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Items: 48

1.

Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.

Foti RS, Biswas K, Aral J, Be X, Berry L, Cheng Y, Conner K, Falsey JR, Glaus C, Herberich B, Hickman D, Ikotun T, Li H, Long J, Huang L, Miranda LP, Murray J, Moyer B, Netirojjanakul C, Nixey TE, Sham K, Soto M, Tegley CM, Tran L, Wu B, Yin L, Rock DA.

Drug Metab Dispos. 2019 Aug 6. pii: dmd.119.087742. doi: 10.1124/dmd.119.087742. [Epub ahead of print]

2.

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring.

Jorgolli M, Nevill T, Winters A, Chen I, Chong S, Lin FF, Mock M, Chen C, Le K, Tan C, Jess P, Xu H, Hamburger A, Stevens J, Munro T, Wu M, Tagari P, Miranda LP.

Biotechnol Bioeng. 2019 Sep;116(9):2393-2411. doi: 10.1002/bit.27024. Epub 2019 Jun 24. Review.

PMID:
31112285
3.

Engineering NaV1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.

Murray JK, Wu B, Tegley CM, Nixey TE, Falsey JR, Herberich B, Yin L, Sham K, Long J, Aral J, Cheng Y, Netirojjanakul C, Doherty L, Glaus C, Ikotun T, Li H, Tran L, Soto M, Salimi-Moosavi H, Ligutti J, Amagasu S, Andrews KL, Be X, Lin MJ, Foti RS, Ilch CP, Youngblood B, Kornecook TJ, Karow M, Walker KW, Moyer BD, Biswas K, Miranda LP.

ACS Chem Biol. 2019 Apr 19;14(4):806-818. doi: 10.1021/acschembio.9b00183. Epub 2019 Mar 27.

PMID:
30875193
4.

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.

Lawrence N, Wu B, Ligutti J, Cheneval O, Agwa AJ, Benfield AH, Biswas K, Craik DJ, Miranda LP, Henriques ST, Schroeder CI.

ACS Chem Biol. 2019 Jan 18;14(1):118-130. doi: 10.1021/acschembio.8b00989. Epub 2018 Dec 21.

PMID:
30507158
5.

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Wu B, Murray JK, Andrews KL, Sham K, Long J, Aral J, Ligutti J, Amagasu S, Liu D, Zou A, Min X, Wang Z, Ilch CP, Kornecook TJ, Lin MJ, Be X, Miranda LP, Moyer BD, Biswas K.

J Med Chem. 2018 Nov 8;61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. Epub 2018 Oct 22.

PMID:
30346167
6.

Structure-guided Discovery of Dual-recognition Chemibodies.

Cheng AC, Doherty EM, Johnstone S, DiMauro EF, Dao J, Luthra A, Ye J, Tang J, Nixey T, Min X, Tagari P, Miranda LP, Wang Z.

Sci Rep. 2018 May 15;8(1):7570. doi: 10.1038/s41598-018-25848-0.

7.

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.

Moyer BD, Murray JK, Ligutti J, Andrews K, Favreau P, Jordan JB, Lee JH, Liu D, Long J, Sham K, Shi L, Stöcklin R, Wu B, Yin R, Yu V, Zou A, Biswas K, Miranda LP.

PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018.

8.

1,3-Regiospecific ethanolysis of soybean oil catalyzed by crosslinked porcine pancreas lipase aggregates.

Ramos MD, Miranda LP, Giordano RLC, Fernandez-Lafuente R, Kopp W, Tardioli PW.

Biotechnol Prog. 2018 Jul;34(4):910-920. doi: 10.1002/btpr.2636. Epub 2018 May 7.

PMID:
29693317
9.

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction.

Ross SL, Biswas K, Rottman J, Allen JR, Long J, Miranda LP, Winters A, Arvedson TL.

Front Pharmacol. 2017 Nov 21;8:838. doi: 10.3389/fphar.2017.00838. eCollection 2017.

10.

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.

