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Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide.

Kohler C, Proctor RA, Bayer AS, Yeaman MR, Lalk M, Engelmann S, Mishra NN.

Antibiotics (Basel). 2019 Sep 28;8(4). pii: E169. doi: 10.3390/antibiotics8040169.


Intravesical tacrolimus in treatment of intractable interstitial cystitis/bladder pain syndrome - A pilot study.

Mishra NN, Riedl C, Shah S, Pathak N.

Int J Urol. 2019 Jun;26 Suppl 1:68-72. doi: 10.1111/iju.13978.


Metabolic interventions for the prevention and treatment of daptomycin non-susceptibility in Staphylococcus aureus.

Reed JM, Gardner SG, Mishra NN, Bayer AS, Somerville GA.

J Antimicrob Chemother. 2019 Aug 1;74(8):2274-2283. doi: 10.1093/jac/dkz194.


Daptomycin Dose-Ranging Evaluation with Single-Dose versus Multidose Ceftriaxone Combinations against Streptococcus mitis/oralis in an Ex Vivo Simulated Endocarditis Vegetation Model.

Kebriaei R, Rice SA, Stamper KC, Seepersaud R, Garcia-de-la-Maria C, Mishra NN, Miro JM, Arias CA, Tran TT, Sullam PM, Bayer AS, Rybak MJ.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00386-19. doi: 10.1128/AAC.00386-19. Print 2019 Jun.


Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia.

Abdelhady W, Mishra NN.

Front Med (Lausanne). 2019 Feb 20;6:31. doi: 10.3389/fmed.2019.00031. eCollection 2019.


Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance.

Ernst CM, Slavetinsky CJ, Kuhn S, Hauser JN, Nega M, Mishra NN, Gekeler C, Bayer AS, Peschel A.

MBio. 2018 Dec 18;9(6). pii: e01659-18. doi: 10.1128/mBio.01659-18.


Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery.

Spencer C, Bensing BA, Mishra NN, Sullam PM.

J Biol Chem. 2019 Feb 1;294(5):1502-1515. doi: 10.1074/jbc.RA118.005657. Epub 2018 Dec 4.


Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis.

Tran TT, Mishra NN, Seepersaud R, Diaz L, Rios R, Dinh AQ, Garcia-de-la-Maria C, Rybak MJ, Miro JM, Shelburne SA, Sullam PM, Bayer AS, Arias CA.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18. doi: 10.1128/AAC.01531-18. Print 2019 Feb.


Herbal Gel Formulation Developed for Anti-Human Immunodeficiency Virus (HIV)-1 Activity Also Inhibits In Vitro HSV-2 Infection.

Mishra NN, Kesharwani A, Agarwal A, Polachira SK, Nair R, Gupta SK.

Viruses. 2018 Oct 24;10(11). pii: E580. doi: 10.3390/v10110580.


A qualitative study of Institutional Ethics Committees: Members' understanding of research guidelines, privacy, and challenges to privacy protection.

Mishra NN, Bhatia T, Nimgaonkar VL, Deshpande SN, Parker LS.

Indian J Med Ethics. 2018 Oct-Dec;3(4):315-320. doi: 10.20529/IJME.2018.054. Epub 2018 Jul 10.


Prevention of High-Level Daptomycin-Resistance Emergence In Vitro in Streptococcus mitis-oralis by Using Combination Antimicrobial Strategies.

Zapata B, Alvarez DN, Farah S, Garcia-de-la-Maria C, Miro JM, Sakoulas G, Bayer AS, Mishra NN.

Curr Microbiol. 2018 Aug;75(8):1062-1067. doi: 10.1007/s00284-018-1491-3. Epub 2018 Apr 12.


Impact of Multiple Single-Nucleotide Polymorphisms Within mprF on Daptomycin Resistance in Staphylococcus aureus.

Yang SJ, Mishra NN, Kang KM, Lee GY, Park JH, Bayer AS.

Microb Drug Resist. 2018 Oct;24(8):1075-1081. doi: 10.1089/mdr.2017.0156. Epub 2018 Jan 30.


Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs).

Yim J, Smith JR, Singh NB, Rice S, Stamper K, Garcia de la Maria C, Bayer AS, Mishra NN, Miró JM, Tran TT, Arias CA, Sullam P, Rybak MJ.

J Antimicrob Chemother. 2017 Aug 1;72(8):2290-2296. doi: 10.1093/jac/dkx130.


Impact of High-Level Daptomycin Resistance in the Streptococcus mitis Group on Virulence and Survivability during Daptomycin Treatment in Experimental Infective Endocarditis.

Garcia-de-la-Maria C, Xiong YQ, Pericas JM, Armero Y, Moreno A, Mishra NN, Rybak MJ, Tran TT, Arias CA, Sullam PM, Bayer AS, Miro JM.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02418-16. doi: 10.1128/AAC.02418-16. Print 2017 May.


Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids.

Kesharwani A, Polachira SK, Nair R, Agarwal A, Mishra NN, Gupta SK.

BMC Complement Altern Med. 2017 Feb 14;17(1):110. doi: 10.1186/s12906-017-1620-8.


