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Items: 46

1.

Proteolytic dynamics of human 20S thymoproteasome.

Kuckelkorn U, Stübler S, Textoris-Taube K, Kilian C, Niewienda A, Henklein P, Janek K, Stumpf MPH, Mishto M, Liepe J.

J Biol Chem. 2019 May 10;294(19):7740-7754. doi: 10.1074/jbc.RA118.007347. Epub 2019 Mar 26.

PMID:
30914481
2.

Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis.

Dianzani C, Vecchio D, Clemente N, Chiocchetti A, Martinelli Boneschi F, Galimberti D, Dianzani U, Comi C, Mishto M, Liepe J.

Cells. 2019 Mar 20;8(3). pii: E262. doi: 10.3390/cells8030262.

3.

Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells.

Liepe J, Sidney J, Lorenz FKM, Sette A, Mishto M.

Cancer Immunol Res. 2019 Jan;7(1):62-76. doi: 10.1158/2326-6066.CIR-18-0424. Epub 2018 Nov 13.

PMID:
30425108
4.

Author Correction: NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity.

Hasam-Henderson LA, Gotti GC, Mishto M, Klisch C, Gerevich Z, Geiger JRP, Kovács R.

Sci Rep. 2018 Aug 29;8(1):13170. doi: 10.1038/s41598-018-31011-6.

5.

NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity.

Hasam-Henderson LA, Gotti GC, Mishto M, Klisch C, Gerevich Z, Geiger JRP, Kovács R.

Sci Rep. 2018 Jun 22;8(1):9545. doi: 10.1038/s41598-018-27830-2. Erratum in: Sci Rep. 2018 Aug 29;8(1):13170.

6.

Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

Liepe J, Ovaa H, Mishto M.

Curr Opin Immunol. 2018 Jun;52:81-86. doi: 10.1016/j.coi.2018.04.016. Epub 2018 Jun 1. Review.

7.

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Platteel ACM, Liepe J, van Eden W, Mishto M, Sijts AJAM.

Front Immunol. 2017 Nov 3;8:1441. doi: 10.3389/fimmu.2017.01441. eCollection 2017. Review.

8.

Post-Translational Peptide Splicing and T Cell Responses.

Mishto M, Liepe J.

Trends Immunol. 2017 Dec;38(12):904-915. doi: 10.1016/j.it.2017.07.011. Epub 2017 Aug 19. Review.

PMID:
28830734
9.

Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection.

Platteel ACM, Liepe J, Textoris-Taube K, Keller C, Henklein P, Schalkwijk HH, Cardoso R, Kloetzel PM, Mishto M, Sijts AJAM.

Cell Rep. 2017 Aug 1;20(5):1242-1253. doi: 10.1016/j.celrep.2017.07.026.

10.

Neuroinflammatory targets and treatments for epilepsy validated in experimental models.

Aronica E, Bauer S, Bozzi Y, Caleo M, Dingledine R, Gorter JA, Henshall DC, Kaufer D, Koh S, Löscher W, Louboutin JP, Mishto M, Norwood BA, Palma E, Poulter MO, Terrone G, Vezzani A, Kaminski RM.

Epilepsia. 2017 Jul;58 Suppl 3:27-38. doi: 10.1111/epi.13783. Review.

11.

Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis.

Dianzani C, Bellavista E, Liepe J, Verderio C, Martucci M, Santoro A, Chiocchetti A, Gigliotti CL, Boggio E, Ferrara B, Riganti L, Keller C, Janek K, Niewienda A, Fenoglio C, Sorosina M, Cantello R, Kloetzel PM, Stumpf MP, Paul F, Ruprecht K, Galimberti D, Martinelli Boneschi F, Comi C, Dianzani U, Mishto M.

Sci Rep. 2017 Mar 9;7:43718. doi: 10.1038/srep43718.

12.

A large fraction of HLA class I ligands are proteasome-generated spliced peptides.

Liepe J, Marino F, Sidney J, Jeko A, Bunting DE, Sette A, Kloetzel PM, Stumpf MP, Heck AJ, Mishto M.

Science. 2016 Oct 21;354(6310):354-358. Epub 2016 Oct 20.

13.

Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.

