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Items: 1 to 50 of 221

1.

Use of medical cannabis: perceptions of Israeli oncologists.

Mirelman D, Waissengrin B, Goldway N, Sharon H, Brill S, Wolf I.

Lancet Oncol. 2019 Apr;20(4):475-477. doi: 10.1016/S1470-2045(19)30077-4. No abstract available.

PMID:
30942172
2.

A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1.

Goldsmith M, Ashani Y, Margalit R, Nyska A, Mirelman D, Tawfik DS.

Chem Biol Interact. 2016 Nov 25;259(Pt B):242-251. doi: 10.1016/j.cbi.2016.05.034. Epub 2016 May 30.

PMID:
27256520
3.

A novel mechanism of neuroprotection: Blood glutamate grabber.

Castillo J, Loza MI, Mirelman D, Brea J, Blanco M, Sobrino T, Campos F.

J Cereb Blood Flow Metab. 2016 Feb;36(2):292-301. doi: 10.1177/0271678X15606721. Epub 2015 Oct 2. Review.

4.

Blood glutamate grabbing does not reduce the hematoma in an intracerebral hemorrhage model but it is a safe excitotoxic treatment modality.

da Silva-Candal A, Vieites-Prado A, Gutiérrez-Fernández M, Rey RI, Argibay B, Mirelman D, Sobrino T, Rodríguez-Frutos B, Castillo J, Campos F.

J Cereb Blood Flow Metab. 2015 Jul;35(7):1206-12. doi: 10.1038/jcbfm.2015.28. Epub 2015 Mar 4.

5.

MRS of brain metabolite levels demonstrates the ability of scavenging of excess brain glutamate to protect against nerve agent induced seizures.

Ruban A, Biton IE, Markovich A, Mirelman D.

Int J Mol Sci. 2015 Feb 2;16(2):3226-36. doi: 10.3390/ijms16023226.

6.

Entamoeba histolytica-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism.

Lee YA, Nam YH, Min A, Kim KA, Nozaki T, Saito-Nakano Y, Mirelman D, Shin MH.

Parasite. 2014;21:1. doi: 10.1051/parasite/2014001. Epub 2014 Feb 7.

7.

Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia.

Pérez-Mato M, Ramos-Cabrer P, Sobrino T, Blanco M, Ruban A, Mirelman D, Menendez P, Castillo J, Campos F.

Cell Death Dis. 2014 Jan 9;5:e992. doi: 10.1038/cddis.2013.507.

8.

Glutamate oxaloacetate transaminase: a new key in the dysregulation of glutamate in migraine patients.

Campos F, Sobrino T, Pérez-Mato M, Rodríguez-Osorio X, Leira R, Blanco M, Mirelman D, Castillo J.

Cephalalgia. 2013 Oct;33(14):1148-54. doi: 10.1177/0333102413487444. Epub 2013 May 14.

PMID:
23674828
9.

Nathan Sharon: 1925-2011.

Mirelman D, Bayer EA, Reisner Y.

Adv Carbohydr Chem Biochem. 2012;67:2-18. No abstract available.

PMID:
22973609
10.

Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma.

Appel E, Rabinkov A, Neeman M, Kohen F, Mirelman D.

J Drug Target. 2011 Jun;19(5):326-35. doi: 10.3109/1061186X.2010.504265. Epub 2010 Aug 3.

PMID:
20678009
11.

In memoriam: Louis S. "Buddy" Diamond (1920-2009).

Clark CG, Gillin FD, Bhattacharya A, Bhattacharya S, Mirelman D.

J Eukaryot Microbiol. 2010 Sep-Oct;57(5):449-51. doi: 10.1111/j.1550-7408.2010.00493.x. Epub 2010 Jul 15. No abstract available.

PMID:
20662997
12.

S-allyl-mercapto-captopril: a novel compound in the treatment of Cohen-Rosenthal diabetic hypertensive rats.

Younis F, Mirelman D, Rabinkov A, Rosenthal T.

J Clin Hypertens (Greenwich). 2010 Jun;12(6):451-5. doi: 10.1111/j.1751-7176.2010.00270.x.

13.

Downregulation of an Entamoeba histolytica rhomboid protease reveals roles in regulating parasite adhesion and phagocytosis.

Baxt LA, Rastew E, Bracha R, Mirelman D, Singh U.

Eukaryot Cell. 2010 Aug;9(8):1283-93. doi: 10.1128/EC.00015-10. Epub 2010 Jun 25.

14.

Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin.

Appel E, Vallon-Eberhard A, Rabinkov A, Brenner O, Shin I, Sasson K, Shadkchan Y, Osherov N, Jung S, Mirelman D.

Antimicrob Agents Chemother. 2010 Feb;54(2):898-906. doi: 10.1128/AAC.01267-09. Epub 2009 Nov 30.

