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Items: 1 to 50 of 300

1.

The non-canonical BMP signaling pathway plays an important role in club cell regeneration.

Shafiquzzaman M, Biswas S, Li P, Mishina Y, Li B, Liu H.

Stem Cells. 2019 Nov 23. doi: 10.1002/stem.3125. [Epub ahead of print]

PMID:
31758827
2.

Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation.

Agarwal S, Loder SJ, Cholok D, Li J, Bian G, Yalavarthi S, Li S, Carson WF, Hwang C, Marini S, Pagani C, Edwards N, Delano MJ, Standiford TJ, Knight JS, Kunkel SL, Mishina Y, Ward PA, Levi B.

Front Immunol. 2019 Oct 24;10:2148. doi: 10.3389/fimmu.2019.02148. eCollection 2019.

3.

Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway.

Omi M, Kaartinen V, Mishina Y.

J Biol Chem. 2019 Nov 22;294(47):17818-17836. doi: 10.1074/jbc.RA119.009521. Epub 2019 Oct 16.

PMID:
31619522
4.

Covalent Attachment of P15 Peptide to Ti Alloy Surface Modified with Polymer to Enhance Osseointegration of Implants.

Fu L, Omi M, Sun M, Cheng B, Mao G, Liu T, Mendonça G, Averick SE, Mishina Y, Matyjaszewski K.

ACS Appl Mater Interfaces. 2019 Oct 23;11(42):38531-38536. doi: 10.1021/acsami.9b14651. Epub 2019 Oct 10.

PMID:
31599570
5.

Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues.

Ishan M, Chen G, Sun C, Chen SY, Komatsu Y, Mishina Y, Liu HX.

Genesis. 2019 Sep 30:e23337. doi: 10.1002/dvg.23337. [Epub ahead of print]

PMID:
31571391
6.

Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification.

Valer JA, Sánchez-de-Diego C, Gámez B, Mishina Y, Rosa JL, Ventura F.

EMBO Mol Med. 2019 Sep;11(9):e10567. doi: 10.15252/emmm.201910567. Epub 2019 Aug 2.

7.

Autophagy Regulates Craniofacial Bone Acquisition.

Thomas N, Choi HK, Wei X, Wang L, Mishina Y, Guan JL, Liu F.

Calcif Tissue Int. 2019 Nov;105(5):518-530. doi: 10.1007/s00223-019-00593-2. Epub 2019 Aug 1.

PMID:
31372669
8.

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone.

Yang J, Pan H, Mishina Y.

J Vis Exp. 2019 May 10;(147). doi: 10.3791/59113.

PMID:
31132049
9.

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Sellers WR, Lees E, Shao W, Dillon MP, Stuart DD.

J Med Chem. 2019 May 16. doi: 10.1021/acs.jmedchem.9b00161. [Epub ahead of print]

PMID:
31059256
10.

Trim33 is required for appropriate development of pre-cardiogenic mesoderm.

Rajderkar S, Mann JM, Panaretos C, Yumoto K, Li HD, Mishina Y, Ralston B, Kaartinen V.

Dev Biol. 2019 Jun 15;450(2):101-114. doi: 10.1016/j.ydbio.2019.03.018. Epub 2019 Mar 30.

PMID:
30940539
11.

Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation.

Hsieh HHS, Agarwal S, Cholok DJ, Loder SJ, Kaneko K, Huber A, Chung MT, Ranganathan K, Habbouche J, Li J, Butts J, Reimer J, Kaura A, Drake J, Breuler C, Priest CR, Nguyen J, Brownley C, Peterson J, Ozgurel SU, Niknafs YS, Li S, Inagaki M, Scott G, Krebsbach PH, Longaker MT, Westover K, Gray N, Ninomiya-Tsuji J, Mishina Y, Levi B.

Stem Cells. 2019 Jun;37(6):766-778. doi: 10.1002/stem.2991. Epub 2019 Mar 14.

PMID:
30786091
12.

Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.

Zhang X, Shi C, Zhao H, Zhou Y, Hu Y, Yan G, Liu C, Li D, Hao X, Mishina Y, Liu Q, Sun H.

J Mol Histol. 2019 Feb;50(1):43-61. doi: 10.1007/s10735-018-9806-z. Epub 2018 Dec 5.

PMID:
30519900
13.

Phenotypic Analyses of Genetically Modified Mice for BMP Receptors.

Yang J, Mishina Y.

Methods Mol Biol. 2019;1891:179-189. doi: 10.1007/978-1-4939-8904-1_13.

PMID:
30414133
14.

Generation and Identification of Genetically Modified Mice for BMP Receptors.

Yang J, Mishina Y.