Phenotypic and genotypic correlates of daptomycin-resistant methicillin-susceptible Staphylococcus aureus clinical isolates.

Kang KM, Mishra NN, Park KT, Lee GY, Park YH, Bayer AS, Yang SJ.

J Microbiol. 2017 Feb;55(2):153-159. doi: 10.1007/s12275-017-6509-1. Epub 2017 Jan 26.


Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism.

Mishra NN, Tran TT, Seepersaud R, Garcia-de-la-Maria C, Faull K, Yoon A, Proctor R, Miro JM, Rybak MJ, Bayer AS, Arias CA, Sullam PM.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02435-16. doi: 10.1128/AAC.02435-16. Print 2017 Apr.


Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Malik A, Mallajosyula V, Mishra NN, Arukha AP, Varadarajan R, Gupta SK.

Indian J Med Microbiol. 2016 Oct-Dec;34(4):489-494. doi: 10.4103/0255-0857.195366.


Stratifying empiric risk of schizophrenia among first degree relatives using multiple predictors in two independent Indian samples.

Bhatia T, Gettig EA, Gottesman II, Berliner J, Mishra NN, Nimgaonkar VL, Deshpande SN.

Asian J Psychiatr. 2016 Dec;24:79-84. doi: 10.1016/j.ajp.2016.08.015. Epub 2016 Aug 21.


Dysregulation of mprF and dltABCD expression among daptomycin-non-susceptible MRSA clinical isolates.

Bayer AS, Mishra NN, Cheung AL, Rubio A, Yang SJ.

J Antimicrob Chemother. 2016 Aug;71(8):2100-4. doi: 10.1093/jac/dkw142. Epub 2016 Apr 27.


Clinical presentation and treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in India.

Mishra NN.

Transl Androl Urol. 2015 Oct;4(5):512-23. doi: 10.3978/j.issn.2223-4683.2015.10.05. Review.


Generation and Characterization of Monoclonal Antibodies Specific to Avian Influenza H5N1 Hemagglutinin Protein.

Malik A, Mallajosyula VV, Mishra NN, Varadarajan R, Gupta SK.

Monoclon Antib Immunodiagn Immunother. 2015 Dec;34(6):436-41. doi: 10.1089/mab.2015.0047.


The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model.

Xiong YQ, Yang SJ, Tong SY, Alvarez DN, Mishra NN.

Pathog Dis. 2015 Oct;73(7). pii: ftv056. doi: 10.1093/femspd/ftv056. Epub 2015 Aug 4.


Author's response.

Mishra NN, Bhatia T, Kumar N, Nimogaonkar VL, Parker L, Deshpande SN.

Indian J Med Res. 2014 Dec;140(6):788-9. No abstract available.


Mental illness, poverty and stigma in India: a case-control study.

Trani JF, Bakhshi P, Kuhlberg J, Narayanan SS, Venkataraman H, Mishra NN, Groce NE, Jadhav S, Deshpande S.

BMJ Open. 2015 Feb 23;5(2):e006355. doi: 10.1136/bmjopen-2014-006355.


Corneal targeted nanoparticles for sustained natamycin delivery and their PK/PD indices: an approach to reduce dose and dosing frequency.

Chandasana H, Prasad YD, Chhonker YS, Chaitanya TK, Mishra NN, Mitra K, Shukla PK, Bhatta RS.

Int J Pharm. 2014 Dec 30;477(1-2):317-25. doi: 10.1016/j.ijpharm.2014.10.035. Epub 2014 Oct 16.


A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis.

Reyes J, Panesso D, Tran TT, Mishra NN, Cruz MR, Munita JM, Singh KV, Yeaman MR, Murray BE, Shamoo Y, Garsin D, Bayer AS, Arias CA.

J Infect Dis. 2015 Apr 15;211(8):1317-25. doi: 10.1093/infdis/jiu602. Epub 2014 Oct 31.


A monoclonal antibody against 47.2 kDa cell surface antigen prevents adherence and affects biofilm formation of Candida albicans.

Mishra NN, Ali S, Shukla PK.

World J Microbiol Biotechnol. 2015 Jan;31(1):11-21. doi: 10.1007/s11274-014-1760-7. Epub 2014 Oct 18.


Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides.

Bayer AS, Mishra NN, Sakoulas G, Nonejuie P, Nast CC, Pogliano J, Chen KT, Ellison SN, Yeaman MR, Yang SJ.

Antimicrob Agents Chemother. 2014 Dec;58(12):7462-7. doi: 10.1128/AAC.03422-14. Epub 2014 Oct 6.


Protocol to evaluate the impact of yoga supplementation on cognitive function in schizophrenia: a randomised controlled trial.

Bhatia T, Mazumdar S, Mishra NN, Gur RE, Gur RC, Nimgaonkar VL, Deshpande SN.

Acta Neuropsychiatr. 2014 Oct;26(5):280-90. doi: 10.1017/neu.2014.9.


Phenotypic and genotypic characterization of daptomycin-resistant methicillin-resistant Staphylococcus aureus strains: relative roles of mprF and dlt operons.