15.

An ex-vivo human intestinal model to study Entamoeba histolytica pathogenesis.

Bansal D, Ave P, Kerneis S, Frileux P, Boché O, Baglin AC, Dubost G, Leguern AS, Prevost MC, Bracha R, Mirelman D, Guillén N, Labruyère E.

PLoS Negl Trop Dis. 2009 Nov 17;3(11):e551. doi: 10.1371/journal.pntd.0000551.

16.

Epigenetic transcriptional gene silencing in Entamoeba histolytica: insight into histone and chromatin modifications.

Huguenin M, Bracha R, Chookajorn T, Mirelman D.

Parasitology. 2010 Apr;137(4):619-27. doi: 10.1017/S0031182009991363. Epub 2009 Oct 23.

PMID:
19849886
17.

Thiol-disulfide organization in alliin lyase (alliinase) from garlic (Allium sativum).

Weiner L, Shin I, Shimon LJ, Miron T, Wilchek M, Mirelman D, Frolow F, Rabinkov A.

Protein Sci. 2009 Jan;18(1):196-205. doi: 10.1002/pro.10.

18.

Allicin up-regulates cellular glutathione level in vascular endothelial cells.

Horev-Azaria L, Eliav S, Izigov N, Pri-Chen S, Mirelman D, Miron T, Rabinkov A, Wilchek M, Jacob-Hirsch J, Amariglio N, Savion N.

Eur J Nutr. 2009 Mar;48(2):67-74. doi: 10.1007/s00394-008-0762-3. Epub 2008 Dec 1.

PMID:
19048328
19.

Entamoeba histolytica: effect on virulence, growth and gene expression in response to monoxenic culture with Escherichia coli 055.

Mendoza-Macías CL, Barrios-Ceballos MP, de la Peña LP, Rangel-Serrano A, Anaya-Velázquez F, Mirelman D, Padilla-Vaca F.

Exp Parasitol. 2009 Feb;121(2):167-74. doi: 10.1016/j.exppara.2008.10.011. Epub 2008 Nov 5.

PMID:
19014938
20.
21.

Epigenetic transcriptional gene silencing in Entamoeba histolytica.

Mirelman D, Anbar M, Bracha R.

IUBMB Life. 2008 Sep;60(9):598-604. doi: 10.1002/iub.96. Review.

22.

Novel derivatives of 6-mercaptopurine: synthesis, characterization and antiproliferative activities of S-allylthio-mercaptopurines.

Miron T, Arditti F, Konstantinovski L, Rabinkov A, Mirelman D, Berrebi A, Wilchek M.

Eur J Med Chem. 2009 Feb;44(2):541-50. doi: 10.1016/j.ejmech.2008.03.027. Epub 2008 Apr 4.

PMID:
18467007
23.

Transcriptional gene silencing reveals two distinct groups of Entamoeba histolytica Gal/GalNAc-lectin light subunits.

Bracha R, Nuchamowitz Y, Wender N, Mirelman D.

Eukaryot Cell. 2007 Oct;6(10):1758-65. Epub 2007 Aug 31.

24.

Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome.

Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ.

Am J Hypertens. 2007 Aug;20(8):866-74.

25.

EhLimA, a novel LIM protein, localizes to the plasma membrane in Entamoeba histolytica.

Wender N, Villalobo E, Mirelman D.

Eukaryot Cell. 2007 Sep;6(9):1646-55. Epub 2007 Jul 13.

26.

Allicin inhibits cell polarization, migration and division via its direct effect on microtubules.

Prager-Khoutorsky M, Goncharov I, Rabinkov A, Mirelman D, Geiger B, Bershadsky AD.

Cell Motil Cytoskeleton. 2007 May;64(5):321-37.

PMID:
17323373
27.

Two structures of alliinase from Alliium sativum L.: apo form and ternary complex with aminoacrylate reaction intermediate covalently bound to the PLP cofactor.

Shimon LJ, Rabinkov A, Shin I, Miron T, Mirelman D, Wilchek M, Frolow F.

J Mol Biol. 2007 Feb 16;366(2):611-25. Epub 2006 Nov 14.

PMID:
17174334
28.

Progress in research on Entamoeba histolytica pathogenesis.

Ackers JP, Mirelman D.

Curr Opin Microbiol. 2006 Aug;9(4):367-73. Epub 2006 Jul 7. Review.

PMID:
16824782
29.

Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica.

Tillack M, Nowak N, Lotter H, Bracha R, Mirelman D, Tannich E, Bruchhaus I.

Mol Biochem Parasitol. 2006 Sep;149(1):58-64. Epub 2006 May 19.

PMID:
16753229
30.

Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica.

Bracha R, Nuchamowitz Y, Anbar M, Mirelman D.

PLoS Pathog. 2006 May;2(5):e48. Epub 2006 May 26.

