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Items: 1 to 50 of 237


A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation.

Babahosseini H, Padmanabhan S, Misteli T, DeVoe DL.

Biomicrofluidics. 2020 Feb 5;14(1):014112. doi: 10.1063/1.5143434. eCollection 2020 Jan.


A Scalable Random Access Micro-traps Array for Formation, Selective Retrieval and Capturing of Individual Droplets.

Babahosseini H, Padmanabhan S, Misteli T, DeVoe DL.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:1054-1057. doi: 10.1109/EMBC.2019.8857768.


Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers.

Meaburn KJ, Misteli T.

Front Genet. 2019 Oct 17;10:1029. doi: 10.3389/fgene.2019.01029. eCollection 2019.


Molecular basis and biological function of variability in spatial genome organization.

Finn EH, Misteli T.

Science. 2019 Sep 6;365(6457). pii: eaaw9498. doi: 10.1126/science.aaw9498. Review.


A genome disconnect.

Finn EH, Misteli T.

Nat Genet. 2019 Aug;51(8):1205-1206. doi: 10.1038/s41588-019-0476-x. No abstract available.


The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity.

Jevtić P, Schibler AC, Wesley CC, Pegoraro G, Misteli T, Levy DL.

EMBO Rep. 2019 Jun;20(6). pii: e47283. doi: 10.15252/embr.201847283. Epub 2019 May 13.


Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome.

Shilo A, Tosto FA, Rausch JW, Le Grice SFJ, Misteli T.

Nucleic Acids Res. 2019 Jun 20;47(11):5922-5935. doi: 10.1093/nar/gkz259.


Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells.

Hamczyk MR, Villa-Bellosta R, Quesada V, Gonzalo P, Vidak S, Nevado RM, Andrés-Manzano MJ, Misteli T, López-Otín C, Andrés V.

EMBO Mol Med. 2019 Apr;11(4). pii: e9736. doi: 10.15252/emmm.201809736.


Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization.

Finn EH, Pegoraro G, Brandão HB, Valton AL, Oomen ME, Dekker J, Mirny L, Misteli T.

Cell. 2019 Mar 7;176(6):1502-1515.e10. doi: 10.1016/j.cell.2019.01.020. Epub 2019 Feb 21.


Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing.

Babahosseini H, Misteli T, DeVoe DL.

Lab Chip. 2019 Jan 29;19(3):493-502. doi: 10.1039/c8lc01178h.


RefCell: multi-dimensional analysis of image-based high-throughput screens based on 'typical cells'.

Shen Y, Kubben N, Candia J, Morozov AV, Misteli T, Losert W.

BMC Bioinformatics. 2018 Nov 16;19(1):427. doi: 10.1186/s12859-018-2454-1.


Active or Passive On-Demand Droplet Merging in a Microfluidic Valve-Based Trap.

Babahosseini H, Misteli T, DeVoe DL.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:5350-5353. doi: 10.1109/EMBC.2018.8513481.


HiPLA: High-throughput imaging proximity ligation assay.

Serebryannyy LA, Misteli T.

Methods. 2019 Mar 15;157:80-87. doi: 10.1016/j.ymeth.2018.11.004. Epub 2018 Nov 10.


Blank spots on the map: some current questions on nuclear organization and genome architecture.

Adriaens C, Serebryannyy LA, Feric M, Schibler A, Meaburn KJ, Kubben N, Trzaskoma P, Shachar S, Vidak S, Finn EH, Sood V, Pegoraro G, Misteli T.

Histochem Cell Biol. 2018 Dec;150(6):579-592. doi: 10.1007/s00418-018-1726-1. Epub 2018 Sep 20. Review.


Single molecule analysis of lamin dynamics.

Serebryannyy LA, Ball DA, Karpova TS, Misteli T.

Methods. 2019 Mar 15;157:56-65. doi: 10.1016/j.ymeth.2018.08.009. Epub 2018 Aug 24.


Effects of human sex chromosome dosage on spatial chromosome organization.

Jowhar Z, Shachar S, Gudla PR, Wangsa D, Torres E, Russ JL, Pegoraro G, Ried T, Raznahan A, Misteli T.

Mol Biol Cell. 2018 Oct 1;29(20):2458-2469. doi: 10.1091/mbc.E18-06-0359. Epub 2018 Aug 9.


The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y.

