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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.

Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T.

Nat Neurosci. 2019 Oct;22(10):1731-1742. doi: 10.1038/s41593-019-0479-z. Epub 2019 Sep 9.


Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters.

Sigmund F, Pettinger S, Kube M, Schneider F, Schifferer M, Schneider S, Efremova MV, Pujol-Martí J, Aichler M, Walch A, Misgeld T, Dietz H, Westmeyer GG.

ACS Nano. 2019 Jul 23;13(7):8114-8123. doi: 10.1021/acsnano.9b03140. Epub 2019 Jun 13.


Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.

Schneider A, Kurz S, Manske K, Janas M, Heikenwälder M, Misgeld T, Aichler M, Weissmann SF, Zischka H, Knolle P, Wohlleber D.

Sci Rep. 2019 Jun 11;9(1):8492. doi: 10.1038/s41598-019-44922-9.


Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo.

Wehnekamp F, Plucińska G, Thong R, Misgeld T, Lamb DC.

Elife. 2019 Jun 10;8. pii: e46059. doi: 10.7554/eLife.46059.


Imaging the execution phase of neuroinflammatory disease models.

Schumacher AM, Misgeld T, Kerschensteiner M, Snaidero N.

Exp Neurol. 2019 Oct;320:112968. doi: 10.1016/j.expneurol.2019.112968. Epub 2019 May 29. Review.


Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.

Witte ME, Schumacher AM, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M.

Neuron. 2019 Feb 20;101(4):615-624.e5. doi: 10.1016/j.neuron.2018.12.023. Epub 2019 Jan 24.


Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization.

Kiss A, Fischer I, Kleele T, Misgeld T, Propst F.

Front Cell Neurosci. 2018 Jul 17;12:195. doi: 10.3389/fncel.2018.00195. eCollection 2018.


Non-cell-autonomous function of DR6 in Schwann cell proliferation.

Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF.

EMBO J. 2018 Apr 3;37(7). pii: e97390. doi: 10.15252/embj.201797390. Epub 2018 Feb 19.


In Vivo Imaging of CNS Injury and Disease.

Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B.

J Neurosci. 2017 Nov 8;37(45):10808-10816. doi: 10.1523/JNEUROSCI.1826-17.2017. Review.


Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture.

Misgeld T, Schwarz TL.

Neuron. 2017 Nov 1;96(3):651-666. doi: 10.1016/j.neuron.2017.09.055. Review.


TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C.

EMBO Rep. 2017 Jul;18(7):1186-1198. doi: 10.15252/embr.201743922. Epub 2017 May 8.


Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Mar 22;18(4):474. doi: 10.1038/ni0417-474b. No abstract available.


Uncoupling of neurogenesis and differentiation during retinal development.

Engerer P, Suzuki SC, Yoshimatsu T, Chapouton P, Obeng N, Odermatt B, Williams PR, Misgeld T, Godinho L.

EMBO J. 2017 May 2;36(9):1134-1146. doi: 10.15252/embj.201694230. Epub 2017 Mar 3.


Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T.

Nat Immunol. 2017 Jan;18(1):74-85. doi: 10.1038/ni.3632. Epub 2016 Nov 28. Erratum in: Nat Immunol. 2017 Mar 22;18(4):474.


Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model.

Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M.

Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275.


Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T.

Neuron. 2016 Nov 23;92(4):845-856. doi: 10.1016/j.neuron.2016.09.049. Epub 2016 Oct 20.


Super-resolution microscopy writ large.

Engerer P, Fecher C, Misgeld T.

Nat Biotechnol. 2016 Sep 8;34(9):928-30. doi: 10.1038/nbt.3669. No abstract available.


Imaging of neuronal mitochondria in situ.

Plucińska G, Misgeld T.

Curr Opin Neurobiol. 2016 Aug;39:152-63. doi: 10.1016/j.conb.2016.06.006. Epub 2016 Jul 22. Review.


Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish.

