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Deep Vein Thrombosis in Europe-Health-Related Quality of Life and Mortality.

Monreal M, Agnelli G, Chuang LH, Cohen AT, Gumbs PD, Bauersachs R, Mismetti P, Gitt AK, Kroep S, Willich SN, Van Hout B.

Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619883946. doi: 10.1177/1076029619883946.


Monitoring of biological response to clopidogrel after treatment for non-cardioembolic ischemic stroke or transient ischemic attack.

Varvat J, Montmartin A, Epinat M, Accassat S, Garcin A, Li G, Garnier P, Lambert C, Mismetti P, Mallouk N.

Am J Transl Res. 2019 Sep 15;11(9):5332-5337. eCollection 2019. Review.


Chronic thromboembolic pulmonary hypertension suspicion after pulmonary embolism in cancer patients.

Catella-Chatron J, Merah A, De Magalhaes E, Moulin N, Accassat S, Duvillard C, Mismetti P, Bertoletti L.

Respir Med Res. 2019 Nov;76:34-37. doi: 10.1016/j.resmer.2019.08.002. Epub 2019 Aug 27.


Direct Oral Anticoagulants for the Treatment of Cerebral Venous Thrombosis.

Lurkin A, Derex L, Fambrini A, Bertoletti L, Epinat M, Mismetti P, Dargaud Y.

Cerebrovasc Dis. 2019;48(1-2):32-37. doi: 10.1159/000502454. Epub 2019 Sep 3.


Platelet Inflammatory Response to Stress.

Cognasse F, Laradi S, Berthelot P, Bourlet T, Marotte H, Mismetti P, Garraud O, Hamzeh-Cognasse H.

Front Immunol. 2019 Jun 28;10:1478. doi: 10.3389/fimmu.2019.01478. eCollection 2019. Review.


Evaluation of the predictive value of the bleeding prediction score VTE-BLEED for recurrent venous thromboembolism.

Klok FA, Presles E, Tromeur C, Barco S, Konstantinides SV, Sanchez O, Pernod G, Raj L, Robin P, Le Roux PY, Hoffman C, Mélac S, Bertoletti L, Girard P, Laporte S, Mismetti P, Meyer G, Leroyer C, Couturaud F; PADIS‐PE Investigators.

Res Pract Thromb Haemost. 2019 May 25;3(3):364-371. doi: 10.1002/rth2.12214. eCollection 2019 Jul.


[Recommendations for best practice in the management of venous thromboembolic disease in adults. Long version].

Sanchez O, Benhamou Y, Bertoletti L, Constans J, Couturaud F, Delluc A, Elias A, Fischer AM, Frappé P, Gendron N, Girard P, Godier A, Gut-Gobert C, Laporte S, Mahé I, Mauge L, Meneveau N, Meyer G, Mismetti P, Parent F, Pernod G, Quéré I, Revel MP, Roy PM, Salaün PY, Smadja DM, Sevestre MA.

Rev Mal Respir. 2019 Jul 4. pii: S0761-8425(19)30210-4. doi: 10.1016/j.rmr.2019.05.038. [Epub ahead of print] French. No abstract available.


Comparative Real-Life Effectiveness and Safety of Dabigatran or Rivaroxaban vs. Vitamin K Antagonists: A High-Dimensional Propensity Score Matched New Users Cohort Study in the French National Healthcare Data System SNDS.

Blin P, Dureau-Pournin C, Bénichou J, Cottin Y, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.

Am J Cardiovasc Drugs. 2020 Feb;20(1):81-103. doi: 10.1007/s40256-019-00359-z.


Predictors for Residual Pulmonary Vascular Obstruction after Unprovoked Pulmonary Embolism: Implications for Clinical Practice-The PADIS-PE Trial.

Raj L, Robin P, Le Mao R, Presles E, Tromeur C, Sanchez O, Pernod G, Bertoletti L, Jego P, Leven F, Lemarié CA, Martin A, Planquette B, Le Roux PY, Salaun PY, Nonent M, Girard P, Lacut K, Melac S, Mismetti P, Laporte S, Meyer G, Leroyer C, Couturaud F; PADIS-PE Investigators.

Thromb Haemost. 2019 Sep;119(9):1489-1497. doi: 10.1055/s-0039-1692424. Epub 2019 Jun 23.


