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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.

Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C.

Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9.


Comparative analysis of diagnostic platforms for measurement of differentially methylated insulin DNA.

Farr RJ, Wong WKM, Maynard CL, Tersey SA, Mirmira RG, Hardikar AA, Joglekar MV.

J Biol Methods. 2019;6(2). pii: e113. doi: 10.14440/jbm.2019.280. Epub 2019 Jun 3.


The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

Nakayasu ES, Qian WJ, Evans-Molina C, Mirmira RG, Eizirik DL, Metz TO.

Expert Rev Proteomics. 2019 Jul;16(7):569-582. doi: 10.1080/14789450.2019.1634548. Epub 2019 Jun 24.


A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo.

Reissaus CA, Piñeros AR, Twigg AN, Orr KS, Conteh AM, Martinez MM, Kamocka MM, Day RN, Tersey SA, Mirmira RG, Dunn KW, Linnemann AK.

Sci Rep. 2019 Jun 11;9(1):8449. doi: 10.1038/s41598-019-44777-0.


Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C.

Diabetes Care. 2019 May;42(5):e85-e86. doi: 10.2337/dci19-0012. No abstract available.


Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.

Conteh AM, Reissaus CA, Hernandez-Perez M, Nakshatri S, Anderson RM, Mirmira RG, Tersey SA, Linnemann AK.

J Biol Chem. 2019 Apr 19;294(16):6612-6620. doi: 10.1074/jbc.RA118.007102. Epub 2019 Feb 21.


eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes.

Imam S, Prathibha R, Dar P, Almotah K, Al-Khudhair A, Hasan SA, Salim N, Jilani TN, Mirmira RG, Jaume JC.

Sci Rep. 2019 Feb 7;9(1):1533. doi: 10.1038/s41598-018-38341-5.


Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.

Ganapathi M, Padgett LR, Yamada K, Devinsky O, Willaert R, Person R, Au PB, Tagoe J, McDonald M, Karlowicz D, Wolf B, Lee J, Shen Y, Okur V, Deng L, LeDuc CA, Wang J, Hanner A, Mirmira RG, Park MH, Mastracci TL, Chung WK.

Am J Hum Genet. 2019 Feb 7;104(2):287-298. doi: 10.1016/j.ajhg.2018.12.017. Epub 2019 Jan 17.


Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes.

Ocaña GJ, Sims EK, Watkins RA, Ragg S, Mather KJ, Oram RA, Mirmira RG, DiMeglio LA, Blum JS, Evans-Molina C.

PLoS One. 2019 Jan 10;14(1):e0208456. doi: 10.1371/journal.pone.0208456. eCollection 2019.


Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C; T1D Exchange Residual C-peptide Study Group.

Diabetes Care. 2019 Feb;42(2):258-264. doi: 10.2337/dc17-2625. Epub 2018 Dec 10.


Cellular metabolism constrains innate immune responses in early human ontogeny.

Kan B, Michalski C, Fu H, Au HHT, Lee K, Marchant EA, Cheng MF, Anderson-Baucum E, Aharoni-Simon M, Tilley P, Mirmira RG, Ross CJ, Luciani DS, Jan E, Lavoie PM.

Nat Commun. 2018 Nov 16;9(1):4822. doi: 10.1038/s41467-018-07215-9.


Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.

Dobrian AD, Morris MA, Taylor-Fishwick DA, Holman TR, Imai Y, Mirmira RG, Nadler JL.

Pharmacol Ther. 2019 Mar;195:100-110. doi: 10.1016/j.pharmthera.2018.10.010. Epub 2018 Oct 19. Review.


Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.

Roels S, Costa OR, Tersey SA, Stangé G, De Smet D, Balti EV, Gillard P, Keymeulen B, Ling Z, Pipeleers DG, Gorus FK, Mirmira RG, Martens GA.

J Clin Endocrinol Metab. 2019 Feb 1;104(2):451-460. doi: 10.1210/jc.2017-02520.


Biomarkers of islet beta cell stress and death in type 1 diabetes.

Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG.

Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15. Review.


Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes.

Neyman A, Nelson J, Tersey SA, Mirmira RG, Evans-Molina C, Sims EK.

Diabetes Obes Metab. 2019 Jan;21(1):95-102. doi: 10.1111/dom.13489. Epub 2018 Aug 24.


1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.