Bert B, Chmielewska J, Bergmann S, Busch M, Driever W, Finger-Baier K, Hößler J, Köhler A, Leich N, Misgeld T, Nöldner T, Reiher A, Schartl M, Seebach-Sproedt A, Thumberger T, Schönfelder G, Grune B.

EMBO J. 2016 Jun 1;35(11):1151-4. doi: 10.15252/embj.201694448. Epub 2016 Apr 22. No abstract available.


Mouse redox histology using genetically encoded probes.

Fujikawa Y, Roma LP, Sobotta MC, Rose AJ, Diaz MB, Locatelli G, Breckwoldt MO, Misgeld T, Kerschensteiner M, Herzig S, Müller-Decker K, Dick TP.

Sci Signal. 2016 Mar 15;9(419):rs1. doi: 10.1126/scisignal.aad3895.


In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.

Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B.

Ann Neurol. 2016 May;79(5):794-805. doi: 10.1002/ana.24630. Epub 2016 Apr 18.


Generation and Screening of Transgenic Mice with Neuronal Labeling Controlled by Thy1 Regulatory Elements.

Marinković P, Godinho L, Misgeld T.

Cold Spring Harb Protoc. 2015 Oct 1;2015(10):875-82. doi: 10.1101/pdb.top087668.


Generation of Thy1 Constructs for Pronuclear Injection.

Marinković P, Godinho L, Misgeld T.

Cold Spring Harb Protoc. 2015 Oct 1;2015(10):937-40. doi: 10.1101/pdb.prot087676.


Imaging Acute Neuromuscular Explants from Thy1 Mouse Lines.

Marinković P, Godinho L, Misgeld T.

Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.prot087692. doi: 10.1101/pdb.prot087692.


Generation of Tissue Sections for Screening Thy1 Mouse Lines.

Marinković P, Godinho L, Misgeld T.

Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.prot087684. doi: 10.1101/pdb.prot087684.


αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features.

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K.

Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2(4):e107. doi: 10.1212/NXI.0000000000000107. eCollection 2015 Aug.


Redox imaging using genetically encoded redox indicators in zebrafish and mice.

Breckwoldt MO, Wittmann C, Misgeld T, Kerschensteiner M, Grabher C.

Biol Chem. 2015 May;396(5):511-22. doi: 10.1515/hsz-2014-0294. Review.


A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M, Misgeld T.

Nat Commun. 2014 Dec 16;5:5683. doi: 10.1038/ncomms6683.


Pervasive axonal transport deficits in multiple sclerosis models.

Sorbara CD, Wagner NE, Ladwig A, Nikić I, Merkler D, Kleele T, Marinković P, Naumann R, Godinho L, Bareyre FM, Bishop D, Misgeld T, Kerschensteiner M.

Neuron. 2014 Dec 17;84(6):1183-90. doi: 10.1016/j.neuron.2014.11.006. Epub 2014 Nov 26.


In vivo imaging of mitochondria in intact zebrafish larvae.

Paquet D, Plucińska G, Misgeld T.

Methods Enzymol. 2014;547:151-64. doi: 10.1016/B978-0-12-801415-8.00009-6.


The use of a laser for correlating light and electron microscopic images in thick tissue specimens.

Bishop D, Nikic I, Kerschensteiner M, Misgeld T.

Methods Cell Biol. 2014;124:323-37. doi: 10.1016/B978-0-12-801075-4.00015-X.


An assay to image neuronal microtubule dynamics in mice.

Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T.

Nat Commun. 2014 Sep 12;5:4827. doi: 10.1038/ncomms5827.


A unified cell biological perspective on axon-myelin injury.

Simons M, Misgeld T, Kerschensteiner M.

J Cell Biol. 2014 Aug 4;206(3):335-45. doi: 10.1083/jcb.201404154. Review.


STIM1 controls neuronal Ca²⁺ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior.

Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A.

Neuron. 2014 May 7;82(3):635-44. doi: 10.1016/j.neuron.2014.03.027.


CNS axons globally increase axonal transport after peripheral conditioning.