Rivaroxaban pharmacodynamics in healthy volunteers evaluated with thrombin generation and the active protein C system: Modeling and assessing interindividual variability.

Siguret V, Abdoul J, Delavenne X, Curis E, Carlo A, Blanchard A, Salem JE, Gaussem P, Funck-Brentano C, Azizi M, Mismetti P, Loriot MA, Lecompte T, Gouin-Thibault I.

J Thromb Haemost. 2019 Oct;17(10):1670-1682. doi: 10.1111/jth.14541. Epub 2019 Jul 9.


High tolerance of progressive elastic compression in peripheral arterial disease.

Couzan S, Pouget JF, Le Hello C, Chapelle C, Laporte S, Mismetti P.

Vasa. 2019 Aug;48(5):413-417. doi: 10.1024/0301-1526/a000799. Epub 2019 Jun 4.


Direct oral anticoagulants are associated with limited damage of endothelial cells of the blood-brain barrier mediated by the thrombin/PAR-1 pathway.

Puech C, Delavenne X, He Z, Forest V, Mismetti P, Perek N.

Brain Res. 2019 Sep 15;1719:57-63. doi: 10.1016/j.brainres.2019.05.024. Epub 2019 May 20.


Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries.

Chuang LH, Gumbs P, van Hout B, Agnelli G, Kroep S, Monreal M, Bauersachs R, Willich SN, Gitt A, Mismetti P, Cohen A, Jimenez D.

Qual Life Res. 2019 Aug;28(8):2111-2124. doi: 10.1007/s11136-019-02175-z. Epub 2019 Apr 4.


Extended anticoagulant therapy in venous thromboembolism: a balanced, fractional factorial, clinical vignette-based study.

Cate VT, Lensing AWA, Weitz JI, Beyer-Westendorf J, Wells PS, Mismetti P, Prandoni P, Cohen AT, Davidson BL, Prins MH.

Haematologica. 2019 Oct;104(10):e474-e477. doi: 10.3324/haematol.2018.209924. Epub 2019 Mar 7. No abstract available.


[Recommendations of good practice for the management of thromboembolic venous disease in adults. Short version].

Sanchez O, Benhamou Y, Bertoletti L, Constant J, Couturaud F, Delluc A, Elias A, Fischer AM, Frappé P, Gendron N, Girard P, Godier A, Gut-Gobert C, Laporte S, Mahé I, Mauge L, Meneveau N, Meyer G, Mismetti P, Parent F, Pernod G, Quéré I, Revel MP, Roy PM, Salaün PY, Smadja DM, Sevestre MA.

Rev Mal Respir. 2019 Feb;36(2):249-283. doi: 10.1016/j.rmr.2019.01.003. Epub 2019 Feb 22. French. No abstract available.


Effects of heparin and derivatives on podocytes: An in vitro functional and morphological evaluation.

Delézay O, Hé Z, Sabido O, Hodin S, Bin V, Saleem MA, Mismetti P, Delavenne X.

J Cell Physiol. 2019 Jan 26. doi: 10.1002/jcp.28191. [Epub ahead of print]


Six months versus two years of oral anticoagulation after a first episode of unprovoked deep-vein thrombosis. The PADIS-DVT randomized clinical trial.

Couturaud F, Pernod G, Presles E, Duhamel E, Jego P, Provost K, Pan-Petesch B, Sollier CBD, Tromeur C, Hoffmann C, Bressollette L, Lorillon P, Girard P, Le Moigne E, Le Hir A, Guégan M, Laporte S, Mismetti P, Lacut K, Bosson JL, Bertoletti L, Sanchez O, Meyer G, Leroyer C, Mottier D; “PADIS-DVT” investigators.

Haematologica. 2019 Jul;104(7):1493-1501. doi: 10.3324/haematol.2018.210971. Epub 2019 Jan 3.


Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after total hip or knee replacement: A nationwide database cohort study.

Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, Lorrain S, Lassalle R, Droz-Perroteau C, Mismetti P, Moore N.

Pharmacol Res. 2019 Mar;141:201-207. doi: 10.1016/j.phrs.2018.12.018. Epub 2018 Dec 21.


Comparative Effectiveness and Safety of Standard or Reduced Dose Dabigatran vs. Rivaroxaban in Nonvalvular Atrial Fibrillation.

Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.

Clin Pharmacol Ther. 2019 Jun;105(6):1439-1455. doi: 10.1002/cpt.1318. Epub 2019 Feb 6.


