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Electrospinning 3D bioactive glasses for wound healing.

Norris E, Ramos-Rivera C, Poologasundarampillai G, Clark JP, Ju Q, Obata A, Hanna JV, Kasuga T, Mitchell CA, Jell G, Jones JR.

Biomed Mater. 2019 Nov 19. doi: 10.1088/1748-605X/ab591d. [Epub ahead of print]


AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.

Conduit SE, Davies EM, Ooms LM, Gurung R, McGrath MJ, Hakim S, Cottle DL, Smyth IM, Dyson JM, Mitchell CA.

Hum Mol Genet. 2019 Oct 18. pii: ddz232. doi: 10.1093/hmg/ddz232. [Epub ahead of print]


Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.

Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP.

Nat Genet. 2019 Oct;51(10):1518-1529. doi: 10.1038/s41588-019-0502-z. Epub 2019 Sep 30.


The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis.

Sheffield DA, Jepsen MR, Feeney SJ, Bertucci MC, Sriratana A, Naughtin MJ, Dyson JM, Coppel RL, Mitchell CA.

J Biol Chem. 2019 Nov 8;294(45):16684-16697. doi: 10.1074/jbc.RA119.009133. Epub 2019 Sep 22.


Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.

Dodd GT, Xirouchaki CE, Eramo M, Mitchell CA, Andrews ZB, Henry BA, Cowley MA, Tiganis T.

Cell Rep. 2019 Sep 10;28(11):2905-2922.e5. doi: 10.1016/j.celrep.2019.08.019.


Women in cancer research.

Mitchell CA, Roussel MF, Walsh L, Weeraratna AT.

Nat Rev Cancer. 2019 Oct;19(10):547-552. doi: 10.1038/s41568-019-0176-y. Epub 2019 Aug 15.


Complex Interplay Among Nuclear Receptor Ligands, Cytosine Methylation, and the Metabolome in Driving Tris(1,3-dichloro-2-propyl)phosphate-Induced Epiboly Defects in Zebrafish.

Dasgupta S, Vliet SMF, Cheng V, Mitchell CA, Kirkwood J, Vollaro A, Hur M, Mehdizadeh C, Volz DC.

Environ Sci Technol. 2019 Sep 3;53(17):10497-10505. doi: 10.1021/acs.est.9b04127. Epub 2019 Aug 20.


mRNA-Sequencing Identifies Liver as a Potential Target Organ for Triphenyl Phosphate in Embryonic Zebrafish.

Reddam A, Mitchell CA, Dasgupta S, Kirkwood JS, Vollaro A, Hur M, Volz DC.

Toxicol Sci. 2019 Jul 31. pii: kfz169. doi: 10.1093/toxsci/kfz169. [Epub ahead of print]


Prospective review to evaluate the impact of medication changes recommended by consultant geriatricians.

Poudel A, Peel NM, Mitchell CA, Gray LC, Hubbard RE, Nissen LM.

Intern Med J. 2019 Jul;49(7):935. doi: 10.1111/imj.14352. No abstract available.


Diphenyl Phosphate-Induced Toxicity During Embryonic Development.

Mitchell CA, Reddam A, Dasgupta S, Zhang S, Stapleton HM, Volz DC.

Environ Sci Technol. 2019 Apr 2;53(7):3908-3916. doi: 10.1021/acs.est.8b07238. Epub 2019 Mar 20.


Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation.

Ma X, Zhang L, Song J, Nguyen E, Lee RS, Rodgers SJ, Li F, Huang C, Schittenhelm RB, Chan H, Chheang C, Wu J, Brown KK, Mitchell CA, Simpson KJ, Daly RJ.

Nat Commun. 2019 Jan 17;10(1):296. doi: 10.1038/s41467-018-08154-1.


Effective angiogenesis requires regulation of phosphoinositide signaling.

Davies EM, Gurung R, Le KQ, Mitchell CA.

Adv Biol Regul. 2019 Jan;71:69-78. doi: 10.1016/j.jbior.2018.11.008. Epub 2018 Nov 26. Review.


β-catenin ablation exacerbates polycystic kidney disease progression.

Conduit SE, Hakim S, Feeney SJ, Ooms LM, Dyson JM, Abud HE, Mitchell CA.

