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Items: 1 to 50 of 53

1.

Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection.

Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder JI.

J Clin Invest. 2019 Nov 12. pii: 128368. doi: 10.1172/JCI128368. [Epub ahead of print]

2.

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signaling in monocyte-derived alveolar macrophages.

Joshi N, Watanabe S, Verma R, Jablonski RP, Chen CI, Cheresh P, Markov NS, Reyfman PA, McQuattie-Pimentel AC, Sichizya L, Lu Z, Piseaux R, Kirchenbuechler D, Flozak AS, Gottardi CJ, Cuda CM, Perlman H, Jain M, Kamp DW, Scott Budinger GR, Misharin AV.

Eur Respir J. 2019 Oct 10. pii: 1900646. doi: 10.1183/13993003.00646-2019. [Epub ahead of print]

PMID:
31601718
3.

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.

Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, Misharin AV.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):150-161. doi: 10.1165/rcmb.2019-0191ST.

PMID:
31368812
4.

The role of macrophages in the resolution of inflammation.

Watanabe S, Alexander M, Misharin AV, Budinger GRS.

J Clin Invest. 2019 May 20;129(7):2619-2628. doi: 10.1172/JCI124615. eCollection 2019 May 20. Review.

5.

The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease.

Schiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M, Vieira Braga FA, Timens W, Koppelman GH, Budinger GRS, Burgess JK, Waghray A, van den Berge M, Theis FJ, Regev A, Kaminski N, Rajagopal J, Teichmann SA, Misharin AV, Nawijn MC.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):31-41. doi: 10.1165/rcmb.2018-0416TR.

PMID:
30995076
6.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

7.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC.

8.

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.

PMID:
30530483
9.

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis.

Sala MA, Balderas-Martínez YI, Buendía-Roldan I, Abdala-Valencia H, Nam K, Jain M, Bhorade S, Bharat A, Reyfman PA, Ridge KM, Pardo A, Sznajder JI, Budinger GRS, Misharin AV, Selman M.

Respir Res. 2018 Nov 26;19(1):233. doi: 10.1186/s12931-018-0932-7.

10.

Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia.

Walter JM, Ren Z, Yacoub T, Reyfman PA, Shah RD, Abdala-Valencia H, Nam K, Morgan VK, Anekalla KR, Joshi N, McQuattie-Pimentel AC, Chen CI, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Aillon RP, Watanabe S, Williams KJN, Lu Z, Paonessa J, Hountras P, Breganio M, Borkowski N, Donnelly HK, Allen JP, Amaral LA, Bharat A, Misharin AV, Bagheri N, Hauser AR, Budinger GRS, Wunderink RG.

Am J Respir Crit Care Med. 2019 May 15;199(10):1225-1237. doi: 10.1164/rccm.201804-0650OC.

PMID:
30398927
11.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

PMID:
30318339
12.

Targeting the Myofibroblast in Pulmonary Fibrosis.

Misharin AV, Budinger GRS.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):834-835. doi: 10.1164/rccm.201806-1037ED. No abstract available.

PMID:
29966099
13.

Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β.

Hsiao HM, Fernandez R, Tanaka S, Li W, Spahn JH, Chiu S, Akbarpour M, Ruiz-Perez D, Wu Q, Turam C, Scozzi D, Takahashi T, Luehmann HP, Puri V, Budinger GRS, Krupnick AS, Misharin AV, Lavine KJ, Liu Y, Gelman AE, Bharat A, Kreisel D.

J Clin Invest. 2018 Jul 2;128(7):2833-2847. doi: 10.1172/JCI98436. Epub 2018 May 21.

14.

Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.

Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM.

J Immunol. 2018 Apr 1;200(7):2391-2404. doi: 10.4049/jimmunol.1701543. Epub 2018 Feb 14.

15.

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis.

Mandelin AM 2nd, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges SL Jr, Bathon JM, Atkinson JP, Fox DA, Matteson EL, Buckley CD, Pitzalis C, Parks D, Hughes LB, Geraldino-Pardilla L, Ike R, Phillips K, Wright K, Filer A, Kelly S, Ruderman EM, Morgan V, Abdala-Valencia H, Misharin AV, Budinger GS, Bartom ET, Pope RM, Perlman H, Winter DR.

Arthritis Rheumatol. 2018 Jun;70(6):841-854. doi: 10.1002/art.40453. Epub 2018 May 3.

16.

Alveolar Macrophages.

Joshi N, Walter JM, Misharin AV.

Cell Immunol. 2018 Aug;330:86-90. doi: 10.1016/j.cellimm.2018.01.005. Epub 2018 Jan 20. Review.

PMID:
29370889
17.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.

18.

Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H.

J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7.

19.

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.

20.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

21.

Lung Interstitial Macrophages: Establishing Identity and Uncovering Heterogeneity.

Koch CM, Chiu SF, Misharin AV, Ridge KM.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):7-9. doi: 10.1165/rcmb.2017-0150ED. No abstract available.

PMID:
28665216
22.

Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction.

Zheng Z, Chiu S, Akbarpour M, Sun H, Reyfman PA, Anekalla KR, Abdala-Valencia H, Edgren D, Li W, Kreisel D, Korobova FV, Fernandez R, McQuattie-Pimentel A, Zhang ZJ, Perlman H, Misharin AV, Scott Budinger GR, Bharat A.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaal4508. doi: 10.1126/scitranslmed.aal4508.

23.

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C.

Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556.

24.

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.

Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, James CD, Shilatifard A.

Nat Med. 2017 Apr;23(4):493-500. doi: 10.1038/nm.4296. Epub 2017 Feb 27.

25.

Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.