Mol Cell. 2018 Mar 1;69(5):866-878.e7. doi: 10.1016/j.molcel.2018.02.002.


HiCTMap: Detection and analysis of chromosome territory structure and position by high-throughput imaging.

Jowhar Z, Gudla PR, Shachar S, Wangsa D, Russ JL, Pegoraro G, Ried T, Raznahan A, Misteli T.

Methods. 2018 Jun 1;142:30-38. doi: 10.1016/j.ymeth.2018.01.013. Epub 2018 Feb 10.


SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches.

Gudla PR, Nakayama K, Pegoraro G, Misteli T.

Cold Spring Harb Symp Quant Biol. 2017;82:57-70. doi: 10.1101/sqb.2017.82.033761. Epub 2017 Nov 28.


Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging.

Serebryannyy L, Misteli T.

J Cell Biol. 2018 Jan 2;217(1):21-37. doi: 10.1083/jcb.201706061. Epub 2017 Oct 19. Review.


Controlled droplet discretization and manipulation using membrane displacement traps.

Padmanabhan S, Misteli T, DeVoe DL.

Lab Chip. 2017 Oct 25;17(21):3717-3724. doi: 10.1039/c7lc00910k.


Identification of novel RNA isoforms of LMNA.

DeBoy E, Puttaraju M, Jailwala P, Kasoji M, Cam M, Misteli T.

Nucleus. 2017 Sep 3;8(5):573-582. doi: 10.1080/19491034.2017.1348449. Epub 2017 Aug 31.


Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation.

Kieffer-Kwon KR, Nimura K, Rao SSP, Xu J, Jung S, Pekowska A, Dose M, Stevens E, Mathe E, Dong P, Huang SC, Ricci MA, Baranello L, Zheng Y, Tomassoni Ardori F, Resch W, Stavreva D, Nelson S, McAndrew M, Casellas A, Finn E, Gregory C, St Hilaire BG, Johnson SM, Dubois W, Cosma MP, Batchelor E, Levens D, Phair RD, Misteli T, Tessarollo L, Hager G, Lakadamyali M, Liu Z, Floer M, Shroff H, Aiden EL, Casellas R.

Mol Cell. 2017 Aug 17;67(4):566-578.e10. doi: 10.1016/j.molcel.2017.07.013. Epub 2017 Aug 10.


Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.

Kubben N, Misteli T.

Nat Rev Mol Cell Biol. 2017 Oct;18(10):595-609. doi: 10.1038/nrm.2017.68. Epub 2017 Aug 9. Review.


The genome-seeing it clearly now.

Larson DR, Misteli T.

Science. 2017 Jul 28;357(6349):354-355. doi: 10.1126/science.aao1893. No abstract available.


High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease.

Pegoraro G, Misteli T.

Trends Genet. 2017 Sep;33(9):604-615. doi: 10.1016/j.tig.2017.06.005. Epub 2017 Jul 18. Review.


HiHiMap: single-cell quantitation of histones and histone posttranslational modifications across the cell cycle by high-throughput imaging.

Zane L, Chapus F, Pegoraro G, Misteli T.

Mol Biol Cell. 2017 Aug 15;28(17):2290-2302. doi: 10.1091/mbc.E16-12-0870. Epub 2017 Jun 14.


Causes and consequences of nuclear gene positioning.

Shachar S, Misteli T.

J Cell Sci. 2017 May 1;130(9):1501-1508. doi: 10.1242/jcs.199786. Epub 2017 Apr 12. Review.


Genome Architecture from a Different Angle.

Finn EH, Misteli T.

Dev Cell. 2017 Apr 10;41(1):3-4. doi: 10.1016/j.devcel.2017.03.017.


Comparative analysis of 2D and 3D distance measurements to study spatial genome organization.

Finn EH, Pegoraro G, Shachar S, Misteli T.

Methods. 2017 Jul 1;123:47-55. doi: 10.1016/j.ymeth.2017.01.007. Epub 2017 Feb 5.


The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.

Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P.

Science. 2016 Sep 30;353(6307). pii: aaf1644. doi: 10.1126/science.aaf1644.


Repression of the Antioxidant NRF2 Pathway in Premature Aging.

Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH, Misteli T.

Cell. 2016 Jun 2;165(6):1361-1374. doi: 10.1016/j.cell.2016.05.017.


The decision-making process and criteria in selecting candidate drugs for progeria clinical trials.

Gordon LB, Kieran MW, Kleinman ME, Misteli T.

