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Decreased Jagged1 Expression in Vascular Smooth Muscle Cells Delays Endothelial Regeneration in Arteriovenous Graft.

Guo Q, Huang F, Qing Y, Feng S, Xiao X, Wang Y, Liang M, Wang T, Mitch WE, Cheng J.

Cardiovasc Res. 2020 Jan 8. pii: cvz333. doi: 10.1093/cvr/cvz333. [Epub ahead of print]


Effects of Sodium Bicarbonate in CKD Stages 3 and 4: A Randomized, Placebo-Controlled, Multicenter Clinical Trial.

Melamed ML, Horwitz EJ, Dobre MA, Abramowitz MK, Zhang L, Lo Y, Mitch WE, Hostetter TH.

Am J Kidney Dis. 2019 Nov 5. pii: S0272-6386(19)30945-X. doi: 10.1053/j.ajkd.2019.07.016. [Epub ahead of print]


Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.

Wu J, Dong J, Verzola D, Hruska K, Garibotto G, Hu Z, Mitch WE, Thomas SS.

J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1210-1227. doi: 10.1002/jcsm.12459. Epub 2019 Sep 11.


Successful Kidney Transplantation Is Associated With Weight Gain From Truncal Obesity and Insulin Resistance.

Workeneh B, Moore LW, Nolte Fong JV, Shypailo R, Gaber AO, Mitch WE.

J Ren Nutr. 2019 Nov;29(6):548-555. doi: 10.1053/j.jrn.2019.01.009. Epub 2019 Mar 7.


Notch signaling in bone marrow-derived FSP-1 cells initiates neointima formation in arteriovenous fistulas.

Liang M, Guo Q, Huang F, Han G, Song K, Luo J, Cheng H, Hu H, Peden EK, Chen C, Mitch WE, Du J, Fu X, Truong L, Cheng J.

Kidney Int. 2019 Jun;95(6):1347-1358. doi: 10.1016/j.kint.2018.11.027. Epub 2019 Feb 21.


Proton Pump Inhibitors, Histamine-2 Receptor Antagonists, and Hip Fracture Risk among Patients on Hemodialysis.

Vangala C, Niu J, Lenihan CR, Mitch WE, Navaneethan SD, Winkelmayer WC.

Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1534-1541. doi: 10.2215/CJN.02190218. Epub 2018 Sep 27.


Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis.

Mindikoglu AL, Opekun AR, Mitch WE, Magder LS, Christenson RH, Dowling TC, Weir MR, Seliger SL, Howell CD, Raufman JP, Rana A, Goss JA, Khaderi SA, Vierling JM.

Dig Dis Sci. 2018 Mar;63(3):665-675. doi: 10.1007/s10620-017-4897-z. Epub 2018 Feb 1.


Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.

Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA.

JCI Insight. 2017 Nov 16;2(22). pii: 95185. doi: 10.1172/jci.insight.95185. eCollection 2017 Nov 16.


Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys.

Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z.

Nat Commun. 2017 Nov 14;8(1):1493. doi: 10.1038/s41467-017-01646-6.


AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis.

Wang Y, Jia L, Hu Z, Entman ML, Mitch WE, Wang Y.

Kidney Int. 2018 Jan;93(1):81-94. doi: 10.1016/j.kint.2017.04.033. Epub 2017 Jul 21.


The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis.

Liang H, Zhang Z, Yan J, Wang Y, Hu Z, Mitch WE, Wang Y.

Kidney Int. 2017 Dec;92(6):1433-1443. doi: 10.1016/j.kint.2017.04.021. Epub 2017 Jul 21.


Recent Advances in Magnetic Resonance Imaging Assessment of Renal Fibrosis.

Li J, An C, Kang L, Mitch WE, Wang Y.

Adv Chronic Kidney Dis. 2017 May;24(3):150-153. doi: 10.1053/j.ackd.2017.03.005. Review.


Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting.

Thomas SS, Mitch WE.

Curr Opin Clin Nutr Metab Care. 2017 May;20(3):153-157. doi: 10.1097/MCO.0000000000000357. Review.


The pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease.

Dong J, Dong Y, Chen Z, Mitch WE, Zhang L.

Kidney Int. 2017 Jan;91(1):119-128. doi: 10.1016/j.kint.2016.07.029. Epub 2016 Sep 18.


Diets for patients with chronic kidney disease, should we reconsider?

Mitch WE, Remuzzi G.

