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ALG9 Mutation Carriers Develop Kidney and Liver Cysts.

Besse W, Chang AR, Luo JZ, Triffo WJ, Moore BS, Gulati A, Hartzel DN, Mane S; Regeneron Genetics Center, Torres VE, Somlo S, Mirshahi T.

J Am Soc Nephrol. 2019 Aug 8. pii: ASN.2019030298. doi: 10.1681/ASN.2019030298. [Epub ahead of print]


DiaRem2: Incorporating duration of diabetes to improve prediction of diabetes remission after metabolic surgery.

Still CD, Benotti P, Mirshahi T, Cook A, Wood GC.

Surg Obes Relat Dis. 2019 May;15(5):717-724. doi: 10.1016/j.soard.2018.12.020. Epub 2018 Dec 22.


Trajectory of exonic variant discovery in a large clinical population: implications for variant curation.

Mirshahi UL, Luo JZ, Manickam K, Wardeh AH, Mirshahi T, Murray MF, Carey DJ.

Genet Med. 2019 Jun;21(6):1417-1424. doi: 10.1038/s41436-018-0353-5. Epub 2018 Nov 19.


Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis.

Lee LYW, Woolley C, Starkey T, Biswas S, Mirshahi T, Bardella C, Segditsas S, Irshad S, Tomlinson I.

Clin Cancer Res. 2019 Jan 15;25(2):629-640. doi: 10.1158/1078-0432.CCR-18-1033. Epub 2018 Oct 15.


Whole-Exome Sequencing in Adults With Chronic Kidney Disease.

Chang AR, Luo JZ, Ho K, Mirshahi T, Murray MF.

Ann Intern Med. 2018 Jul 17;169(2):131-132. doi: 10.7326/L18-0206. No abstract available.


Genetic variants help define the role of the MC4R C-terminus in signaling and cell surface stability.

Moore BS, Mirshahi T.

Sci Rep. 2018 Jul 10;8(1):10397. doi: 10.1038/s41598-018-28758-3.


Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, Scott RA, Lee WJ, Small A, Kwee LC, Dwivedi OP, Prasad RB, Bruse S, Lopez AE, Penn J, Marcketta A, Leader JB, Still CD, Kirchner HL, Mirshahi UL, Wardeh AH, Hartle CM, Habegger L, Fetterolf SN, Tusie-Luna T, Morris AP, Holm H, Steinthorsdottir V, Sulem P, Thorsteinsdottir U, Rotter JI, Chuang LM, Damrauer S, Birtwell D, Brummett CM, Khera AV, Natarajan P, Orho-Melander M, Flannick J, Lotta LA, Willer CJ, Holmen OL, Ritchie MD, Ledbetter DH, Murphy AJ, Borecki IB, Reid JG, Overton JD, Hansson O, Groop L, Shah SH, Kraus WE, Rader DJ, Chen YI, Hveem K, Wareham NJ, Kathiresan S, Melander O, Stefansson K, Nordestgaard BG, Tybjærg-Hansen A, Abecasis GR, Altshuler D, Florez JC, Boehnke M, McCarthy MI, Yancopoulos GD, Carey DJ, Shuldiner AR, Baras A, Dewey FE, Gromada J.

Nat Commun. 2018 Jun 13;9(1):2252. doi: 10.1038/s41467-018-04611-z.


Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2.

Hall AR, Anderson CL, Smith JL, Mirshahi T, Elayi CS, January CT, Delisle BP.

Front Physiol. 2018 May 23;9:584. doi: 10.3389/fphys.2018.00584. eCollection 2018.


Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel.

Smith JL, Tester DJ, Hall AR, Burgess DE, Hsu CC, Elayi SC, Anderson CL, January CT, Luo JZ, Hartzel DN, Mirshahi UL, Murray MF, Mirshahi T, Ackerman MJ, Delisle BP.

Circ Arrhythm Electrophysiol. 2018 May;11(5):e005859. doi: 10.1161/CIRCEP.117.005859.


CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading.

Chu X, Jin Q, Chen H, Wood GC, Petrick A, Strodel W, Gabrielsen J, Benotti P, Mirshahi T, Carey DJ, Still CD, DiStefano JK, Gerhard GS.

J Transl Med. 2018 Apr 24;16(1):108. doi: 10.1186/s12967-018-1490-y.


A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

Abul-Husn NS, Cheng X, Li AH, Xin Y, Schurmann C, Stevis P, Liu Y, Kozlitina J, Stender S, Wood GC, Stepanchick AN, Still MD, McCarthy S, O'Dushlaine C, Packer JS, Balasubramanian S, Gosalia N, Esopi D, Kim SY, Mukherjee S, Lopez AE, Fuller ED, Penn J, Chu X, Luo JZ, Mirshahi UL, Carey DJ, Still CD, Feldman MD, Small A, Damrauer SM, Rader DJ, Zambrowicz B, Olson W, Murphy AJ, Borecki IB, Shuldiner AR, Reid JG, Overton JD, Yancopoulos GD, Hobbs HH, Cohen JC, Gottesman O, Teslovich TM, Baras A, Mirshahi T, Gromada J, Dewey FE.

N Engl J Med. 2018 Mar 22;378(12):1096-1106. doi: 10.1056/NEJMoa1712191.


Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits.

Badheka D, Yudin Y, Borbiro I, Hartle CM, Yazici A, Mirshahi T, Rohacs T.

Elife. 2017 Aug 15;6. pii: e26147. doi: 10.7554/eLife.26147.


All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes.

Lent MR, Benotti PN, Mirshahi T, Gerhard GS, Strodel WE, Petrick AT, Gabrielsen JD, Rolston DD, Still CD, Hirsch AG, Zubair F, Cook A, Carey DJ, Wood GC.

Diabetes Care. 2017 Oct;40(10):1379-1385. doi: 10.2337/dc17-0519. Epub 2017 Jul 31.


Performance of the DiaRem Score for Predicting Diabetes Remission in Two Health Systems Following Bariatric Surgery Procedures in Hispanic and non-Hispanic White Patients.

Craig Wood G, Horwitz D, Still CD, Mirshahi T, Benotti P, Parikh M, Hirsch AG.

Obes Surg. 2018 Jan;28(1):61-68. doi: 10.1007/s11695-017-2799-y.


Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long-Term Risks of Congestive Heart Failure.

Benotti PN, Wood GC, Carey DJ, Mehra VC, Mirshahi T, Lent MR, Petrick AT, Still C, Gerhard GS, Hirsch AG.

J Am Heart Assoc. 2017 May 23;6(5). pii: e005126. doi: 10.1161/JAHA.116.005126.


A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains.

Wood GC, Chu X, Argyropoulos G, Benotti P, Rolston D, Mirshahi T, Petrick A, Gabrielson J, Carey DJ, DiStefano JK, Still CD, Gerhard GS.

Sci Rep. 2017 Mar 7;7:43238. doi: 10.1038/srep43238.


Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics.

Moore BS, Stepanchick AN, Tewson PH, Hartle CM, Zhang J, Quinn AM, Hughes TE, Mirshahi T.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13069-13074. Epub 2016 Oct 31.


Evaluation of the Association Between Preoperative Clinical Factors and Long-term Weight Loss After Roux-en-Y Gastric Bypass.

Wood GC, Benotti PN, Lee CJ, Mirshahi T, Still CD, Gerhard GS, Lent MR.

JAMA Surg. 2016 Nov 1;151(11):1056-1062. doi: 10.1001/jamasurg.2016.2334.


The impact of bariatric surgery on inflammation: quenching the fire of obesity?

Hafida S, Mirshahi T, Nikolajczyk BS.

Curr Opin Endocrinol Diabetes Obes. 2016 Oct;23(5):373-8. doi: 10.1097/MED.0000000000000277. Review.


