E, Sun L, Chamberlin M, Van Waes C, Hodge JW, Mitchell JB, Friedman J, Allen CT.

Oncoimmunology. 2017 Nov 27;7(3):e1395996. doi: 10.1080/2162402X.2017.1395996. eCollection 2018.


Comparative studies with EPR and MRI on the in vivo tissue redox status estimation using redox-sensitive nitroxyl probes: influence of the choice of the region of interest.

Matsumoto KI, Mitchell JB, Krishna MC.

Free Radic Res. 2018 Feb;52(2):248-255. doi: 10.1080/10715762.2018.1427235. Epub 2018 Jan 31.


Molecular imaging of tumor photoimmunotherapy: Evidence of photosensitized tumor necrosis and hemodynamic changes.

Kishimoto S, Oshima N, Yamamoto K, Munasinghe J, Ardenkjaer-Larsen JH, Mitchell JB, Choyke PL, Krishna MC.

Free Radic Biol Med. 2018 Feb 20;116:1-10. doi: 10.1016/j.freeradbiomed.2017.12.034. Epub 2017 Dec 29.


Can human experts predict solubility better than computers?

Boobier S, Osbourn A, Mitchell JBO.

J Cheminform. 2017 Dec 13;9(1):63. doi: 10.1186/s13321-017-0250-y.


Effect of body temperature on the pharmacokinetics of a triarylmethyl-type paramagnetic contrast agent used in EPR oximetry.

Matsumoto KI, Hyodo F, Mitchell JB, Krishna MC.

Magn Reson Med. 2018 Feb;79(2):1212-1218. doi: 10.1002/mrm.27008. Epub 2017 Nov 16.


Pulsed Electron Paramagnetic Resonance Imaging: Applications in the Studies of Tumor Physiology.

Kishimoto S, Matsumoto KI, Saito K, Enomoto A, Matsumoto S, Mitchell JB, Devasahayam N, Krishna MC.

Antioxid Redox Signal. 2018 May 20;28(15):1378-1393. doi: 10.1089/ars.2017.7391. Epub 2018 Jan 9. Review.


Enzyme function and its evolution.

Mitchell JB.

Curr Opin Struct Biol. 2017 Dec;47:151-156. doi: 10.1016/ Epub 2017 Oct 27. Review.


Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation.

Yasui H, Kawai T, Matsumoto S, Saito K, Devasahayam N, Mitchell JB, Camphausen K, Inanami O, Krishna MC.

Free Radic Res. 2017 Oct;51(9-10):861-871. doi: 10.1080/10715762.2017.1388506.


Mechanisms of Normal Tissue Injury From Irradiation.

Citrin DE, Mitchell JB.

Semin Radiat Oncol. 2017 Oct;27(4):316-324. doi: 10.1016/j.semradonc.2017.04.001. Review.


Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies.

Takakusagi Y, Kishimoto S, Naz S, Matsumoto S, Saito K, Hart CP, Mitchell JB, Krishna MC.

Antioxid Redox Signal. 2018 Jan 10;28(2):131-140. doi: 10.1089/ars.2017.7106. Epub 2017 Sep 8.


Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches.

Vucicevic J, Nikolic K, Mitchell JBO.

Curr Med Chem. 2019;26(21):3874-3889. doi: 10.2174/0929867324666170712115411. Review.


Dose-dependent enhancement of T-lymphocyte priming and CTL lysis following ionizing radiation in an engineered model of oral cancer.

Morisada M, Moore EC, Hodge R, Friedman J, Cash HA, Hodge JW, Mitchell JB, Allen CT.

Oral Oncol. 2017 Aug;71:87-94. doi: 10.1016/j.oraloncology.2017.06.005. Epub 2017 Jun 10.


Effect of amifostine, a radiation-protecting drug, on oxygen concentration in tissue measured by EPR oximetry and imaging.

Ueno M, Matsumoto S, Matsumoto A, Manda S, Nakanishi I, Matsumoto KI, Mitchell JB, Krishna MC, Anzai K.

J Clin Biochem Nutr. 2017 May;60(3):151-155. doi: 10.3164/jcbn.15-130. Epub 2017 Mar 25.


Dissociative Recombination of Acetone Fragments, Adducts, and Dimer Ions.

Al Shammari S, Almeida GC, Rocco MLM, Le Garrec JL, Mitchell JBA.

J Phys Chem A. 2017 Jun 1;121(21):4114-4122. doi: 10.1021/acs.jpca.7b00987. Epub 2017 May 18.