Hum Mol Genet. 2019 Jan 15;28(2):230-244. doi: 10.1093/hmg/ddy309.


Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the Early-Blastula Stage Alters the Normal Trajectory of Zebrafish Embryogenesis.

Dasgupta S, Cheng V, Vliet SMF, Mitchell CA, Volz DC.

Environ Sci Technol. 2018 Sep 18;52(18):10820-10828. doi: 10.1021/acs.est.8b03730. Epub 2018 Sep 10.


Tenacic Acids: A New Class of Tenacious Binders to Metal Oxide Surfaces.

Komati R, Mitchell CA, LeBeaud A, Do H, Goloverda GZ, Kolesnichenko VL.

Chemistry. 2018 Oct 1;24(55):14824-14829. doi: 10.1002/chem.201803242. Epub 2018 Sep 6.


Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels.

Abdelkader DH, Tambuwala MM, Mitchell CA, Osman MA, El-Gizawy SA, Faheem AM, El-Tanani M, McCarron PA.

Drug Deliv Transl Res. 2018 Oct;8(5):1053-1065. doi: 10.1007/s13346-018-0554-0.


Incidental Metastatic Melanoma Identified on 68Ga-Prostate-Specific Membrane Antigen PET/CT for Metastatic Prostate Cancer.

Snow HA, Hofman MS, Mitchell CA, Gyorki DE, Smith MJF.

Clin Nucl Med. 2018 Jul;43(7):509-511. doi: 10.1097/RLU.0000000000002111.


From Dark Dens to Suburban Townhouses: Creating a Centralized System for Prescription Opiate Monitoring to Combat the Addiction Epidemic in the United States.

Mitchell CA.

J Leg Med. 2018 Jan-Mar;38(1):119-162. doi: 10.1080/01947648.2018.1438018. No abstract available.


Options and Limitations in Clinical Investigation of Bacterial Biofilms.

Magana M, Sereti C, Ioannidis A, Mitchell CA, Ball AR, Magiorkinis E, Chatzipanagiotou S, Hamblin MR, Hadjifrangiskou M, Tegos GP.

Clin Microbiol Rev. 2018 Apr 4;31(3). pii: e00084-16. doi: 10.1128/CMR.00084-16. Print 2018 Jul. Review.


Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos.

Mitchell CA, Dasgupta S, Zhang S, Stapleton HM, Volz DC.

Toxicol Sci. 2018 May 1;163(1):307-318. doi: 10.1093/toxsci/kfy037.


Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.

Du L, Risinger AL, Mitchell CA, You J, Stamps BW, Pan N, King JB, Bopassa JC, Judge SIV, Yang Z, Stevenson BS, Cichewicz RH.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8957-E8966. doi: 10.1073/pnas.1707565114. Epub 2017 Oct 10.


Oligometastatic Renal Cell Carcinoma With Sarcomatoid Differentiation Demonstrating Variable Imaging Phenotypes on 68Ga-PSMA and 18F-FDG PET/CT: A Case Report and Review of the Literature.

Nadebaum DP, Hofman MS, Mitchell CA, Siva S, Hicks RJ.

Clin Genitourin Cancer. 2017 Aug 23. pii: S1558-7673(17)30250-1. doi: 10.1016/j.clgc.2017.08.009. [Epub ahead of print] No abstract available.


The Structure and Measurement of Unusual Sensory Experiences in Different Modalities: The Multi-Modality Unusual Sensory Experiences Questionnaire (MUSEQ).

Mitchell CAA, Maybery MT, Russell-Smith SN, Collerton D, Gignac GE, Waters F.

Front Psychol. 2017 Aug 11;8:1363. doi: 10.3389/fpsyg.2017.01363. eCollection 2017.


In Vivo Toxicity Assessment of Occupational Components of the Carbon Nanotube Life Cycle To Provide Context to Potential Health Effects.

Bishop L, Cena L, Orandle M, Yanamala N, Dahm MM, Birch ME, Evans DE, Kodali VK, Eye T, Battelli L, Zeidler-Erdely PC, Casuccio G, Bunker K, Lupoi JS, Lersch TL, Stefaniak AB, Sager T, Afshari A, Schwegler-Berry D, Friend S, Kang J, Siegrist KJ, Mitchell CA, Lowry DT, Kashon ML, Mercer RR, Geraci CL, Schubauer-Berigan MK, Sargent LM, Erdely A.