Kjalarsdottir L, Tersey SA, Vishwanath M, Chuang JC, Posner BA, Mirmira RG, Repa JJ.

J Steroid Biochem Mol Biol. 2019 Jan;185:17-26. doi: 10.1016/j.jsbmb.2018.07.004. Epub 2018 Jul 30.


In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo.

Stephens CH, Orr KS, Acton AJ, Tersey SA, Mirmira RG, Considine RV, Voytik-Harbin SL.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E650-E661. doi: 10.1152/ajpendo.00073.2018. Epub 2018 Jun 12.


Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice.

Tersey SA, Levasseur EM, Syed F, Farb TB, Orr KS, Nelson JB, Shaw JL, Bokvist K, Mather KJ, Mirmira RG.

FASEB J. 2018 May 29:fj201800150RR. doi: 10.1096/fj.201800150RR. [Epub ahead of print]


Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function.

Sims EK, Park G, Mather KJ, Mirmira RG, Liu Z, Gupta SK.

PLoS One. 2018 May 24;13(5):e0197080. doi: 10.1371/journal.pone.0197080. eCollection 2018.


An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic β-Cell Injury, Response, and Prevention.

Kulkarni AA, Conteh AM, Sorrell CA, Mirmira A, Tersey SA, Mirmira RG, Linnemann AK, Anderson RM.

Oxid Med Cell Longev. 2018 Mar 28;2018:1324739. doi: 10.1155/2018/1324739. eCollection 2018.


Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response.

Marasco MR, Conteh AM, Reissaus CA, Cupit JE 5th, Appleman EM, Mirmira RG, Linnemann AK.

Diabetes. 2018 Aug;67(8):1576-1588. doi: 10.2337/db17-1280. Epub 2018 May 21.


Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB.

Diabetes. 2018 Sep;67(9):1867-1879. doi: 10.2337/db18-0158. Epub 2018 Apr 30.


Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes.

Mastracci TL, Turatsinze JV, Book BK, Restrepo IA, Pugia MJ, Wiebke EA, Pescovitz MD, Eizirik DL, Mirmira RG.

Diabetes Obes Metab. 2018 Aug;20(8):1859-1867. doi: 10.1111/dom.13298. Epub 2018 Apr 16.


Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors.

Simons ZB, Morgan RC, Rose L, Nelson JB, Tersey SA, Mirmira RG.

J Endocr Soc. 2018 Jan 16;2(2):172-177. doi: 10.1210/js.2017-00409. eCollection 2018 Feb 1.


IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

Coomans de Brachène A, Dos Santos RS, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL.

Diabetologia. 2018 Mar;61(3):636-640. doi: 10.1007/s00125-017-4536-4. Epub 2018 Jan 5.


Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.

Mulukutla SN, Tersey SA, Hampe CS, Mirmira RG, Balasubramanyam A.

J Diabetes Complications. 2018 Feb;32(2):193-195. doi: 10.1016/j.jdiacomp.2017.10.013. Epub 2017 Oct 31.


A system for detecting high impact-low frequency mutations in primary tumors and metastases.

Anjanappa M, Hao Y, Simpson ER, Bhat-Nakshatri P, Nelson JB, Tersey SA, Mirmira RG, Cohen-Gadol AA, Saadatzadeh MR, Li L, Fang F, Nephew KP, Miller KD, Liu Y, Nakshatri H.

Oncogene. 2018 Jan 11;37(2):185-196. doi: 10.1038/onc.2017.322. Epub 2017 Sep 11.


Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.

Samala N, Tersey SA, Chalasani N, Anderson RM, Mirmira RG.

J Diabetes Complications. 2017 Nov;31(11):1630-1637. doi: 10.1016/j.jdiacomp.2017.07.014. Epub 2017 Jul 31. Review.


Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes.

Nyalwidhe JO, Grzesik WJ, Burch TC, Semeraro ML, Waseem T, Gerling IC, Mirmira RG, Morris MA, Nadler JL.

PLoS One. 2017 Sep 6;12(9):e0183908. doi: 10.1371/journal.pone.0183908. eCollection 2017.


Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.

Hernandez-Perez M, Chopra G, Fine J, Conteh AM, Anderson RM, Linnemann AK, Benjamin C, Nelson JB, Benninger KS, Nadler JL, Maloney DJ, Tersey SA, Mirmira RG.

