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Retreatment with anti-PD-1 antibody in non-small cell lung cancer patients previously treated with anti-PD-L1 antibody.

Fujita K, Yamamoto Y, Kanai O, Okamura M, Hashimoto M, Nakatani K, Sawai S, Mio T.

Thorac Cancer. 2019 Nov 7. doi: 10.1111/1759-7714.13241. [Epub ahead of print]


Case Report: Disseminated Mycobacterium kansasii Disease in a Patient with Anti-Interferon-Gamma Antibody.

Kashihara E, Fujita K, Uchida N, Yamamoto Y, Mio T, Koyama H.

Am J Trop Med Hyg. 2019 Nov;101(5):1066-1069. doi: 10.4269/ajtmh.19-0047.


YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification.

Hamanaka N, Nakanishi Y, Mizuno T, Horiguchi-Takei K, Akiyama N, Tanimura H, Hasegawa M, Satoh Y, Tachibana Y, Fujii T, Sakata K, Ogasawara K, Ebiike H, Koyano H, Sato H, Ishii N, Mio T.

Cancer Res. 2019 Nov 15;79(22):5734-5745. doi: 10.1158/0008-5472.CAN-18-3376. Epub 2019 Aug 7.


Retreatment With Anti-PD-L1 Antibody in Advanced Non-small Cell Lung Cancer Previously Treated With Anti-PD-1 Antibodies.

Fujita K, Uchida N, Yamamoto Y, Kanai O, Okamura M, Nakatani K, Sawai S, Mio T.

Anticancer Res. 2019 Jul;39(7):3917-3921. doi: 10.21873/anticanres.13543.


A case of pulmonary lymphoproliferative disorder presenting rapidly progressive respiratory failure.

Fujita K, Ishigami K, Tanaka H, Moriyoshi K, Mio T.

Respirol Case Rep. 2019 Apr 2;7(5):e00422. doi: 10.1002/rcr2.422. eCollection 2019 Jul.


Perspectives on End-of-Life Treatment among Patients with COPD: A Multicenter, Cross-sectional Study in Japan.

Fuseya Y, Muro S, Sato S, Sato A, Tanimura K, Hasegawa K, Uemasu K, Hamakawa Y, Takahashi Y, Nakayama T, Sakai N, Fukui M, Kita H, Mio T, Mishima M, Hirai T.

COPD. 2019 Feb;16(1):75-81. doi: 10.1080/15412555.2019.1573888. Epub 2019 Feb 21.


Synthesis, Structures, and Assembly of Geodesic Phenine Frameworks with Isoreticular Networks of [ n]Cyclo- para-phenylenes.

Sun Z, Mio T, Ikemoto K, Sato S, Isobe H.

J Org Chem. 2019 Mar 15;84(6):3500-3507. doi: 10.1021/acs.joc.9b00085. Epub 2019 Feb 21.


Emerging concerns of infectious diseases in lung cancer patients receiving immune checkpoint inhibitor therapy.

Fujita K, Kim YH, Kanai O, Yoshida H, Mio T, Hirai T.

Respir Med. 2019 Jan;146:66-70. doi: 10.1016/j.rmed.2018.11.021. Epub 2018 Dec 13.


Therapy-related acute myeloid leukemia after chemotherapy in extensive disease-small cell lung cancer.

Ueda N, Fujita K, Okuno Y, Nakatani K, Mio T.

Clin Case Rep. 2018 Nov 19;7(1):100-103. doi: 10.1002/ccr3.1931. eCollection 2019 Jan.


Osimertinib in Elderly Patients with Epidermal Growth Factor Receptor T790M-Positive Non-Small-Cell Lung Cancer Who Progressed During Prior Treatment: A Phase II Trial.

Nakao A, Hiranuma O, Uchino J, Sakaguchi C, Kita T, Hiraoka N, Ishizuka T, Kubota Y, Kawasaki M, Goto Y, Imai H, Hattori N, Nakatomi K, Uramoto H, Uryu K, Fukuda M, Uchida Y, Yokoyama T, Akai M, Mio T, Nagashima S, Chihara Y, Tamiya N, Kaneko Y, Mouri T, Yamada T, Yoshimura K, Fujita M, Takayama K.

Oncologist. 2019 May;24(5):593-e170. doi: 10.1634/theoncologist.2019-0003. Epub 2019 Jan 16.


Unbiased Rotational Motions of an Ellipsoidal Guest in a Tight Yet Pliable Host.

Sun Z, Mio T, Okada T, Matsuno T, Sato S, Kono H, Isobe H.

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):2040-2044. doi: 10.1002/anie.201812771. Epub 2019 Jan 15.


The clinical benefits of immune checkpoint inhibitor for thymic carcinomas ∼experience of single public hospital in Japan∼.