Biswas K, Nixey TE, Murray JK, Falsey JR, Yin L, Liu H, Gingras J, Hall BE, Herberich B, Holder JR, Li H, Ligutti J, Lin MJ, Liu D, Soriano BD, Soto M, Tran L, Tegley CM, Zou A, Gunasekaran K, Moyer BD, Doherty L, Miranda LP.

ACS Chem Biol. 2017 Sep 15;12(9):2427-2435. doi: 10.1021/acschembio.7b00542. Epub 2017 Aug 28.

PMID:
28800217
11.

Progress and challenges in the optimization of toxin peptides for development as pain therapeutics.

Netirojjanakul C, Miranda LP.

Curr Opin Chem Biol. 2017 Jun;38:70-79. doi: 10.1016/j.cbpa.2017.03.004. Epub 2017 Apr 1. Review.

PMID:
28376346
12.

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.

Murray JK, Long J, Zou A, Ligutti J, Andrews KL, Poppe L, Biswas K, Moyer BD, McDonough SI, Miranda LP.

J Med Chem. 2016 Mar 24;59(6):2704-17. doi: 10.1021/acs.jmedchem.5b01947. Epub 2016 Mar 10.

PMID:
26890998
13.

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.

Uppalapati M, Lee DJ, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riché D, Kent SB, Sidhu SS.

ACS Chem Biol. 2016 Apr 15;11(4):1058-65. doi: 10.1021/acschembio.5b01006. Epub 2016 Feb 3.

PMID:
26745345
14.

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.

Murray JK, Qian YX, Liu B, Elliott R, Aral J, Park C, Zhang X, Stenkilsson M, Salyers K, Rose M, Li H, Yu S, Andrews KL, Colombero A, Werner J, Gaida K, Sickmier EA, Miu P, Itano A, McGivern J, Gegg CV, Sullivan JK, Miranda LP.

J Med Chem. 2015 Sep 10;58(17):6784-802. doi: 10.1021/acs.jmedchem.5b00495. Epub 2015 Aug 31.

PMID:
26288216
15.

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

Murray JK, Biswas K, Holder JR, Zou A, Ligutti J, Liu D, Poppe L, Andrews KL, Lin FF, Meng SY, Moyer BD, McDonough SI, Miranda LP.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4866-4871. doi: 10.1016/j.bmcl.2015.06.033. Epub 2015 Jun 16.

PMID:
26112439
16.

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

Murray JK, Ligutti J, Liu D, Zou A, Poppe L, Li H, Andrews KL, Moyer BD, McDonough SI, Favreau P, Stöcklin R, Miranda LP.

J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.

PMID:
25658507
17.

Prevalence of rheumatic heart disease in a public school of Belo Horizonte.

Miranda LP, Camargos PA, Torres RM, Meira ZM.

Arq Bras Cardiol. 2014 Aug;103(2):89-97. English, Portuguese.

18.

Epitope discovery for a synthetic polymer nanoparticle: a new strategy for developing a peptide tag.

Yoshimatsu K, Yamazaki T, Hoshino Y, Rose PE, Epstein LF, Miranda LP, Tagari P, Beierle JM, Yonamine Y, Shea KJ.

J Am Chem Soc. 2014 Jan 29;136(4):1194-7. doi: 10.1021/ja410817p. Epub 2014 Jan 16.

19.

Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics.

Miranda LP, Shi L, Holder JR, Wright M, Gegg CV, Johnson E, Wild K, Stenkilsson M, Doellgast G, Manning BH, Salyers K.

Biopolymers. 2013 Jul;100(4):422-30. doi: 10.1002/bip.22270.

PMID:
23868210
20.

Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.

Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL.

Cell Metab. 2012 Jun 6;15(6):905-17. doi: 10.1016/j.cmet.2012.03.017.

21.

Utilization of tyrosine- and histidine-containing dipeptides to enhance productivity and culture viability.

Kang S, Mullen J, Miranda LP, Deshpande R.

Biotechnol Bioeng. 2012 Sep;109(9):2286-94. doi: 10.1002/bit.24507. Epub 2012 Apr 8.

