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Items: 41


Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies.

Kim HK, Premaratna R, Missiakas DM, Schneewind O.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19659-19664. doi: 10.1073/pnas.1911922116. Epub 2019 Aug 14.


Staphylococcal Protein Secretion and Envelope Assembly.

Schneewind O, Missiakas DM.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0070-2019.


The transmembrane domain of the Staphylococcus aureus ESAT-6 component EssB mediates interaction with the integral membrane protein EsaA, facilitating partially regulated secretion in a heterologous host.

Ahmed MM, Aboshanab KM, Ragab YM, Missiakas DM, Aly KA.

Arch Microbiol. 2018 Sep;200(7):1075-1086. doi: 10.1007/s00203-018-1519-x. Epub 2018 May 8.


Galactosylation of the Secondary Cell Wall Polysaccharide of Bacillus anthracis and Its Contribution to Anthrax Pathogenesis.

Chateau A, Lunderberg JM, Oh SY, Abshire T, Friedlander A, Quinn CP, Missiakas DM, Schneewind O.

J Bacteriol. 2018 Feb 7;200(5). pii: e00562-17. doi: 10.1128/JB.00562-17. Print 2018 Mar 1.


Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection.

Malachowa N, Kobayashi SD, Porter AR, Braughton KR, Scott DP, Gardner DJ, Missiakas DM, Schneewind O, DeLeo FR.

PLoS One. 2016 Jun 23;11(6):e0158293. doi: 10.1371/journal.pone.0158293. eCollection 2016.


Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection.

Kim HK, Falugi F, Missiakas DM, Schneewind O.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5718-23. doi: 10.1073/pnas.1524267113. Epub 2016 May 2.


Glutamate Racemase Mutants of Bacillus anthracis.

Oh SY, Richter SG, Missiakas DM, Schneewind O.

J Bacteriol. 2015 Jun;197(11):1854-61. doi: 10.1128/JB.00070-15. Epub 2015 Mar 16.


Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs.

Kim HK, Falugi F, Thomer L, Missiakas DM, Schneewind O.

MBio. 2015 Jan 6;6(1). pii: e02369-14. doi: 10.1128/mBio.02369-14.


Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus.

Thammavongsa V, Rauch S, Kim HK, Missiakas DM, Schneewind O.

Vaccine. 2015 Jan 15;33(4):523-6. doi: 10.1016/j.vaccine.2014.11.051. Epub 2014 Dec 6.


Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.

Thammavongsa V, Missiakas DM, Schneewind O.

Science. 2013 Nov 15;342(6160):863-6. doi: 10.1126/science.1242255.


Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus.

Falugi F, Kim HK, Missiakas DM, Schneewind O.

MBio. 2013 Aug 27;4(5):e00575-13. doi: 10.1128/mBio.00575-13.


The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.

Vanassche T, Peetermans M, Van Aelst LN, Peetermans WE, Verhaegen J, Missiakas DM, Schneewind O, Hoylaerts MF, Verhamme P.

J Infect Dis. 2013 Jul;208(1):92-100. doi: 10.1093/infdis/jit130. Epub 2013 Mar 26.


Growth and laboratory maintenance of Staphylococcus aureus.

Missiakas DM, Schneewind O.

Curr Protoc Microbiol. 2013 Feb;Chapter 9:Unit 9C.1. doi: 10.1002/9780471729259.mc09c01s28.


Vaccine protection against Bacillus cereus-mediated respiratory anthrax-like disease in mice.

Oh SY, Maier H, Schroeder J, Richter GS, Elli D, Musser JM, Quenee LE, Missiakas DM, Schneewind O.

Infect Immun. 2013 Mar;81(3):1008-17. doi: 10.1128/IAI.01346-12. Epub 2013 Jan 14.


Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins.

Lunderberg JM, Nguyen-Mau SM, Richter GS, Wang YT, Dworkin J, Missiakas DM, Schneewind O.

J Bacteriol. 2013 Mar;195(5):977-89. doi: 10.1128/JB.01274-12. Epub 2012 Dec 14.


Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice.

Kim HK, Emolo C, DeDent AC, Falugi F, Missiakas DM, Schneewind O.

Infect Immun. 2012 Oct;80(10):3460-70. doi: 10.1128/IAI.00230-12. Epub 2012 Jul 23.


Coagulases as determinants of protective immune responses against Staphylococcus aureus.

McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O.

Infect Immun. 2012 Oct;80(10):3389-98. doi: 10.1128/IAI.00562-12. Epub 2012 Jul 23.


Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection.

Rauch S, DeDent AC, Kim HK, Bubeck Wardenburg J, Missiakas DM, Schneewind O.

Infect Immun. 2012 Oct;80(10):3721-32. doi: 10.1128/IAI.00442-12. Epub 2012 Jul 16.


Secretion genes as determinants of Bacillus anthracis chain length.

Nguyen-Mau SM, Oh SY, Kern VJ, Missiakas DM, Schneewind O.