Diabetes. 2017 Nov;66(11):2875-2887. doi: 10.2337/db17-0215. Epub 2017 Aug 25.


Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E.

Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014.


Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.

Hatanaka M, Anderson-Baucum E, Lakhter A, Kono T, Maier B, Tersey SA, Tanizawa Y, Evans-Molina C, Mirmira RG, Sims EK.

Sci Rep. 2017 Jun 19;7(1):3758. doi: 10.1038/s41598-017-03869-5.


12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets.

Ma K, Xiao A, Park SH, Glenn L, Jackson L, Barot T, Weaver JR, Taylor-Fishwick DA, Luci DK, Maloney DJ, Mirmira RG, Imai Y, Nadler JL.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2789-2797. doi: 10.1210/jc.2017-00267.


Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death.

Tersey SA, Nelson JB, Fisher MM, Mirmira RG.

J Vis Exp. 2016 Dec 21;(118). doi: 10.3791/54838.


The Morphogenesis of Cranial Sutures in Zebrafish.

Topczewska JM, Shoela RA, Tomaszewski JP, Mirmira RB, Gosain AK.

PLoS One. 2016 Nov 9;11(11):e0165775. doi: 10.1371/journal.pone.0165775. eCollection 2016.


Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Oct 10;6:34969. doi: 10.1038/srep34969. No abstract available.


Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.

Maganti AV, Tersey SA, Syed F, Nelson JB, Colvin SC, Maier B, Mirmira RG.

J Biol Chem. 2016 Oct 21;291(43):22524-22533. Epub 2016 Sep 9.


Biomarkers of β-Cell Stress and Death in Type 1 Diabetes.

Mirmira RG, Sims EK, Syed F, Evans-Molina C.

Curr Diab Rep. 2016 Oct;16(10):95. doi: 10.1007/s11892-016-0783-x. Review.


Elevations in the Fasting Serum Proinsulin-to-C-Peptide Ratio Precede the Onset of Type 1 Diabetes.

Sims EK, Chaudhry Z, Watkins R, Syed F, Blum J, Ouyang F, Perkins SM, Mirmira RG, Sosenko J, DiMeglio LA, Evans-Molina C.

Diabetes Care. 2016 Sep;39(9):1519-26. doi: 10.2337/dc15-2849. Epub 2016 Jul 6.


IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Jul 5;6:28177. doi: 10.1038/srep28177. Erratum in: Sci Rep. 2016 Oct 10;6:34969.


Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.

Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT.

Sci Rep. 2016 Jun 21;6:28159. doi: 10.1038/srep28159.


Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.

Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC.

Diabetologia. 2016 Jan;59(1):151-160. doi: 10.1007/s00125-015-3778-2.


Editorial: Lessons From the Classic Scientific Literature.

Mirmira RG.

Mol Endocrinol. 2015 Oct;29(10):1385-7. doi: 10.1210/me.2015-1231. No abstract available.


Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.

Watkins RA, Evans-Molina C, Terrell JK, Day KH, Guindon L, Restrepo IA, Mirmira RG, Blum JS, DiMeglio LA.

Transl Res. 2016 Feb;168:96-106.e1. doi: 10.1016/j.trsl.2015.08.010. Epub 2015 Sep 4.


Polyamine biosynthesis is critical for growth and differentiation of the pancreas.

Mastracci TL, Robertson MA, Mirmira RG, Anderson RM.

Sci Rep. 2015 Aug 24;5:13269. doi: 10.1038/srep13269.


Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.

Fisher MM, Watkins RA, Blum J, Evans-Molina C, Chalasani N, DiMeglio LA, Mather KJ, Tersey SA, Mirmira RG.

Diabetes. 2015 Nov;64(11):3867-72. doi: 10.2337/db15-0430. Epub 2015 Jul 27.


An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.

Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT.

Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Erratum in: Mol Endocrinol. 2016 Jul;30(7):826.


SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.

Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H.

J Biol Chem. 2015 Jul 3;290(27):16607-18. doi: 10.1074/jbc.M115.661777. Epub 2015 May 20.


Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.

Tersey SA, Bolanis E, Holman TR, Maloney DJ, Nadler JL, Mirmira RG.

Mol Endocrinol. 2015 Jun;29(6):791-800. doi: 10.1210/me.2015-1041. Epub 2015 Mar 24. Review.

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