31.

Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica.

Weber C, Guigon G, Bouchier C, Frangeul L, Moreira S, Sismeiro O, Gouyette C, Mirelman D, Coppee JY, Guillén N.

Eukaryot Cell. 2006 May;5(5):871-5.

32.

Antimalarial activity of allicin, a biologically active compound from garlic cloves.

Coppi A, Cabinian M, Mirelman D, Sinnis P.

Antimicrob Agents Chemother. 2006 May;50(5):1731-7.

33.

The antiatherogenic effect of allicin: possible mode of action.

Gonen A, Harats D, Rabinkov A, Miron T, Mirelman D, Wilchek M, Weiner L, Ulman E, Levkovitz H, Ben-Shushan D, Shaish A.

Pathobiology. 2005;72(6):325-34.

PMID:
16582584
34.

Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation.

Moncada D, Keller K, Ankri S, Mirelman D, Chadee K.

Gastroenterology. 2006 Mar;130(3):721-30.

PMID:
16530514
35.

A method for continuous production of allicin using immobilized alliinase.

Miron T, SivaRaman H, Rabinkov A, Mirelman D, Wilchek M.

Anal Biochem. 2006 Apr 1;351(1):152-4. Epub 2006 Feb 9. No abstract available.

PMID:
16500603
36.

Epigenetic silencing of gene expression in Entamoeba histolytica.

Mirelman D, Anbar M, Nuchamowitz Y, Bracha R.

Arch Med Res. 2006 Feb;37(2):226-33. Review.

PMID:
16380323
37.

The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome.

Oron-Herman M, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA.

Atherosclerosis. 2005 Dec;183(2):238-43. Epub 2005 Apr 14.

PMID:
16285991
38.

Involvement of a short interspersed element in epigenetic transcriptional silencing of the amoebapore gene in Entamoeba histolytica.

Anbar M, Bracha R, Nuchamowitz Y, Li Y, Florentin A, Mirelman D.

Eukaryot Cell. 2005 Nov;4(11):1775-84.

39.

Entamoeba histolytica: identification and characterization of an N-ethylmaleimide sensitive fusion protein homologue.

Libros-Ziv P, Villalobo E, Mirelman D.

Exp Parasitol. 2005 Jul;110(3):276-9. Epub 2005 Apr 1.

PMID:
15955324
40.

A novel protease from Entamoeba histolytica homologous to members of the family S28 of serine proteases.

Barrios-Ceballos MP, Martínez-Gallardo NA, Anaya-Velázquez F, Mirelman D, Padilla-Vaca F.

Exp Parasitol. 2005 Jul;110(3):270-5. Epub 2005 Apr 1.

PMID:
15955323
41.

Report on the 2nd EMBO Workshop on "Pathogenesis of Amoebiasis: From Genomics to Disease" held at Ein Gedi, Israel, November 16-20, 2004.

Ackers J, Mirelman D.

Exp Parasitol. 2005 Jul;110(3):170-2. Epub 2005 Mar 21. No abstract available.

PMID:
15955307
42.

Entamoeba histolytica: molecular characterization of an aldose 1-epimerase (mutarotase).

Villalobo E, Wender N, Mirelman D.

Exp Parasitol. 2005 Jul;110(3):298-302.

PMID:
15869755
43.

Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate.

Arditti FD, Rabinkov A, Miron T, Reisner Y, Berrebi A, Wilchek M, Mirelman D.

Mol Cancer Ther. 2005 Feb;4(2):325-31.

44.

[3H]Allicin: preparation and applications.

Miron T, Bercovici T, Rabinkov A, Wilchek M, Mirelman D.

Anal Biochem. 2004 Aug 15;331(2):364-9.

PMID:
15265743
45.

Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression.

Sela U, Ganor S, Hecht I, Brill A, Miron T, Rabinkov A, Wilchek M, Mirelman D, Lider O, Hershkoviz R.

Immunology. 2004 Apr;111(4):391-9.

46.

Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis.

Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N.

J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24.

PMID:
15044429
48.

Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras.

Patya M, Zahalka MA, Vanichkin A, Rabinkov A, Miron T, Mirelman D, Wilchek M, Lander HM, Novogrodsky A.

Int Immunol. 2004 Feb;16(2):275-81.

PMID:
14734613
49.

Inhibition of tumor growth by a novel approach: in situ allicin generation using targeted alliinase delivery.

Miron T, Mironchik M, Mirelman D, Wilchek M, Rabinkov A.

Mol Cancer Ther. 2003 Dec;2(12):1295-301.

50.

Allylmercaptocaptopril: a new antihypertensive drug.

Miron T, Rabinkov A, Peleg E, Rosenthal T, Mirelman D, Wilchek M.

Am J Hypertens. 2004 Jan;17(1):71-3.

PMID:
14700516

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