Methods Mol Biol. 2019;1891:165-177. doi: 10.1007/978-1-4939-8904-1_12.

PMID:
30414132
15.

A Ciliary Protein EVC2/LIMBIN Plays a Critical Role in the Skull Base for Mid-Facial Development.

Kulkarni AK, Louie KW, Yatabe M, Ruellas ACO, Mochida Y, Cevidanes LHS, Mishina Y, Zhang H.

Front Physiol. 2018 Oct 25;9:1484. doi: 10.3389/fphys.2018.01484. eCollection 2018.

16.

Genome Editing: A New Horizon for Oral and Craniofacial Research.

Yu N, Yang J, Mishina Y, Giannobile WV.

J Dent Res. 2019 Jan;98(1):36-45. doi: 10.1177/0022034518805978. Epub 2018 Oct 24.

PMID:
30354846
17.

Pore size directs bone marrow stromal cell fate and tissue regeneration in nanofibrous macroporous scaffolds by mediating vascularization.

Gupte MJ, Swanson WB, Hu J, Jin X, Ma H, Zhang Z, Liu Z, Feng K, Feng G, Xiao G, Hatch N, Mishina Y, Ma PX.

Acta Biomater. 2018 Dec;82:1-11. doi: 10.1016/j.actbio.2018.10.016. Epub 2018 Oct 13.

18.

Cationic Hyperbranched Polymers with Biocompatible Shells for siRNA Delivery.

Li S, Omi M, Cartieri F, Konkolewicz D, Mao G, Gao H, Averick SE, Mishina Y, Matyjaszewski K.

Biomacromolecules. 2018 Sep 10;19(9):3754-3765. doi: 10.1021/acs.biomac.8b00902. Epub 2018 Aug 27.

19.

Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model.

Kramer K, Yang J, Swanson WB, Hayano S, Toda M, Pan H, Kim JK, Krebsbach PH, Mishina Y.

Genesis. 2018 Jun;56(6-7):e23220. doi: 10.1002/dvg.23220.

20.

ACVR1 is essential for periodontium development and promotes alveolar bone formation.

Zhang X, Liu Q, Zhao H, Hu Y, Liu C, Yan G, Li D, Mishina Y, Shi C, Sun H.

Arch Oral Biol. 2018 Nov;95:108-117. doi: 10.1016/j.archoralbio.2018.07.019. Epub 2018 Jul 31.

PMID:
30098439
21.

VWC2 Increases Bone Formation Through Inhibiting Activin Signaling.

Almehmadi A, Ohyama Y, Kaku M, Alamoudi A, Husein D, Katafuchi M, Mishina Y, Mochida Y.

Calcif Tissue Int. 2018 Dec;103(6):663-674. doi: 10.1007/s00223-018-0462-9. Epub 2018 Aug 3.

22.

BMPRIA is required for osteogenic differentiation and RANKL expression in adult bone marrow mesenchymal stromal cells.

Biswas S, Li P, Wu H, Shafiquzzaman M, Murakami S, Schneider MD, Mishina Y, Li B, Li J.

Sci Rep. 2018 May 31;8(1):8475. doi: 10.1038/s41598-018-26820-8.

23.

The Role of Cell Autonomous Signaling by BMP in Endocardial Cushion Cells in AV Valvuloseptal Morphogenesis.

Sugi Y, Zhou B, Inai K, Mishina Y, Burnside JL.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 22.
2016 Jun 25.

24.

Recovery of active recombinant EGFP from the excrement of transgenic mice: A possible source of recombinant protein.

Magotani M, Nakamura A, Ikegami H, Kunii S, Mishina Y, Morimoto K, Kishigami S.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):817-823. doi: 10.1016/j.bbrc.2018.04.166. Epub 2018 Apr 27.

PMID:
29689268
25.

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

Tria GS, Abrams T, Baird J, Burks HE, Firestone B, Gaither LA, Hamann LG, He G, Kirby CA, Kim S, Lombardo F, Macchi KJ, McDonnell DP, Mishina Y, Norris JD, Nunez J, Springer C, Sun Y, Thomsen NM, Wang C, Wang J, Yu B, Tiong-Yip CL, Peukert S.

J Med Chem. 2018 Apr 12;61(7):2837-2864. doi: 10.1021/acs.jmedchem.7b01682. Epub 2018 Mar 22.

PMID:
29562737
26.

Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice.

Wang X, Li F, Xie L, Crane J, Zhen G, Mishina Y, Deng R, Gao B, Chen H, Liu S, Yang P, Gao M, Tu M, Wang Y, Wan M, Fan C, Cao X.

Nat Commun. 2018 Feb 7;9(1):551. doi: 10.1038/s41467-018-02988-5.