Platteel ACM, Marit de Groot A, Keller C, Andersen P, Ovaa H, Kloetzel PM, Mishto M, Sijts AJAM.

Vaccine. 2016 Sep 30;34(42):5132-5140. doi: 10.1016/j.vaccine.2016.08.039. Epub 2016 Sep 1.

PMID:
27593157
14.

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

Ebstein F, Textoris-Taube K, Keller C, Golnik R, Vigneron N, Van den Eynde BJ, Schuler-Thurner B, Schadendorf D, Lorenz FK, Uckert W, Urban S, Lehmann A, Albrecht-Koepke N, Janek K, Henklein P, Niewienda A, Kloetzel PM, Mishto M.

Sci Rep. 2016 Apr 6;6:24032. doi: 10.1038/srep24032.

15.

CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products.

Platteel AC, Mishto M, Textoris-Taube K, Keller C, Liepe J, Busch DH, Kloetzel PM, Sijts AJ.

Eur J Immunol. 2016 May;46(5):1109-18. doi: 10.1002/eji.201545989. Epub 2016 Mar 16.

16.

The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing.

Textoris-Taube K, Keller C, Liepe J, Henklein P, Sidney J, Sette A, Kloetzel PM, Mishto M.

J Biol Chem. 2015 Dec 18;290(51):30417-28. doi: 10.1074/jbc.M115.695189. Epub 2015 Oct 27.

17.

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes.

Liepe J, Holzhütter HG, Bellavista E, Kloetzel PM, Stumpf MP, Mishto M.

Elife. 2015 Sep 22;4:e07545. doi: 10.7554/eLife.07545.

18.

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy.

Mishto M, Raza ML, de Biase D, Ravizza T, Vasuri F, Martucci M, Keller C, Bellavista E, Buchholz TJ, Kloetzel PM, Pession A, Vezzani A, Heinemann U.

Brain Behav Immun. 2015 Oct;49:188-96. doi: 10.1016/j.bbi.2015.05.007. Epub 2015 Jun 1.

PMID:
26044087
19.

Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver.

Bellavista E, Martucci M, Vasuri F, Santoro A, Mishto M, Kloss A, Capizzi E, Degiovanni A, Lanzarini C, Remondini D, Dazzi A, Pellegrini S, Cescon M, Capri M, Salvioli S, D'Errico-Grigioni A, Dahlmann B, Grazi GL, Franceschi C.

Mech Ageing Dev. 2014 Nov-Dec;141-142:26-34. doi: 10.1016/j.mad.2014.09.003. Epub 2014 Oct 1.

20.

Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation.

Mishto M, Liepe J, Textoris-Taube K, Keller C, Henklein P, Weberruß M, Dahlmann B, Enenkel C, Voigt A, Kuckelkorn U, Stumpf MP, Kloetzel PM.

Eur J Immunol. 2014 Dec;44(12):3508-21. doi: 10.1002/eji.201444902. Epub 2014 Nov 20.

21.

Modelling proteasome and proteasome regulator activities.

Liepe J, Holzhütter HG, Kloetzel PM, Stumpf MP, Mishto M.

Biomolecules. 2014 Jun 20;4(2):585-99. doi: 10.3390/biom4020585. Review.

22.

Towards a liquid self: how time, geography, and life experiences reshape the biological identity.

Grignolio A, Mishto M, Faria AM, Garagnani P, Franceschi C, Tieri P.

Front Immunol. 2014 Apr 9;5:153. doi: 10.3389/fimmu.2014.00153. eCollection 2014.

23.

Current understanding on the role of standard and immunoproteasomes in inflammatory/immunological pathways of multiple sclerosis.

Bellavista E, Santoro A, Galimberti D, Comi C, Luciani F, Mishto M.

Autoimmune Dis. 2014;2014:739705. doi: 10.1155/2014/739705. Epub 2014 Jan 2. Review.

24.

Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities.

Gohlke S, Mishto M, Textoris-Taube K, Keller C, Giannini C, Vasuri F, Capizzi E, D'Errico-Grigioni A, Kloetzel PM, Dahlmann B.

Age (Dordr). 2014 Feb;36(1):57-72. doi: 10.1007/s11357-013-9543-x. Epub 2013 May 22.