PMID:
22447498
22.

Direct quantitative analysis of a 20 kDa PEGylated human calcitonin gene peptide antagonist in cynomolgus monkey serum using in-source CID and UPLC-MS/MS.

Li H, Rose MJ, Holder JR, Wright M, Miranda LP, James CA.

J Am Soc Mass Spectrom. 2011 Sep;22(9):1660-7. doi: 10.1007/s13361-011-0180-2. Epub 2011 Jun 23.

PMID:
21953269
23.

Solid-phase peptide synthesis using microwave irradiation.

Murray JK, Aral J, Miranda LP.

Methods Mol Biol. 2011;716:73-88. doi: 10.1007/978-1-61779-012-6_5.

PMID:
21318901
24.

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.

Murray JK, Balan C, Allgeier AM, Kasparian A, Viswanadhan V, Wilde C, Allen JR, Yoder SC, Biddlecome G, Hungate RW, Miranda LP.

J Comb Chem. 2010 Sep 13;12(5):676-86. doi: 10.1021/cc100073a.

PMID:
20666436
25.

Saliva as a source of HCMV DNA in allogeneic stem cell transplantation patients.

Correia-Silva JF, Bruna-Romero O, Resende RG, Miranda LP, Oliveira FE, Costa FO, Xavier SG, Figueiredo-Neves SP, Almeida HC, Bittencourt H, Gomez RS.

Oral Dis. 2010 Mar;16(2):210-6. doi: 10.1111/j.1601-0825.2009.01637.x.

PMID:
20374507
26.

Oxidative folding of hepcidin at acidic pH.

Zhang J, Diamond S, Arvedson T, Sasu BJ, Miranda LP.

Biopolymers. 2010;94(2):257-64. doi: 10.1002/bip.21383. Review.

PMID:
20225300
27.

Hepcidin revisited, disulfide connectivity, dynamics, and structure.

Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ.

J Biol Chem. 2009 Sep 4;284(36):24155-67. doi: 10.1074/jbc.M109.017764. Epub 2009 Jun 24.

28.

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS.

Li H, Rose MJ, Tran L, Zhang J, Miranda LP, James CA, Sasu BJ.

J Pharmacol Toxicol Methods. 2009 May-Jun;59(3):171-80. doi: 10.1016/j.vascn.2009.02.004. Epub 2009 Feb 28.

PMID:
19258043
29.

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K.

J Med Chem. 2008 Dec 25;51(24):7889-97. doi: 10.1021/jm8009298.

PMID:
19053766
30.

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S, Ma M, Li H, Rose MJ, Poppe L, Véniant MM.

J Med Chem. 2008 May 8;51(9):2758-65. doi: 10.1021/jm701522b. Epub 2008 Apr 15.

PMID:
18412318
31.

A chemical approach to the pharmaceutical optimization of an anti-HIV protein.

Miranda LP, Shao H, Williams J, Chen SY, Kong T, Garcia R, Chinn Y, Fraud N, O'Dwyer B, Ye J, Wilken J, Low DE, Cagle EN, Carnevali M, Lee A, Song D, Kung A, Bradburne JA, Paliard X, Kochendoerfer GG.

J Am Chem Soc. 2007 Oct 31;129(43):13153-9. Epub 2007 Oct 4.

PMID:
17915868
32.

Site-specific polymer attachment to a CCL-5 (RANTES) analogue by oxime exchange.

Shao H, Crnogorac MM, Kong T, Chen SY, Williams JM, Tack JM, Gueriguian V, Cagle EN, Carnevali M, Tumelty D, Paliard X, Miranda LP, Bradburne JA, Kochendoerfer GG.

J Am Chem Soc. 2005 Feb 9;127(5):1350-1.

PMID:
15686348
33.

Probing the S100 protein family through genomic and functional analysis.

Ravasi T, Hsu K, Goyette J, Schroder K, Yang Z, Rahimi F, Miranda LP, Alewood PF, Hume DA, Geczy C.

Genomics. 2004 Jul;84(1):10-22.