Effectiveness and safety of 110 or 150 mg dabigatran vs. vitamin K antagonists in nonvalvular atrial fibrillation.

Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.

Br J Clin Pharmacol. 2019 Feb;85(2):432-441. doi: 10.1111/bcp.13815. Epub 2018 Dec 16.


Management and outcome of major bleeding in patients receiving vitamin K antagonists for venous thromboembolism.

Moustafa F, Stehouwer A, Kamphuisen P, Sahuquillo JC, Sampériz Á, Alfonso M, Pace F, Suriñach JM, Blanco-Molina Á, Mismetti P, Monreal M; RIETE Investigators.

Thromb Res. 2018 Nov;171:74-80. doi: 10.1016/j.thromres.2018.09.049. Epub 2018 Sep 22.


Assessment of HBEC-5i endothelial cell line cultivated in astrocyte conditioned medium as a human blood-brain barrier model for ABC drug transport studies.

Puech C, Hodin S, Forest V, He Z, Mismetti P, Delavenne X, Perek N.

Int J Pharm. 2018 Nov 15;551(1-2):281-289. doi: 10.1016/j.ijpharm.2018.09.040. Epub 2018 Sep 18.


Role of platelet α2-adrenoreceptor in biological low response to Clopidogrel for patients with non cardioembolic ischemic stroke or transient ischemic attack.

Varvat J, Epinat M, Montmartin A, Accassat S, Boutet C, Garcin A, Li G, Malergue F, Chapelle C, Laporte S, Garnier P, Lambert C, Mallouk N, Mismetti P.

Am J Transl Res. 2018 Aug 15;10(8):2712-2721. eCollection 2018.


Assessment of a flow cytometry technique for studying signaling pathways in platelets: Monitoring of VASP phosphorylation in clinical samples.

Mallouk N, Varvat J, Berger A, Epinat M, Accassat S, Garcin A, Montmartin A, Li G, Garnier P, Mismetti P, Lambert C.

Pract Lab Med. 2018 Feb 16;11:10-18. doi: 10.1016/j.plabm.2018.02.002. eCollection 2018 Jul.


The prothrombin time does not predict the risk of recurrent venous thromboembolism or major bleeding in rivaroxaban-treated patients.

Ten Cate H, Lensing AWA, Weitz JI, Middeldorp S, Beyer-Westendorf J, Kubitza D, Brighton T, Raskob GE, Mismetti P, Prandoni P, Gebel M, Prins MH.

Thromb Res. 2018 Oct;170:75-83. doi: 10.1016/j.thromres.2018.08.008. Epub 2018 Aug 15.


Benefit of Risk Score-Guided Prophylaxis in Pregnant Women at Risk of Thrombotic Events: A Controlled Before-and-After Implementation Study.

Chauleur C, Gris JC, Laporte S, Chapelle C, Bertoletti L, Equy V, Gaucherand P, Bazan E, Dupuis O, Gallot D, Mismetti P; STRATHEGE Investigators and The STRATHEGE Group.

Thromb Haemost. 2018 Sep;118(9):1564-1571. doi: 10.1055/s-0038-1668524. Epub 2018 Aug 13.


Screening cancer after venous thromboembolism: How many abnormal tests before diagnosing cancer? An analysis of practice.

Duvillard C, De Magalhaes E, Moulin N, Accassat S, Mismetti P, Bertoletti L.

Presse Med. 2018 Jul - Aug;47(7-8 Pt 1):e99-e106. doi: 10.1016/j.lpm.2018.01.026. Epub 2018 Jul 31.


Incidence and risk factors of major bleeding following major orthopaedic surgery with fondaparinux thromboprophylaxis. A time-to-event analysis.

Zufferey PJ, Ollier E, Delavenne X, Laporte S, Mismetti P, Duffull SB.

Br J Clin Pharmacol. 2018 Oct;84(10):2242-2251. doi: 10.1111/bcp.13663. Epub 2018 Jul 14.


Individualized PK-based prophylaxis in severe haemophilia.

Dargaud Y, Delavenne X, Hart DP, Meunier S, Mismetti P.

Haemophilia. 2018 Mar;24 Suppl 2:3-17. doi: 10.1111/hae.13397. Review.


Statistical controversies in clinical research: limitations of open-label studies assessing antiangiogenic therapies with regard to evaluation of vascular adverse drug events-a meta-analysis.