Mishra NN, Bayer AS, Weidenmaier C, Grau T, Wanner S, Stefani S, Cafiso V, Bertuccio T, Yeaman MR, Nast CC, Yang SJ.

PLoS One. 2014 Sep 16;9(9):e107426. doi: 10.1371/journal.pone.0107426. eCollection 2014.


Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions.

Munita JM, Mishra NN, Alvarez D, Tran TT, Diaz L, Panesso D, Reyes J, Murray BE, Adachi JA, Bayer AS, Arias CA.

Clin Infect Dis. 2014 Nov 1;59(9):1277-80. doi: 10.1093/cid/ciu642. Epub 2014 Aug 8.


Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms.

Ahmad A, Azmi S, Srivastava S, Kumar A, Tripathi JK, Mishra NN, Shukla PK, Ghosh JK.

Amino Acids. 2014 Nov;46(11):2531-43. doi: 10.1007/s00726-014-1802-3. Epub 2014 Jul 29.


Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents.

Sharma S, Saquib M, Verma S, Mishra NN, Shukla PK, Srivastava R, Prabhakar YS, Shaw AK.

Eur J Med Chem. 2014 Aug 18;83:474-89. doi: 10.1016/j.ejmech.2014.06.048. Epub 2014 Jun 24.


Knowledge & attitudes of mental health professionals regarding psychiatric research.

Mishra NN, Bhatia T, Kumar N, Nimgaonkar VL, Parker LS, Deshpande SN.

Indian J Med Res. 2014 Feb;139(2):246-51.


Arachidonic acid affects biofilm formation and PGE2 level in Candida albicans and non-albicans species in presence of subinhibitory concentration of fluconazole and terbinafine.

Mishra NN, Ali S, Shukla PK.

Braz J Infect Dis. 2014 May-Jun;18(3):287-93. doi: 10.1016/j.bjid.2013.09.006. Epub 2014 Jan 2.


Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance.

Yang SJ, Mishra NN, Rubio A, Bayer AS.

Antimicrob Agents Chemother. 2013 Nov;57(11):5658-64. doi: 10.1128/AAC.01184-13. Epub 2013 Sep 3.


Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.

Mishra NN, Yang SJ, Chen L, Muller C, Saleh-Mghir A, Kuhn S, Peschel A, Yeaman MR, Nast CC, Kreiswirth BN, Crémieux AC, Bayer AS.

PLoS One. 2013 Aug 19;8(8):e71151. doi: 10.1371/journal.pone.0071151. eCollection 2013.


Tutorials on basics of bioethics: an experience with post-graduate health professionals.

Mishra NN, Bhatia T, Parker LS, Nimgaonkar VL, Deshpande SN.

Stud Health Technol Inform. 2013;192:1054.


Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids.

Tran TT, Panesso D, Mishra NN, Mileykovskaya E, Guan Z, Munita JM, Reyes J, Diaz L, Weinstock GM, Murray BE, Shamoo Y, Dowhan W, Bayer AS, Arias CA.

MBio. 2013 Jul 23;4(4). pii: e00281-13. doi: 10.1128/mBio.00281-13.


Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates.

Bertsche U, Yang SJ, Kuehner D, Wanner S, Mishra NN, Roth T, Nega M, Schneider A, Mayer C, Grau T, Bayer AS, Weidenmaier C.

PLoS One. 2013 Jun 13;8(6):e67398. doi: 10.1371/journal.pone.0067398. Print 2013.


Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin.

Tong SY, Sharma-Kuinkel BK, Thaden JT, Whitney AR, Yang SJ, Mishra NN, Rude T, Lilliebridge RA, Selim MA, Ahn SH, Holt DC, Giffard PM, Bayer AS, Deleo FR, Fowler VG Jr.

J Infect Dis. 2013 Aug 1;208(3):520-7. doi: 10.1093/infdis/jit173. Epub 2013 Apr 18.


Characterization of antimicrobial, cytotoxic, and antiendotoxin properties of short peptides with different hydrophobic amino acids at "a" and "d" positions of a heptad repeat sequence.

Azmi S, Srivastava S, Mishra NN, Tripathi JK, Shukla PK, Ghosh JK.

J Med Chem. 2013 Feb 14;56(3):924-39. doi: 10.1021/jm301407k. Epub 2013 Jan 30.


Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant Staphylococcus aureus.

Mishra NN, Bayer AS.

Antimicrob Agents Chemother. 2013 Feb;57(2):1082-5. doi: 10.1128/AAC.02182-12. Epub 2012 Dec 17.


Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy.

Tran TT, Panesso D, Gao H, Roh JH, Munita JM, Reyes J, Diaz L, Lobos EA, Shamoo Y, Mishra NN, Bayer AS, Murray BE, Weinstock GM, Arias CA.

Antimicrob Agents Chemother. 2013 Jan;57(1):261-8. doi: 10.1128/AAC.01454-12. Epub 2012 Oct 31.


Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content.

Mishra NN, Bayer AS, Tran TT, Shamoo Y, Mileykovskaya E, Dowhan W, Guan Z, Arias CA.

PLoS One. 2012;7(8):e43958. doi: 10.1371/journal.pone.0043958. Epub 2012 Aug 27.


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