25.

Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain.

Giannini C, Kloß A, Gohlke S, Mishto M, Nicholson TP, Sheppard PW, Kloetzel PM, Dahlmann B.

PLoS One. 2013 May 7;8(5):e64042. doi: 10.1371/journal.pone.0064042. Print 2013.

26.

Immunoproteasome in cancer and neuropathologies: a new therapeutic target?

Bellavista E, Andreoli F, Parenti MD, Martucci M, Santoro A, Salvioli S, Capri M, Baruzzi A, Del Rio A, Franceschi C, Mishto M.

Curr Pharm Des. 2013;19(4):702-18. Review.

PMID:
23016859
27.

Driving forces of proteasome-catalyzed peptide splicing in yeast and humans.

Mishto M, Goede A, Taube KT, Keller C, Janek K, Henklein P, Niewienda A, Kloss A, Gohlke S, Dahlmann B, Enenkel C, Kloetzel PM.

Mol Cell Proteomics. 2012 Oct;11(10):1008-23. Epub 2012 Jul 20.

28.

Immunoproteasome expression is induced in mesial temporal lobe epilepsy.

Mishto M, Ligorio C, Bellavista E, Martucci M, Santoro A, Giulioni M, Marucci G, Franceschi C.

Biochem Biophys Res Commun. 2011 Apr 29;408(1):65-70. doi: 10.1016/j.bbrc.2011.03.117. Epub 2011 Mar 30.

PMID:
21458417
29.

Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system.

Tieri P, Grignolio A, Zaikin A, Mishto M, Remondini D, Castellani GC, Franceschi C.

Theor Biol Med Model. 2010 Aug 11;7:32. doi: 10.1186/1742-4682-7-32.

30.

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.

Santoro A, Balbi V, Balducci E, Pirazzini C, Rosini F, Tavano F, Achilli A, Siviero P, Minicuci N, Bellavista E, Mishto M, Salvioli S, Marchegiani F, Cardelli M, Olivieri F, Nacmias B, Chiamenti AM, Benussi L, Ghidoni R, Rose G, Gabelli C, Binetti G, Sorbi S, Crepaldi G, Passarino G, Torroni A, Franceschi C.

PLoS One. 2010 Aug 6;5(8):e12037. doi: 10.1371/journal.pone.0012037.

31.

The 20S proteasome splicing activity discovered by SpliceMet.

Liepe J, Mishto M, Textoris-Taube K, Janek K, Keller C, Henklein P, Kloetzel PM, Zaikin A.

PLoS Comput Biol. 2010 Jun 24;6(6):e1000830. doi: 10.1371/journal.pcbi.1000830.

32.

Studies on immunoproteasome in human liver. Part I: absence in fetuses, presence in normal subjects, and increased levels in chronic active hepatitis and cirrhosis.

Vasuri F, Capizzi E, Bellavista E, Mishto M, Santoro A, Fiorentino M, Capri M, Cescon M, Grazi GL, Grigioni WF, D'Errico-Grigioni A, Franceschi C.

Biochem Biophys Res Commun. 2010 Jun 25;397(2):301-6. doi: 10.1016/j.bbrc.2010.05.104. Epub 2010 May 26.

PMID:
20510670
33.

Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies.

Cevenini E, Bellavista E, Tieri P, Castellani G, Lescai F, Francesconi M, Mishto M, Santoro A, Valensin S, Salvioli S, Capri M, Zaikin A, Monti D, de Magalhães JP, Franceschi C.

Curr Pharm Des. 2010;16(7):802-13. Review.

PMID:
20388091
34.

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

Mishto M, Bellavista E, Ligorio C, Textoris-Taube K, Santoro A, Giordano M, D'Alfonso S, Listì F, Nacmias B, Cellini E, Leone M, Grimaldi LM, Fenoglio C, Esposito F, Martinelli-Boneschi F, Galimberti D, Scarpini E, Seifert U, Amato MP, Caruso C, Foschini MP, Kloetzel PM, Franceschi C.

PLoS One. 2010 Feb 18;5(2):e9287. doi: 10.1371/journal.pone.0009287.

35.

Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study.