Trone JC, Ollier E, Chapelle C, Bertoletti L, Cucherat M, Mismetti P, Magné N, Laporte S.

Ann Oncol. 2018 Apr 1;29(4):803-811. doi: 10.1093/annonc/mdy035.


Risk factors for recurrent venous thromboembolism after unprovoked pulmonary embolism: the PADIS-PE randomised trial.

Tromeur C, Sanchez O, Presles E, Pernod G, Bertoletti L, Jego P, Duhamel E, Provost K, Parent F, Robin P, Deloire L, Leven F, Mingant F, Bressollette L, Le Roux PY, Salaun PY, Nonent M, Pan-Petesch B, Planquette B, Girard P, Lacut K, Melac S, Mismetti P, Laporte S, Meyer G, Mottier D, Leroyer C, Couturaud F; PADIS-PE Investigators18.

Eur Respir J. 2018 Jan 4;51(1). pii: 1701202. doi: 10.1183/13993003.01202-2017. Print 2018 Jan.


European guidelines on perioperative venous thromboembolism prophylaxis: Inferior vena cava filters.

Comes RF, Mismetti P, Afshari A; ESA VTE Guidelines Task Force.

Eur J Anaesthesiol. 2018 Feb;35(2):108-111. doi: 10.1097/EJA.0000000000000730.


Glomerular filtration drug injury: In vitro evaluation of functional and morphological podocyte perturbations.

Delézay O, He Z, Hodin S, Saleem MA, Mismetti P, Perek N, Delavenne X.

Exp Cell Res. 2017 Dec 15;361(2):300-307. doi: 10.1016/j.yexcr.2017.10.031. Epub 2017 Oct 31.


In Vitro Comparison of the Role of P-Glycoprotein and Breast Cancer Resistance Protein on Direct Oral Anticoagulants Disposition.

Hodin S, Basset T, Jacqueroux E, Delezay O, Clotagatide A, Perek N, Mismetti P, Delavenne X.

Eur J Drug Metab Pharmacokinet. 2018 Apr;43(2):183-191. doi: 10.1007/s13318-017-0434-x.


The role of heparin lead-in in the real-world management of acute venous thromboembolism: The PREFER in VTE registry.

Bauersachs R, Agnelli G, Gitt AK, Monreal M, Mismetti P, Willich SN, Laeis P, Fronk EM, Bramlage P, Cohen AT; PREFER in VTE Scientific Steering Committee.

Thromb Res. 2017 Sep;157:181-188. doi: 10.1016/j.thromres.2017.07.029. Epub 2017 Jul 28.


Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta-analysis of randomized controlled trials.

Laporte S, Chapelle C, Bertoletti L, Ollier E, Zufferey P, Lega JC, Merah A, Décousus H, Schulman S, Meyer G, Cucherat M, Mismetti P.

J Thromb Haemost. 2017 Aug;15(8):1547-1558. doi: 10.1111/jth.13740. Epub 2017 Jul 5. Review.


Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass.

Delavenne X, Ollier E, Chollet S, Sandri F, Lanoiselée J, Hodin S, Montmartin A, Fuzellier JF, Mismetti P, Gergelé L.

Br J Anaesth. 2017 May 1;118(5):705-712. doi: 10.1093/bja/aex044.


The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry.

Cohen AT, Gitt AK, Bauersachs R, Fronk EM, Laeis P, Mismetti P, Monreal M, Willich SN, Bramlage P, Agnelli G, Prefer In Vte Scientific Steering Committee And The Prefer In Vte Investigators OBOT.

Thromb Haemost. 2017 Jun 27;117(7):1326-1337. doi: 10.1160/TH16-10-0793. Epub 2017 Apr 13.


Validating the HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis: multinational prospective cohort management study.

Rodger MA, Le Gal G, Anderson DR, Schmidt J, Pernod G, Kahn SR, Righini M, Mismetti P, Kearon C, Meyer G, Elias A, Ramsay T, Ortel TL, Huisman MV, Kovacs MJ; REVERSE II Study Investigators.

BMJ. 2017 Mar 17;356:j1065. doi: 10.1136/bmj.j1065.


Effect of Activated Charcoal on Rivaroxaban Complex Absorption.

Ollier E, Hodin S, Lanoiselée J, Escal J, Accassat S, De Magalhaes E, Basset T, Bertoletti L, Mismetti P, Delavenne X.