Effect of Tempol on the prevention of irradiation-induced mucositis in miniature pigs.

Hu L, Wang Y, Cotrim AP, Zhu Z, Gao R, Zheng C, Goldsmith CM, Jin L, Zhang C, Mitchell JB, Baum BJ, Wang S.

Oral Dis. 2017 Sep;23(6):801-808. doi: 10.1111/odi.12667. Epub 2017 Apr 27.


Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models.

Neil S, Huh J, Baronas V, Li X, McFarland HF, Cherukuri M, Mitchell JB, Quandt JA.

Brain Behav Immun. 2017 May;62:332-343. doi: 10.1016/j.bbi.2017.02.018. Epub 2017 Feb 24.


Are the Sublimation Thermodynamics of Organic Molecules Predictable?

McDonagh JL, Palmer DS, Mourik TV, Mitchell JB.

J Chem Inf Model. 2016 Nov 28;56(11):2162-2179. Epub 2016 Nov 2.


Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model.

Chung EJ, Sowers A, Thetford A, McKay-Corkum G, Chung SI, Mitchell JB, Citrin DE.

Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):857-866. doi: 10.1016/j.ijrobp.2016.07.026. Epub 2016 Jul 28.


Erratum: Predicting Melting Points of Organic Molecules: Applications to Aqueous Solubility Prediction Using the General Solubility Equation.

McDonagh JL, van Mourik T, Mitchell JB.

Mol Inform. 2016 Oct;35(10):538. doi: 10.1002/minf.201681041. No abstract available.


Ingestion of High Molecular Weight Carbohydrate Enhances Subsequent Repeated Maximal Power: A Randomized Controlled Trial.

Oliver JM, Almada AL, Van Eck LE, Shah M, Mitchell JB, Jones MT, Jagim AR, Rowlands DS.

PLoS One. 2016 Sep 16;11(9):e0163009. doi: 10.1371/journal.pone.0163009. eCollection 2016.


Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study.

Oliver JM, Stoner L, Rowlands DS, Caldwell AR, Sanders E, Kreutzer A, Mitchell JB, Purpura M, Jäger R.

J Nutr Metab. 2016;2016:1089653. doi: 10.1155/2016/1089653. Epub 2016 Aug 17.


A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.

Chen AS, Westwood NJ, Brear P, Rogers GW, Mavridis L, Mitchell JB.

Mol Inform. 2016 Apr;35(3-4):125-35. doi: 10.1002/minf.201500108. Epub 2016 Jan 21.


Predicting Melting Points of Organic Molecules: Applications to Aqueous Solubility Prediction Using the General Solubility Equation.

McDonagh JL, van Mourik T, Mitchell JB.

Mol Inform. 2015 Nov;34(11-12):715-24. doi: 10.1002/minf.201500052. Epub 2015 Jul 20. Erratum in: Mol Inform. 2016 Oct;35(10 ):538.


Greedy and Linear Ensembles of Machine Learning Methods Outperform Single Approaches for QSPR Regression Problems.

Kew W, Mitchell JB.

Mol Inform. 2015 Sep;34(9):634-47. doi: 10.1002/minf.201400122. Epub 2015 Mar 25.


SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.

Eytan DF, Snow GE, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers AL, Hernandez L, Mitchell JB, Annunziata CM, Chen Z, Van Waes C.

Cancer Res. 2016 Sep 15;76(18):5442-5454. doi: 10.1158/0008-5472.CAN-15-3317. Epub 2016 Jul 28.


Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors.

Mizrachi A, Cotrim AP, Katabi N, Mitchell JB, Verheij M, Haimovitz-Friedman A.

Radiat Res. 2016 Aug;186(2):189-95. doi: 10.1667/RR14431.1. Epub 2016 Jul 26.


Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies.

Nikolic K, Mavridis L, Djikic T, Vucicevic J, Agbaba D, Yelekci K, Mitchell JB.

Front Neurosci. 2016 Jun 10;10:265. doi: 10.3389/fnins.2016.00265. eCollection 2016. Review.


Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations.

Stone HB, Bernhard EJ, Coleman CN, Deye J, Capala J, Mitchell JB, Brown JM.

Transl Oncol. 2016 Feb;9(1):46-56. doi: 10.1016/j.tranon.2016.01.002. Review.


Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model.

Chung EJ, McKay-Corkum G, Chung S, White A, Scroggins BT, Mitchell JB, Mulligan-Kehoe MJ, Citrin D.

Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1163-72. doi: 10.1016/j.ijrobp.2015.11.044. Epub 2015 Dec 14.

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