27.

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death.

Liu X, Hayano S, Pan H, Inagaki M, Ninomiya-Tsuji J, Sun H, Mishina Y.

Genesis. 2018 Mar;56(3):e23093. doi: 10.1002/dvg.23093. Epub 2018 Feb 22.

28.

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

Shao W, Mishina YM, Feng Y, Caponigro G, Cooke VG, Rivera S, Wang Y, Shen F, Korn JM, Mathews Griner LA, Nishiguchi G, Rico A, Tellew J, Haling JR, Aversa R, Polyakov V, Zang R, Hekmat-Nejad M, Amiri P, Singh M, Keen N, Dillon MP, Lees E, Ramurthy S, Sellers WR, Stuart DD.

Cancer Res. 2018 Mar 15;78(6):1537-1548. doi: 10.1158/0008-5472.CAN-17-2033. Epub 2018 Jan 17.

29.

Bone morphogenetic protein signaling through ACVR1 and BMPR1A negatively regulates bone mass along with alterations in bone composition.

Shi C, Mandair GS, Zhang H, Vanrenterghem GG, Ridella R, Takahashi A, Zhang Y, Kohn DH, Morris MD, Mishina Y, Sun H.

J Struct Biol. 2018 Mar;201(3):237-246. doi: 10.1016/j.jsb.2017.11.010. Epub 2017 Nov 23.

30.

Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.

Townsend KL, Madden CJ, Blaszkiewicz M, McDougall L, Tupone D, Lynes MD, Mishina Y, Yu P, Morrison SF, Tseng YH.

Endocrinology. 2017 Dec 1;158(12):4233-4245. doi: 10.1210/en.2017-00212.

31.

Heterotopic ossification and the elucidation of pathologic differentiation.

Cholok D, Chung MT, Ranganathan K, Ucer S, Day D, Davis TA, Mishina Y, Levi B.

Bone. 2018 Apr;109:12-21. doi: 10.1016/j.bone.2017.09.019. Epub 2017 Oct 5. Review.

32.

The Role of Ellis-Van Creveld 2(EVC2) in Mice During Cranial Bone Development.

Kwon EK, Louie K, Kulkarni A, Yatabe M, Ruellas ACO, Snider TN, Mochida Y, Cevidanes LHS, Mishina Y, Zhang H.

Anat Rec (Hoboken). 2018 Jan;301(1):46-55. doi: 10.1002/ar.23692. Epub 2017 Oct 6.

33.

Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation".

Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CSC, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00284-17. doi: 10.1128/MCB.00284-17. Print 2017 Oct 1. No abstract available.

34.

BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling.

Saxon JG, Baer DR, Barton JA, Hawkins T, Wu B, Trusk TC, Harris SE, Zhou B, Mishina Y, Sugi Y.

Dev Biol. 2017 Oct 1;430(1):113-128. doi: 10.1016/j.ydbio.2017.08.008. Epub 2017 Aug 6.

35.

Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.

He Y, Sun X, Wang L, Mishina Y, Guan JL, Liu F.

Genesis. 2017 Sep;55(9). doi: 10.1002/dvg.23048. Epub 2017 Aug 14.

36.

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.

Agarwal S, Loder SJ, Breuler C, Li J, Cholok D, Brownley C, Peterson J, Hsieh HH, Drake J, Ranganathan K, Niknafs YS, Xiao W, Li S, Kumar R, Tompkins R, Longaker MT, Davis TA, Yu PB, Mishina Y, Levi B.

Mol Ther. 2017 Aug 2;25(8):1974-1987. doi: 10.1016/j.ymthe.2017.01.008. Epub 2017 Jul 15.

37.

BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.

Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, Mishina Y.

Dev Biol. 2017 Sep 1;429(1):260-270. doi: 10.1016/j.ydbio.2017.06.020. Epub 2017 Jun 19.

38.

Hair follicle specific ACVR1/ALK2 critically affects skin morphogenesis and attenuates wound healing.

Sorkin M, Agarwal S, Ranganathan K, Loder S, Cholok D, Fireman D, Li J, Li S, Zhao B, Mishina Y, Cederna P, Levi B.

Wound Repair Regen. 2017 May;25(3):521-525. doi: 10.1111/wrr.12549. Epub 2017 Jun 21.

39.

TGF-β Family Signaling in Mesenchymal Differentiation.

Grafe I, Alexander S, Peterson JR, Snider TN, Levi B, Lee B, Mishina Y.

Cold Spring Harb Perspect Biol. 2018 May 1;10(5). pii: a022202. doi: 10.1101/cshperspect.a022202. Review.

40.

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.