Uchida N, Fujita K, Okamura M, Nakatani K, Mio T.

Respir Med Case Rep. 2018 Nov 13;26:39-41. doi: 10.1016/j.rmcr.2018.11.007. eCollection 2019.


Septic pulmonary embolism complicated by pyogenic spondylitis and psoas abscesses in a patient with methicillin-sensitive Staphylococcus aureus bacteraemia.

Kashihara E, Fujita K, Koyama H, Mio T.

Oxf Med Case Reports. 2018 Nov 26;2018(12):omy108. doi: 10.1093/omcr/omy108. eCollection 2018 Dec.


Pseudoprogression in Previously Treated Patients with Non-Small Cell Lung Cancer Who Received Nivolumab Monotherapy.

Fujimoto D, Yoshioka H, Kataoka Y, Morimoto T, Hata T, Kim YH, Tomii K, Ishida T, Hirabayashi M, Hara S, Ishitoko M, Fukuda Y, Hwang MH, Sakai N, Fukui M, Nakaji H, Morita M, Mio T, Yasuda T, Sugita T, Hirai T.

J Thorac Oncol. 2019 Mar;14(3):468-474. doi: 10.1016/j.jtho.2018.10.167. Epub 2018 Nov 20.


Nivolumab-induced severe acute kidney injury with a long latent phase in a patient with non-small-cell lung cancer: A case report.

Uchida N, Tsuji S, Fujita K, Koizumi M, Moriyoshi K, Mio T.

Clin Case Rep. 2018 Oct 2;6(11):2185-2188. doi: 10.1002/ccr3.1848. eCollection 2018 Nov.


An implicit threat: dolutegravir-induced schizophrenic brief psychotic disorder and persistent cenesthopathy.

Kanai O, Fujita K, Mio T.

AIDS. 2018 Nov 28;32(18):2853-2854. doi: 10.1097/QAD.0000000000002029. No abstract available.


Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer.

Tanaka H, Sase H, Tsukaguchi T, Hasegawa M, Tanimura H, Yoshida M, Sakata K, Fujii T, Tachibana Y, Takanashi K, Higashida A, Hasegawa K, Ono Y, Oikawa N, Mio T.

Mol Cancer Ther. 2018 Dec;17(12):2519-2529. doi: 10.1158/1535-7163.MCT-17-1180. Epub 2018 Sep 21.


Association between Mycobacterium avium complex lung disease and serum vitamin D status, antimicrobial peptide levels, and bone mineral density.

Fujita K, Ito Y, Oguma T, Mio T, Niimi A, Hirai T.

Medicine (Baltimore). 2018 Sep;97(38):e12463. doi: 10.1097/MD.0000000000012463.


Acquired JHDM1D-BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric Cancer.

Sase H, Nakanishi Y, Aida S, Horiguchi-Takei K, Akiyama N, Fujii T, Sakata K, Mio T, Aoki M, Ishii N.

Mol Cancer Ther. 2018 Oct;17(10):2217-2225. doi: 10.1158/1535-7163.MCT-17-1022. Epub 2018 Jul 25.


Two cases of cavitary lung cancer with concomitant chronic infectious disease.

Fujita K, Uchida N, Horimoto K, Hashimoto M, Nakatani K, Moriyoshi K, Sawai S, Mio T.

Respir Med Case Rep. 2018 May 11;24:122-124. doi: 10.1016/j.rmcr.2018.05.010. eCollection 2018.


Efficacy and safety of nivolumab in non-small cell lung cancer with preexisting interstitial lung disease.

Kanai O, Kim YH, Demura Y, Kanai M, Ito T, Fujita K, Yoshida H, Akai M, Mio T, Hirai T.

Thorac Cancer. 2018 Jul;9(7):847-855. doi: 10.1111/1759-7714.12759. Epub 2018 May 21.


Retreatment with pembrolizumab in advanced non-small cell lung cancer patients previously treated with nivolumab: emerging reports of 12 cases.

Fujita K, Uchida N, Kanai O, Okamura M, Nakatani K, Mio T.

Cancer Chemother Pharmacol. 2018 Jun;81(6):1105-1109. doi: 10.1007/s00280-018-3585-9. Epub 2018 Apr 19.


Cutaneous lymphangitis carcinomatosa made cervicofacial oedema intractable in a patient with superior vena cava syndrome.

Kashihara E, Kanai O, Okamura M, Mio T.

BMJ Case Rep. 2018 Apr 19;2018. pii: bcr-2018-224206. doi: 10.1136/bcr-2018-224206.


Efficacy and safety of nivolumab in previously treated patients with non-small cell lung cancer: A multicenter retrospective cohort study.