Sennello JA, Misharin AV, Flozak AS, Berdnikovs S, Cheresh P, Varga J, Kamp DW, Budinger GR, Gottardi CJ, Lam AP.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):191-201. doi: 10.1165/rcmb.2016-0147OC.

26.

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model.

Archer AM, Saber R, Rose S, Shaffer A, Misharin AV, Tsai F, Haines Iii GK, Dominguez S, Eren M, Vaughan DE, Cuda CM, Perlman H.

J Transl Med. 2016 Jun 10;14(1):170. doi: 10.1186/s12967-016-0912-y.

27.

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H.

Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z.

28.

Phenotypic plasticity and targeting of Siglec-F(high) CD11c(low) eosinophils to the airway in a murine model of asthma.

Abdala Valencia H, Loffredo LF, Misharin AV, Berdnikovs S.

Allergy. 2016 Feb;71(2):267-71. doi: 10.1111/all.12776. Epub 2015 Oct 20.

PMID:
26414117
29.

Modeling human influenza infection in the laboratory.

Radigan KA, Misharin AV, Chi M, Budinger GS.

Infect Drug Resist. 2015 Aug 31;8:311-20. eCollection 2015. Review.

30.

The heterogeneity of lung macrophages in the susceptibility to disease.

Morales-Nebreda L, Misharin AV, Perlman H, Budinger GR.

Eur Respir Rev. 2015 Sep;24(137):505-9. doi: 10.1183/16000617.0031-2015. Review.

31.

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.

32.

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice.

Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GR, Misharin AV.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):147-9. doi: 10.1165/rcmb.2015-0147LE. No abstract available.

33.

Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.

Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK 3rd, Berdnikovs S, Filer A, Clark AR, Buckley CD, Mutlu GM, Budinger GR, Perlman H.

Cell Rep. 2014 Oct 23;9(2):591-604. doi: 10.1016/j.celrep.2014.09.032. Epub 2014 Oct 16.

34.

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM.

PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014.

35.

Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC.

36.

β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.

Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM.

J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27.

37.

Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H.

J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7.

38.

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.

Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.

39.

Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung.

Misharin AV, Morales-Nebreda L, Mutlu GM, Budinger GR, Perlman H.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):503-10. doi: 10.1165/rcmb.2013-0086MA.

40.

Development of a new humanized mouse model to study acute inflammatory arthritis.

Misharin AV, Haines GK 3rd, Rose S, Gierut AK, Hotchkiss RS, Perlman H.

J Transl Med. 2012 Sep 13;10:190. doi: 10.1186/1479-5876-10-190.

41.

Eosinophil contamination of thioglycollate-elicited peritoneal macrophage cultures skews the functional readouts of in vitro assays.

Misharin AV, Saber R, Perlman H.

J Leukoc Biol. 2012 Aug;92(2):325-31. doi: 10.1189/jlb.1111560. Epub 2012 Jun 15.

42.

The effect of rosuvastatin in a murine model of influenza A infection.

Radigan KA, Urich D, Misharin AV, Chiarella SE, Soberanes S, Gonzalez A, Perlman H, Wunderink RG, Budinger GR, Mutlu GM.

PLoS One. 2012;7(4):e35788. doi: 10.1371/journal.pone.0035788. Epub 2012 Apr 20.

43.

Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice.

Cuda CM, Agrawal H, Misharin AV, Haines GK 3rd, Hutcheson J, Weber E, Schoenfeldt JA, Mohan C, Pope RM, Perlman H.

Arthritis Rheum. 2012 Mar;64(3):808-20. doi: 10.1002/art.34317.

44.

Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis.

Mavers M, Cuda CM, Misharin AV, Gierut AK, Agrawal H, Weber E, Novack DV, Haines GK 3rd, Balomenos D, Perlman H.

Arthritis Rheum. 2012 Jan;64(1):141-52. doi: 10.1002/art.33311.

45.

The lung macrophage: a Jack of all trades.

Misharin AV, Scott Budinger GR, Perlman H.

Am J Respir Crit Care Med. 2011 Sep 1;184(5):497-8. doi: 10.1164/rccm.201107-1343ED. No abstract available.

46.

Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.

Urich D, Eisenberg JL, Hamill KJ, Takawira D, Chiarella SE, Soberanes S, Gonzalez A, Koentgen F, Manghi T, Hopkinson SB, Misharin AV, Perlman H, Mutlu GM, Budinger GR, Jones JC.

J Cell Sci. 2011 Sep 1;124(Pt 17):2927-37. doi: 10.1242/jcs.080911.

47.

Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis.

Lagishetty V, Misharin AV, Liu NQ, Lisse TS, Chun RF, Ouyang Y, McLachlan SM, Adams JS, Hewison M.

Endocrinology. 2010 Jun;151(6):2423-32. doi: 10.1210/en.2010-0089. Epub 2010 Apr 14.

48.

Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies.

Misharin AV, Nagayama Y, Aliesky HA, Mizutori Y, Rapoport B, McLachlan SM.

Endocrinology. 2009 Aug;150(8):3944-52. doi: 10.1210/en.2009-0181. Epub 2009 Apr 23.

49.

Thyroid antigens, not central tolerance, control responses to immunization in BALB/c versus C57BL/6 mice.

Misharin AV, Rapoport B, McLachlan SM.

Thyroid. 2009 May;19(5):503-9. doi: 10.1089/thy.2008.0420.

50.

Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.

Misharin AV, Nagayama Y, Aliesky HA, Rapoport B, McLachlan SM.

Endocrinology. 2009 Jun;150(6):2948-56. doi: 10.1210/en.2008-1690. Epub 2009 Mar 5.

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