Sort by
Items per page

Send to

Choose Destination

Search results

Items: 6


Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors.

Mirts EN, Bhagi-Damodaran A, Lu Y.

Acc Chem Res. 2019 Apr 16;52(4):935-944. doi: 10.1021/acs.accounts.9b00011. Epub 2019 Mar 26.


A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme.

Mirts EN, Petrik ID, Hosseinzadeh P, Nilges MJ, Lu Y.

Science. 2018 Sep 14;361(6407):1098-1101. doi: 10.1126/science.aat8474.


Heme redox potentials hold the key to reactivity differences between nitric oxide reductase and heme-copper oxidase.

Bhagi-Damodaran A, Reed JH, Zhu Q, Shi Y, Hosseinzadeh P, Sandoval BA, Harnden KA, Wang S, Sponholtz MR, Mirts EN, Dwaraknath S, Zhang Y, Moënne-Loccoz P, Lu Y.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6195-6200. doi: 10.1073/pnas.1720298115. Epub 2018 May 25.


Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism.

Reed JH, Shi Y, Zhu Q, Chakraborty S, Mirts EN, Petrik ID, Bhagi-Damodaran A, Ross M, Moënne-Loccoz P, Zhang Y, Lu Y.

J Am Chem Soc. 2017 Sep 6;139(35):12209-12218. doi: 10.1021/jacs.7b05800. Epub 2017 Aug 25.


Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases.

Bhagi-Damodaran A, Michael MA, Zhu Q, Reed J, Sandoval BA, Mirts EN, Chakraborty S, Moënne-Loccoz P, Zhang Y, Lu Y.

Nat Chem. 2017 Mar;9(3):257-263. doi: 10.1038/nchem.2643. Epub 2016 Nov 7.


Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions.

Hosseinzadeh P, Mirts EN, Pfister TD, Gao YG, Mayne C, Robinson H, Tajkhorshid E, Lu Y.

Biochemistry. 2016 Mar 15;55(10):1494-502. doi: 10.1021/acs.biochem.5b01299. Epub 2016 Mar 2.

Supplemental Content

Loading ...
Support Center