Kaucka M, Zikmund T, Tesarova M, Gyllborg D, Hellander A, Jaros J, Kaiser J, Petersen J, Szarowska B, Newton PT, Dyachuk V, Li L, Qian H, Johansson AS, Mishina Y, Currie JD, Tanaka EM, Erickson A, Dudley A, Brismar H, Southam P, Coen E, Chen M, Weinstein LS, Hampl A, Arenas E, Chagin AS, Fried K, Adameyko I.

Elife. 2017 Apr 17;6. pii: e25902. doi: 10.7554/eLife.25902.

41.

Inhibition of prenylated KRAS in a lipid environment.

Jansen JM, Wartchow C, Jahnke W, Fong S, Tsang T, Pfister K, Zavorotinskaya T, Bussiere D, Cheng JM, Crawford K, Dai Y, Dove J, Fang E, Feng Y, Florent JM, Fuller J, Gossert AD, Hekmat-Nejad M, Henry C, Klopp J, Lenahan WP, Lingel A, Ma S, Meyer A, Mishina Y, Narberes J, Pardee G, Ramurthy S, Rieffel S, Stuart D, Subramanian S, Tandeske L, Widger S, Widmer A, Winterhalter A, Zaror I, Hardy S.

PLoS One. 2017 Apr 6;12(4):e0174706. doi: 10.1371/journal.pone.0174706. eCollection 2017.

42.

Specific and spatial labeling of P0-Cre versus Wnt1-Cre in cranial neural crest in early mouse embryos.

Chen G, Ishan M, Yang J, Kishigami S, Fukuda T, Scott G, Ray MK, Sun C, Chen SY, Komatsu Y, Mishina Y, Liu HX.

Genesis. 2017 Jun;55(6). doi: 10.1002/dvg.23034. Epub 2017 Apr 18.

43.

Pharmacologic Calcitriol Inhibits Osteoclast Lineage Commitment via the BMP-Smad1 and IκB-NF-κB Pathways.

Li A, Cong Q, Xia X, Leong WF, Yeh J, Miao D, Mishina Y, Liu H, Li B.

J Bone Miner Res. 2017 Jul;32(7):1406-1420. doi: 10.1002/jbmr.3146. Epub 2017 May 9.

44.

Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer.

Burks HE, Abrams T, Kirby CA, Baird J, Fekete A, Hamann LG, Kim S, Lombardo F, Loo A, Lubicka D, Macchi K, McDonnell DP, Mishina Y, Norris JD, Nunez J, Saran C, Sun Y, Thomsen NM, Wang C, Wang J, Peukert S.

J Med Chem. 2017 Apr 13;60(7):2790-2818. doi: 10.1021/acs.jmedchem.6b01468. Epub 2017 Mar 15.

PMID:
28296398
45.

Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel.

Zhang H, Takeda H, Tsuji T, Kamiya N, Kunieda T, Mochida Y, Mishina Y.

J Dent Res. 2017 Apr;96(4):421-429. doi: 10.1177/0022034516683674. Epub 2017 Jan 12.

46.

Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.

Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y.

PLoS Genet. 2016 Dec 27;12(12):e1006510. doi: 10.1371/journal.pgen.1006510. eCollection 2016 Dec.

47.

mTOR inhibition and BMP signaling act synergistically to reduce muscle fibrosis and improve myofiber regeneration.

Agarwal S, Cholok D, Loder S, Li J, Breuler C, Chung MT, Sung HH, Ranganathan K, Habbouche J, Drake J, Peterson J, Priest C, Li S, Mishina Y, Levi B.

JCI Insight. 2016 Dec 8;1(20):e89805. doi: 10.1172/jci.insight.89805.

48.

Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon.

Agarwal S, Loder SJ, Cholok D, Peterson J, Li J, Breuler C, Cameron Brownley R, Hsin Sung H, Chung MT, Kamiya N, Li S, Zhao B, Kaartinen V, Davis TA, Qureshi AT, Schipani E, Mishina Y, Levi B.

Stem Cells. 2017 Mar;35(3):705-710. doi: 10.1002/stem.2515. Epub 2016 Nov 8.

49.

An epistatic explanation.

Komatsu Y, Mishina Y.

Elife. 2016 Sep 30;5. pii: e21162. doi: 10.7554/eLife.21162.

50.

BMP Signaling Mediated by BMPR1A in Osteoclasts Negatively Regulates Osteoblast Mineralization Through Suppression of Cx43.

Shi C, Zhang H, Louie K, Mishina Y, Sun H.

J Cell Biochem. 2017 Mar;118(3):605-614. doi: 10.1002/jcb.25746. Epub 2016 Sep 30.

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