Clin Pharmacokinet. 2017 Jul;56(7):793-801. doi: 10.1007/s40262-016-0485-1.


Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin.

Gouin-Thibault I, Delavenne X, Blanchard A, Siguret V, Salem JE, Narjoz C, Gaussem P, Beaune P, Funck-Brentano C, Azizi M, Mismetti P, Loriot MA.

J Thromb Haemost. 2017 Feb;15(2):273-283. doi: 10.1111/jth.13577. Epub 2017 Feb 6.


Management of direct oral anticoagulants in patients undergoing elective surgeries and invasive procedures: Updated guidelines from the French Working Group on Perioperative Hemostasis (GIHP) - September 2015.

Albaladejo P, Bonhomme F, Blais N, Collet JP, Faraoni D, Fontana P, Godier A, Llau J, Longrois D, Marret E, Mismetti P, Rosencher N, Roullet S, Samama CM, Schved JF, Sié P, Steib A, Susen S; French Working Group on Perioperative Hemostasis (GIHP).

Anaesth Crit Care Pain Med. 2017 Feb;36(1):73-76. doi: 10.1016/j.accpm.2016.09.002. Epub 2016 Sep 20.


Bleeding risk under selective serotonin reuptake inhibitor (SSRI) antidepressants: A meta-analysis of observational studies.

Laporte S, Chapelle C, Caillet P, Beyens MN, Bellet F, Delavenne X, Mismetti P, Bertoletti L.

Pharmacol Res. 2017 Apr;118:19-32. doi: 10.1016/j.phrs.2016.08.017. Epub 2016 Aug 10.


Direct oral anticoagulants: Current indications and unmet needs in the treatment of venous thromboembolism.

Bertoletti L, Ollier E, Duvillard C, Delavenne X, Beyens MN, De Magalhaes E, Bellet F, Basset T, Mismetti P, Laporte S.

Pharmacol Res. 2017 Apr;118:33-42. doi: 10.1016/j.phrs.2016.06.023. Epub 2016 Jun 24. Review.


Comparison of blood coagulation factors between patients with gastrointestinal or intracranial bleeding under vitamin K antagonists.

Moustafa F, Saint-Denis J, Laporte S, Mismetti P, Schmidt J.

Eur J Intern Med. 2016 Sep;33:e22-4. doi: 10.1016/j.ejim.2016.05.001. Epub 2016 May 18. No abstract available.


Treatment of pulmonary embolism.

Décousus H, Mismetti P, Couturaud F, Ageno W, Bauersachs R.

Presse Med. 2015 Dec;44(12 Pt 2):e393-9. doi: 10.1016/j.lpm.2015.10.008. Epub 2015 Nov 4. Review.


The management of acute venous thromboembolism in clinical practice - study rationale and protocol of the European PREFER in VTE Registry.

Agnelli G, Gitt AK, Bauersachs R, Fronk EM, Laeis P, Mismetti P, Monreal M, Willich SN, Wolf WP, Cohen AT; PREFER in VTE investigators.

Thromb J. 2015 Oct 21;13:41. doi: 10.1186/s12959-015-0071-z. eCollection 2015.


In vitro and in vivo evaluation of drug-drug interaction between dabigatran and proton pump inhibitors.

Ollier E, Hodin S, Basset T, Accassat S, Bertoletti L, Mismetti P, Delavenne X.

Fundam Clin Pharmacol. 2015 Dec;29(6):604-14. doi: 10.1111/fcp.12154. Epub 2015 Oct 7.


Inferior Vena Cava Filter and Recurrent Pulmonary Embolism--Reply.

Mismetti P, Laporte S, Meyer G.

JAMA. 2015 Aug 18;314(7):729-30. doi: 10.1001/jama.2015.8012. No abstract available.


Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial.

Couturaud F, Sanchez O, Pernod G, Mismetti P, Jego P, Duhamel E, Provost K, dit Sollier CB, Presles E, Castellant P, Parent F, Salaun PY, Bressollette L, Nonent M, Lorillon P, Girard P, Lacut K, Guégan M, Bosson JL, Laporte S, Leroyer C, Décousus H, Meyer G, Mottier D; PADIS-PE Investigators.

JAMA. 2015 Jul 7;314(1):31-40. doi: 10.1001/jama.2015.7046.


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