Association of DiaRem Score With Cure of Type 2 Diabetes Following Bariatric Surgery.

Wood GC, Mirshahi T, Still CD, Hirsch AG.

JAMA Surg. 2016 Aug 1;151(8):779-81. doi: 10.1001/jamasurg.2016.0251. No abstract available.


T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.

Emechebe U, Kumar P P, Rozenberg JM, Moore B, Firment A, Mirshahi T, Moon AM.

Elife. 2016 Apr 5;5. pii: e07897. doi: 10.7554/eLife.07897.


Comment on: Comparative physiogenomic analyses of weight loss in response to two modes of bariatric surgery: demonstration with candidate neuropsychiatric and cardiometabolic genes.

Mirshahi T, Benotti PN.

Surg Obes Relat Dis. 2016 Feb;12(2):377-8. doi: 10.1016/j.soard.2015.10.083. Epub 2015 Oct 31. No abstract available.


The metabolic syndrome and DYRK1B.

Mirshahi T, Murray MF, Carey DJ.

N Engl J Med. 2014 Aug 21;371(8):784-5. doi: 10.1056/NEJMc1408235. No abstract available.


Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.

Moore BS, Mirshahi UL, Yost EA, Stepanchick AN, Bedrin MD, Styer AM, Jackson KK, Still CD, Breitwieser GE, Gerhard GS, Carey DJ, Mirshahi T.

PLoS One. 2014 Apr 4;9(4):e93629. doi: 10.1371/journal.pone.0093629. eCollection 2014.


Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery.

Still CD, Wood GC, Chu X, Manney C, Strodel W, Petrick A, Gabrielsen J, Mirshahi T, Argyropoulos G, Seiler J, Yung M, Benotti P, Gerhard GS.

Obesity (Silver Spring). 2014 Mar;22(3):888-94. doi: 10.1002/oby.20529. Epub 2014 Feb 6.


A conserved mechanism for gating in an ionotropic glutamate receptor.

Moore BS, Mirshahi UL, Ebersole TL, Mirshahi T.

J Biol Chem. 2013 Jun 28;288(26):18842-52. doi: 10.1074/jbc.M113.465187. Epub 2013 May 13.


Weight-independent effects of roux-en-Y gastric bypass on glucose homeostasis via melanocortin-4 receptors in mice and humans.

Zechner JF, Mirshahi UL, Satapati S, Berglund ED, Rossi J, Scott MM, Still CD, Gerhard GS, Burgess SC, Mirshahi T, Aguirre V.

Gastroenterology. 2013 Mar;144(3):580-590.e7. doi: 10.1053/j.gastro.2012.11.022. Epub 2012 Nov 15.


Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice.

Schwindinger WF, Mirshahi UL, Baylor KA, Sheridan KM, Stauffer AM, Usefof S, Stecker MM, Mirshahi T, Robishaw JD.

J Biol Chem. 2012 Mar 2;287(10):7121-33. doi: 10.1074/jbc.M111.308395. Epub 2011 Dec 29.


The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery.

Mirshahi UL, Still CD, Masker KK, Gerhard GS, Carey DJ, Mirshahi T.

J Clin Endocrinol Metab. 2011 Dec;96(12):E2088-96. doi: 10.1210/jc.2011-1549. Epub 2011 Oct 5.


High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery.

Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T, Carey DJ, Gerhard GS.

Obesity (Silver Spring). 2011 Aug;19(8):1676-83. doi: 10.1038/oby.2011.3. Epub 2011 Feb 10.


G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels.

Styer AM, Mirshahi UL, Wang C, Girard L, Jin T, Logothetis DE, Mirshahi T.

J Biol Chem. 2010 Dec 31;285(53):41290-9. doi: 10.1074/jbc.M110.178541. Epub 2010 Nov 2.


Generation of a novel high-affinity monoclonal antibody with conformational recognition epitope on human IgM.

Sarikhani S, Mirshahi M, Gharaati MR, Mirshahi T.