PMID:
15203200
34.

A new approach to the chemical synthesis of keto-proteins.

Tumelty D, Carnevali M, Miranda LP.

J Am Chem Soc. 2003 Nov 26;125(47):14238-9.

PMID:
14624547
35.

[Children and adolescents with developmental disabilities in the pediatrics ambulatory service].

Miranda LP, Resegue R, De Melo Figueiras AC.

J Pediatr (Rio J). 2003 May;79 Suppl 1:S33-42. Review. Portuguese.

36.

Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein.

Kochendoerfer GG, Chen SY, Mao F, Cressman S, Traviglia S, Shao H, Hunter CL, Low DW, Cagle EN, Carnevali M, Gueriguian V, Keogh PJ, Porter H, Stratton SM, Wiedeke MC, Wilken J, Tang J, Levy JJ, Miranda LP, Crnogorac MM, Kalbag S, Botti P, Schindler-Horvat J, Savatski L, Adamson JW, Kung A, Kent SB, Bradburne JA.

Science. 2003 Feb 7;299(5608):884-7.

37.

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis.

Miranda LP, Lubell WD, Halkes KM, Groth T, Grøtli M, Rademann J, Gotfredsen CH, Meldal M.

J Comb Chem. 2002 Sep-Oct;4(5):523-9.

PMID:
12217026
38.

Unichemo Protection: A Concept for Chemical Synthesis This work was supported by the Danish National Research Foundation.

Miranda LP, Meldal M.

Angew Chem Int Ed Engl. 2001 Oct 1;40(19):3655-3657. No abstract available.

PMID:
11592212
39.

Graphical Abstract.

Miranda LP, Meldal M.

Angew Chem Int Ed Engl. 2001 Oct 1;40(19):3489. No abstract available.

PMID:
11592179
40.

Solid-phase glycosylation of peptide templates and on-bead MAS-NMR analysis: perspectives for glycopeptide libraries.

Halkes KM, Gotfredsen CH, Grøtli M, Miranda LP, Duus JO, Meldal M.

Chemistry. 2001 Aug 17;7(16):3584-91.

PMID:
11560330
41.

Total chemical synthesis and chemotactic activity of human S100A12 (EN-RAGE).

Miranda LP, Tao T, Jones A, Chernushevich I, Standing KG, Geczy CL, Alewood PF.

FEBS Lett. 2001 Jan 12;488(1-2):85-90.

42.

Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-Based Resins in Silicon Oil: Beaded SPOCC 1500 and POEPOP 1500.

Grøtli M, Rademan J, Groth T, Lubell WD, Miranda LP, Meldal M.

J Comb Chem. 2001 Jan 8;3(1):28-33.

PMID:
11148061
43.

Challenges for protein chemical synthesis in the 21st century: bridging genomics and proteomics.

Miranda LP, Alewood PF.

Biopolymers. 2000;55(3):217-26. Review.

PMID:
11074416
44.

An activated O --> N acyl transfer auxiliary: efficient amide-backbone substitution of hindered "difficult" peptides.

Miranda LP, Meutermans WD, Smythe ML, Alewood PF.

J Org Chem. 2000 Sep 8;65(18):5460-8.

PMID:
10970282
45.

Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor.

Hogg RC, Miranda LP, Craik DJ, Lewis RJ, Alewood PF, Adams DJ.

J Biol Chem. 1999 Dec 17;274(51):36559-64.

46.

[Reliability of the information on the recent use of medication in a hospital based case-control study].

Coutinho ES, da Silva SD, Paiva CH, Freitas GG, Miranda LP, Mendonça R.

Cad Saude Publica. 1999 Jul-Sep;15(3):553-8. Portuguese.

PMID:
10502151
47.

Accelerated chemical synthesis of peptides and small proteins.

Miranda LP, Alewood PF.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1181-6.

48.

Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity.

Hill JM, Oomen CJ, Miranda LP, Bingham JP, Alewood PF, Craik DJ.

Biochemistry. 1998 Nov 10;37(45):15621-30.

PMID:
9843366

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