Santoro A, Siviero P, Minicuci N, Bellavista E, Mishto M, Olivieri F, Marchegiani F, Chiamenti AM, Benussi L, Ghidoni R, Nacmias B, Bagnoli S, Ginestroni A, Scarpino O, Feraco E, Gianni W, Cruciani G, Paganelli R, Di Iorio A, Scognamiglio M, Grimaldi LM, Gabelli C, Sorbi S, Binetti G, Crepaldi G, Franceschi C.

CNS Drugs. 2010 Feb;24(2):163-76. doi: 10.2165/11310960-000000000-00000.

PMID:
20088621
36.

Association of p53 polymorphisms and colorectal cancer: modulation of risk and progression.

Mammano E, Belluco C, Bonafé M, Olivieri F, Mugianesi E, Barbi C, Mishto M, Cosci M, Franceschi C, Lise M, Nitti D.

Eur J Surg Oncol. 2009 Apr;35(4):415-9. doi: 10.1016/j.ejso.2008.03.003. Epub 2008 May 12.

PMID:
18468835
37.

Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics.

Mishto M, Luciani F, Holzhütter HG, Bellavista E, Santoro A, Textoris-Taube K, Franceschi C, Kloetzel PM, Zaikin A.

J Mol Biol. 2008 Apr 11;377(5):1607-17. doi: 10.1016/j.jmb.2008.01.086. Epub 2008 Feb 8.

PMID:
18336834
38.

Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural model.

Bellavista E, Mishto M, Santoro A, Bertoni-Freddari C, Sessions RB, Franceschi C.

Rejuvenation Res. 2008 Feb;11(1):73-82.

PMID:
17985946
39.

Genes, ageing and longevity in humans: problems, advantages and perspectives.

Salvioli S, Olivieri F, Marchegiani F, Cardelli M, Santoro A, Bellavista E, Mishto M, Invidia L, Capri M, Valensin S, Sevini F, Cevenini E, Celani L, Lescai F, Gonos E, Caruso C, Paolisso G, De Benedictis G, Monti D, Franceschi C.

Free Radic Res. 2006 Dec;40(12):1303-23. Review.

PMID:
17090420
40.

A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms.

Mishto M, Santoro A, Bellavista E, Sessions R, Textoris-Taube K, Dal Piaz F, Carrard G, Forti K, Salvioli S, Friguet B, Kloetzel PM, Rivett AJ, Franceschi C.

Biol Chem. 2006 Apr;387(4):417-29.

PMID:
16606340
41.

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains.

Mishto M, Bellavista E, Santoro A, Stolzing A, Ligorio C, Nacmias B, Spazzafumo L, Chiappelli M, Licastro F, Sorbi S, Pession A, Ohm T, Grune T, Franceschi C.

Neurobiol Aging. 2006 Jan;27(1):54-66.

PMID:
16298241
42.

A mathematical model of protein degradation by the proteasome.

Luciani F, Keşmir C, Mishto M, Or-Guil M, de Boer RJ.

Biophys J. 2005 Apr;88(4):2422-32. Epub 2005 Jan 21.

43.

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

Bonafé M, Salvioli S, Barbi C, Trapassi C, Tocco F, Storci G, Invidia L, Vannini I, Rossi M, Marzi E, Mishto M, Capri M, Olivieri F, Antonicelli R, Memo M, Uberti D, Nacmias B, Sorbi S, Monti D, Franceschi C.

Cell Death Differ. 2004 Sep;11(9):962-73.

44.

Immunoproteasomes and immunosenescence.

Mishto M, Santoro A, Bellavista E, Bonafé M, Monti D, Franceschi C.

Ageing Res Rev. 2003 Oct;2(4):419-32. Review.

PMID:
14522244
45.

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes.

Bonafè M, Salvioli S, Barbi C, Mishto M, Trapassi C, Gemelli C, Storci G, Olivieri F, Monti D, Franceschi C.

Biochem Biophys Res Commun. 2002 Dec 13;299(4):539-41.

PMID:
12459171
46.

Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells.

Mishto M, Bonafè M, Salvioli S, Olivieri F, Franceschi C.

Exp Gerontol. 2002 Jan-Mar;37(2-3):301-8.

PMID:
11772516

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