Fujimoto D, Yoshioka H, Kataoka Y, Morimoto T, Kim YH, Tomii K, Ishida T, Hirabayashi M, Hara S, Ishitoko M, Fukuda Y, Hwang MH, Sakai N, Fukui M, Nakaji H, Morita M, Mio T, Yasuda T, Sugita T, Hirai T.

Lung Cancer. 2018 May;119:14-20. doi: 10.1016/j.lungcan.2018.02.017. Epub 2018 Mar 2.


Acute progression of aspergillosis in a patient with lung cancer receiving nivolumab.

Uchida N, Fujita K, Nakatani K, Mio T.

Respirol Case Rep. 2017 Dec 22;6(2):e00289. doi: 10.1002/rcr2.289. eCollection 2018 Feb.


Acute onset of ulcerative colitis during chemoradiotherapy for anaplastic lymphoma kinase-positive lung adenocarcinoma.

Fujita K, Mizumoto Y, Moriyoshi K, Araki N, Mio T.

Respirol Case Rep. 2017 Dec 22;6(2):e00288. doi: 10.1002/rcr2.288. eCollection 2018 Feb.


Concurrence of nivolumab-induced interstitial lung disease and cancer invasion.

Kanai O, Nakatani K, Fujita K, Okamura M, Mio T.

Respirol Case Rep. 2017 Aug 11;5(6):e00257. doi: 10.1002/rcr2.257. eCollection 2017 Nov.


Nasogastric tube-administered alectinib achieved long-term survival in a crizotinib-refractory nonsmall cell lung cancer patient with a poor performance status.

Kanai O, Kim YH, Nakatani K, Fujita K, Mio T.

Clin Case Rep. 2017 Apr 26;5(6):927-930. doi: 10.1002/ccr3.973. eCollection 2017 Jun.


Small cell lung cancer transformation during immunotherapy with nivolumab: A case report.

Imakita T, Fujita K, Kanai O, Terashima T, Mio T.

Respir Med Case Rep. 2017 Mar 29;21:52-55. doi: 10.1016/j.rmcr.2017.03.019. eCollection 2017.


Giant mature teratoma in the mediastinum presenting with rapid growth.

Fujita K, Hayashi K, Motoishi M, Sawai S, Terashima T, Mio T.

Oxf Med Case Reports. 2016 Dec 1;2016(12):omw093. doi: 10.1093/omcr/omw093. eCollection 2016 Dec.


Concomitant T790M mutation and small-cell lung cancer transformation after acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor.

Fujita K, Kim YH, Yoshizawa A, Mio T, Mishima M.

Respirol Case Rep. 2016 Dec 1;5(1):e00206. doi: 10.1002/rcr2.206. eCollection 2017 Jan.


Preliminary Evaluation of a Sitafloxacin-Containing Regimen for Relapsed or Refractory Pulmonary Mycobacterium avium Complex Disease.

Fujita K, Fujita M, Ito Y, Hirai T, Mio T, Watanabe K, Mishima M.

Open Forum Infect Dis. 2016 Jul 13;3(3):ofw147. eCollection 2016 Sep.


Anti-PD1 Antibody Treatment and the Development of Acute Pulmonary Tuberculosis.

Fujita K, Terashima T, Mio T.

J Thorac Oncol. 2016 Dec;11(12):2238-2240. doi: 10.1016/j.jtho.2016.07.006. Epub 2016 Jul 14.


Impact of industrial structure and soil exposure on the regional variations in pulmonary nontuberculous mycobacterial disease prevalence.

Hamada S, Ito Y, Hirai T, Murase K, Tsuji T, Fujita K, Mio T, Maekawa K, Fujii T, Ono S, Nishimura T, Hayashi A, Komori T, Fujita N, Niimi A, Ichiyama S, Chin K, Mishima M.

Int J Mycobacteriol. 2016 Jun;5(2):170-6. doi: 10.1016/j.ijmyco.2016.02.006. Epub 2016 Mar 8.


Severe exacerbation or manifestation of primary disease related to nivolumab in non-small-cell lung cancer patients with poor performance status or brain metastases.

Kanai O, Fujita K, Okamura M, Nakatani K, Mio T.

Ann Oncol. 2016 Jul;27(7):1354-6. doi: 10.1093/annonc/mdw148. Epub 2016 Mar 31. No abstract available.


Repetitive responses to nanoparticle albumin-bound paclitaxel and carboplatin in malignant pleural mesothelioma.

Kanai O, Fujita K, Nakatani K, Mio T.

Respirol Case Rep. 2016 Jan 14;4(1):28-31. doi: 10.1002/rcr2.145. eCollection 2016 Mar.


Rapidly progressive sarcomatoid malignant mesothelioma of the pleura mimicking pulmonary empyema.

Fujita K, Kim YH, Nakatani K, Mio T.

Clin Case Rep. 2015 Oct;3(10):875-8. doi: 10.1002/ccr3.371. Epub 2015 Sep 7.