J Bacteriol. 2012 Aug;194(15):3841-50. doi: 10.1128/JB.00384-12. Epub 2012 May 18.


Sortase-conjugation generates a capsule vaccine that protects guinea pigs against Bacillus anthracis.

Garufi G, Wang YT, Oh SY, Maier H, Missiakas DM, Schneewind O.

Vaccine. 2012 May 14;30(23):3435-44. doi: 10.1016/j.vaccine.2012.03.023. Epub 2012 Mar 23.


Protein secretion and surface display in Gram-positive bacteria.

Schneewind O, Missiakas DM.

Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1123-39. doi: 10.1098/rstb.2011.0210. Review.


Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections.

McAdow M, Missiakas DM, Schneewind O.

J Innate Immun. 2012;4(2):141-8. doi: 10.1159/000333447. Epub 2012 Jan 3. Review.


Enzymatic properties of Staphylococcus aureus adenosine synthase (AdsA).

Thammavongsa V, Schneewind O, Missiakas DM.

BMC Biochem. 2011 Oct 28;12:56. doi: 10.1186/1471-2091-12-56.


Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood.

McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM.

PLoS Pathog. 2011 Oct;7(10):e1002307. doi: 10.1371/journal.ppat.1002307. Epub 2011 Oct 20.


LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly.

Frankel MB, Hendrickx AP, Missiakas DM, Schneewind O.

J Biol Chem. 2011 Sep 16;286(37):32593-605. doi: 10.1074/jbc.M111.258863. Epub 2011 Jul 22.


EsaD, a secretion factor for the Ess pathway in Staphylococcus aureus.

Anderson M, Chen YH, Butler EK, Missiakas DM.

J Bacteriol. 2011 Apr;193(7):1583-9. doi: 10.1128/JB.01096-10. Epub 2011 Jan 28.


ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus.

Frankel MB, Wojcik BM, DeDent AC, Missiakas DM, Schneewind O.

Mol Microbiol. 2010 Oct;78(1):238-52. doi: 10.1111/j.1365-2958.2010.07334.x.


Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice.

Kim HK, Cheng AG, Kim HY, Missiakas DM, Schneewind O.

J Exp Med. 2010 Aug 30;207(9):1863-70. doi: 10.1084/jem.20092514. Epub 2010 Aug 16.


Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.

Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O.

PLoS Pathog. 2010 Aug 5;6(8):e1001036. doi: 10.1371/journal.ppat.1001036.


IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge.

Kim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O.

Vaccine. 2010 Aug 31;28(38):6382-92. doi: 10.1016/j.vaccine.2010.02.097. Epub 2010 Mar 10.


Staphylococcus aureus synthesizes adenosine to escape host immune responses.

Thammavongsa V, Kern JW, Missiakas DM, Schneewind O.

J Exp Med. 2009 Oct 26;206(11):2417-27. doi: 10.1084/jem.20090097. Epub 2009 Sep 28.


Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues.

Cheng AG, Kim HK, Burts ML, Krausz T, Schneewind O, Missiakas DM.

FASEB J. 2009 Oct;23(10):3393-404. doi: 10.1096/fj.09-135467. Epub 2009 Jun 12. Erratum in: FASEB J. 2010 Feb;24(2):648.


Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus.

DeDent A, Bae T, Missiakas DM, Schneewind O.

EMBO J. 2008 Oct 22;27(20):2656-68. doi: 10.1038/emboj.2008.185. Epub 2008 Sep 18.


EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus.

Burts ML, DeDent AC, Missiakas DM.

Mol Microbiol. 2008 Aug;69(3):736-46. doi: 10.1111/j.1365-2958.2008.06324.x. Epub 2008 Jun 28.


Activation of inhibitors by sortase triggers irreversible modification of the active site.

Maresso AW, Wu R, Kern JW, Zhang R, Janik D, Missiakas DM, Duban ME, Joachimiak A, Schneewind O.

J Biol Chem. 2007 Aug 10;282(32):23129-39. Epub 2007 Jun 1.


Staphylococcus aureus mutants with increased lysostaphin resistance.

Gr√ľndling A, Missiakas DM, Schneewind O.

J Bacteriol. 2006 Sep;188(17):6286-97.


Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL.

Blaylock B, Riordan KE, Missiakas DM, Schneewind O.

J Bacteriol. 2006 May;188(10):3525-34.


EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.

Burts ML, Williams WA, DeBord K, Missiakas DM.

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1169-74. Epub 2005 Jan 18.


Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing.

Bae T, Banger AK, Wallace A, Glass EM, Aslund F, Schneewind O, Missiakas DM.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12312-7. Epub 2004 Aug 10.


Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site.

Zhang R, Wu R, Joachimiak G, Mazmanian SK, Missiakas DM, Gornicki P, Schneewind O, Joachimiak A.

Structure. 2004 Jul;12(7):1147-56.


Passage of heme-iron across the envelope of Staphylococcus aureus.

Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O.

Science. 2003 Feb 7;299(5608):906-9.

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