EMBO Mol Med. 2016 Jul 1;8(7):685-7. doi: 10.15252/emmm.201606280. Print 2016 Jul. No abstract available.


Nongenetic functions of the genome.

Bustin M, Misteli T.

Science. 2016 May 6;352(6286):aad6933. doi: 10.1126/science.aad6933. Review.


Painting a Clearer Picture of Chromatin.

Finn EH, Misteli T, Shachar S.

Dev Cell. 2016 Feb 22;36(4):356-7. doi: 10.1016/j.devcel.2016.02.002.


Tissue-of-origin-specific gene repositioning in breast and prostate cancer.

Meaburn KJ, Agunloye O, Devine M, Leshner M, Roloff GW, True LD, Misteli T.

Histochem Cell Biol. 2016 Apr;145(4):433-46. doi: 10.1007/s00418-015-1401-8. Epub 2016 Jan 20.


High-throughput Imaging as a versatile and unbiased discovery tool.

Pegoraro G, Misteli T.

Methods. 2016 Mar 1;96:1-2. doi: 10.1016/j.ymeth.2016.01.003. Epub 2016 Jan 13. No abstract available.


Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy.

Salton M, Misteli T.

Trends Mol Med. 2016 Jan;22(1):28-37. doi: 10.1016/j.molmed.2015.11.005. Epub 2015 Dec 14. Review.


Gene expression analysis upon lncRNA DDSR1 knockdown in human fibroblasts.

Jia L, Sun Z, Wu X, Misteli T, Sharma V.

Genom Data. 2015 Oct 23;6:277-9. doi: 10.1016/j.gdata.2015.10.017. eCollection 2015 Dec.


3D Chromosome Regulatory Landscape of Human Pluripotent Cells.

Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.

Cell Stem Cell. 2016 Feb 4;18(2):262-75. doi: 10.1016/j.stem.2015.11.007. Epub 2015 Dec 10.


Locus-specific gene repositioning in prostate cancer.

Leshner M, Devine M, Roloff GW, True LD, Misteli T, Meaburn KJ.

Mol Biol Cell. 2016 Jan 15;27(2):236-46. doi: 10.1091/mbc.E15-05-0280. Epub 2015 Nov 12.


HIPMap: A High-Throughput Imaging Method for Mapping Spatial Gene Positions.

Shachar S, Pegoraro G, Misteli T.

Cold Spring Harb Symp Quant Biol. 2015;80:73-81. doi: 10.1101/sqb.2015.80.027417. Epub 2015 Oct 15. Review.


Long-Range Chromatin Interactions.

Dekker J, Misteli T.

Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10):a019356. doi: 10.1101/cshperspect.a019356. Review.


A BRCA1-interacting lncRNA regulates homologous recombination.

Sharma V, Khurana S, Kubben N, Abdelmohsen K, Oberdoerffer P, Gorospe M, Misteli T.

EMBO Rep. 2015 Nov;16(11):1520-34. doi: 10.15252/embr.201540437. Epub 2015 Sep 27.


A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.

Kubben N, Brimacombe KR, Donegan M, Li Z, Misteli T.

Methods. 2016 Mar 1;96:46-58. doi: 10.1016/j.ymeth.2015.08.024. Epub 2015 Sep 1.


Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses.

Burgess RC, Misteli T.

Cell. 2015 Aug 27;162(5):944-7. doi: 10.1016/j.cell.2015.08.006. Review.


Quantitative detection of rare interphase chromosome breaks and translocations by high-throughput imaging.

Burman B, Misteli T, Pegoraro G.

Genome Biol. 2015 Aug 3;16:146. doi: 10.1186/s13059-015-0718-x.


Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping.

Shachar S, Voss TC, Pegoraro G, Sciascia N, Misteli T.

Cell. 2015 Aug 13;162(4):911-23. doi: 10.1016/j.cell.2015.07.035.


Histone modifications predispose genome regions to breakage and translocation.

Burman B, Zhang ZZ, Pegoraro G, Lieb JD, Misteli T.

Genes Dev. 2015 Jul 1;29(13):1393-402. doi: 10.1101/gad.262170.115. Epub 2015 Jun 23.


Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing.

Salton M, Kasprzak WK, Voss T, Shapiro BA, Poulikakos PI, Misteli T.

Nat Commun. 2015 May 14;6:7103. doi: 10.1038/ncomms8103.

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