Patient with lung adenocarcinoma manifesting as an unusual migratory pulmonary infiltration.

Fujita K, Shim J, Nakatani K, Mio T.

BMJ Case Rep. 2015 Jul 31;2015. pii: bcr2015211771. doi: 10.1136/bcr-2015-211771. No abstract available.


Hypereosinophilic obliterative bronchiolitis clinically mimicking diffuse panbronchiolitis: four-year follow-up.

Kobayashi T, Inoue H, Mio T.

Intern Med. 2015;54(9):1091-4. doi: 10.2169/internalmedicine.54.3767. Epub 2015 May 1.


The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor.

Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Sakata K, Sase H, Isobe T, Morikami K, Shindoh H, Mio T, Ebiike H, Taka N, Aoki Y, Ishii N.

Mol Cancer Ther. 2014 Nov;13(11):2547-58. doi: 10.1158/1535-7163.MCT-14-0248. Epub 2014 Aug 28.


Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome.

Hayama M, Shime N, Mio T.

BMJ Case Rep. 2014 May 23;2014. pii: bcr2014203764. doi: 10.1136/bcr-2014-203764.


Massive haemoptysis following dabigatran administration in a patient with bronchiectasis.

Hayama M, Inoue H, Wada H, Mio T.

BMJ Case Rep. 2014 Feb 19;2014. pii: bcr2013201001. doi: 10.1136/bcr-2013-201001.


[A case of lung paragonimiasis superinfection with hookworm presenting difficulty in discrimination].

Minezaki S, Hirama T, Shiono A, Masumoto A, Mio T, Utsugi H, Uchida Y, Kaga A, Hagiwara K, Kanazawa M.

Kansenshogaku Zasshi. 2013 Nov;87(6):756-60. Japanese.


[Case report; a case of lung and skin nocardiosis in a non-immunocompromised patient].

Masumoto A, Hirama T, Kawana H, Kawashima A, Shiono A, Mio T, Nagata M, Hagiwara K, Kanazawa M.

Nihon Naika Gakkai Zasshi. 2013 Oct 10;102(10):2679-81. Japanese. No abstract available.


[A case of postoperative thymic carcinoma recurrence that was effectively treated with combination chemotherapy of nedaplatin and docetaxel].

Kataoka Y, Okamoto K, Kitamura T, Hayama M, Tanaka H, Kanai O, Kobayashi T, Okamura M, Inoue H, Oshio M, Motoishi M, Mio T, Sawai S, Hanaoka J.

Gan To Kagaku Ryoho. 2013 Dec;40(13):2561-3. Review. Japanese.


Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non-small-cell lung cancer.

Ono N, Yamazaki T, Tsukaguchi T, Fujii T, Sakata K, Suda A, Tsukuda T, Mio T, Ishii N, Kondoh O, Aoki Y.

Cancer Sci. 2013 Oct;104(10):1346-52. doi: 10.1111/cas.12237. Epub 2013 Aug 20.


Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer.

Fukudo M, Ikemi Y, Togashi Y, Masago K, Kim YH, Mio T, Terada T, Teramukai S, Mishima M, Inui K, Katsura T.

Clin Pharmacokinet. 2013 Jul;52(7):593-609. doi: 10.1007/s40262-013-0058-5.


Phase II study of carboplatin and pemetrexed in advanced non-squamous, non-small-cell lung cancer: Kyoto Thoracic Oncology Research Group Trial 0902.

Kim YH, Hirabayashi M, Togashi Y, Hirano K, Tomii K, Masago K, Kaneda T, Yoshimatsu H, Otsuka K, Mio T, Tomioka H, Suzuki Y, Mishima M.

Cancer Chemother Pharmacol. 2012 Aug;70(2):271-6. doi: 10.1007/s00280-012-1910-2. Epub 2012 Jun 30.


Customized chemotherapy based on epidermal growth factor receptor mutation status for elderly patients with advanced non-small-cell lung cancer: a phase II trial.

Fujita S, Katakami N, Masago K, Yoshioka H, Tomii K, Kaneda T, Hirabayashi M, Kunimasa K, Morizane T, Mio T.

BMC Cancer. 2012 May 21;12:185. doi: 10.1186/1471-2407-12-185.


Nitric oxide (NO) enhances pemetrexed cytotoxicity via NO‑cGMP signaling in lung adenocarcinoma cells in vitro and in vivo.

Nagai H, Yasuda H, Hatachi Y, Xue D, Sasaki T, Yamaya M, Sakamori Y, Togashi Y, Masago K, Ito I, Kim YH, Mio T, Mishima M.

Int J Oncol. 2012 Jul;41(1):24-30. doi: 10.3892/ijo.2012.1461. Epub 2012 May 2.


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