ACS Nano. 2017 Sep 26;11(9):8849-8863. doi: 10.1021/acsnano.7b03038. Epub 2017 Aug 4.


Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.

Kelly P, Denver P, Satchell SC, Ackermann M, Konerding MA, Mitchell CA.

Angiogenesis. 2017 Nov;20(4):567-580. doi: 10.1007/s10456-017-9568-3. Epub 2017 Jul 25.


P-Rex1 and P-Rex2 RacGEFs and cancer.

Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA.

Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14. Review.


Examining How Neighborhood Socioeconomic Status, Geographic Accessibility, and Informational Accessibility Influence the Uptake of a Free Population-Level Physical Activity Intervention for Children.

Clark AF, Wilk P, Mitchell CA, Smith C, Archer J, Gilliland JA.

Am J Health Promot. 2018 Feb;32(2):315-324. doi: 10.1177/0890117117718433. Epub 2017 Jul 5.


A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, Taylor MD, Mitchell CA, Dyson JM.

Oncogene. 2017 Oct 26;36(43):5969-5984. doi: 10.1038/onc.2017.208. Epub 2017 Jun 26.


Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens.

Valotteau C, Banat IM, Mitchell CA, Lydon H, Marchant R, Babonneau F, Pradier CM, Baccile N, Humblot V.

Colloids Surf B Biointerfaces. 2017 Sep 1;157:325-334. doi: 10.1016/j.colsurfb.2017.05.072. Epub 2017 Jun 2.


Biotransformation of Silver Released from Nanoparticle Coated Titanium Implants Revealed in Regenerating Bone.

Geng H, Poologasundarampillai G, Todd N, Devlin-Mullin A, Moore KL, Golrokhi Z, Gilchrist JB, Jones E, Potter RJ, Sutcliffe C, O'Brien M, Hukins DWL, Cartmell S, Mitchell CA, Lee PD.

ACS Appl Mater Interfaces. 2017 Jun 28;9(25):21169-21180. doi: 10.1021/acsami.7b05150. Epub 2017 Jun 16.


Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.

Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI.

J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31.


Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration.

Nommeots-Nomm A, Labbaf S, Devlin A, Todd N, Geng H, Solanki AK, Tang HM, Perdika P, Pinna A, Ejeian F, Tsigkou O, Lee PD, Esfahani MHN, Mitchell CA, Jones JR.

Acta Biomater. 2017 Jul 15;57:449-461. doi: 10.1016/j.actbio.2017.04.030. Epub 2017 Apr 27.


Functional in vivo imaging using fluorescence lifetime light-sheet microscopy.

Mitchell CA, Poland SP, Seyforth J, Nedbal J, Gelot T, Huq T, Holst G, Knight RD, Ameer-Beg SM.

Opt Lett. 2017 Apr 1;42(7):1269-1272. doi: 10.1364/OL.42.001269.


Correction to Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-Anthropoidal Mammalian Microbiomes.

Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH.

J Nat Prod. 2017 Apr 28;80(4):1233. doi: 10.1021/acs.jnatprod.7b00234. Epub 2017 Mar 24. No abstract available.


Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes.

Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH.

J Nat Prod. 2017 Mar 24;80(3):598-608. doi: 10.1021/acs.jnatprod.6b00772. Epub 2016 Nov 21. Erratum in: J Nat Prod. 2017 Apr 28;80(4):1233.


Antiviral lectins: Selective inhibitors of viral entry.

Mitchell CA, Ramessar K, O'Keefe BR.

Antiviral Res. 2017 Jun;142:37-54. doi: 10.1016/j.antiviral.2017.03.007. Epub 2017 Mar 18. Review.


Atomic Layer Deposition of a Silver Nanolayer on Advanced Titanium Orthopedic Implants Inhibits Bacterial Colonization and Supports Vascularized de Novo Bone Ingrowth.

Devlin-Mullin A, Todd NM, Golrokhi Z, Geng H, Konerding MA, Ternan NG, Hunt JA, Potter RJ, Sutcliffe C, Jones E, Lee PD, Mitchell CA.