Appl Biochem Biotechnol. 2010 Nov;162(5):1249-57. doi: 10.1007/s12010-009-8873-8. Epub 2010 Feb 18.


The orphan G protein-coupled receptor 161 is required for left-right patterning.

Leung T, Humbert JE, Stauffer AM, Giger KE, Chen H, Tsai HJ, Wang C, Mirshahi T, Robishaw JD.

Dev Biol. 2008 Nov 1;323(1):31-40. doi: 10.1016/j.ydbio.2008.08.001. Epub 2008 Aug 7.


Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels.

Wheeler A, Wang C, Yang K, Fang K, Davis K, Styer AM, Mirshahi U, Moreau C, Revilloud J, Vivaudou M, Liu S, Mirshahi T, Chan KW.

Mol Pharmacol. 2008 Nov;74(5):1333-44. doi: 10.1124/mol.108.048355. Epub 2008 Aug 22.


Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions.

Wang C, Mirshahi UL, Liu B, Jia Z, Mirshahi T, Zhang H.

Mol Pharmacol. 2008 Apr;73(4):1185-94. doi: 10.1124/mol.107.043067. Epub 2008 Jan 17.


Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits.

Rusinova R, Mirshahi T, Logothetis DE.

J Biol Chem. 2007 Nov 23;282(47):34019-30. Epub 2007 Sep 14.


Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin.

Michailidis IE, Helton TD, Petrou VI, Mirshahi T, Ehlers MD, Logothetis DE.

J Neurosci. 2007 May 16;27(20):5523-32.


A novel monoclonal antibody with catalytic activity against beta human chorionic gonadotropin.

Mirshahi M, Shamsipour F, Mirshahi T, Khajeh K, Naderi-Manesh H.

Immunol Lett. 2006 Jul 15;106(1):57-62. Epub 2006 May 15.


Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation.

Mirshahi T, Logothetis DE, Rosenhouse-Dantsker A.

Biophys J. 2006 Apr 15;90(8):2776-85. Epub 2006 Jan 20.


Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.

Du X, Zhang H, Lopes C, Mirshahi T, Rohacs T, Logothetis DE.

J Biol Chem. 2004 Sep 3;279(36):37271-81. Epub 2004 May 20.


Aldosterone signaling modifies capillary formation by human bone marrow endothelial cells.

Chen W, Valamanesh F, Mirshahi T, Soria J, Tang R, Agarwal MK, Mirshahi M.

Vascul Pharmacol. 2004 Jan;40(6):269-77.


GIRK channel trafficking: different paths for different family members.

Mirshahi T, Logothetis DE.

Mol Interv. 2002 Sep;2(5):289-91. No abstract available.


Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.

Peng L, Mirshahi T, Zhang H, Hirsch JP, Logothetis DE.

J Biol Chem. 2003 Dec 12;278(50):50203-11. Epub 2003 Sep 15.


G beta gamma and KACh: old story, new insights.

Mirshahi T, Jin T, Logothetis DE.

Sci STKE. 2003 Aug 5;2003(194):PE32. Review.


Adaptive immune responses of legumin nanoparticles.

Mirshahi T, Irache JM, Nicolas C, Mirshahi M, Faure JP, Gueguen J, Hecquet C, Orecchioni AM.

J Drug Target. 2002 Dec;10(8):625-31.


PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.

Zhang H, Craciun LC, Mirshahi T, Rohács T, Lopes CM, Jin T, Logothetis DE.

Neuron. 2003 Mar 27;37(6):963-75.


The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.

Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE.

Mol Cell. 2002 Sep;10(3):469-81.


Distinct sites on G protein beta gamma subunits regulate different effector functions.

Mirshahi T, Mittal V, Zhang H, Linder ME, Logothetis DE.

J Biol Chem. 2002 Sep 27;277(39):36345-50. Epub 2002 Jul 17.


Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins.

He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE.

J Biol Chem. 2002 Feb 22;277(8):6088-96. Epub 2001 Dec 7.

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