Mar FM, Simões AR, Leite S, Morgado MM, Santos TE, Rodrigo IS, Teixeira CA, Misgeld T, Sousa MM.

J Neurosci. 2014 Apr 23;34(17):5965-70. doi: 10.1523/JNEUROSCI.4680-13.2014.


Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.

Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T.

Nat Med. 2014 May;20(5):555-60. doi: 10.1038/nm.3520. Epub 2014 Apr 20.


Rapid adaptive optical recovery of optimal resolution over large volumes.

Wang K, Milkie DE, Saxena A, Engerer P, Misgeld T, Bronner ME, Mumm J, Betzig E.

Nat Methods. 2014 Jun;11(6):625-8. doi: 10.1038/nmeth.2925. Epub 2014 Apr 13.


Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.

Kreutzfeldt M, Bergthaler A, Fernandez M, Brück W, Steinbach K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD, Merkler D.

J Exp Med. 2013 Sep 23;210(10):2087-103. doi: 10.1084/jem.20122143. Epub 2013 Sep 2.


Between new genetic discoveries and large randomized trials--neurological research in the era of systems medicine.

Misgeld T, Lichtenthaler SF, Dichgans M.

EMBO Rep. 2013 Jun;14(6):489-92. doi: 10.1038/embor.2013.70. Epub 2013 May 14.


Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes.

Romanelli E, Sorbara CD, Nikić I, Dagkalis A, Misgeld T, Kerschensteiner M.

Nat Protoc. 2013 Mar;8(3):481-90. doi: 10.1038/nprot.2013.022. Epub 2013 Feb 7.


Sequential photo-bleaching to delineate single Schwann cells at the neuromuscular junction.

Brill MS, Marinković P, Misgeld T.

J Vis Exp. 2013 Jan 11;(71):e4460. doi: 10.3791/4460.


In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system.

Plucińska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T.

J Neurosci. 2012 Nov 14;32(46):16203-12. doi: 10.1523/JNEUROSCI.1327-12.2012.


In vivo imaging of the diseased nervous system: an update.

Sorbara C, Misgeld T, Kerschensteiner M.

Curr Pharm Des. 2012;18(29):4465-70. Review.


Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

Marinkovic P, Reuter MS, Brill MS, Godinho L, Kerschensteiner M, Misgeld T.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4296-301. doi: 10.1073/pnas.1200658109. Epub 2012 Feb 27.


Spatial constraints dictate glial territories at murine neuromuscular junctions.

Brill MS, Lichtman JW, Thompson W, Zuo Y, Misgeld T.

J Cell Biol. 2011 Oct 17;195(2):293-305. doi: 10.1083/jcb.201108005.


Near-infrared branding efficiently correlates light and electron microscopy.

Bishop D, Nikić I, Brinkoetter M, Knecht S, Potz S, Kerschensteiner M, Misgeld T.

Nat Methods. 2011 Jun 5;8(7):568-70. doi: 10.1038/nmeth.1622.


Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.

Gilley J, Seereeram A, Ando K, Mosely S, Andrews S, Kerschensteiner M, Misgeld T, Brion JP, Anderton B, Hanger DP, Coleman MP.

Neurobiol Aging. 2012 Mar;33(3):621.e1-621.e15. doi: 10.1016/j.neurobiolaging.2011.02.014. Epub 2011 Apr 13.


In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.

Bareyre FM, Garzorz N, Lang C, Misgeld T, Büning H, Kerschensteiner M.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6282-7. doi: 10.1073/pnas.1015239108. Epub 2011 Mar 29.


A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis.

Nikić I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeldt M, Bareyre FM, Brück W, Bishop D, Misgeld T, Kerschensteiner M.

Nat Med. 2011 Apr;17(4):495-9. doi: 10.1038/nm.2324. Epub 2011 Mar 27.


Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.

Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D.

J Biol Chem. 2010 Aug 27;285(35):27411-7. doi: 10.1074/jbc.M110.131243. Epub 2010 Jun 15.

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