BMC Nephrol. 2016 Jul 11;17(1):80. doi: 10.1186/s12882-016-0283-x.


Adherence to ketoacids/essential amino acids-supplemented low protein diets and new indications for patients with chronic kidney disease.

Fouque D, Chen J, Chen W, Garneata L, Hwang SJ, Kalantar-Zadeh K, Kopple JD, Mitch WE, Piccoli G, Teplan V, Chauveau P.

BMC Nephrol. 2016 Jul 7;17(1):63. doi: 10.1186/s12882-016-0278-7. Review.


In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia.

Wyatt CM, Mitch WE.

Kidney Int. 2016 May;89(5):973-975. doi: 10.1016/j.kint.2016.03.003.


Molecular mechanisms of insulin resistance in chronic kidney disease.

Thomas SS, Zhang L, Mitch WE.

Kidney Int. 2015 Dec;88(6):1233-1239. doi: 10.1038/ki.2015.305. Epub 2015 Oct 7.


Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues.

Dong J, Dong Y, Dong Y, Chen F, Mitch WE, Zhang L.

Int J Obes (Lond). 2016 Mar;40(3):434-442. doi: 10.1038/ijo.2015.200. Epub 2015 Oct 5.


Adverse Effects of Sporadic Dialysis on Body Composition.

Workeneh B, Shypailo R, DeCastro I, Shah M, Guffey D, Minard CG, Mitch WE.

Nephron. 2015;131(1):73-7. doi: 10.1159/000439201. Epub 2015 Aug 29.


Causes for Withdrawal in an Urban Peritoneal Dialysis Program.

Workeneh B, Guffey D, Minard CG, Mitch WE.

Int J Nephrol. 2015;2015:652953. doi: 10.1155/2015/652953. Epub 2015 Apr 30.


CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation.

Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z.

J Am Soc Nephrol. 2016 Feb;27(2):509-19. doi: 10.1681/ASN.2014121208. Epub 2015 Jun 8.


JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis.

Yan J, Zhang Z, Yang J, Mitch WE, Wang Y.

J Am Soc Nephrol. 2015 Dec;26(12):3060-71. doi: 10.1681/ASN.2014070717. Epub 2015 Jun 1.


Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.

Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE.

J Biol Chem. 2015 Apr 24;290(17):11177-87. doi: 10.1074/jbc.M115.641514. Epub 2015 Mar 18.


Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima.

Liang M, Wang Y, Liang A, Mitch WE, Roy-Chaudhury P, Han G, Cheng J.

Kidney Int. 2015 Sep;88(3):490-502. doi: 10.1038/ki.2015.73. Epub 2015 Mar 18.


Protective role of insulin-like growth factor-1 receptor in endothelial cells against unilateral ureteral obstruction-induced renal fibrosis.

Liang M, Woodard LE, Liang A, Luo J, Wilson MH, Mitch WE, Cheng J.

Am J Pathol. 2015 May;185(5):1234-50. doi: 10.1016/j.ajpath.2015.01.027. Epub 2015 Mar 14.


FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice.

Luo J, Liang M, Mitch WE, Danesh FR, Yu M, Cheng J.

Endocrinology. 2015 Jun;156(6):2200-10. doi: 10.1210/en.2014-1841. Epub 2015 Mar 16.


Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology.

Ikizler TA, Lovett DH, Chertow GM, Mitch WE, Schiller B.

Am J Kidney Dis. 2015 Mar;65(3):381-3. doi: 10.1053/j.ajkd.2014.11.008. Epub 2014 Dec 24. Review.


Low-protein diets in chronic kidney disease: are we finally reaching a consensus?

Fouque D, Mitch WE.

Nephrol Dial Transplant. 2015 Jan;30(1):6-8. doi: 10.1093/ndt/gfu340. Epub 2014 Oct 30. No abstract available.


Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion.

Weiner ID, Mitch WE, Sands JM.

Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1444-58. doi: 10.2215/CJN.10311013. Epub 2014 Jul 30. Review.


Can muscle-kidney crosstalk slow progression of CKD?

Rondon-Berrios H, Wang Y, Mitch WE.

J Am Soc Nephrol. 2014 Dec;25(12):2681-3. doi: 10.1681/ASN.2014060566. Epub 2014 Jul 10. No abstract available.


Mechanisms of muscle wasting in chronic kidney disease.

Wang XH, Mitch WE.

Nat Rev Nephrol. 2014 Sep;10(9):504-16. doi: 10.1038/nrneph.2014.112. Epub 2014 Jul 1. Review.


MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways.

Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH.

Aging (Albany NY). 2014 Mar;6(3):160-75.


Blocking Notch in endothelial cells prevents arteriovenous fistula failure despite CKD.

Wang Y, Liang A, Luo J, Liang M, Han G, Mitch WE, Cheng J.

J Am Soc Nephrol. 2014 Apr;25(4):773-83. doi: 10.1681/ASN.2013050490. Epub 2014 Jan 30.


A dedication to Alfred L. Goldberg.

Attaix D, Mitch WE.

Int J Biochem Cell Biol. 2013 Oct;45(10):2120. No abstract available.


Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass.

Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE.

Cell Metab. 2013 Sep 3;18(3):368-79. doi: 10.1016/j.cmet.2013.07.012.


Muscle wasting from kidney failure-a model for catabolic conditions.

Wang XH, Mitch WE.

Int J Biochem Cell Biol. 2013 Oct;45(10):2230-8. doi: 10.1016/j.biocel.2013.06.027. Epub 2013 Jul 16. Review.


High-protein diet in diabetic nephropathy: what is really safe?

Workeneh B, Mitch WE.

Am J Clin Nutr. 2013 Aug;98(2):266-8. doi: 10.3945/ajcn.113.067223. Epub 2013 Jul 3. No abstract available.


Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia.

Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, Delafontaine P.

Int J Biochem Cell Biol. 2013 Oct;45(10):2322-32. doi: 10.1016/j.biocel.2013.05.035. Epub 2013 Jun 13. Review.


Myostatin/activin pathway antagonism: molecular basis and therapeutic potential.

Han HQ, Zhou X, Mitch WE, Goldberg AL.

Int J Biochem Cell Biol. 2013 Oct;45(10):2333-47. doi: 10.1016/j.biocel.2013.05.019. Epub 2013 May 28. Review.


Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.

Thomas SS, Dong Y, Zhang L, Mitch WE.

Kidney Int. 2013 Aug;84(2):308-16. doi: 10.1038/ki.2013.97. Epub 2013 Mar 20.


Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM).

Carrero JJ, Stenvinkel P, Cuppari L, Ikizler TA, Kalantar-Zadeh K, Kaysen G, Mitch WE, Price SR, Wanner C, Wang AY, ter Wee P, Franch HA.

J Ren Nutr. 2013 Mar;23(2):77-90. doi: 10.1053/j.jrn.2013.01.001. Review.


The mean dietary protein intake at different stages of chronic kidney disease is higher than current guidelines.

Moore LW, Byham-Gray LD, Scott Parrott J, Rigassio-Radler D, Mandayam S, Jones SL, Mitch WE, Osama Gaber A.

Kidney Int. 2013 Apr;83(4):724-32. doi: 10.1038/ki.2012.420. Epub 2013 Jan 9.


Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin.

Thomas SS, Mitch WE.

Clin Exp Nephrol. 2013 Apr;17(2):174-82. doi: 10.1007/s10157-012-0729-9. Epub 2013 Jan 5. Review.


Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis.

Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J.

J Pathol. 2012 Dec;228(4):448-58. doi: 10.1002/path.4067. Epub 2012 Jul 26.


Keto acid therapy in predialysis chronic kidney disease patients: final consensus.

Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X.

J Ren Nutr. 2012 Mar;22(2 Suppl):S22-4. doi: 10.1053/j.jrn.2011.09.006. No abstract available.


Protein-restricted diets plus keto/amino acids--a valid therapeutic approach for chronic kidney disease patients.

Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X.

J Ren Nutr. 2012 Mar;22(2 Suppl):S1-21. doi: 10.1053/j.jrn.2011.09.005. Review.


Requirement of argininosuccinate lyase for systemic nitric oxide production.

Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B.

Nat Med. 2011 Nov 13;17(12):1619-26. doi: 10.1038/nm.2544.


Targeting the myostatin signaling pathway to treat muscle wasting diseases.

Han HQ, Mitch WE.

Curr Opin Support Palliat Care. 2011 Dec;5(4):334-41. doi: 10.1097/SPC.0b013e32834bddf9. Review.


Decreased miR-29 suppresses myogenesis in CKD.

Wang XH, Hu Z, Klein JD, Zhang L, Fang F, Mitch WE.

J Am Soc Nephrol. 2011 Nov;22(11):2068-76. doi: 10.1681/ASN.2010121278. Epub 2011 Sep 30.

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