Adv Healthc Mater. 2017 Jun;6(11). doi: 10.1002/adhm.201700033. Epub 2017 Mar 21.


Morbidity and Survival in Elderly Patients Undergoing Free Flap Reconstruction: A Retrospective Cohort Study.

Mitchell CA, Goldman RA, Curry JM, Cognetti DM, Krein H, Heffelfinger R, Luginbuhl A.

Otolaryngol Head Neck Surg. 2017 Jul;157(1):42-47. doi: 10.1177/0194599817696301. Epub 2017 Mar 7.


Adjuvant Antibiotic Activity of Acidic Sophorolipids with Potential for Facilitating Wound Healing.

Lydon HL, Baccile N, Callaghan B, Marchant R, Mitchell CA, Banat IM.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02547-16. doi: 10.1128/AAC.02547-16. Print 2017 May.


Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.

Rodgers SJ, Ferguson DT, Mitchell CA, Ooms LM.

Biosci Rep. 2017 Feb 10;37(1). pii: BSR20160432. doi: 10.1042/BSR20160432. Print 2017 Feb 28. Review.


INPP5E regulates phosphoinositide-dependent cilia transition zone function.

Dyson JM, Conduit SE, Feeney SJ, Hakim S, DiTommaso T, Fulcher AJ, Sriratana A, Ramm G, Horan KA, Gurung R, Wicking C, Smyth I, Mitchell CA.

J Cell Biol. 2017 Jan 2;216(1):247-263. doi: 10.1083/jcb.201511055. Epub 2016 Dec 20.


Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.

Hakim S, Dyson JM, Feeney SJ, Davies EM, Sriratana A, Koenig MN, Plotnikova OV, Smyth IM, Ricardo SD, Hobbs RM, Mitchell CA.

Hum Mol Genet. 2016 Jun 1;25(11):2295-2313. Epub 2016 Apr 7.


Respiratory health screening for opiate misusers in a specialist community clinic: a mixed-methods pilot study, with integrated staff and service user feedback.

Mitchell CA, Pitt A, Hulin J, Lawson R, Ashby F, Appelqvist I, Delaney B.

BMJ Open. 2016 Oct 14;6(10):e012823. doi: 10.1136/bmjopen-2016-012823.


Manipulating Sensory and Phytochemical Profiles of Greenhouse Tomatoes Using Environmentally Relevant Doses of Ultraviolet Radiation.

Dzakovich MP, Ferruzzi MG, Mitchell CA.

J Agric Food Chem. 2016 Sep 14;64(36):6801-8. doi: 10.1021/acs.jafc.6b02983. Epub 2016 Aug 31.


Riverine Response of Sulfate to Declining Atmospheric Sulfur Deposition in Agricultural Watersheds.

David MB, Gentry LE, Mitchell CA.

J Environ Qual. 2016 Jul;45(4):1313-9. doi: 10.2134/jeq2015.12.0613.


Long-term clinical evaluation of the automatic stance-phase lock-controlled prosthetic knee joint in young adults with unilateral above-knee amputation.

Andrysek J, Wright FV, Rotter K, Garcia D, Valdebenito R, Mitchell CA, Rozbaczylo C, Cubillos R.

Disabil Rehabil Assist Technol. 2017 May;12(4):378-384. doi: 10.3109/17483107.2016.1173730. Epub 2016 Jul 4.


Adverse Outcomes in Relation to Polypharmacy in Robust and Frail Older Hospital Patients.

Poudel A, Peel NM, Nissen LM, Mitchell CA, Gray LC, Hubbard RE.

J Am Med Dir Assoc. 2016 Aug 1;17(8):767.e9-767.e13. doi: 10.1016/j.jamda.2016.05.017. Epub 2016 Jun 30.


PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.

Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA.

J Biol Chem. 2016 Aug 12;291(33):17258-70. doi: 10.1074/jbc.M116.743401. Epub 2016 Jun 29.


Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/- Mice.

Callaghan B, Lydon H, Roelants SL, Van Bogaert IN, Marchant R, Banat IM, Mitchell CA.

PLoS One. 2016 Jun 6;11(6):e0156845. doi: 10.1371/journal.pone.0156845. eCollection 2016.

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